Oxidative stress and aberrant signaling in aging and cognitive decline

Free Radicals in the Physiological Control of Cell Function

Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855 · see citing works

Oxidants, oxidative stress and the biology of ageing

Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413 · see citing works

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works

Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases

Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455 · see citing works

Hydroperoxide metabolism in mammalian organs.

Chance, B., Sies, H., & Boveris, A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.527 · Cited by 5,827 · see citing works

Oxyl radicals, redox-sensitive signalling cascades and antioxidants

Genestra, M. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.04.009 · Cited by 4,930 · see citing works

Mitochondria, Oxidants, and Aging

Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388 · see citing works

Resveratrol improves health and survival of mice on a high-calorie diet

Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290 · see citing works

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882 · see citing works

The Free Radical Theory of Aging Matures

BECKMAN, K. B., & AMES, B. N. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.2.547 · Cited by 3,879 · see citing works

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796 · see citing works

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J.-I., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., et al. (2006) · Nature · doi:10.1038/nature04723 · Cited by 3,500 · see citing works

A C. elegans mutant that lives twice as long as wild type

Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387 · see citing works

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160 · see citing works

Oxidative Stress, Caloric Restriction, and Aging

Sohal, R. S., & Weindruch, R. H. (1996) · Science · doi:10.1126/science.273.5271.59 · Cited by 3,133 · see citing works

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

Kimura, K. D., Tissenbaum, H. A., Liu, Y., & Ruvkun, G. (1997) · Science · doi:10.1126/science.277.5328.942 · Cited by 2,250 · see citing works

Iron, brain ageing and neurodegenerative disorders

Zecca, L., Youdim, M. B. H., Riederer, P., Connor, J. R., & Crichton, R. R. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1537 · Cited by 1,801 · see citing works

The p66shc adaptor protein controls oxidative stress response and life span in mammals

Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., & Pelicci, P. G. (1999) · Nature · doi:10.1038/46311 · Cited by 1,712 · see citing works

The roles of intracellular protein-degradation pathways in neurodegeneration

Rubinsztein, D. C. (2006) · Nature · doi:10.1038/nature05291 · Cited by 1,625 · see citing works

Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study

Nixon, R. A., Wegiel, J., Kumar, A., Yu, W. H., Peterhoff, C., Cataldo, A., & Cuervo, A. M. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/64.2.113 · Cited by 1,588 · see citing works

Gene expression profile of aging and its retardation by caloric restriction

Lee, C.-K., Klopp, R. G., Weindruch, R., & Prolla, T. A. (1999) · Science · doi:10.1126/science.285.5432.1390 · Cited by 1,473 · see citing works

Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in Drosophila melanogaster

Orr, W. C., & Sohal, R. S. (1994) · Science · doi:10.1126/science.8108730 · Cited by 1,461 · see citing works

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

Rogina, B., & Helfand, S. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404184101 · Cited by 1,361 · see citing works

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V., & Benzer, S. (2004) · Current Biology · doi:10.1016/j.cub.2004.03.059 · Cited by 1,293 · see citing works

Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in <i>C. elegans</i>

Meléndez, A., Tallóczy, Z., Seaman, M., Eskelinen, E.-L., Hall, D. H., & Levine, B. (2003) · Science · doi:10.1126/science.1087782 · Cited by 1,270 · see citing works

The Ubiquitin Proteasome System in Neurodegenerative Diseases

Ciechanover, A. J., & Brundin, P. (2003) · Neuron · doi:10.1016/s0896-6273(03)00606-8 · Cited by 984 · see citing works

Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons

Parkes, T. L., Elia, A., Dickinson, D., Hilliker, A. J., Phillips, J. P., & Boulianne, G. L. (1998) · Nature Genetics · doi:10.1038/534 · Cited by 862 · see citing works

Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine

Bindokas, V. P., Jordán, J., Lee, C., & Miller, R. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-04-01324.1996 · Cited by 859 · see citing works

Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah

Lin, Y.-J., Seroude, L., & Benzer, S. (1998) · Science · doi:10.1126/science.282.5390.943 · Cited by 804 · see citing works

Calorie restriction–the SIR2 connection

Guarente, L., & Picard, F. (2005) · Cell · doi:10.1016/j.cell.2005.01.029 · Cited by 793 · see citing works

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

Sohal, R. S., Ku, H.-H., Agarwal, S., Forster, M. J., & Lal, H. (1994) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(94)90104-x · Cited by 788 · see citing works

Resveratrol Prolongs Lifespan and Retards the Onset of Age-Related Markers in a Short-Lived Vertebrate

Valenzano, D. R., Tozzini, E. T., Genade, T., Cattaneo, A., Domenici, L., & Cellerino, A. (2006) · Current Biology · doi:10.1016/j.cub.2005.12.038 · Cited by 786 · see citing works

Does oxidative damage to DNA increase with age?

