Cited by 186Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.

Regulation of Drug Reward by cAMP Response Element-Binding Protein: Evidence for Two Functionally Distinct Subregions of the Ventral Tegmental Area

Open access

Olson, V. G.·2005·Journal of Neuroscience

DOI 10.1523/jneurosci.0345-05.2005PMC PMC6724971

Open this paper in CoChat — free account Open PDF

Abstract

The transcription factor cAMP response element binding protein (CREB) is implicated in the actions of drugs of abuse in several brain areas, but little information is available about a role for CREB in the ventral tegmental area (VTA), one of the key reward regions of the brain. Here, we demonstrate that chronic exposure to drugs of abuse induces CREB activity throughout the VTA. Using viral-mediated gene transfer, we expressed green fluorescent protein (GFP)-tagged CREB or mCREB (a dominant-negative form of CREB) in the VTA and, using a conditioned place-preference paradigm, found that CREB activation within the rostral versus caudal subregions of the VTA produces opposite effects on drug reward. We identified VTA subregion-specific differences in the proportion of dopaminergic and GABAergic neurons and in the dopaminergic projections to the nucleus accumbens, another brain region implicated in drug reward, and suggest that this may contribute to behavioral differences in this study. We also measured expression levels of tyrosine hydroxylase and the AMPA glutamate receptor subunit GluR1, both of which are known to contribute to drug reward in the VTA, and found that both of these genes are upregulated following the expression of CREB-GFP and downregulated following expression of mCREB-GFP, raising the possibility that CREB may exert its effects on drug reward, in part, via regulation of these genes. These results suggest a novel role for CREB in mediating drug-induced plasticity in the VTA and establish two functionally distinct subregions of the VTA in which CREB differentially regulates drug reward.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.0345-05.2005

Cites

63 of 63 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Autoradiographic localization of dopamine D1 and D2 receptors in rat nucleus accumbens: Resistance to differential rearing conditions
Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229
Drug Addiction, Dysregulation of Reward, and Allostasis
Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953
Transcriptional regulation by the phosphorylation-dependent factor CREB
Mayr, B., & Montminy, M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35085068 · Cited by 2,587
CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals
Shaywitz, A. J., & Greenberg, M. E. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.821 · Cited by 2,133
Molecular basis of long-term plasticity underlying addiction
Nestler, E. J. (2001) · Nature reviews. Neuroscience · doi:10.1038/35053570 · Cited by 1,893
The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat
Swanson, L. W. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90145-9 · Cited by 1,718 · cited 10×
“Another mechanism that could account for the effects of CREB in rostral VTA is a similar excitation of mesocortical neurons, which predominate in this subregion (Swanson, 1982; Loughlin and Fallon , 1984).”
BackgroundResultInfluential
DOPAMINERGIC NEURONS: EFFECT OF ANTIPSYCHOTIC DRUGS AND AMPHETAMINE ON SINGLE CELL ACTIVITY
Bunney, B. S., Walters, J. R., Roth, R. H., & Aghajanian, G. K. (1973) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)29539-8 · Cited by 1,283
Neurobiology of addiction
Wise, R. A. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80079-1 · Cited by 1,072
Brain Reward Circuitry
Wise, R. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00965-0 · Cited by 881
Regulation of cocaine reward by CREB
Carlezon, W. A., Thome, J., Olson, V. G., Lane-Ladd, S. B., Brodkin, E. S., Hiroi, N., Duman, R. S., Neve, R. L., & Nestler, E. J. (1998) · Science · doi:10.1126/science.282.5397.2272 · Cited by 767
Self-citation

Show all 63 references

Research works printed but not linked: 1

Paxinos G (1995) The rat nervous system, Ed 2, p 218. New York: Elsevier.

