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Cowhage-Evoked Itch Is Mediated by a Novel Cysteine Protease: A Ligand of Protease-Activated Receptors
Open accessAbstract
Cowhage spicules provide an important model for histamine-independent itch. We determined that the active component of cowhage, termed mucunain, is a novel cysteine protease. We isolated mucunain and demonstrate that both native and recombinant mucunain evoke the same quality of itch in humans. We also show that mucunain is a ligand for protease-activated receptors two and four. These results support and expand the relationship between proteases, protease-activated receptors, and itch.
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Citations
Cited by
TRPA1 is required for histamine-independent, Mas-related G protein–coupled receptor–mediated itch
Wilson, S. R., Gerhold, K. A., Bifolck-Fisher, A., Liu, Q., Patel, K. N., Dong, X., & Bautista, D. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2789 · Cited by 599
Nilius, B., & Szallasi, A. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008268 · Cited by 506
Behavioral differentiation between itch and pain in mouse
Shimada, S. G., & LaMotte, R. H. (2008) · Pain · doi:10.1016/j.pain.2008.08.002 · Cited by 374
Self-citationMediators of Chronic Pruritus in Atopic Dermatitis: Getting the Itch Out?
Mollanazar, N. K., Smith, P. K., & Yosipovitch, G. (2016) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-015-8488-5 · Cited by 353
Physiology and Pathophysiology of Itch
Cevikbas, F., & Lerner, E. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00017.2019 · Cited by 282
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Metadata
- Authors
- Reddy, V. B., Iuga, A. O., Shimada, S. G., LaMotte, R. H., & Lerner, E. A.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-04-23
- Volume
- 28
- Issue
- 17
- Pages
- 4331-4335
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1993874766
- Cited by
- 256
- References
- 0
- FWCI
- 17.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Reddy, V. B., Iuga, A. O., Shimada, S. G., LaMotte, R. H., & Lerner, E. A. (2008). Cowhage-Evoked Itch Is Mediated by a Novel Cysteine Protease: A Ligand of Protease-Activated Receptors. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.0716-08.2008
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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