Hamilton, M. L., Van Remmen, H., Drake, J. A., Yang, H., Guo, Z. M., Kewitt, K., Walter, C. A., & Richardson, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171202698 · Cited by 768 · see citing works

The biochemistry of sirtuins

Sauve, A. A., Wolberger, C., Schramm, V. L., & Boeke, J. D. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133500 · Cited by 763 · see citing works

Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer

Speakman, J. R., Talbot, D. A., Selman, C., Snart, S., McLaren, J. S., Redman, P., Krol, E., Jackson, D. M., Johnson, M. S., & Brand, M. D. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00097.x · Cited by 761 · see citing works

Caloric Intake and Aging

Weindruch, R. H., & Sohal, R. S. (1997) · New England Journal of Medicine · doi:10.1056/nejm199710023371407 · Cited by 743 · see citing works

Molecular pathways to neurodegeneration

Bossy-Wetzel, E., Schwarzenbacher, R., & Lipton, S. A. (2004) · Nature Medicine · doi:10.1038/nm1067 · Cited by 740 · see citing works

The daf‐2 gene network for longevity regulates oxidative stress resistance and Mn‐superoxide dismutase gene expression in Caenorhabditis elegans

Honda, Y., & Honda, S. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.11.1385 · Cited by 730 · see citing works

The mitochondrial‐lysosomal axis theory of aging

Brunk, U. T., & Terman, A. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.02869.x · Cited by 729 · see citing works

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

Carney, J. M., Starke-Reed, P. E., Oliver, C., Landum, R. W., Cheng, M. S., Wu, J., & Floyd, R. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3633 · Cited by 724 · see citing works

Parallel information processing in the water maze: Evidence for independent memory systems involving dorsal striatum and hippocampus

McDonald, R. J., & White, N. M. (1994) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(05)80009-3 · Cited by 722 · see citing works

Neuroprotection by the Metabolic Antioxidant α-Lipoic Acid

Packer, L., Tritschler, H. J., & Wessel, K. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00269-9 · Cited by 639 · see citing works

Mechanisms of aging: an appraisal of the oxidative stress hypothesis1,2 1This article is part of a series of reviews on “Oxidative Stress and Aging.” The full list of papers may be found on the homepage of the journal. 2Guest Editor: Rajindar S. Sohal

Sohal, R. S., Mockett, R. J., & Orr, W. C. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00886-9 · Cited by 593 · see citing works

Redox regulation of cardiac calcium channels and transporters

Zima, A. V., & Blatter, L. A. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.02.019 · Cited by 592 · see citing works

Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer’s disease

Rinaldi, P., Polidori, M. C., Metastasio, A., Mariani, E., Mattioli, P., Cherubini, A., Catani, M., Cecchetti, R., Senin, U., & Mecocci, P. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00031-9 · Cited by 562 · see citing works

Antioxidant and Prooxidant Activities of α-Lipoic Acid and Dihydrolipoic Acid

Moini, H., Packer, L., & Saris, N.-E. L. (2002) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2002.9437 · Cited by 533 · see citing works

Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl- l -carnitine and/or R -α-lipoic acid

Liu, J., Head, E., Gharib, A., Yuan, W., Ingersoll, R. T., Hagen, T. M., Cotman, C. W., & Ames, B. N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261709299 · Cited by 504 · see citing works

Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain.

Forster, M. J., Dubey, A., Dawson, K. M., Stutts, W. A., Lal, H., & Sohal, R. S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4765 · Cited by 494 · see citing works

Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse

Aoyama, K., Suh, S. W., Hamby, A. M., Liu, J., Chan, W. Y., Chen, Y., & Swanson, R. A. (2006) · Nature Neuroscience · doi:10.1038/nn1609 · Cited by 484 · see citing works

Beneficial effects of moderate exercise on mice aging: survival, behavior, oxidative stress, and mitochondrial electron transfer

Navarro, A., Gómez, C., López-Cepero, J. M., & Boveris, A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00208.2003 · Cited by 464 · see citing works

The Response of Muscle Protein Anabolism to Combined Hyperaminoacidemia and Glucose-Induced Hyperinsulinemia Is Impaired in the Elderly¹

Volpi, E., Mittendorfer, B., Rasmussen, B. B., & Wolfe, R. R. (2000) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jcem.85.12.7021 · Cited by 464 · see citing works

The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans.

Dorman, J. B., Albinder, B., Shroyer, T., & Kenyon, C. J. (1995) · Genetics · doi:10.1093/genetics/141.4.1399 · Cited by 449 · see citing works

GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1α

Lerin, C., Rodgers, J. T., Kalume, D. E., Kim, S.-H., Pandey, A., & Puigserver, P. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.013 · Cited by 443 · see citing works

Genetics and the Specificity of the Aging Process

Hekimi, S., & Guarente, L. (2003) · Science · doi:10.1126/science.1082358 · Cited by 434 · see citing works

Reactive oxygen species and synaptic plasticity in the aging hippocampus

Serrano, F., & Klann, E. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2004.05.002 · Cited by 421 · see citing works

Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain

Soong, N. W., Hinton, D. R., Cortopassi, G. A., & Arnheim, N. (1992) · Nature Genetics · doi:10.1038/ng1292-318 · Cited by 414 · see citing works

Role of membrane transport in metabolism and function of glutathione in mammals

Bannai, S., & Tateishi, N. (1986) · The Journal of Membrane Biology · doi:10.1007/bf01870891 · Cited by 386 · see citing works

Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics

Liu, R., Liu, I. Y., Bi, X., Thompson, R. F., Doctrow, S. R., Malfroy, B., & Baudry, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1332809100 · Cited by 365 · see citing works

Evidence That Increased Hippocampal Expression of the Cytokine Interleukin-1β Is a Common Trigger for Age- and Stress-Induced Impairments in Long-Term Potentiation

Murray, C. A., & Lynch, M. A. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-08-02974.1998 · Cited by 359 · see citing works