Sorted by citations

Items 101–186 of 186

The role of neuropeptide CART in the lateral hypothalamic-ventral tegmental area (LH-VTA) circuit in motivation
Somalwar, A. R., Shelkar, G. P., Subhedar, N. K., & Kokare, D. M. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.09.054 · Cited by 27
Short-term sleep deprivation disrupts the molecular composition of ionotropic glutamate receptors in entorhinal cortex and impairs the rat spatial reference memory
Xie, M., Li, C., He, C., Li, Y., Tan, G., Yan, J. Y., Wang, J., & Hu, Z. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.10.002 · Cited by 25
Conditioned drug reward enhances subsequent spatial learning and memory in rats
Zhai, H., Zhang, Z.-Y., Zhao, M., Qiu, Y., Ghitza, U. E., & Lü, L. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0893-x · Cited by 25
Anatomically dissociable effects of dopamine D1 receptor agonists on reward and relief of withdrawal in morphine-dependent rats
Chartoff, E. H., Barhight, M. F., Mague, S. D., Sawyer, A. M., & Carlezon, W. A. (2009) · Psychopharmacology · doi:10.1007/s00213-008-1454-7 · Cited by 28
The rewarding and locomotor-sensitizing effects of repeated cocaine administration are distinct and separable in mice
Riday, T. T., Kosofsky, B. E., & Malanga, C. J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.12.011 · Cited by 23
Basal variability in CREB phosphorylation predicts trait-like differences in amygdala-dependent memory
Cowansage, K. K., Bush, D. E. A., Josselyn, S. A., Klann, E., & LeDoux, J. E. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1304665110 · Cited by 23
Effects of psychotropic drugs on second messenger signaling and preference for nicotine in juvenile male mice
Parise, L. F., Warren, B. L., Parise, E. M., Iñiguez, S. D., & Bolaños‐Guzmán, C. A. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3434-4 · Cited by 23
CREB1 and CREB-binding protein in striatal medium spiny neurons regulate behavioural responses to psychostimulants
Madsen, H. B., Navaratnarajah, S., Farrugia, J., Djouma, E., Ehrlich, M. E., Mantamadiotis, T., van Deursen, J., & Lawrence, A. J. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2406-1 · Cited by 22
Evidence for a role of CaMKIV in the development of opioid analgesic tolerance
Ko, S. W., Jia, Y., Xu, H., Yim, S., Jang, D., Lee, Y., Zhao, M., Toyoda, H., Wu, L., Chatila, T. A., et al. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04748.x · Cited by 22
Adolescent gain in positive valence of a socially relevant stimulus: engagement of the mesocorticolimbic reward circuitry
Bell, M. R., Lorme, K. C. D., Figueira, R. J., Kashy, D. A., & Sisk, C. L. (2012) · European Journal of Neuroscience · doi:10.1111/ejn.12058 · Cited by 23
Regulation of cocaine-reinstated drug-seeking behavior by κ-opioid receptors in the ventral tegmental area of rats
Sun, W., Xue, Y.-Q., Huang, Z., & Steketee, J. D. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1812-0 · Cited by 20
Maternal separation increases cocaine intake through a mechanism involving plasticity in glutamate signalling
Castro‐Zavala, A., Martín‐Sánchez, A., Luján, M. Á., & Valverde, O. (2020) · Addiction Biology · doi:10.1111/adb.12911 · Cited by 19
Huzhang Tongfeng Granule Improves Monosodium Urate‐Induced Inflammation of Gouty Arthritis Rat Model by Downregulation of Cyr61 and Related Cytokines
Zhou, M., Ze, K., Wang, Y., Li, X., Hua, L., Lu, Y., Chen, X., Ding, X., Chen, S., Ru, Y., et al. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/9238797 · Cited by 20
Blockade of TrkB receptors in the nucleus accumbens prior to heterotypic stress alters corticotropin-releasing hormone (CRH), vesicular glutamate transporter 2 (vGluT2) and glucocorticoid receptor (GR) within the mesolimbic pathway
Azogu, I., & Plamondon, H. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.02.012 · Cited by 20
Cyr61 Promotes Inflammation of a Gouty Arthritis Model in Rats
Zhou, M., Ze, K., Hua, L., Liu, L., Kuai, L., Zhang, M., Li, B., Wang, Y., & Li, X. (2020) · Mediators of Inflammation · doi:10.1155/2020/8298615 · Cited by 19
Alterations in the levels of heterotrimeric G protein subunits induced by psychostimulants, opiates, barbiturates, and ethanol: Implications for drug dependence, tolerance, and withdrawal
