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Interpreting DNA Mixtures
Abstract
The interpretation of mixed DNA stains is explained in the context of likelihood ratios. The probabilities for the mixed-stain profile are evaluated under alternative explanations that specify the numbers of contributors and the profiles of any known contributors. Interpretations based simply on the frequencies with which random members of a population would not be excluded from a mixed-stain profile do not make use of all the information, and may overstate the strength of the evidence against included people. The effects of the numbers of contributors depends on whether all the alleles at a locus are present in the mixed stain. A general equation is given to allow likelihood ratios to be calculated, and includes the “2p” modification suggested by the 1996 NRC report. This modification is not always conservative. A computer program to perform calculations is available.
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Cited by
Homer, N., Szelinger, S., Redman, M., Duggan, D., Tembe, W., Muehling, J., Pearson, J. V., Stephan, D. A., Nelson, S. F., & Craig, D. W. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000167 · Cited by 1,221
Encoded evidence: DNA in forensic analysis
Jobling, M. A., & Gill, P. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1455 · Cited by 623
Gill, P., Brenner, C. H., Buckleton, J. S., Carracedo, A., Krawczak, M., Mayr, W. R., Morling, N., Prinz, M., Schneider, P. M., & Weir, B. S. (2006) · Forensic Science International · doi:10.1016/j.forsciint.2006.04.009 · Cited by 403
Self-citationSubjectivity and bias in forensic DNA mixture interpretation
Dror, I. E., & Hampikian, G. (2011) · Science & Justice · doi:10.1016/j.scijus.2011.08.004 · Cited by 348
Short-read, high-throughput sequencing technology for STR genotyping
Bornman, D., Hester, M., Schuetter, J., Kasoji, M., Minard-Smith, A., Barden, C., Nelson, S., Godbold, G., Baker, C., Yang, B., et al. (2012) · BioTechniques · doi:10.2144/000113857 · Cited by 93
Metadata
- Authors
- Weir, B., Triggs, C., Starling, L., Stowell, L., Walsh, K., & Buckleton, J.
- Venue
- Journal of Forensic Sciences
- Publisher
- ASTM International
- Published
- 1997-03-01
- Volume
- 42
- Issue
- 2
- Pages
- 213-222
- ISSN
- 0022-1198 (ISSN-L)
- OpenAlex
- W2151343700
- Cited by
- 174
- References
- 0
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Weir, B., Triggs, C., Starling, L., Stowell, L., Walsh, K., & Buckleton, J. (1997). Interpreting DNA Mixtures. Journal of Forensic Sciences. https://doi.org/10.1520/jfs14100j
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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