The Relation Between Antioxidants and Memory Performance in the Old and Very Old

Perrig, W. J., Perrig, P., & Stähelin, H. B. (1997) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1997.tb01476.x · Cited by 344 · see citing works

The role of mitochondrial oxidative stress in aging

Sastre, J. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00184-9 · Cited by 342 · see citing works

Mitochondrial calcium and oxidative stress as mediators of ischemic brain injury

Starkov, A. A., Chinopoulos, C., & Fiskum, G. M. (2004) · Cell Calcium · doi:10.1016/j.ceca.2004.02.012 · Cited by 339 · see citing works

Mitochondrial reactive oxygen species and Ca ²⁺ signaling

Camello-Almaraz, C., Gomez-Pinilla, P. J., Pozo, M. J., & Camello, P. J. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00217.2006 · Cited by 336 · see citing works

Increased interleukin-6 expression by microglia from brain of aged mice

Ye, S.-M., & Johnson, R. W. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00217-3 · Cited by 327 · see citing works

Involvement of hippocampal synaptic plasticity in age-related memory decline

Foster, T. C. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00017-x · Cited by 317 · see citing works

Autophagy in neurodegenerative disease: friend, foe or turncoat?

Nixon, R. A. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.07.003 · Cited by 315 · see citing works

Rat brain and liver mitochondria develop oxidative stress and lose enzymatic activities on aging

Navarro, A., & Boveris, A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00226.2004 · Cited by 309 · see citing works

Patterns of Motor Impairment in Normal Aging, Mild Cognitive Decline, and Early Alzheimer' Disease

Kluger, A., Gianutsos, J. G., Golomb, J. B., Ferris, S. H., GEORGE, A. E., Franssen, E., & Reisberg, ‌. (1997) · The Journals of Gerontology Series B · doi:10.1093/geronb/52b.1.p28 · Cited by 304 · see citing works

Alterations of Antioxidant Enzymes and Oxidative Damage to Macromolecules in Different Organs of Rats During Aging

Tiana, L., Caib, Q., & Wei, H. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00025-2 · Cited by 300 · see citing works

Age-related changes in glutathione and glutathione-related enzymes in rat brain

Zhu, Y., Carvey, P. M., & Ling, Z. (2006) · Brain Research · doi:10.1016/j.brainres.2006.03.063 · Cited by 279 · see citing works

Cognitive Decline Is Associated with Systemic Oxidative Stress: The EVA Study

Berr, C., Balansard, B., Arnaud, J., Roussel, A., Alpérovitch, A., & EVA Study Group (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb02603.x · Cited by 279 · see citing works

Mitochondrial oxidative stress and cell death in astrocytes —requirement for stored Ca2+ and sustained opening of the permeability transition pore

Jacobson, J., & Duchen, M. R. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.6.1175 · Cited by 268 · see citing works

Effects of age and caloric restriction on glutathione redox state in mice

Rebrin, I., Kamzalov, S., & Sohal, R. S. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00388-5 · Cited by 243 · see citing works

Controlled trial of N-acetylcysteine for patients with probable Alzheimer’s disease

Adair, J. C., Knoefel, J. E., & Morgan, N. (2001) · Neurology · doi:10.1212/wnl.57.8.1515 · Cited by 240 · see citing works

Association of Antioxidants with Memory in a Multiethnic Elderly Sample Using the Third National Health and Nutrition Examination Survey

Perkins, A. J., Hendrie, H. C., Callahan, C. M., Gao, S., Unverzagt, F. W., Xu, Y., Hall, K. S., & Hui, S. L. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009915 · Cited by 237 · see citing works

Aging of the brain, entropy, and Alzheimer disease

Drachman, D. A. (2006) · Neurology · doi:10.1212/01.wnl.0000240127.89601.83 · Cited by 230 · see citing works

Dissociation of Hippocampal and Striatal Contributions to Spatial Navigation in the Water Maze

Devan, B. D., Goad, E. H., & Petri, H. L. (1996) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.0072 · Cited by 223 · see citing works

Insulin receptor signaling in long-term memory consolidation following spatial learningPreprint

Dou, J., Chen, M., Dufour, F., Alkon, D. L., & Zhao, W. (2005) · Learning & Memory · doi:10.1101/lm.88005 · Cited by 217 · see citing works

Cellular management of iron in the brain

Connor, J. R., & Menzies, S. L. (1995) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(95)00206-h · Cited by 213 · see citing works

Oxidative stress and ageing: is ageing a cysteine deficiency syndrome?

Dröge, W. (2005) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2005.1770 · Cited by 209 · see citing works

Delaying Brain Mitochondrial Decay and Aging with Mitochondrial Antioxidants and Metabolites

Liu, J., Atamna, H., Kuratsune, H., & Ames, B. N. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02090.x · Cited by 203 · see citing works

Amino Acids and Muscle Loss with Aging

Fujita, S., & Volpi, E. (2006) · Journal of Nutrition · doi:10.1093/jn/136.1.277s · Cited by 191 · see citing works

Postprandial Stimulation of Muscle Protein Synthesis in Old Rats Can Be Restored by a Leucine-Supplemented Meal

Dardevet, D. P., Sornet, C., Bayle, G., Prugnaud, J., Pouyet, C., & Grizard, J. (2002) · Journal of Nutrition · doi:10.1093/jn/132.1.95 · Cited by 185 · see citing works

