Cited by 382Neurogenesis and neuroplasticity mechanismsAxon Guidance and Neuronal SignalingNeuroscience and Neuropharmacology Research

Evidence that the early postnatal restriction of the cells of origin of the callosal projection is due to the elimination of axonal collaterals rather than to the death of neurons

O'Leary, D.D.M., Stanfield, B.B., Cowan, W.M.·1981·Developmental Brain Research

Abstract

By using two fluorescent dyes that are retrogradely transported along axons, we have been able to demonstrate that many of the neurons in the parietal region of the rat cerebral cortex that can be labeled from the contralateral hemisphere early in postnatal development, persist well beyond the period when the callosal projection normally becomes restricted. This indicates that the major factor in the progressive restriction of the callosal projection is the withdrawal or degeneration of axon collaterals, rather than the selective death of many of the cells that initially project to the opposite side.

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Crossref · 10.1016/0165-3806(81)90012-2

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24 of 24 references verified0 citation errors · 0 not checkable

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  • A second pervasive form of degeneration in the developing brain is degeneration limited to axonal connections leaving the neurons of origin intact.

    “A second, pervasive form of degeneration in the developing brain is degeneration limited to axonal connections leaving the neurons of origin intact.”

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Authors
O'Leary, D. D. M., Stanfield, B. B., & Cowan, W. M.
Affiliations
Salk Institute for Biological Studies (US)
Venue
Developmental Brain Research
Publisher
Elsevier BV
Published
1981-07
Volume
1
Issue
4
Pages
607-617
ISSN
0165-3806 (ISSN-L)
OpenAlex
W2026120575
Cited by
382
References
24
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 4 · 2012: 6
FWCI
10.77
Type
journal article
Language
en
Open access
closed
Locations
  • Developmental Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
corpus callosum, callosal projections, axon collaterals, axonal degeneration, parietal cortex, postnatal development, neuronal cell death, interhemispheric connections, rats
MeSH terms
Animals, Animals, Newborn, Axons, Cell Differentiation, Cell Survival, Corpus Callosum, Dominance, Cerebral, Microscopy, Fluorescence, Nerve Degeneration, Neural Pathways, Neurons, Parietal Lobe, Rats

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