The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Locus Ceruleus Control of State-Dependent Gene Expression
Open accessAbstract
Wakefulness and sleep are accompanied by changes in behavior and neural activity, as well as by the upregulation of different functional categories of genes. However, the mechanisms responsible for such state-dependent changes in gene expression are unknown. Here we investigate to what extent state-dependent changes in gene expression depend on the central noradrenergic (NA) system, which is active in wakefulness and reduces its firing during sleep. We measured the levels of approximately 5000 transcripts expressed in the cerebral cortex of control rats and in rats pretreated with DSP-4 [N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine], a neurotoxin that removes the noradrenergic innervation of the cortex. We found that NA depletion reduces the expression of approximately 20% of known wakefulness-related transcripts. Most of these transcripts are involved in synaptic plasticity and in the cellular response to stress. In contrast, NA depletion increased the expression of the sleep-related gene encoding the translation elongation factor 2. These results indicate that the activity of the central NA system during wakefulness modulates neuronal transcription to favor synaptic potentiation and counteract cellular stress, whereas its inactivity during sleep may play a permissive role to enhance brain protein synthesis.
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“Both monoamines support synaptic remodeling via increasing activity of plasticity related immediate early genes (205,208,475).”
From About Sleep's Role in Memory (2013) · cites this paper as [208]
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Self-citationNatural waking and sleep states: a view from inside neocortical neurons
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Research works printed but not linked: 1
- Tononi G, Cirelli C, Shaw PJ (2000) The molecular correlates of sleep, wak- ing, and sleep deprivation. Human Frontier Workshop VIII, The regula- tion of sleep, (Borbely AA, Hayaishi O, Seinowski TJ, Altman JS, eds), pp 155-168. Strasbourg, France: HFSP.
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Mécanismes responsables de l'activation corticale pendant le sommeil paradoxal
Renouard, L. (2011) · theses.fr (ABES) · doi:10.70675/fb03b5cez134bz4527zb76cz110ad804221c
Impact of DSP4-induced locus coeruleus dysfunction on sleep: Systematic review and methodology
Knopper, R. W., & Hansen, B. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107457
Progressive neurodegeneration of the locus coeruleus drives rapid eye movement sleep fragmentationPreprint
Zelinger, N., Regev, N., Burian, E., Kimchy, U., Gabay, N., & Nir, Y. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.12.758491
Metadata
- Authors
- Cirelli, C.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Cirelli, C.
- ORCID
- Cirelli, C.
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2004-06-09
- Volume
- 24
- Issue
- 23
- Pages
- 5410-5419
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6729294
- OpenAlex
- W2076224262
- Cited by
- 103
- References
- 67
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 6 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 7
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Defense
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- locus coeruleus, noradrenergic system, wakefulness, sleep, synaptic plasticity, stress response, elongation factor 2, brain protein synthesis, norepinephrine depletion
- MeSH terms
- Animals, Brain Chemistry, Circadian Rhythm, Dopamine, Gene Expression Regulation, Locus Coeruleus, Male, Neuronal Plasticity, Norepinephrine, Rats, Inbred WKY, Serotonin, Sleep, Sleep Stages, Synapses, Transcription, Genetic, Wakefulness, DNA, Complementary, Oligonucleotide Array Sequence Analysis, Peptide Elongation Factor 2, Rats
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