Cited by 579Neuroinflammation and Neurodegeneration MechanismsAlcohol Consumption and Health EffectsImmune Response and Inflammation

The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.

Pivotal Role of TLR4 Receptors in Alcohol-Induced Neuroinflammation and Brain Damage

Open access

Alfonso-Loeches, S., Pascual-Lucas, M., Blanco, A. M., Sanchez-Vera, I., Guerri, C.·2010·Journal of Neuroscience

DOI 10.1523/jneurosci.0976-10.2010PMC PMC6634595

Open this paper in CoChat — free account Open PDF

Abstract

Toll-like receptors play an important role in the innate immune response, although emerging evidence indicates their role in brain injury and neurodegeneration. Alcohol abuse induces brain damage and can sometimes lead to neurodegeneration. We recently found that ethanol can promote TLR4 signaling in glial cells by triggering the induction of inflammatory mediators and causing cell death, suggesting that the TLR4 response could be an important mechanism of ethanol-induced neuroinflammation. This study aims to establish the potential role of TLR4 in both ethanol-induced glial activation and brain damage. Here we report that TLR4 is critical for ethanol-induced inflammatory signaling in glial cells since the knockdown of TLR4, by using both small interfering RNA or cells from TLR4-deficient mice, abolished the activation of microtubule-associated protein kinase and nuclear factor-kappaB pathways and the production of inflammatory mediators by astrocytes. Our results demonstrate, for the first time, that whereas chronic ethanol intake upregulates the immunoreactive levels of CD11b (microglial marker) and glial fibrillary acidic protein (astrocyte marker), and also increases caspase-3 activity and inducible nitric oxide synthase, COX-2, and cytokine levels [interleukin (IL)-1beta, tumor necrosis factor-alpha, IL-6] in the cerebral cortex of female wild-type mice, TLR4 deficiency protects against ethanol-induced glial activation, induction of inflammatory mediators, and apoptosis. Our findings support the critical role of the TLR4 response in the neuroinflammation, brain injury, and possibly in the neurodegeneration induced by chronic ethanol intake.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.0976-10.2010

Cites

68 of 68 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Toll-like receptor signalling
Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110
TLR signaling pathways
Takeda, K., & Akira, S. (2004) · Seminars in Immunology · doi:10.1016/j.smim.2003.10.003 · Cited by 2,528
Astrocytes are active players in cerebral innate immunity
Farina, C., Aloisi, F., & Meinl, E. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.01.005 · Cited by 1,304
The role of inflammation in CNS injury and disease
Lucas, S., Rothwell, N. J., & Gibson, R. M. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706400 · Cited by 1,272
Caspase-3-Generated Fragment of Gelsolin: Effector of Morphological Change in Apoptosis
Kothakota, S., Azuma, T., Reinhard, C., Klippel, A., Tang, J. X., Chu, K., McGarry, T. J., Kirschner, M. W., Koths, K. E., Kwiatkowski, D. J., et al. (1997) · Science · doi:10.1126/science.278.5336.294 · Cited by 1,226
Microglia and neuroinflammation: a pathological perspective
Streit (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-14 · Cited by 1,039
Mechanisms of Disease: astrocytes in neurodegenerative disease
Maragakis, N. J., & Rothstein, J. D. (2006) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0355 · Cited by 836
Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
Tang, S.-C., Arumugam, T. V., Xu, X., Cheng, A., Mughal, M. R., Jo, D. G., Lathia, J. D., Siler, D. A., Chigurupati, S., Ouyang, X., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702553104 · Cited by 779
Redefining the concept of reactive astrocytes as cells that remain within their unique domains upon reaction to injury
Wilhelmsson, U., Bushong, E. A., Price, D. L., Smarr, B. L., Phung, V., Terada, M., Ellisman, M. H., & Pekny, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602841103 · Cited by 643 · cited 1×
“Our immunohistochemical and biochemical data reveal that in vivo chronic ethanol intake induces astroglial activation and astrogliosis in the cerebral cortices of normal mice, as demonstrated by the marked upregulation of GFAP immunoreactivity along with hypertrophic astrocytes, which are events associated with CNS in…”
Background

