The DOI matches its Crossref record, with a small difference in title or year; 69 of the 69 references it cites were found in a registry or an index.
Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus
Open accessAbstract
During the past 100 years clinical studies of amnesia have linked memory impairment to damage of the hippocampus. Yet the damage in these cases has not usually been confined to the hippocampus, and the status of memory functions has often been based on incomplete neuropsychological information. Thus, the human cases have until now left some uncertainty as to whether lesions limited to the hippocampus are sufficient to cause amnesia. Here we report a case of amnesia in a patient (R.B.) who developed memory impairment following an ischemic episode. During the 5 years until his death, R.B. exhibited marked anterograde amnesia, little if any retrograde amnesia, and showed no signs of cognitive impairment other than memory. Thorough histological examination revealed a circumscribed bilateral lesion involving the entire CA1 field of the hippocampus. Minor pathology was found elsewhere in the brain (e.g., left globus pallidus, right postcentral gyrus, left internal capsule), but the only damage that could be reasonably associated with the memory defect was the lesion in the hippocampus. To our knowledge, this is the first reported case of amnesia following a lesion limited to the hippocampus in which extensive neuropsychological and neuropathological analyses have been carried out.
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“It is well known that lesions of the hippocampus in humans and other mammals produce severe amnesia for certain memories (Scoville and Milner, 1957; Morris et al., 1982; Zola-Morgan et al., 1986; reviewed by Squire, 1987).”
From The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. (1996) · cites this paper as Zola-Morgan et al., 1986
Citations
Cites
LOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONS
Scoville, W. B., & Milner, B. (1957) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.20.1.11 · Cited by 7,322
Le test de copie d'une figure complexe
Osterrieth, P. M. (1944) · Medical Entomology and Zoology · Cited by 2,336
Hippocampus, space, and memory
Olton, D. S., Becker, J. T., & Handelmann, G. E. (1979) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00062713 · Cited by 2,018
de Nó, R. L. (1934) · Cited by 1,974
A new model of bilateral hemispheric ischemia in the unanesthetized rat.
Pulsinelli, W. A., & Brierley, J. B. (1979) · Stroke · doi:10.1161/01.str.10.3.267 · Cited by 1,947
Cell Damage in the Brain: A Speculative Synthesis
Siesjö, B. K. (1981) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1981.18 · Cited by 1,807
EPILEPSY AND THE TEMPORAL LOBES
Margerison, J. H., & Corsellis, J. (1966) · Brain · doi:10.1093/brain/89.3.499 · Cited by 1,260
The information that amnesic patients do not forget.
Graf, P., Squire, L. R., & Mandler, G. (1984) · Journal of Experimental Psychology Learning Memory and Cognition · doi:10.1037//0278-7393.10.1.164 · Cited by 883
Self-citationDisorders of Learning and Memory after Temporal Lobe Lesions in Man
Milner, B. A. (1972) · Neurosurgery · doi:10.1093/neurosurgery/19.cn_suppl_1.421 · Cited by 882
THE WERNICKE-KORSAKOFF SYNDROME
Russell, R. W. R. (1972) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.35.2.277 · Cited by 815
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Genome-wide atlas of gene expression in the adult mouse brain
Lein, E. S., Hawrylycz, M. J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., Boe, A. F., Boguski, M. S., Brockway, K. S., Byrnes, E. J., et al. (2007) · Nature · doi:10.1038/nature05453 · Cited by 5,572
A psychobiological model of temperament and character
Cloninger, C. R. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820240059008 · Cited by 5,458
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376
Self-citationMcClelland, J. L., McNaughton, B. L., & O'Reilly, R. C. (1995) · Psychological Review · doi:10.1037/0033-295x.102.3.419 · Cited by 5,256
The Medial Temporal Lobe Memory System
Squire, L. R., & Zola-Morgan, S. (1991) · Science · doi:10.1126/science.1896849 · Cited by 3,282
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Metadata
- Authors
- Zola-Morgan, S., Squire, L., & Amaral, D.
- Affiliations
- University of California San Diego (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1986-10-01
- Volume
- 6
- Issue
- 10
- Pages
- 2950-2967
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6568782
- OpenAlex
- W1598800837
- Cited by
- 1,997
- References
- 69
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 50 · 2023: 19 · 2022: 25 · 2021: 23 · 2020: 58 · 2019: 30 · 2018: 39 · 2017: 52 · 2016: 36 · 2015: 52 · 2014: 56 · 2013: 51 · 2012: 58
- FWCI
- 25.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (MH24600)
- National Institute of Neurological Disorders and Stroke (NS 20004, NS19063)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- anterograde amnesia, hippocampal CA1, bilateral hippocampal lesions, memory impairment, ischemic stroke, medial temporal lobe, retrograde amnesia, neuropathology, neuropsychological assessment
- MeSH terms
- Amnesia, Cerebral Cortex, Brain Ischemia, Diencephalon, Hippocampus, Humans, Male, Memory Disorders, Middle Aged, Temporal Lobe
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