Kitanaka, N., Kitanaka, J., Hall, F. S., Tatsuta, T., Morita, Y., Takemura, M., Wang, X., & Uhl, G. R. (2008) · Synapse · doi:10.1002/syn.20543 · Cited by 19
Differential effects of dopamine D2 and GABAA receptor antagonists on dopamine neurons between the anterior and posterior ventral tegmental area of female Wistar rats
Ding, Z., Liu, W., Engleman, E. A., Rodd, Z. A., & McBride, W. J. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.01.004 · Cited by 19
The role of thioredoxin-1 in resisting methamphetamine-induced rewarding effect
Huang, M., Kong, L., Yang, L., Li, X., Zhou, X., Li, Y., & Bai, J. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.07.047 · Cited by 18
Off the Beaten Path: Drug Addiction and the Pontine Laterodorsal Tegmentum
Kohlmeier, K. A. (2013) · ISRN Neuroscience · doi:10.1155/2013/604847 · Cited by 20
Retrieval of morphine‐associated context induces cFos in dentate gyrus neurons
Rivera, P. D., Raghavan, R. K., Yun, S., Latchney, S. E., McGovern, M., García, E. F., Birnbaum, S. G., & Eisch, A. J. (2014) · Hippocampus · doi:10.1002/hipo.22393 · Cited by 17
NMDA receptor dependent changes in c-fos and p-CREB signaling following extinction and reinstatement of morphine place preference
Siahposht-Khachaki, A., Ezzatpanah, S., Razavi, Y., & Haghparast, A. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.10.028 · Cited by 17
Regulation of morphine reward and feeding by CREB in the lateral hypothalamus
Olson, V. G., Green, T. A., Neve, R. L., & Nestler, E. J. (2006) · Synapse · doi:10.1002/syn.20344 · Cited by 18
Self-citation
Topographical Fos induction within the ventral midbrain and projection sites following self-stimulation of the posterior mesencephalon
Marcangione, C., & Rompré, P.-P. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.05.014 · Cited by 16
Electrical stimulation of the ventral tegmental area exerts opposite effects on male rat sexual behaviour expression depending on the stimulated sub region
Rodrı́guez–Manzo, G., & Pellicer, F. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.02.006 · Cited by 16
Ginsenoside Rb1 attenuates methamphetamine (METH)-induced neurotoxicity through the NR2B/ERK/CREB/BDNF signalings in vitro and in vivo models
Yang, G., Li, J., Peng, Y., Shen, B., Li, Y., Liu, L., Wang, C., Xu, Y., Lin, S., Zhang, S., et al. (2021) · Journal of Ginseng Research · doi:10.1016/j.jgr.2021.07.005 · Cited by 15
Integrative Pharmacology in the Treatment of Substance Use Disorders
Donlon, J., Kumari, P., Varghese, S. P., Bai, M. Y., Florentin, O. D., Frost, E. D., Banks, J., Vadlapatla, N., Kam, O., Shad, M. U., et al. (2023) · Journal of Dual Diagnosis · doi:10.1080/15504263.2023.2293854 · Cited by 15
Levo-tetrahydropalmatine attenuates the acquisition of fentanyl-induced conditioned place preference and the changes in ERK and CREB phosphorylation expression in mice
Du, K., Wang, Z., Zhang, H., Zhang, Y., Su, H., Wei, Z., Zhang, C., Yun, K., & Cong, B. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135984 · Cited by 15
Nanotherapeutic Approach for Opiate Addiction Using DARPP-32 Gene Silencing in an Animal Model of Opiate Addiction
Ignatowski, T. A., Aalinkeel, R., Reynolds, J. L., Nair, B. B., Sykes, D., Gleason, C. P. K., Law, W., Mammen, M. J., Prasad, P. N., Schwartz, S. A., et al. (2015) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9585-1 · Cited by 15
Differential effects of free versus imposed motor activity on alcohol consumption in C57BL/6J versus DBA/2J mice
Pichard, C., Gorwood, P. A. P. M., Hamon, M., & Cohen‐Salmon, C. (2009) · Alcohol · doi:10.1016/j.alcohol.2009.10.007 · Cited by 15
Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses towards morphine- and morphine withdrawal-related cues
Sanchis‐Segura, C. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.030.2009 · Cited by 14
Anterior ventral tegmental area dopaminergic neurons are not involved in the motivational effects of bromocriptine, pramipexole and cocaine in drug-free rats
Ouachikh, O., Dieb, W., Durif, F., & Hafidi, A. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.12.021 · Cited by 14
