The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Ablation of the Inflammatory Enzyme Myeloperoxidase Mitigates Features of Parkinson's Disease in Mice
Open accessAbstract
Parkinson's disease (PD) is characterized by a loss of ventral midbrain dopaminergic neurons, which can be modeled by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Inflammatory oxidants have emerged as key contributors to PD- and MPTP-related neurodegeneration. Here, we show that myeloperoxidase (MPO), a key oxidant-producing enzyme during inflammation, is upregulated in the ventral midbrain of human PD and MPTP mice. We also show that ventral midbrain dopaminergic neurons of mutant mice deficient in MPO are more resistant to MPTP-induced cytotoxicity than their wild-type littermates. Supporting the oxidative damaging role of MPO in this PD model are the demonstrations that MPO-specific biomarkers 3-chlorotyrosine and hypochlorous acid-modified proteins increase in the brains of MPTP-injected mice. This study demonstrates that MPO participates in the MPTP neurotoxic process and suggests that inhibitors of MPO may provide a protective benefit in PD.
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“However, epidemiological studies suggest that inflammation increases the risk of developing PD (Chen et al., 2003), and experimental models of PD show that inflammatory oxidants modulate SNpc dopaminergic neuronal death (Liberatore et al., 1999; Gao et al., 2002; Wu et al., 2002, 2003).”
BackgroundInfluentialSelf-citationNew stereological methods for counting neurons
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Nitric oxide synthase and neuronal vulnerability in parkinson's disease
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D-β-Hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease
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Cited by
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110
Neuroinflammation in Parkinson’s disease: A target for neuroprotection?
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Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond
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Microglia and neurodegeneration: The role of systemic inflammation
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Mammalian Heme Peroxidases: From Molecular Mechanisms to Health Implications
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Metadata
- Authors
- Choi, D.-K., Pennathur, S., Perier, C., Tieu, K., Teismann, P., Wu, D.-C., Jackson-Lewis, V., Vila, M., Vonsattel, J.-P., Heinecke, J. W., & Przedborski, S.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2005-07-13
- Volume
- 25
- Issue
- 28
- Pages
- 6594-6600
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2142360514
- Cited by
- 282
- References
- 7
- FWCI
- 5.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Ablation of the Inflammatory Enzyme Myeloperoxidase Mitigates Features of Parkinson's Disease in Mice. https://app.cochat.ai/papers/10.1523/jneurosci.0970-05.2005
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- Choi, D.-K., Pennathur, S., Perier, C., Tieu, K., Teismann, P., Wu, D.-C., Jackson-Lewis, V., Vila, M., Vonsattel, J.-P., Heinecke, J. W., & Przedborski, S. (2005). Ablation of the Inflammatory Enzyme Myeloperoxidase Mitigates Features of Parkinson's Disease in Mice. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.0970-05.2005
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