Brain iron deposition and the free radical-mitochondrial theory of ageing

Schipper, H. M. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2004.02.001 · Cited by 177 · see citing works

A leucine‐supplemented diet restores the defective postprandial inhibition of proteasome‐dependent proteolysis in aged rat skeletal muscle

Combaret, L., Dardevet, D. P., Rieu, I., Pouch-Pélissier, M.-N., Béchet, D., Taillandier, D., Grizard, J., & Attaix, D. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.098004 · Cited by 165 · see citing works

Cysteine Concentration Regulates Cysteine Metabolism to Glutathione, Sulfate and Taurine in Rat Hepatocytes

Stipanuk, M. H., Coloso, R. M., Garcia, R. A. G., et al. (1992) · Journal of Nutrition · doi:10.1093/jn/122.3.420 · Cited by 165 · see citing works

Increased expression of heat shock proteins in rat brain during aging: relationship with mitochondrial function and glutathione redox state

Calabrese, V. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.01.003 · Cited by 162 · see citing works

Tissue-specific changes of mitochondrial functions in aged rats: Effect of a long-term dietary treatment with N-acetylcysteine

Cocco, T., Sgobbo, P., Clemente, M. T., Lopriore, B., Grattagliano, I., Paola, M. D., & Villani, G. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.11.034 · Cited by 157 · see citing works

(R)-α-Lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis

Suh, J. H., Wang, H., Liu, R.-M., Liu, J., & Hagen, T. M. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.12.020 · Cited by 147 · see citing works

Mitochondrial Theory of Aging: Importance to Explain Why Females Live Longer Than Males

Viña, J., Sastre, J., Pallardó, F. V., & Borrás, C. (2003) · Antioxidants and Redox Signaling · doi:10.1089/152308603770310194 · Cited by 145 · see citing works

Human Sir2 and the ‘silencing’ of p53 activity

Smith, J. S. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(02)02342-5 · Cited by 141 · see citing works

Iron accumulation in aging: modulation by dietary restriction

Cook, C. I., & Yu, B. P. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00005-0 · Cited by 137 · see citing works

Studies on lipid peroxidation and protein oxidation in the aging brain

Cini, M., & Moretti, A. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)80007-e · Cited by 137 · see citing works

The role of superoxide and hydroxyl radicals in phospholipid peroxidation catalysed by iron salts

Gutteridge, J. M. C. (1982) · FEBS Letters · doi:10.1016/0014-5793(82)80788-6 · Cited by 135 · see citing works

Mitochondrial DNA mutation and the ageing process: bioenergy and pharmacological intervention

Linnane, A. W., Zhang, C., Baumer, A., & Nagley, P. (1992) · Mutation Research/DNAging · doi:10.1016/0921-8734(92)90023-i · Cited by 127 · see citing works

Increasing striatal iron content associated with normal aging

Martin, W. R. W., Ye, F. Q., & Allen, P. S. (1998) · Movement Disorders · doi:10.1002/mds.870130214 · Cited by 122 · see citing works

Aging affects oxidative state in hippocampus, hypothalamus and adrenal glands of Wistar rats

Siqueira, I. R., Fochesatto, C., Torres, I. L. D. S., Dalmaz, C., & Netto, C. A. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.04.044 · Cited by 121 · see citing works

Biological Markers of Age-Related Memory Deficits

Foster, T. C. (2006) · CNS Drugs · doi:10.2165/00023210-200620020-00006 · Cited by 119 · see citing works

Alterations in oxidative stress scavenger system in aging rat brain and lymphocytes

Sandhu, S. K., & Kaur, G. (2002) · Biogerontology · doi:10.1023/a:1015643107449 · Cited by 115 · see citing works

The Effect of Aging on Glutathione and Cysteine Levels in Different Regions of the Mouse Brain

Chen, T. S., Richie, J. P., & Lang, C. A. (1989) · Experimental Biology and Medicine · doi:10.3181/00379727-190-42879 · Cited by 110 · see citing works

Motor learning deficits in aged rats are correlated with loss of cerebellar noradrenergic function

Bickford, P. C. (1993) · Brain Research · doi:10.1016/0006-8993(93)90279-v · Cited by 108 · see citing works

Dietary supplementation with (R)-α-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex

Suh, J., Moreau, R., Heath, S.-H. D., & Hagen, T. (2005) · Redox Report · doi:10.1179/135100005x21624 · Cited by 107 · see citing works

Age‐related oxidative protein damages in central nervous system of rats: modulatory role of grape seed extract

Balu, M., Sangeetha, P., Murali, G., & Panneerselvam, C. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2005.06.001 · Cited by 106 · see citing works

Regulation of interleukin-6 gene expression in brain of aged mice by nuclear factor κB

Ye, S.-M., & Johnson, R. W. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00316-2 · Cited by 103 · see citing works

Strategies Used by Hippocampal- and Caudate-Putamen-Lesioned Rats in a Learning Task

Oliveira, M. G. M., Bueno, O. F. A., Pomarico, A. C., & Gugliano, E. B. (1997) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.3761 · Cited by 102 · see citing works

The Redox State as a Correlate of Senescence and Wasting and as a Target for Therapeutic Intervention

Hack, V., Breitkreutz, R., Kinscherf, R., Röhrer, H., Bärtsch, P., Taut, F. J. H., Benner, A., & Dröge, W. (1998) · Blood · doi:10.1182/blood.v92.1.59.413a05_59_67 · Cited by 101 · see citing works

