The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Laboratory Investigation of Deaths Due to Anaphylaxis
Abstract
To establish a useful laboratory protocol to investigate possible cases of fatal anaphylaxis, we measured mast-cell-derived tryptase levels and allergen-specific immunoglobulin E (IgE) antibody levels in sera obtained prior to or within 24 h after death from 19 anaphylaxis victims. Elevated serum tryptase levels (range = 12 ng/mL to 150 μg/mL) were found in nine of nine Hymenoptera sting fatalities, six of eight food-induced fatalities, and two of two reactions to diagnostic/therapeutic agents. Tryptase levels were normal (<10 ng/mL) in 57 sequential sera obtained postmortem from six control patients. Tryptase could not be measured by pleural or pericardial fluids for technical reasons. Serum IgE antibodies were elevated in five of the nine Hymenoptera sting fatalities and in eight of the eight fatal food reactions; assays were unavailable for the two diagnostic/therapeutic agents. If elevated, the victim's serum IgE antibodies to food could be used to identify allergens in uneaten portions of foods consumed shortly before the anaphylactic event. IgE antibodies were moderately stable during storage in a variety of anticoagulants at room temperature for up to 11 weeks. Elevated mast-cell-derived tryptase levels in postmortem sera reflect antemortem mast cell activation and may be used as a marker for fatal anaphylaxis. If assays are available for IgE antibodies to relevant allergens, such assays provide evidence for antemortem sensitization; these assays may be modified to identify allergens in foods consumed by victims of food-induced anaphylaxis.
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Citations
Cites
Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis
Schwartz, L. B., Metcalfe, D. D., Miller, J. S., Earl, H., & Sullivan, T. (1987) · New England Journal of Medicine · doi:10.1056/nejm198706253162603 · Cited by 784
Self-citationSchwartz, L. B., Yunginger, J. W., Miller, J., Bokhari, R., & Dull, D. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114051 · Cited by 456
Self-citation
Cited by
Fatal and Near-Fatal Anaphylactic Reactions to Food in Children and Adolescents
Sampson, H. A., Mendelson, L., & Rosen, J. P. (1992) · New England Journal of Medicine · doi:10.1056/nejm199208063270603 · Cited by 1,609
Diagnostic Value of Tryptase in Anaphylaxis and Mastocytosis
Schwartz, L. B. (2006) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2006.05.010 · Cited by 477
Self-citationAnaphylaxis—a practice parameter update 2015
Lieberman, P., Nicklas, R. A., Randolph, C., Oppenheimer, J., Bernstein, D., Bernstein, J., Ellis, A., Golden, D. B. K., Greenberger, P., Kemp, S., et al. (2015) · Annals of Allergy, Asthma & Immunology · doi:10.1016/j.anai.2015.07.019 · Cited by 474
Epidemiology of life-threatening and lethal anaphylaxis: a review
Moneret‐Vautrin, D. A., Morisset, M., Flabbee, J., Beaudouin, E., & Kanny, G. (2005) · Allergy · doi:10.1111/j.1398-9995.2005.00785.x · Cited by 386
Development of a new, more sensitive immunoassay for human tryptase: use in systemic anaphylaxis
Schwartz, L. B., Bradford, T. R., Rouse, C., Irani, A.-M., Rasp, G., Van Der Zwan, J. K., & Van Der Linden, P.-W. G. (1994) · Journal of Clinical Immunology · doi:10.1007/bf01533368 · Cited by 263
Self-citationSala-Cunill, A., Cardona, V., Labrador-Horrillo, M., Luengo, O., Esteso, O., Garriga, T., Vicario, M., & Guilarte, M. (2013) · International Archives of Allergy and Immunology · doi:10.1159/000339749 · Cited by 179
Soy protein allergy: Incidence and relative severity
Cordle, C. T. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.5.1213s · Cited by 162
Human mast cell tryptase in biology and medicine
Vitte, J. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2014.04.001 · Cited by 152
Clinical utility of tryptase levels in systemic mastocytosis and associated hematologic disorders
Schwartz, L. B. (2001) · Leukemia Research · doi:10.1016/s0145-2126(01)00020-0 · Cited by 110
Self-citationVitte, J., Sabato, V., Tacquard, C., Garvey, L. H., Michel, M., Mertes, P.-M., Ebo, D. G., Schwartz, L. B., & Castells, M. C. (2021) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2021.03.011 · Cited by 79
Self-citation(1990) · PubMed · Cited by 68
Dua, S., Dowey, J., Foley, L., Islam, S., King, Y., Ewan, P., & Clark, A. T. (2018) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2018.01.006 · Cited by 67
Elevated serum tryptase in exercise-induced anaphylaxis
Schwartz, H. J. (1995) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(95)70139-7 · Cited by 57
Metadata
- Authors
- Yunginger, J., Nelson, D., Squillace, D., Jones, R., Holley, K., Hyma, B., Biedrzycki, L., Sweeney, K., Sturner, W., & Schwartz, L.
- Venue
- Journal of Forensic Sciences
- Publisher
- ASTM International
- Published
- 1991-05-01
- Volume
- 36
- Issue
- 3
- Pages
- 857-865
- ISSN
- 0022-1198 (ISSN-L)
- OpenAlex
- W1482796251
- Cited by
- 252
- References
- 2
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- closed
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