Use of surface enhanced laser desorption/ionization-time of flight mass spectrometry (SELDI-TOF MS) to study protein expression in a rat model of cocaine withdrawal
Geng, T., Seitz, P. K., Thomas, M. L., Xu, B., Soman, K. V., Kurosky, A., Luxon, B. A., & Cunningham, K. A. (2006) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2006.04.025 · Cited by 14
Rostral–caudal differences in the effects of intra-VTA muscimol on cocaine self-administration
Lee, D. Y., Guttilla, M., Fung, K. D., McFeron, S., Yan, J., & Ranaldi, R. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.01.017 · Cited by 13
Differences in basal and morphine-induced FosB/ΔFosB and pCREB immunoreactivities in dopaminergic brain regions of alcohol-preferring AA and alcohol-avoiding ANA rats
Kaste, K., Kivinummi, T., Piepponen, P. T., Kiianmaa, K., & Ahtee, L. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.03.004 · Cited by 12
The Molecular Mechanisms of Reward
Winstanley, C. A., & Nestler, E. J. (2008) · Elsevier eBooks · doi:10.1016/b978-012370509-9.00004-8 · Cited by 11
Geranylgeranylacetone blocks the reinstatement of morphine-conditioned place preference
Guo, N., Zhang, X., Huang, M., Li, X., Li, Y., Zhou, X., & Bai, J. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.09.027 · Cited by 11
Intrathecal co-administration of morphine and nimodipine produces higher antinociceptive effect by synergistic interaction as evident by injecting different doses of each drug in rats
Gupta, H., Verma, D., Ahuja, R., Srivastava, D. N., Wadhwa, S., & Ray, S. B. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.01.023 · Cited by 11
Adolescent brain maturation is necessary for adult‐typical mesocorticolimbic responses to a rewarding social cue
Bell, M. R., Meerts, S. H., & Sisk, C. L. (2013) · Developmental Neurobiology · doi:10.1002/dneu.22106 · Cited by 11
Nicotine-induced CREB and DeltaFosB activity is modified by caffeine in the brain reward system of the rat
Kowiański, P., Lietzau, G., Steliga, A., Czuba, E., Ludkiewicz, B., Waśkow, M., Spodnik, J. H., & Moryś, J. (2017) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2017.10.005 · Cited by 10
A visual circuit related to the habenula mediates the prevention of cocaine relapse by bright light treatment
Fu, Y., Yang, Y., Huang, L., Huang, X., Yang, Q., Tao, Q., Wu, J., So, K., Lin, S., Yuan, T., et al. (2023) · 中国科学通报：英文版 · doi:10.1016/j.scib.2023.08.010 · Cited by 9
Modulatory role of the intra-accumbal CB1 receptor in protein level of the c-fos and pCREB/CREB ratio in the nucleus accumbens and ventral tegmental area in extinction and morphine seeking in the rats
Khaleghzadeh‐Ahangar, H., Khodagholi, F., Shaerzadeh, F., & Haghparast, A. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.08.017 · Cited by 9
Granulocyte-Colony-Stimulating Factor Alters the Proteomic Landscape of the Ventral Tegmental Area
Mervosh, N. L., Wilson, R., Rauniyar, N., Hofford, R. S., Kutlu, M. G., Calipari, E. S., Lam, T. T., & Kiraly, D. D. (2018) · Proteomes · doi:10.3390/proteomes6040035 · Cited by 9
Neural Basis of Pleasure and Reward
Knapp, C. M., & Kornetsky, C. H. (2009) · Wiley eBooks · doi:10.1002/9780470478509.neubb002040 · Cited by 9
A comparison of the effects of digoxin, ouabain and milrinone on naloxone-precipitated withdrawal syndrome in mice
Bai, Y., Chu, Q., Li, J., Chen, Y.-Y., Li, W., & Zhang, Q. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.08.004 · Cited by 8
Intra-VTA adenosine A1 receptor activation blocks morphine stimulation of motor behavior and cortical and limbic Fos immunoreactivity
Kaplan, G. B., Leite‐Morris, K. A., Klufas, M. A., & Fan, W. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.10.052 · Cited by 8
Hyperfunction of the stress response system and novelty‐induced hyperactivity correlate with enhanced cocaine‐induced conditioned place preference in NCAM‐deficient mice
Kähler, B., Romswinkel, E. V., Jakovcevski, M., Moses, A. M., Schachner, M., & Morellini, F. (2020) · Addiction Biology · doi:10.1111/adb.12887 · Cited by 8
Region-specific contribution of the ventral tegmental area to heroin-induced conditioned immunomodulation
Hutson, L. W., Szczytkowski, J. L., Saurer, T. B., Lebonville, C. L., Fuchs, R. A., & Lysle, D. T. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.01.008 · Cited by 8