Show all 66 references

Sorted by citations

Items 501–579 of 579

NF-κB/NLRP3 Translational Inhibition by Nanoligomer Therapy Mitigates Ethanol and Advanced Age-Related NeuroinflammationPreprint
Anton, P. E., Nagpal, P., Moreno, J. A., Burchill, M. A., Chatterjee, A., Busquet, N., Mesches, M. H., Kovacs, E. J., & McCullough, R. L. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.26.582114 · Cited by 2
Exploring the Neurobiology of Ethanol Relapse and Its Prevention Using N-Acetylcysteine
Fernández‐Rodríguez, S., Cano-Cebrián, M. J., Polache, A., & Zornoza, T. (2024) · Springer eBooks · doi:10.1007/978-3-031-72219-6_46 · Cited by 1
Neuroglia in substance use disorders
Castro, E. M., Lotfipour, S., & Leslie, F. M. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19102-2.00014-4 · Cited by 2
Effects of Alcohol and Opioids on Neuroregeneration
Zolali, E., McMahon, L. R., & Obeng, S. (2025) · Springer eBooks · doi:10.1007/978-3-031-93677-7_12 · Cited by 1
The Protective Effect of Isosorbide Dinitrate or L-arginine on Acute Ethanol-induced Oxidative Stress and Histopathological Changes in Different Organs
Abdel‐Salam, O. M. E., Youness, E. R., Morsy, F. A., & Sleem, A. A. (2025) · MOLECULAR SCIENCES AND APPLICATIONS · doi:10.37394/232023.2025.5.7 · Cited by 1
The Role of Toll-like Receptor 3 Signaling in Cognitive Impairment Induced by Propofol Addiction
Wu, J., Deng, L., Gao, R., Cui, Y., Tang, Y., Liu, C., Zhu, T., & Chen, C. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05613-x · Cited by 1
Ethanol drinking involves astrocytes in male Wistar rats
Tan, X., & Ding, Z. (2026) · Behavioural Brain Research · doi:10.1016/j.bbr.2026.116311 · Cited by 1
Neuroimaging and Clinical Studies on Brain–Immune Interactions
Hannestad, J. O. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4729-0_4 · Cited by 1
MICROGLIA ACTIVATION IN A RODENT MODEL OF AN ALCOHOL USE DISORDER: THE IMPORTANCE OF PHENOTYPE, INITIATION, AND DURATION OF ACTIVATION
Marshall, S. A. (2013) · UKnowledge (University of Kentucky) · Cited by 1
Efficient Subtractive Cloning of Genes Activated by Lipopolysaccharide and Interferon γ in Primary-Cultured Cortical Cells of Newborn Mice
Miyauchi, O., Iwase, K., Itoh, K., Kato, M., Seki, N., Braissant, O., Bachmann, C., Shozu, M., Sekiya, S., Osada, H., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079236 · Cited by 1
Mood Disorders and Immunity
Walker, A. K., Dantzer, R., & Kelley, K. W. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4729-0_6 · Cited by 1
Alcoholic Brain Damage
Ward, R. J. (2013) · Royal Society of Chemistry eBooks · doi:10.1039/9781849735896-00186 · Cited by 1
Synthesis and immunological evaluation of a low molecular weight saccharide with TLR-4 agonist activity
Basava, V., Romlein, H., Bitsaktsis, C., & Marzabadi, C. H. (2016) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2016.11.044 · Cited by 1
Neuroimmune consequences of chronic alcohol exposure: relationship to stress
Whitman, B. A. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/0ppt-7f35 · Cited by 1
The effect of substance misuse on HIV persistence in the CNS
LuPone, T., Duyne, R. V., O’Brien, E. V., Matt, S. M., Dampier, W., Nonnemacher, M. R., Wigdahl, B. L., Gaskill, P. J., & Klase, Z. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99744-7.00022-5 · Cited by 1
Mesenchymal stem cells as a promising therapy for alcohol use disorder
