Evidence that the early postnatal restriction of the cells of origin of the callosal projection is due to the elimination of axonal collaterals rather than to the death of neurons
Abstract
By using two fluorescent dyes that are retrogradely transported along axons, we have been able to demonstrate that many of the neurons in the parietal region of the rat cerebral cortex that can be labeled from the contralateral hemisphere early in postnatal development, persist well beyond the period when the callosal projection normally becomes restricted. This indicates that the major factor in the progressive restriction of the callosal projection is the withdrawal or degeneration of axon collaterals, rather than the selective death of many of the cells that initially project to the opposite side.
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A second pervasive form of degeneration in the developing brain is degeneration limited to axonal connections leaving the neurons of origin intact.
“A second, pervasive form of degeneration in the developing brain is degeneration limited to axonal connections leaving the neurons of origin intact.”
From A role for synaptic plasticity in the adolescent development of executive function (2013) · cites this paper as [27]
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- Authors
- O'Leary, D. D. M., Stanfield, B. B., & Cowan, W. M.
- Affiliations
- Salk Institute for Biological Studies (US)
- Venue
- Developmental Brain Research
- Publisher
- Elsevier BV
- Published
- 1981-07
- Volume
- 1
- Issue
- 4
- Pages
- 607-617
- ISSN
- 0165-3806 (ISSN-L)
- OpenAlex
- W2026120575
- Cited by
- 382
- References
- 24
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 4 · 2012: 6
- FWCI
- 10.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- corpus callosum, callosal projections, axon collaterals, axonal degeneration, parietal cortex, postnatal development, neuronal cell death, interhemispheric connections, rats
- MeSH terms
- Animals, Animals, Newborn, Axons, Cell Differentiation, Cell Survival, Corpus Callosum, Dominance, Cerebral, Microscopy, Fluorescence, Nerve Degeneration, Neural Pathways, Neurons, Parietal Lobe, Rats
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