Proteomics Analyses of Specific Protein Oxidation and Protein Expression in Aged Rat Brain and Its Modulation by L-Acetylcarnitine: Insights Into the Mechanisms of Action of This Proposed Therapeutic Agent for CNS Disorders Associated with Oxidative Stress

Poon, H. F., Calabrese, V., Calvani, M., & Butterfield, D. A. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.381 · Cited by 99 · see citing works

New Twist on Neuronal Insulin Receptor Signaling in Health, Disease, and Therapeutics

Wada, A., Yokoo, H., Yanagita, T., & Kobayashi, H. (2005) · Journal of Pharmacological Sciences · doi:10.1254/jphs.crj05006x · Cited by 95 · see citing works

Neuronal ageing from an intraneuronal perspective: roles of endoplasmic reticulum and mitochondria

Toescu, E. C., & Verkhratsky, A. (2003) · Cell Calcium · doi:10.1016/s0143-4160(03)00142-8 · Cited by 92 · see citing works

Role of mitochondrial Ca2+ in the oxidative stress-induced dissipation of the mitochondrial membrane potential. Studies in isolated proximal tubular cells using the nephrotoxin 1,2-dichlorovinyl-L-cysteine.

van de Water, B., Zoeteweij, J. P., de Bont, H. J., Mulder, G. J., & Nagelkerke, J. F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36658-9 · Cited by 90 · see citing works

Gender difference in glutathione metabolism during aging in mice

Wang, H. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00036-6 · Cited by 89 · see citing works

N-Acetylcysteine protects against age-related decline of oxidative phosphorylation in liver mitochondria

Miquel, J., Ferrándiz, M. L., de Juan, E., Sevila, I., & Martı́nez, M. (1995) · European Journal of Pharmacology Environmental Toxicology and Pharmacology · doi:10.1016/0926-6917(95)90041-1 · Cited by 88 · see citing works

Drugs to Treat Age‐Related Neurodegenerative Problems The Final Frontier of Medical Science?

Bartus, R. T. (1990) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1990.tb01430.x · Cited by 87 · see citing works

Dietary antioxidant supplementation reverses age-related neuronal changes

O'Donnell, E., & Lynch, M. A. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00082-7 · Cited by 85 · see citing works

Regulation of cysteine dioxygenase and γ-glutamylcysteine synthetase is associated with hepatic cysteine level

Lee, J.-I., Londono, M. P., Hirschberger, L. L., & Stipanuk, M. H. (2004) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2003.10.005 · Cited by 84 · see citing works

Calorie restriction delays lipid oxidative damage in Drosophila melanogaster

Zheng, J., Mutcherson, R. J., & Helfand, S. L. (2005) · Aging Cell · doi:10.1111/j.1474-9726.2005.00159.x · Cited by 83 · see citing works

Age-associated changes in protein oxidation and proteasome activities in rat brain: Modulation by antioxidants

Mohsen, M. M. A. E., Iravani, M. M., Spencer, J. P. E., Rose, S., Fahim, A. T., Motawi, T. K., Ismail, N. A. F., & Jenner, P. G. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.07.201 · Cited by 83 · see citing works

Hippocampal Neurodegeneration in Aging

Gallagher, M., Landfield, P. W., McEwen, B. S., Meaney, M. J., Rapp, P. R., Sapolsky, R. M., & West, M. J. (1996) · Science · doi:10.1126/science.274.5287.484 · Cited by 80 · see citing works

Age-Related Elevation of Lipid Peroxidation Products: Diminution of Superoxide Dismutase Activity in the Central Nervous System of Rats

Gupta, A., Hasan, M. N., Chander, R., & Kapoor, N. K. (2009) · Gerontology · doi:10.1159/000213277 · Cited by 80 · see citing works

Down‐regulation of γ‐glutamylcysteine synthetase regulatory subunit gene expression in rat brain tissue during aging

Liu, R.-M. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10217 · Cited by 77 · see citing works

N-Acetylcysteine delays age-associated memory impairment in mice: role in synaptic mitochondria

Martı́nez, M., Hernández, A. I., & Martínez-Banaclocha, N. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02349-5 · Cited by 72 · see citing works

Hydrogen peroxide modulates whole cell Ca2+ currents through L-type channels in cultured rat dentate granule cells

Akaishi, T., Nakazawa, K., Sato, K., Saito, H., Ohno, Y., & Ito, Y. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2003.11.012 · Cited by 67 · see citing works

Calcium-dependent mitochondrial superoxide modulates nuclear CREB phosphorylation in hippocampal neurons

Hongpaisan, J., Winters, C. A., & Andrews, S. B. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2003.09.003 · Cited by 67 · see citing works

Tissue Glutathione as a Cyst(e)ine Reservoir during Cystine Depletion in Growing Rats

Cho, E. S., Johnson, N. J., & Snider, B. C. F. (1984) · Journal of Nutrition · doi:10.1093/jn/114.10.1853 · Cited by 64 · see citing works

Nitrones as Neuroprotectants and Antiaging Drugs

Floyd, R. A., Hensley, K., Forster, M. J., Kelleher, J. A., & Wood, P. L. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02103.x · Cited by 64 · see citing works

N-Acetylcysteine protects against age-related increase in oxidized proteins in mouse synaptic mitochondria

Martı́nez, M., Hernández, A. I., Martínez-Banaclocha, N., & Ferrándiz, M. L. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00493-9 · Cited by 60 · see citing works

The putative role of free radicals in the loss of neuronal functioning in senescence

Joseph, J. A. (1992) · Integrative Psychological and Behavioral Science · doi:10.1007/bf02690894 · Cited by 57 · see citing works

Improvement in muscular performance and decrease in tumor necrosis factor level in old age after antioxidant treatment

Hauer, K. A., Hildebrandt, W., Sehl, Y., Edler, L., Oster, P., & Dröge, W. (2003) · Journal of Molecular Medicine · doi:10.1007/s00109-002-0406-7 · Cited by 57 · see citing works

Functional Role of Hyperreactive Sulfhydryl Moieties Within the Ryanodine Receptor Complex

Pessah, I. N., & Feng, W. (2000) · Antioxidants and Redox Signaling · doi:10.1089/ars.2000.2.1-17 · Cited by 56 · see citing works

Improved psychomotor performance in aged mice fed diet high in antioxidants is associated with reduced ex vivo brain interleukin-6 production

Richwine, A. F., Godbout, J. P., Berg, B. M., Chen, J., Escobar, J., MILLARD, D. K., & Johnson, R. W. (2005) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2004.12.005 · Cited by 56 · see citing works

Effect of age and caloric restriction on bleomycin-chelatable and nonheme iron in different tissues of C57BL/6 mice

Sohal, R. S., Wennberg-Kirch, E., Jaiswal, K. R., Kwong, L. K., & Forster, M. J. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00052-0 · Cited by 54 · see citing works

Calmodulin and Cyclic ADP-Ribose Interaction in Ca 2+ Signaling Related to Cardiac Sarcoplasmic Reticulum: Superoxide Anion Radical-Triggered Ca 2+ Release

Okabe, E., Tsujimoto, Y., & Kobayashi, Y. (2000) · Antioxidants and Redox Signaling · doi:10.1089/ars.2000.2.1-47 · Cited by 48 · see citing works

Age-related changes of glutathione content, glucose transport and metabolism, and mitochondrial electron transfer function in mouse brain

Sasaki, T., Senda, M., Kim, S.-N., Kojima, S., & Kubodera, A. (2001) · Nuclear Medicine and Biology · doi:10.1016/s0969-8051(00)00180-3 · Cited by 46 · see citing works

Effect of thiol antioxidant on body fat and insulin reactivity

Hildebrandt, W., Hamann, A., Krakowski‐Roosen, H., Kinscherf, R., Dugi, K. A., Sauer, R., Lacher, S., N�bel, N., Bodens, A., Bellou, V., et al. (2004) · Journal of Molecular Medicine · doi:10.1007/s00109-004-0532-5 · Cited by 46 · see citing works

Age and GSH metabolism in rat cerebral cortex, as related to oxidative and energy parameters

Iantomasi, T., Favilli, F., Marraccini, P., Stio, M., Treves, C., Quatrone, A., Capaccioli, S., & VINCENZINI, M. T. (1993) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(93)90060-5 · Cited by 45 · see citing works

Autophagy and aging—importance of amino acid levels

Dröge, W. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2003.12.003 · Cited by 44 · see citing works

Growth hormone administration to aged animals reduces disulfide glutathione levels in hippocampus

Donahue, A., Aschner, M., Lash, L. H., Syversen, T. L. M., & Sonntag, W. E. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.09.003 · Cited by 44 · see citing works

Is defective electron transport at the hub of aging?

Maklashina, E., & Ackrell, B. A. C. (2003) · Aging Cell · doi:10.1111/j.1474-9728.2003.00078.x · Cited by 43 · see citing works

A Dietary Supplement Abolishes Age-Related Cognitive Decline in Transgenic Mice Expressing Elevated Free Radical Processes

Lemon, J. A., Boreham, D. R., & Rollo, C. D. (2003) · Experimental Biology and Medicine · doi:10.1177/15353702-0322807-05 · Cited by 40 · see citing works

H2O2 Mobilizes Ca2+ from Agonist- and Thapsigargin-sensitive and Insensitive Intracellular Stores and Stimulates Glutamate Secretion in Rat Hippocampal Astrocytes

González, A., Granados, M. P., Pariente, J. A., et al. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9078-y · Cited by 39 · see citing works

Interdependent Regulation of Insulin Receptor Kinase Activity by ADP and Hydrogen Peroxide

Schmitt, T. L., Hotz‐Wagenblatt, A., Klein, H. W., & Dröge, W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410352200 · Cited by 39 · see citing works

Effect of intracellular iron loading on lipid peroxidation of brain slices

Oubidar, M., Boquillon, M., Marie, C., et al. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(96)00173-6 · Cited by 35 · see citing works

Oxidative Aging and Insulin Receptor Signaling

Dröge, W. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.11.1378 · Cited by 35 · see citing works

Late onset administration of oral antioxidants prevents age-related loss of motor co-ordination and brain mitochondrial DNA damage

Pallardó, F. V., Asensi, M. A., de la Asunción, J. G., Antón, V., Lloret, A., Sastre, J., & Viña, J. (1998) · Free Radical Research · doi:10.1080/10715769800300671 · Cited by 32 · see citing works

The Potent Free Radical Scavenger α‐Lipoic Acid Improves Cognition in Rodents

Stoll, S., Rostock, A., Bartsch, R., Korn, E. L., Meichelböck, A., & Müller, W. E. G. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb12079.x · Cited by 30 · see citing works

