The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Medullary regions mediating atonia
Open accessAbstract
Electrical stimulation studies have implicated the medial medulla in the inhibition of muscle tone. In the present report we present evidence for suppression of muscle tone by chemical activation of the medial medulla. We find 2 distinct zones within the classically defined medial medullary inhibitory area. A rostral region corresponding to the nucleus magnocellularis (NMC) is sensitive to glutamate. Atonia produced by activation of this region is mediated by non-NMDA receptors. A caudal region, corresponding to the nucleus paramedianus (NPM) is sensitive to ACh. Atonia produced by activation of this region is mediated by muscarinic receptors. Activation of these regions both in acute decerebrate and intact cats suppresses muscle tone. We find that the cholinoceptive dorsolateral pontine region, previously implicated in atonia control, can be activated by glutamate-sensitive non-NMDA receptors. Microinjection of atropine into the NPM or of glutamylglycine into the NMC blocks atonia elicited by pontine carbachol injection. The medullary regions identified here are hypothesized to mediate the suppression of muscle tone that occurs in rapid eye movement sleep and in cataplexy and may have a role in postural control in waking.
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Cites
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Cited by
Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477
Neural Circuitry of Wakefulness and Sleep
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Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease
Boeve, B. F., Silber, M. H., Saper, C. B., Ferman, T. J., Dickson, D. W., Parisi, J. E., Benarroch, E. E., Ahlskog, J. E., Smith, G. E., Caselli, R. C., et al. (2007) · Brain · doi:10.1093/brain/awm056 · Cited by 957
Takakusaki, K., Habaguchi, T., Ohtinata-Sugimoto, J., Saitoh, K., & Sakamoto, T. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00095-2 · Cited by 408
Paradoxical sleep and its chemical/structural substrates in the brain
Jones, B. E. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90002-6 · Cited by 398
Metadata
- Authors
- Lai, Y., & Siegel, J.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1988-12-01
- Volume
- 8
- Issue
- 12
- Pages
- 4790-4796
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1588053646
- Cited by
- 362
- References
- 31
- FWCI
- 4.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
