Neural Circuitry of Wakefulness and Sleep

Scammell, Thomas E.; Arrigoni, Elda; Lipton, Jonathan O.

doi:10.1016/j.neuron.2017.01.014

Cited by 966Sleep and Wakefulness ResearchCircadian rhythm and melatoninNeuroscience of respiration and sleep

Neural Circuitry of Wakefulness and Sleep

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Scammell, Thomas E., Arrigoni, Elda, Lipton, Jonathan O.·2017·Neuron

DOI 10.1016/j.neuron.2017.01.014PMC PMC5325713

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Abstract

Sleep remains one of the most mysterious yet ubiquitous animal behaviors. We review current perspectives on the neural systems that regulate sleep/wake states in mammals and the circadian mechanisms that control their timing. We also outline key models for the regulation of rapid eye movement (REM) sleep and non-REM sleep, how mutual inhibition between specific pathways gives rise to these distinct states, and how dysfunction in these circuits can give rise to sleep disorders.

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Such micro-arousals might be responsible for sleep misperception, the feeling that one was not asleep that may occur even during deep slow wave sleep.
“In addition, such micro-arousals might be responsible for sleep misperception—the feeling that one was not asleep that may occur even during deep slow wave sleep6.”
From Consciousness and sleep (2024) · cites this paper as [6]
The Overview of Sleep and Wake States (page unavailable) says arousal levels vary during NREM sleep, including deep stage N3, but does not discuss feeling awake while asleep. Searches for sleep misperception and micro-arousals found no passage linking them or describing misperception during deep slow-wave sleep. (LLM, conf=0.73)
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Authors: Scammell, T. E., Arrigoni, E., & Lipton, J. O.
Affiliations: Boston Children's Hospital (US)
Beth Israel Deaconess Medical Center (US)
Corresponding author: Scammell, Thomas E.
ORCID: Scammell, Thomas E.
Arrigoni, Elda
Lipton, Jonathan O.
Venue: Neuron
Publisher: Elsevier BV
Published: 2017-02
Volume: 93
Issue: 4
Pages: 747-765
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2017.01.014
PMC: PMC5325713
OpenAlex: W2590862290
Cited by: 966
References: 203
Citations by year: 2026: 110 · 2025: 135 · 2024: 120 · 2023: 99 · 2022: 132 · 2021: 113 · 2020: 95 · 2019: 85 · 2018: 56 · 2017: 17 · 2016: 1 · 2013: 1
FWCI: 7.74
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 387 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: NIH (HL095491, DE022912, NS091126, HD071026)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords: sleep regulation, wakefulness, circadian rhythm, REM sleep, NREM sleep, neural circuits, sleep disorders, reciprocal inhibition, mammalian sleep
MeSH terms: Animals, Behavior, Animal, Circadian Rhythm, Humans, Neurons, Sleep, Sleep, REM, Wakefulness

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Neural Circuitry of Wakefulness and Sleep

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