Dopaminergic transmission in the midbrain ventral tegmental area in the induction of hippocampal theta rhythm
Orzeł-Gryglewska, J., Kuśmierczak, M., Matulewicz, P., & Jurkowlaniec, E. (2013) · Brain Research · doi:10.1016/j.brainres.2013.03.021 · Cited by 7
Differential patterns of neuronal activation in rostral versus caudal ventral tegmental area involved in behavioral sensitization induced by an escalating-dose morphine administration paradigm
Bai, Y., Peng, Y.-H., Liang, J., & Zheng, X. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.05.011 · Cited by 7
Glycyl-glutamine reduces ethanol intake at three reward sites in P rats
Resch, G. E., & Simpson, C. W. (2008) · Alcohol · doi:10.1016/j.alcohol.2007.11.002 · Cited by 7
Non‐motor Function of the Midbrain Dopaminergic Neurons
Cunha, C. D., Lovato, E. C. W., Bortolanza, M., Dombrowski, P. A., dos Santos, L. M., Boschen, S. L., Miyoshi, E., Vital, M. A. B. F., Boerngen-Lacerda, R., & Andreatini, R. (2009) · Springer eBooks · doi:10.1007/978-3-211-92660-4_12 · Cited by 7
Alcohol preference and consumption are controlled by the caudal linear nucleus in alcohol‐preferring rats
Dudek, M., & Hyytiä, P. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13245 · Cited by 6
Cav1.3 L-type Ca2+ channel-activated CaMKII/ERK2 pathway in the ventral tegmental area is required for cocaine conditioned place preference
Martínez-Rivera, A., Jin, H., Rice, R. C., Inturrisi, C. E., & Rajadhyaksha, A. M. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109368 · Cited by 5
Segregation of caffeine reward and aversion in the rat nucleus accumbens shell versus core
Yee, M., Maal‐Bared, G., Ting‐A‐Kee, R. A., Chwalek, M., MacKay-Clackett, I., Bergamini, M., Grieder, T. E., & van der Kooy, D. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14718 · Cited by 6
Phospho-CREB Regulation on NMDA Glutamate Receptor 2B and Mitochondrial Calcium Uniporter in the Ventrolateral Periaqueductal Gray Controls Chronic Morphine Withdrawal in Male Rats
Yi, H., Gu, J., Hamilton, P. J., Liu, S., Zhu, S., Ikegami, D., Hayashi, K., Kashiwagi, Y., Iida, T., Liu, Q., et al. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1934-24.2025 · Cited by 4
Glycogen synthase kinase-3β in the ventral tegmental area mediates diurnal variations in cocaine-induced conditioned place preference in rats
Li, S., Wei, Y.-M., Shi, H., Luo, Y., Ding, Z., Xue, Y.-X., Lü, L., & Yu, C. (2013) · Addiction Biology · doi:10.1111/adb.12068 · Cited by 5
Downregulation of cAMP response element-binding protein by lentiviral vector-mediated RNAi attenuates morphine withdrawal syndromes in rats
Wu, Q., Cao, M., Wang, T., Jiang, P., & Zhou, K. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.04.026 · Cited by 4
Cocaine and Transcription Factors
González-Núñez, V., & Rodrı́guez, R. E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803750-8.00012-9 · Cited by 3
Paradoxical Ventral Tegmental Area GABA Signaling Drives Enhanced Morphine Reward After Adolescent Nicotine
Wittenberg, R. E., Yun, S., Yang, K., Swanson, O. K., Wolfman, S. L., Colón, L. M., Eisch, A. J., & Dani, J. A. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.05.027 · Cited by 3
Interaction between cholecystokinin and the fibroblast growth factor system in the ventral tegmental area of selectively bred high- and low-responder rats
Ballaz, S., Perez, J., Waselus, M., Akil, H., & Watson, S. J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.09.063 · Cited by 3
The undeveloped properties of GABA neurons in the ventral tegmental area promote energy intake for growth in juvenile rats
Maejima, Y., Yokota, S., Horita, S., & Shimomura, K. (2019) · Scientific Reports · doi:10.1038/s41598-019-48336-5 · Cited by 2
Circadian circuits
Gamble, M. C., & Logan, R. W. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823453-2.00009-6 · Cited by 1
Linking the Neurobiological Basis and Behavioral Features of Craving
Gargiulo, A. P. Í., Trovato, A., Colombini, A. P., Gargiulo, M. M. L., & Gargiulo, Á. J. M. (2024) · Springer eBooks · doi:10.1007/978-3-031-72219-6_25 · Cited by 1
Transcription and Reward Systems