Effect of Insulin on the Brain Activity Obtained during Visual and Memory Tasks in Healthy Human Subjects

Benedict, L. E., Nelson, C. A., Schunk, E., Sullwold, K., & Seaquist, E. R. (2006) · Neuroendocrinology · doi:10.1159/000093338 · Cited by 29 · see citing works

Relative rates of appearance of nitrogen and sulphur: implications for postprandial synthesis of proteins

Cheema‐Dhadli, S., & Halperin, M. L. (1993) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y93-017 · Cited by 29 · see citing works

Role of the Cellular Stress Response in the Biogenesis of Cysteamine‐Induced Astrocytic Inclusions in Primary Culture

Mydlarski, M. B., Liang, J.-J., & Schipper, H. M. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb09813.x · Cited by 29 · see citing works

Alpha-phenyl-tert-butyl-nitrone (PBN) reverses age-related maze learning performance and motor activity deficits in C57 BL/6 mice

Fredriksson, A., & Archer, T. (1996) · Behavioural Pharmacology · doi:10.1097/00008877-199605000-00005 · Cited by 17 · see citing works

Redox regulation of cell survival

Trachootham, D., Lu, W., Ogasawara, M. A., Valle, N. R.-D., & Huang, P. (2008) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2007.1957 · Cited by 1,781 · see citing works

The role of mitochondria in reactive oxygen species metabolism and signaling

Starkov, A. A. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.015 · Cited by 846 · see citing works

Free radicals and antioxidants – quo vadis?

Halliwell, B. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.12.002 · Cited by 706 · see citing works

Microglial cell dysregulation in brain aging and neurodegeneration

von Bernhardi, R., Eugenín-von Bernhardi, L., & Eugenín, J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00124 · Cited by 556 · see citing works

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554 · see citing works

Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat

Pérez, V. I., Buffenstein, R., Masamsetti, V., Leonard, S., Salmon, A. B., Mele, J., Andziak, B., Yang, T., Edrey, Y., Friguet, B., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809620106 · Cited by 418 · see citing works

Mammalian Mitochondrial Complex I: Biogenesis, Regulation, and Reactive Oxygen Species Generation

Koopman, W. J. H., Nijtmans, L. G. J., Dieteren, C. E. J., Roestenberg, P., Valsecchi, F., Smeitink, J. A. M., & Willems, P. H. G. M. (2010) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2009.2743 · Cited by 411 · see citing works

Polyphenol-Rich Foods in the Mediterranean Diet are Associated with Better Cognitive Function in Elderly Subjects at High Cardiovascular Risk

Valls-Pedret, C., Lamuela-Raventós, R. M., Medina-Remón, A., Quintana, M., Corella, D., Pintó, X., Martínez-González, M. Á., Estruch, R., & Ros, E. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2012-111799 · Cited by 309 · see citing works

Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices

Tremblay, M., Zettel, M. L., Ison, J. R., Allen, P. D., & Majewska, A. K. (2012) · Glia · doi:10.1002/glia.22287 · Cited by 309 · see citing works

Aging‐dependent changes of microglial cells and their relevance for neurodegenerative disorders

Von Bernhardi, R., Tichauer, J. E., & Eugenín, J. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06537.x · Cited by 258 · see citing works

Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts

Kapeta, S., Chondrogianni, N., & Gonos, E. S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.031575 · Cited by 234 · see citing works

Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia

Connell, E., Le Gall, G., Pontifex, M. G., Sami, S., Cryan, J. F., Clarke, G., Müller, M., & Vauzour, D. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00548-6 · Cited by 208 · see citing works

Effect of a Strawberry and Spinach Dietary Supplement on Spatial Learning in Early and Late Middle-Aged Female Rats

Millin, P. M., & Rickert, G. T. (2018) · Antioxidants · doi:10.3390/antiox8010001 · Cited by 169 · see citing works

Blood Brain Barrier Permeability of (-)-epigallocatechin Gallate, its Proliferation-Enhancing Activity of Human Neuroblastoma SH-Sy5y Cells, and its Preventive Effect on Age-Related Cognitive Dysfunction in Mice

Pervin, M., Unno, K., Nakagawa, A., Takahashi, Y., Iguchi, K., Yamamoto, H., Hoshino, M., Hara, A., Takagaki, A., Nanjo, F., et al. (2017) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2016.12.012 · Cited by 137 · see citing works

Thyroid Hormone Signaling and Homeostasis During Aging

Bowers, J., Terrien, J., Clerget-Froidevaux, M. S., Gothié, J. D., Rozing, M. P., Westendorp, R. G. J., van Heemst, D., & Demeneix, B. A. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1056 · Cited by 117 · see citing works

Age-associated decrease of SIRT1 expression in rat hippocampus

Quintas, A., de Solís, A. J., Díez-Guerra, F. J., Carrascosa, J. M., & Bogónez, E. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2011.11.010 · Cited by 110 · see citing works

Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches

Balmus, I. M., Ciobica, A., Antioch, I., Dobrin, R., & Timofte, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3975101 · Cited by 103 · see citing works

Oxidative damage to the promoter region of SQSTM1/p62 is common to neurodegenerative disease

Du, Y., Wooten, M. C., & Wooten, M. W. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.05.015 · Cited by 96 · see citing works

The Impact of Genetic Research on our Understanding of Normal Cognitive Ageing: 1995 to 2009

Payton, A. (2009) · Neuropsychology Review · doi:10.1007/s11065-009-9116-z · Cited by 95 · see citing works

Reversal of age‐related oxidative stress prevents hippocampal synaptic plasticity deficits by protecting <scp>d</scp>‐serine‐dependent NMDA receptor activation

Haxaire, C., Turpin, F. R., Potier, B., Kervern, M., Sinet, P., Barbanel, G., Mothet, J., Dutar, P., & Billard, J. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00792.x · Cited by 88 · see citing works

Enhanced markers of oxidative stress, altered antioxidants and NADPH-oxidase activation in brains from fragile X mental retardation 1-deficient mice, a pathological model for fragile X syndrome

El Bekay, R., Romero‐Zerbo, Y., Decara, J., Sanchez‐Salido, L., Del Arco‐Herrera, I., Rodríguez‐de Fonseca, F., & De Diego‐Otero, Y. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05939.x · Cited by 85 · see citing works

Contributions of DNA interstrand cross-links to aging of cells and organisms

Grillari, J., Katinger, H., & Voglauer, R. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm1065 · Cited by 83 · see citing works

Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer’s disease

Jackson, H. M., Soto, I., Graham, L. C., Carter, G. W., & Howell, G. R. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-831 · Cited by 66 · see citing works

Hemoglobin, Anemia, and Cognitive Function: The Atherosclerosis Risk in Communities Study

Schneider, A. L. C., Jonassaint, C., Sharrett, A. R., Mosley, T. H., Astor, B. C., Selvin, E., Coresh, J., & Gottesman, R. F. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glv158 · Cited by 67 · see citing works

Management of anemia of inflammation in the elderly

Macciò, A., & Madeddu, C. (2012) · Anemia · doi:10.1155/2012/563251 · Cited by 60 · see citing works

Mitochondria-focused gene expression profile reveals common pathways and CPT1B dysregulation in both rodent stress model and human subjects with PTSD

Zhang, L., Li, H., Hu, X., Benedek, D. M., Fullerton, C. S., Forsten, R. D., Naifeh, J. A., Li, X., Wu, H., Benevides, K. N., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.65 · Cited by 53 · see citing works

The Mitochondria-Targeted Antioxidant SkQ1 but Not N-Acetylcysteine Reverses Aging-Related Biomarkers in Rats

Kolosova, N. G., Stefanova, N. A., Muraleva, N. A., & Skulachev, V. P. (2012) · Aging · doi:10.18632/aging.100493 · Cited by 53 · see citing works

Reversal of age-associated memory impairment by rosuvastatin in rats

Rech, R. L., de Lima, M. N. M., Dornelles, A., Garcia, V. A., Alcalde, L. A., Vedana, G., & Schröder, N. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.02.001 · Cited by 35 · see citing works

Acetyl-<scp>L</scp>-carnitine and α-lipoic acid: possible neurotherapeutic agents for mood disorders?

Soczynska, J. K., Kennedy, S. H., Chow, C. S., Woldeyohannes, H. O., Konarski, J. Z., & McIntyre, R. S. (2008) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.17.6.827 · Cited by 23 · see citing works

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor exerts greater efficacy than atorvastatin on improvement of brain function and cognition in obese rats

Arunsak, B., Pratchayasakul, W., Amput, P., Chattipakorn, K., Tosukhowong, T., Kerdphoo, S., Jaiwongkum, T., Thonusin, C., Palee, S., Chattipakorn, N., et al. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108470 · Cited by 19 · see citing works

Effect of estrogens on base excision repair in brain and liver mitochondria of aged female rats

Leclère, R., Torregrosa-Muñumer, R., Kireev, R., García, C., Vara, E., Tresguerres, J. A. F., & Gredilla, R. (2013) · Biogerontology · doi:10.1007/s10522-013-9431-x · Cited by 11 · see citing works

Coenzyme Q10 Alleviates Chronic Nucleoside Reverse Transcriptase Inhibitor-Induced Premature Endothelial Senescence

Chen, Y.-F., Hebert, V. Y., Stadler, K., Xue, S. Y., Slaybaugh, K., Luttrell-Williams, E., Glover, M. C., Krzywanski, D. M., & Dugas, T. R. (2019) · Cardiovascular Toxicology · doi:10.1007/s12012-019-09520-1 · Cited by 10 · see citing works

The control of mitochondrial succinate-dependent H2O2 production

Zoccarato, F., Miotto, C., Cavallini, L., & Alexandre, A. (2011) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-011-9363-6 · Cited by 8 · see citing works

Autophagy in cancer biology and therapy

Noor, N., Gammoh, Simon, 。., et al. (2014) · Acta Scientiarum Naturalium Universitatis Sunyatseni

Is Selective Autophagy Distinct from Starvation-Induced Autophagy?

Guillebaud, G., & Germain, M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802937-4.00005-3

Death and survival of neuronal and astrocytic cells in ischemic brain injury： a role of autophagy

Min, Xü, Huiling, et al. (2011) · 中国药理学报：英文版 · Cited by 1 · see citing works

There is more to autophagy than induction

Klionsky, D. J., & Nemchenko, A. (2011) · Autophagy · doi:10.4161/auto.7.8.16609 · Cited by 4 · see citing works

Roles of autophagy in lymphocytes： reflections and directions

Ian, I., McLeod, You-wen, et al. (2010) · 中国免疫学杂志：英文版 · Cited by 1 · see citing works