Gallardo, J., Berríos‐Cárcamo, P., & Ezquer, F. E. (2024) · International review of neurobiology · doi:10.1016/bs.irn.2024.07.002 · Cited by 1
Alcohol and Neurodegeneration
Persidsky, Y., Gofman, L., & Potula, R. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1071-7_24 · Cited by 1
Consumption of Ethanol and Tissue Changes in the Central Nervous System
Bittencourt, L. O., Teixeira, F. B., Vieira, K. L., dos Santos, D. P., Maia, C. D. S. F., & Lima, R. R. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805373-7.00009-8 · Cited by 1
Hypoxia and Cigarette Smoke - A Combined Threat to the Brain: Role of Toll-like Receptor 4 in Neuroinflammatory Changes
Krishnan, J. (2022) · JOURNAL OF COMMUNICABLE DISEASES · doi:10.24321/0019.5138.202291
Direct Implications between Prenatal Alcohol Consumption and Gut Microbiome in the Neurodevelopment of Mice Offspring – Focusing On Foetal Alcoholic Spectrum DisordersPreprint
Pedroso-Roussado, C., Guppy, F. M., Bowler, L. D., & Inácio, J. (2022) · Preprints.org · doi:10.20944/preprints202212.0205.v1
Preventing Microglial Reactivity Protects from Acute and Progressive Neuronal Dysfunction, Motor Impairments and Sedation following Alcohol AbusePreprint
Paouri, E., Stanko, S., Gasmi, N., Glusauskas, G., Mao, V., Kwak, A., Sarmadi, S., Huang, E., Hershberger, C. E., Watercutter, Q., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.12.658437 · Cited by 1
Therapeutic Strategies to Treat Alcohol-Related Disorders Targeting Central Immune Signaling
Wu, Y. H., & Hutchinson, M. R. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4729-0_17
Flavonoids with Novel Nicotinic Activity as Potential Pharmacotherapies to Treat Ethanol- Induced Neurotoxicity
Lutz, J. A. (2014) · UKnowledge (University of Kentucky)
Immune Responses in HIV Infection, Alcoholism, and Aging: A Neuroimaging Perspective
Zahr, N. M., Manning-Bog, A., Alt, C., Sullivan, E. V., & Adolf Pfefferbaum, A. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4729-0_14
Alcohol and the Neuroimmune Response: Current Status and Future Directions
Grandison, L., Cui, C., & Noronha, A. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4729-0_18
Polimorfismos genéticos en la vía de los Micro-ARN y su relación con el alcoholismo
Veleiro, I. N. (2014) · Gredos (University of Salamanca) · doi:10.14201/gredos.124189
Taking a Toll in Brain: Role of TLR4
Krishnan, J. (2015)
Prevention of Alcohol-Induced Inflammation of Murine Small Intestine by MicroRNA-155 Deficiency
Lippai, D., & Szabó, G. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801770-8.00011-2
Alcohol and Neuroimmune Interactions
Kane, C. J. M., Bergeson, S. E., & Drew, P. D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800213-1.00042-0
Neuropathobiology of Alcohol-Induced Cognitive Deficits
Tiwari, V., & Chopra, K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800213-1.00057-2
Ethanol, Vitamins, and Brain Dysfunction
González‐Reimers, E., Fernández-Rodríguez, C. M., González‐Arnay, E., & Santolaria-Fernández, F. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800213-1.00044-4
Neuropathology of Gene Expression during Alcohol Withdrawal
Aujla, H. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800213-1.00049-3
Exposure of neonatal rats to alcohol has differential effects on cytokine levels in the cerebellum and hippocampus : potential role of microglia and astrocytes
