The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Ontogenetic changes in the projections of neocortical neurons
Open accessAbstract
Development changes in the origins of contra- and ipsilateral projections from the rat parietal cortex were examined using the retrograde transport of horseradish peroxidase and of the fluorescent dyes fast blue and nuclear yellow. The aim of the study was to determine the fate of the neurons which send axons through the corpus callosum in the neonatal, but not the young adult, rat. 1. Neurons which project across the corpus callosum at postnatal day 8 (PND 8), but not at PND 20 or later, do not die; they merely lose their contralateral processes. 2. At PND 8, many of these neurons--in particular, those in lamina Va of the barrel field area--project simultaneously across the corpus callosum and to the ipsilateral motor cortex. 3. By PND 20 and later, many neurons in lamina Va of the barrel field area still project to the ipsilateral motor cortex but not across the corpus callosum. We conclude that at least some neocortical neurons initially elaborate more axonal processes than they will maintain and that they selectively eliminate major projections during development.
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“A second, pervasive form of degeneration in the developing brain is degeneration limited to axonal connections leaving the neurons of origin intact.”
From A role for synaptic plasticity in the adolescent development of executive function (2013) · cites this paper as [28]
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Cites
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Research works printed but not linked: 1
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Schizophrenia: Caused by a fault in programmed synaptic elimination during adolescence?
Feinberg, I. (1982) · Journal of Psychiatric Research · doi:10.1016/0022-3956(82)90038-3 · Cited by 1,395
Regressive Events in Neurogenesis
Cowan, W. M., Fawcett, J. W., O'Leary, D. D. M., & Stanfield, B. B. (1984) · Science · doi:10.1126/science.6474175 · Cited by 1,316
Do cortical areas emerge from a protocortex?
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Axon overproduction and elimination in the corpus callosum of the developing rhesus monkey
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A role for synaptic plasticity in the adolescent development of executive function
Selemon, L. D. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.7 · Cited by 439
Metadata
- Authors
- Ivy, G., & Killackey, H.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1982-06-01
- Volume
- 2
- Issue
- 6
- Pages
- 735-743
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6564341
- OpenAlex
- W1679865271
- Cited by
- 271
- References
- 15
- Citations by year
- 2026: 2 · 2025: 3 · 2023: 1 · 2021: 3 · 2019: 2 · 2018: 1 · 2015: 1 · 2014: 1 · 2013: 3
- FWCI
- 9.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- barrel cortex, postnatal development, retrograde tracing, neuronal fate
- MeSH terms
- Age Factors, Animals, Axons, Corpus Callosum, Motor Cortex, Muridae, Neural Pathways, Neurons, Parietal Lobe, Staining and Labeling
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