Kumar, A., Green, T. A., Russo, S. J., Renthal, W. R., & Nestler, E. J. (2009) · Elsevier eBooks · doi:10.1016/b978-008045046-9.00195-9 · Cited by 1
HSV Amplicon Vectors for Gene Delivery to the Nervous System
Senn, C., Fraefel, C., & Breakefield, X. O. (2006) · Elsevier eBooks · doi:10.1016/b978-012397632-1/50004-6 · Cited by 1
Effects of chronic nicotine on behavioural and neurochemical responses to morphine
Kivinummi, T. (2009) · Työväentutkimus Vuosikirja
Adaptations neuronales dans les maladies psychiatriques associées à une hyperdopaminergie
Rawas, R. E. (2008) · OpenGrey (Institut de l'Information Scientifique et Technique)
ExtracellularSignal-RegulatedKinase-2withintheVentral TegmentalAreaRegulatesResponsestoStress
Warren, B. L., & Neve, R. L. (2010)
JuvenileAdministrationofConcomitantMethylphenidate andFluoxetineAltersBehavioralReactivitytoReward-and Mood-RelatedStimuliandDisruptsVentralTegmentalArea GeneExpressioninAdulthood
Warren, B. L., Iñiguez, S. D., Wright, K. N., & Parise, E. (2011)
"AFERÊNCIAS HIPOTALÂMICAS PARA A ÁREA TEGMENTAL VENTRAL, NÚCLEO TEGMENTAL ROSTROMEDIAL E NÚCLEO DORSAL DA RAFE."
Humana, E. F., & Andreas, M. (2015)
Neurobiological Consequences of Fluoxetine Exposure during Adolescence
Iñiguez, S. D. (2011)
CREB-mediated Enhancement of Hippocampus-dependent Memory Consolidation and Reconsolidation
Sekeres, M. J. (2012) · TSpace (University of Toronto)
Region-SpecificChangesintheSubcellularDistributionof AMPAReceptorGluR1SubunitintheRatVentralTegmental AreaafterAcuteorChronicMorphineAdministration
Colago, O. (2008)
Diurnal Rhythms of Tyrosine Hydroxylase Expression are Regulated by NAD Cellular Redox and SIRT1Preprint
Logan, R. W., Parekh, P. K., Williams, W. P., Kaplan, G. N., Becker‐Krail, D. D., Yamaguchi, S., Yoshino, J., Shelton, M. A., Zhu, X., Zhang, H., et al. (2018) · SSRN Electronic Journal · doi:10.2139/ssrn.3155572
Separate mesolimbic dopaminergic pathways mediate the opposing motivational effects of acute caffeine
Yee, M. (2018) · TSpace (University of Toronto)
Exploration of neuronal ensembles responsible for sleep and body temperature regulation
Ma, Y. (2019) · Spiral (Imperial College London) · doi:10.25560/80152
From the Gut to the Brain: Hormonal Regulation of Brain Dopamine Homeostasis and Cocaine Reward
Reddy, I. A. (2016)
The Role of Trait Impulsivity and Novelty-Seeking as Predisposing Factors to the Acquisition and Reinstatement of MDMA Self-Administration
Bird, J. (2013) · Open Access Victoria University of Wellington | Te Herenga Waka (Figshare) · doi:10.26686/wgtn.17003842
Faculty Opinions recommendation of NAD+ cellular redox and SIRT1 regulate the diurnal rhythms of tyrosine hydroxylase and conditioned cocaine reward.
Karatsoreos, I. N. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733181688.793564070
The Role of Trait Impulsivity and Novelty-Seeking as Predisposing Factors to the Acquisition and Reinstatement of MDMA Self-Administration
Bird, J. (2013) · doi:10.26686/wgtn.17003842.v1
Transcription Factors ∆FosB and CREB in Drug Addiction : Studies in Models of Alcohol Preference and Chronic Nicotine Exposure
Kaste, K. (2009) · Työväentutkimus Vuosikirja
Rôle des récompenses dans la sélection et l'utilisation de différentes formes de mémoire : interactions entre l'hippocampe et le striatum
Baudonnat, M. (2011) · theses.fr (ABES) · doi:10.70675/4ca038a7ze168z4f94zbab6za3541fa6267f
La queue de l’aire tegmentale ventrale : définition anatomo-moléculaire, implication dans la réponse aux stimuli aversifs et influence sur la voie nigrostriée
Faivre, F. (2018) · doi:10.70675/b30f731az3333z44bbz8cb6za26c36c3c9a8
Voluntary cocaine or sugar intake induce neuroadaptations of the endocannabinoid system in reward-related brain regions
Nogueira, D. D. S. (2019) · theses.fr (ABES) · doi:10.70675/d429d5dbz5001z4e60z9622z4f636e667f17
Role of dopaminergic projections from ventral tegmental area to paraventricular thalamus in heroin-induced behavioural sensitization of rats
Zhu, H., Zhou, Y., Xu, Z., Gao, L., Li, L., Hong, Q., Xu, W., Fu, D., Lou, Z., & Liu, H. (2026) · Behavioural Brain Research · doi:10.1016/j.bbr.2026.116493
Gabab Regulation of Methamphetamine-Induced Associative Learning
Voigt, R. M. (2010) · Loyola eCommons (Loyola University of Chicago)

