The DOI matches its Crossref record; 23 of the 24 references it cites were found in a registry or an index.
Pheromonally induced release of luteinizing hormone in male mice: involvement of the vomeronasal system
Open accessAbstract
Evidence has accumulated demonstrating that the vomeronasal (accessory olfactory) system mediates intraspecific chemosensory communication in several mammals. For example, the neuroendocrine effects of priming pheromones in females and the behavioral responses to signaling pheromones in males are disrupted in mice with damage to the vomeronasal system. The experiment reported here examined the potential involvement of the vomeronasal system in the neuroendocrine reflexes observed in male mice following exposure to female and chemosensory stimuli. Excision of the vomeronasal organ (VNO) or sham VNO ablation was performed on sexually experienced males. Next, consecutive blood samples were withdrawn through chronic, intracardiac cannulas while the males were exposed to female mouse urine and then to an ovariectomized female. Plasma levels of luteinizing hormone (LH) were measured in the sequential samples by radioimmunoassay. Removal of the VNO did not affect the spontaneous pattern of episodic LH release that is characteristic of male mice. Reflexive release of LH following the urine stimulus was blocked in males lacking the VNO, but the female stimulus did cause LH responses in these mice. Our results therefore demonstrate that the VNO mediates pheromonally induced release of LH in male mice and that additional cues which emanate from behaving females also effectively stimulate a hormonal response in sexually experienced males.
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“The increase in serum luteinizing hormone and testosterone when male mice and hamsters are exposed to chemosensory stimuli from females appears to be absolutely dependent on vomeronasal integrity (Coquelin et al., 1984;Pfeiffer and Johnston, 1994).”
From Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases (2001) · cites this paper as Coquelin et al., 1984
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Metadata
- Authors
- Coquelin, A., Clancy, A., Macrides, F., Noble, E., & Gorski, R.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1984-09-01
- Volume
- 4
- Issue
- 9
- Pages
- 2230-2236
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6564801
- OpenAlex
- W1868854124
- Cited by
- 127
- References
- 24
- Citations by year
- 2022: 1 · 2021: 1 · 2018: 2 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 3
- FWCI
- 4.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- vomeronasal organ, vomeronasal system, luteinizing hormone, pheromones, chemosensory communication, male mice, female urine, ovariectomized females, reproductive hormones, intraspecific communication
- MeSH terms
- Animals, Castration, Horseradish Peroxidase, Luteinizing Hormone, Male, Mice, Inbred Strains, Nose, Pheromones, Sex Attractants, Mice
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