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Pheromonally induced release of luteinizing hormone in male mice: involvement of the vomeronasal system
Open accessAbstract
Evidence has accumulated demonstrating that the vomeronasal (accessory olfactory) system mediates intraspecific chemosensory communication in several mammals. For example, the neuroendocrine effects of priming pheromones in females and the behavioral responses to signaling pheromones in males are disrupted in mice with damage to the vomeronasal system. The experiment reported here examined the potential involvement of the vomeronasal system in the neuroendocrine reflexes observed in male mice following exposure to female and chemosensory stimuli. Excision of the vomeronasal organ (VNO) or sham VNO ablation was performed on sexually experienced males. Next, consecutive blood samples were withdrawn through chronic, intracardiac cannulas while the males were exposed to female mouse urine and then to an ovariectomized female. Plasma levels of luteinizing hormone (LH) were measured in the sequential samples by radioimmunoassay. Removal of the VNO did not affect the spontaneous pattern of episodic LH release that is characteristic of male mice. Reflexive release of LH following the urine stimulus was blocked in males lacking the VNO, but the female stimulus did cause LH responses in these mice. Our results therefore demonstrate that the VNO mediates pheromonally induced release of LH in male mice and that additional cues which emanate from behaving females also effectively stimulate a hormonal response in sexually experienced males.
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“The increase in serum luteinizing hormone and testosterone when male mice and hamsters are exposed to chemosensory stimuli from females appears to be absolutely dependent on vomeronasal integrity (Coquelin et al., 1984;Pfeiffer and Johnston, 1994).”
From Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases (2001) · cites this paper as Coquelin et al., 1984
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Luteinizing Hormone‐Releasing Hormone in the Vomeronasal System and Terminal Nerve of the Hamster a
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Dulka, J. G., & Stacey, N. E. (1991) · Journal of Experimental Zoology · doi:10.1002/jez.1402570212 · Cited by 25
The Mammalian Vomeronasal System: Its Role in Learning and Social Behaviors
Wysocki, C. J., Bean, N. J., & Beauchamp, G. K. (1986) · Springer eBooks · doi:10.1007/978-1-4613-2235-1_36 · Cited by 24
Booth, K. K., & Webb, E. C. (2010) · Veterinary Medicine International · doi:10.4061/2011/305468 · Cited by 28
“Pheromones, which are detected by the vomeronasal organ [25], are known to influence a variety of animal activities from sexual maturation to maternal offspring recognition during nursing [3, 26–41].”
BackgroundSaito, H., Mimmack, M. L., Keverne, E. B., Kishimoto, J., & Emson, P. C. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00183-1 · Cited by 23
Russell, N. V., Ogaga-Mgbonyebi, E. V., Habteab, B. S., Dunigan, A. I., Tesfay, M. A., & Clancy, A. N. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.04.017 · Cited by 22
Self-citationBeny, Y., & Kimchi, T. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12320 · Cited by 21
“…of cop-ulatory behavioral and physiological responses in sexually naïve males, for example the rapid elevation of circulating luteinizing hormone (Coquelin et al. 1984; Gleason et al. 2009; Goldey & van Anders 2014) and testosterone levels (Amstislavskaya et al. 2013; Gleason et al. 2009; Swaney…”
BackgroundGore, A. C., Wersinger, S. R., & Rissman, E. F. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00578.x · Cited by 22
Blissitt, M. J., Bland, K. P., & Cottrell, D. F. (1990) · Applied Animal Behaviour Science · doi:10.1016/0168-1591(90)90128-z · Cited by 21
Sex-specific Responses to Urinary Chemicals by the Mouse Vomeronasal Organ
Thompson, R. N. (2004) · Chemical Senses · doi:10.1093/chemse/bjh076 · Cited by 21
“For example, in male mice, exposure to female pheromones facilitates luteinizing hormone secretion (Johnston and Bronson, 1982; Coquelin et al., 1984) and stimulates ultrasonic vocalizations (Nyby et al., 1979), whereas exposure to male pheromones elicits inter-male aggressive behavior (Guillot and…”
BackgroundMota‐Rojas, D., Marcet‐Rius, M., Freitas‐de‐Melo, A., Muns, R., Mora‐Medina, P., Domínguez-Oliva, A., & Orihuela, A. (2021) · Animals · doi:10.3390/ani11113092 · Cited by 22
Olfactory Systems in Mate Recognition and Sexual Behavior
Keller, M., Pillon, D., & Bakker, J. (2010) · Vitamins and hormones · doi:10.1016/s0083-6729(10)83014-6 · Cited by 19
“…indirectly) to GnRH neurons (Boehm et al., 2005), and various experiments suggest that pheromonal signals processed through these systems have the potential to activate these neurons (Coquelin et al., 1984; Meredith and Fewell, 2001; Pfeiffer and Johnston, 1994; Westberry and Meredith, 2003a,b).”
BackgroundMoeller, J. F., & Meredith, M. J. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00683-0 · Cited by 17
The Role of the Vomeronasal Organ in Behavioral Control of Reproduction
JOHNS, M. A. (1986) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1986.tb28007.x · Cited by 16
Dudley, C. A., Chakravarty, S., & Barnea, A. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02820-7 · Cited by 15
Wirsig‐Wiechmann, C. R. (1993) · Physiology & Behavior · doi:10.1016/0031-9384(93)90201-p · Cited by 15
Anand, S., Turek, F. W., & Horton, T. H. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.103.019380 · Cited by 14
“This is in contrast with the well-documented ability of urine from female mice to induce LH and testosterone secretion in male mice [5, 6, 9, 30, 31].”
ResultSelective enhancement of main olfactory input to the medial amygdala by GnRH
Blake, C. B., & Meredith, M. J. (2009) · Brain Research · doi:10.1016/j.brainres.2009.10.078 · Cited by 14
“Inmalemice, the LH increase occurs within 5 min of female chemosensory exposure (Coquelin et al., 1984), implying a rapid intracerebral release of GnRH.”
BackgroundInfluentialAlmeida, R. G., Flório, J. C., Spinosa, H. D. S., & Bernardi, M. M. (2002) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(02)00203-9 · Cited by 11
Metadata
- Authors
- Coquelin, A., Clancy, A., Macrides, F., Noble, E., & Gorski, R.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1984-09-01
- Volume
- 4
- Issue
- 9
- Pages
- 2230-2236
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6564801
- OpenAlex
- W1868854124
- Cited by
- 127
- References
- 24
- Citations by year
- 2022: 1 · 2021: 1 · 2018: 2 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 3
- FWCI
- 4.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- vomeronasal organ, vomeronasal system, luteinizing hormone, pheromones, chemosensory communication, male mice, female urine, ovariectomized females, reproductive hormones, intraspecific communication
- MeSH terms
- Animals, Castration, Horseradish Peroxidase, Luteinizing Hormone, Male, Mice, Inbred Strains, Nose, Pheromones, Sex Attractants, Mice
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