The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
2-Aminoethoxydiphenyl Borate Activates and Sensitizes the Heat-Gated Ion Channel TRPV3
Open accessAbstract
Six of the mammalian transient receptor potential (TRP) ion channel subtypes are nonselective cation channels that can be activated by increases or decreases in ambient temperature. Five of them can alternatively be activated by nonthermal stimuli such as capsaicin [transient receptor potential vanilloid 1 (TRPV1)] or hypo-osmolarity (TRPV2 and TRPV4). No nonthermal stimuli have yet been described for TRPV3, a warmth-gated ion channel expressed prominently in skin keratinocytes. Here, we demonstrate that 2-aminoethoxydiphenyl borate (2-APB), a compound used to inhibit store-operated Ca 2+channels and IP 3 receptors, produces robust activation of recombinant TRPV3 in human embryonic kidney 293 cells with an EC 50 of 28 μ m. 2-APB also sensitizes TRPV3 to activation by heat, even at subthreshold concentrations. In inside-out membrane patches from TRPV3-expressing cells, 2-APB increases the open probability of TRPV3. Also, whereas heat alone is capable of activating TRPV3-mediated currents in only a small proportion of primary mouse keratinocytes, 2-APB activates heat-evoked, TRPV3-mediated currents in the majority of these cells. Together, these findings identify 2-APB as the first known chemical activator of TRPV3 and enhance the notion that TRPV3 participates in the detection of heat by keratinocytes.
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Citations
Cites
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
McKemy, D. D., Neuhausser, W. M., & Julius, D. (2002) · Nature · doi:10.1038/nature719 · Cited by 2,709
ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
Story, G. M., Peier, A. M., Reeve, A. J., Eid, S. R., Mosbacher, J., Hricik, T. R., Earley, T. J., Hergarden, A. C., Andersson, D. A., Hwang, S. W., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00158-2 · Cited by 2,486
A TRP Channel that Senses Cold Stimuli and Menthol
Peier, A. M., Moqrich, A., Hergarden, A. C., Reeve, A. J., Andersson, D. A., Story, G. M., Earley, T. J., Dragoni, I., McIntyre, P., Bevan, S., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00652-9 · Cited by 2,355
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
Jordt, S.-E., Bautista, D. M., Chuang, H.-H., McKemy, D. D., Zygmunt, P. M., Högestätt, E. D., Meng, I. D., & Julius, D. (2004) · Nature · doi:10.1038/nature02282 · Cited by 1,899
Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin
Bandell, M., Story, G. M., Hwang, S. W., Viswanath, V., Eid, S. R., Petrus, M. J., Earley, T. J., & Patapoutian, A. (2004) · Neuron · doi:10.1016/s0896-6273(04)00150-3 · Cited by 1,827
The Vanilloid Receptor: A Molecular Gateway to the Pain Pathway
Caterina, M. J., & Julius, D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.487 · Cited by 1,575
Self-citationChuang, H.-H., Prescott, E. D., Kong, H., Shields, S., Jordt, S.-E., Basbaum, A. I., Chao, M. V., & Julius, D. (2001) · Nature · doi:10.1038/35082088 · Cited by 1,258
Heat-Evoked Activation of the Ion Channel, TRPV4
Güler, A. D., Lee, H., Iida, T., Shimizu, I., Tominaga, M., & Caterina, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06408.2002 · Cited by 1,031
Self-citationAnandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels
Watanabe, H., Vriens, J., Prenen, J., Droogmans, G., Voets, T., & Nilius, B. (2003) · Nature · doi:10.1038/nature01807 · Cited by 1,027
A Heat-Sensitive TRP Channel Expressed in Keratinocytes
Peier, A. M., Reeve, A. J., Andersson, D. A., Moqrich, A., Earley, T. J., Hergarden, A. C., Story, G. M., Colley, S., Hogenesch, J. B., McIntyre, P., et al. (2002) · Science · doi:10.1126/science.1073140 · Cited by 970
Cited by
Store-Operated Calcium Channels
Parekh, A. B., & Putney, J. W. (2005) · Physiological Reviews · doi:10.1152/physrev.00057.2003 · Cited by 2,089
Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin
Moqrich, A., Hwang, S. W., Earley, T. J., Petrus, M. J., Murray, A. N., Spencer, K. S. R., Andahazy, M., Story, G. M., & Patapoutian, A. (2005) · Science · doi:10.1126/science.1108609 · Cited by 800
2-Aminoethoxydiphenyl Borate Is a Common Activator of TRPV1, TRPV2, and TRPV3
Hu, H.-Z., Gu, Q., Wang, C., Colton, C. K., Tang, J., Kinoshita-Kawada, M., Lee, L.-Y., Wood, J. D., & Zhu, M. X. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404164200 · Cited by 517
Transient Receptor Potential Channels in the Vasculature
Earley, S., & Brayden, J. E. (2015) · Physiological Reviews · doi:10.1152/physrev.00026.2014 · Cited by 420
The vanilloid transient receptor potential channel TRPV4: From structure to disease
Everaerts, W., Nilius, B., & Owsianik, G. (2010) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2009.10.002 · Cited by 347
Metadata
- Authors
- Chung, M.-K., Lee, H., Mizuno, A., Suzuki, M., & Caterina, M. J.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2004-06-02
- Volume
- 24
- Issue
- 22
- Pages
- 5177-5182
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2144888928
- Cited by
- 313
- References
- 28
- FWCI
- 8.37
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Chung, M.-K., Lee, H., Mizuno, A., Suzuki, M., & Caterina, M. J. (2004). 2-Aminoethoxydiphenyl Borate Activates and Sensitizes the Heat-Gated Ion Channel TRPV3. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.0934-04.2004
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