Authors: Olson, V. G.
Affiliations: The University of Texas Southwestern Medical Center (US)
Corresponding author: Olson, V. G.
ORCID: Olson, V. G.
Venue: Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2005-06-08
Volume: 25
Issue: 23
Pages: 5553-5562
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.0345-05.2005
PMC: PMC6724971
OpenAlex: W2092206787
Cited by: 186
References: 63
Citations by year: 2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 7 · 2019: 4 · 2018: 8 · 2017: 10 · 2016: 4 · 2015: 7 · 2014: 8 · 2013: 15 · 2012: 13
FWCI: 6.87
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: National Institute of Mental Health
National Institute on Drug Abuse
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: CREB, drug reward, ventral tegmental area, drugs of abuse, conditioned place preference, dominant-negative CREB, dopaminergic neurons, GABAergic neurons, tyrosine hydroxylase, transcriptional regulation
MeSH terms: Animals, Behavior, Animal, Cocaine, Conditioning, Psychological, Female, Male, Mice, Inbred C57BL, Mice, Transgenic, Morphine, Narcotics, Neurons, Nucleus Accumbens, Recombinant Fusion Proteins, Reward, Transcription, Genetic, Tyrosine 3-Monooxygenase, Up-Regulation, Cyclic AMP Response Element-Binding Protein, Ventral Tegmental Area, Receptors, AMPA, Green Fluorescent Proteins, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Regulation of Drug Reward by cAMP Response Element-Binding Protein: Evidence for Two Functionally Distinct Subregions of the Ventral Tegmental Area

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks