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The location and function of NMDA receptors in cat and kitten visual cortex
Open accessAbstract
The role of N-methyl-D-aspartate (NMDA) receptors in cat visual cortex was studied as a function of both layer and age by iontophoresis of the NMDA antagonist (D)-2-amino-5-phosphonovaleric acid (APV). Effects on both visual responses and spontaneous activity were observed. In superficial layers (II and III), D-APV reduced visual responses substantially at all ages. Iontophoresis of D-APV with 10 nA of ejecting current for 2–3 min was sufficient to reduce the response to approximately one third of control levels. The magnitude of the reduction did not vary with age. In granular and deep layers (IV, V, and VI), D-APV affected the visual response in young animals but only spontaneous activity in older animals. On average, visual responses were reduced to about half at 20–23 days of age and to about 75% at 4 weeks of age but in most cases were not significantly affected in adults. The rapid change in the functional effect of NMDA receptors over the third and fourth week in granular and deep layers suggests a role in development. There was a reasonable age correlation between the change in effect and the period of geniculocortical afferent segregation. Further experiments will be necessary to determine whether NMDA receptors are necessary for segregation to occur. The presence of an NMDA component to the visual response in the adult in layers II and III argues either that these layers retain some form of plasticity in the adult or that NMDA receptors play a role in the transmission of normal visual input to these layers.
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“Together these findings suggest that the switch from NR2B to NR2A dominated receptors terminates the critical period of experience-dependent plasticity for establishment of ocular dominance columns in the visual cortex.”
From A role for synaptic plasticity in the adolescent development of executive function (2013) · cites this paper as [107]
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Metadata
- Authors
- Fox, K., Sato, H., & Daw, N.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1989-07-01
- Volume
- 9
- Issue
- 7
- Pages
- 2443-2454
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6569778
- OpenAlex
- W2166938907
- Cited by
- 307
- References
- 41
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2020: 2 · 2019: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 5 · 2012: 4
- FWCI
- 9.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Eye Institute (EY-00053)
- National Institute of Neurological Disorders and Stroke (NS18070)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- NMDA receptor, visual cortex, kitten development, D-APV, visual responses, spontaneous activity, cortical layers, synaptic plasticity, cats
- MeSH terms
- Aging, Animals, Cats, Dose-Response Relationship, Drug, Neurons, Tissue Distribution, Valine, Visual Cortex, 2-Amino-5-phosphonovalerate, Receptors, N-Methyl-D-Aspartate, Receptors, Neurotransmitter
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