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Cited by 268

The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.

Communication is the key: biofilms, quorum sensing, formation and prevention

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1Department of Biochemistry and Molecular Biology, University of Bucharest, Faculty of Biology, Bucharest, Romania, Preda, Veronica Georgiana, Săndulescu, Oana, Department of Infectious Diseases I, Carol Davila University of Medicine and Pharmacy, National Institute for Infectious Diseases “Prof. Dr. Matei Balș”, Bucharest, Romania·2019·Discoveries
DOI 10.15190/d.2019.13
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Abstract

Antibiotic resistance is a relevant topic nowadays, representing one of the main causes of infection-related mortality and morbidity at a global level. This phenomenon is worrisome and represents an area of interest for both clinical practice and fundamental research. One important mechanism whereby bacteria acquire resistance to antibiotics and evade the immune system is by forming biofilms. It is estimated that ~80% of the bacteria producing chronic infections can form biofilms. During the process of biofilm formation microorganisms have the ability to communicate with each other through quorum sensing. Quorum sensing regulates the metabolic activity of planktonic cells, and it can induce microbial biofilm formation and increased virulence. In this review we describe the biofilm formation process, quorum sensing, quorum quenching, several key infectious bacteria producing biofilm, methods of prevention and their challenges and limitations. Although progress has been made in the prevention and treatment of biofilm-driven infections, new strategies are required and have to be further developed.

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Metadata

Authors
1Department of Biochemistry and Molecular Biology, U. O. B., Preda, V. G., Săndulescu, O., & Department of Infectious Diseases I, C. D. U. O. M. A. P.
Venue
Discoveries
Publisher
Applied Systems, srl
Published
2019-09-30
Volume
7
Issue
3
Pages
e10
ISSN
2359-7232 (ISSN-L)
DOI
10.15190/d.2019.13
OpenAlex
W2978578629
Cited by
268
References
63
FWCI
2.29
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Communication is the key: biofilms, quorum sensing, formation and prevention. https://app.cochat.ai/papers/10.15190/d.2019.13
The paper
1Department of Biochemistry and Molecular Biology, U. O. B., Preda, V. G., Săndulescu, O., & Department of Infectious Diseases I, C. D. U. O. M. A. P. (2019). Communication is the key: biofilms, quorum sensing, formation and prevention. Discoveries. https://doi.org/10.15190/d.2019.13

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.