The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Investigating Mitochondria as a Target for Treating Age-Related Macular Degeneration
Open accessAbstract
Age-related macular degeneration (AMD) is the leading cause of blindness among older adults in the developed world. Although the pathological mechanisms have not been definitively elucidated, evidence suggests a key role for mitochondrial (mt) dysfunction. The current study used our unique collection of human retinal samples graded for the donor's stage of AMD to address fundamental questions about mtDNA damage in the retina. To evaluate the distribution of mtDNA damage in the diseased retina, damage in the retinal pigment epithelium (RPE) and neural retina from individual donors were compared. To directly test a long-held belief that the macula is selectively damaged with AMD, RPE mtDNA damage was measured in the macula and peripheral sections from individual donors. Small segments of the entire mt genome were examined to determine whether specific regions are preferentially damaged. Our results show that mtDNA damage is limited to the RPE, equivalent mtDNA damage is found in the macular and peripheral RPE, and sites of damage are localized to regions of the mt genome that may impact mt function. These results provide a scientific basis for targeting the RPE mitochondria with therapies that protect and enhance mt function as a strategy for combating AMD.
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Cited by
Mitochondrial DNA in innate immune responses and inflammatory pathology
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Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration
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EMT and EndMT: Emerging Roles in Age-Related Macular Degeneration
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Metadata
- Authors
- Terluk, M. R., Kapphahn, R. J., Soukup, L. M., Gong, H., Gallardo, C., Montezuma, S. R., & Ferrington, D. A.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2015-05-06
- Volume
- 35
- Issue
- 18
- Pages
- 7304-7311
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1955438350
- Cited by
- 253
- References
- 34
- FWCI
- 18.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Terluk, M. R., Kapphahn, R. J., Soukup, L. M., Gong, H., Gallardo, C., Montezuma, S. R., & Ferrington, D. A. (2015). Investigating Mitochondria as a Target for Treating Age-Related Macular Degeneration. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.0190-15.2015
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