Topper, L. A. (2015) · UNM’s Digital Repository (University of New Mexico)
Role of phosphodiesterase-4 in alcohol-induced organ injury.
Avila, D. V. (2016) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/2405
Análisis de la respuesta inflamatoria mediada por receptores tipo toll tras el consumo intensivo de alcohol o binge drinking
Costa‐Alba, P. (2016) · doi:10.14201/gredos.132789
Neuroimmune Aspects of Alcoholism and Affective Comorbidity
Neupane, S. P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813125-1.00019-2
THE LEVEL OF SYSTEMIC INFLAMMATION AND CHANGES IN ADAPTIVE IMMUNITY IN ALCOHOLIC PSYCHOSES
Didkovsky, N. A., Малашенкова, И. К., Ogurtsov, D., Krynskiy, S., Hailov, N. A., Chekulaeva, E. I., Mamoshina, M. V., Ushakov, V., Zakharova, N. V., & Kostyuk, G. P. (2019) · Medical academic journal · doi:10.17816/maj191s168-70
La modulación epigenética de microglia modifica la expresión de citocinas proinflamatorias
Cruz-Carrillo, G., Montalvo-Martínez, L., Fuentes‐Mera, L., & Camacho‐Morales, A. (2020) · Revista de Ciencias Farmaceúticas y Biomedicina
Mechanisms of Neurodegeneration and Clearance: From Caspases to Chemokines.
Sokolowski, J. D. (2013) · doi:10.18130/v3r50v
Papel de las vesículas extracelulares en la propagación y mantenimiento de la neuroinflamación inducida por el consumo de alcohol en la adolescencia
Cabanes, F. I. (2021) · RiuNet (Universitat Politècnica de València) · doi:10.4995/thesis/10251/174214
Cortical Neurons and Astrocytes in Intrauterine Ethanol Exposure: The Role of Exposure Time and Postnatal Timeline
Abijo, A. Z., Ayannuga, O. A., & Bamigboye, O. S. (2021) · Nigerian Journal of Basic and Applied Medical Sciences · doi:10.53994/njbams.202111.7
Firm competitiveness: summary report on the CompNet conference Banque de France 20 and 21 September 2012
Berthou, A., Bourgeon, P., & Vicard, V. (2013) · Quarterly selection of articles - Bulletin de la Banque de France
Alcoholic Brain Damage
Crichton, R. R., & Ward, R. J. (2013) · Wiley eBooks · doi:10.1002/9781118553480.ch12
Alcohol
(2021) · Elsevier eBooks · doi:10.1016/b978-0-12-816793-9.00001-3
Illustration of a Novel Gut-Brain Axis of Alcohol Withdrawal, Withdrawal-Associated Depression, Craving and Alcohol-Severity Index in Alcohol Use Disorder PatientsPreprint
Vatsalya, V., Parthasarathy, R., Verster, J. C., Royer, A., Sagaram, M., Zamani, Z., Hu, H., Schwandt, M. L., Leggio, L., Kong, M., et al. (2022) · medRxiv · doi:10.1101/2022.05.15.22275115
Papel de los receptores TLR4 y de la microbiota intestinal en los procesos inflamatorios y neuroinflamatorios causados por el consumo crónico de alcohol, y posibles terapias con curcuminoides.
Díaz, C. M. C. (2022) · doi:10.4995/thesis/10251/183832
Role of protease inhibitors in the pathogenesis of alcoholic neuropathy
González‐Argote, J. (2021) · Salud Ciencia y Tecnología · doi:10.56294/saludcyt202119
Hormesis – an example of astrocyte response after ethanol exposure
Lipnik‐Štangelj, M., & Šarc, L. (2021) · Acta Medico-Biotechnica · doi:10.18690/actabiomed.77
Brain-Immune Mechanisms in Alcohol Use Disorder Targeting Neuroimmune Signaling in Alcohol Use Disorder: Opportunities for Translation
Grodin, E. N., Meredith, L. R., Burnette, E. M., & Ray, L. A. (2023) · Springer eBooks · doi:10.1007/978-3-031-32483-3_30
The Efficacy of Two Specific Toll-like Receptor 4 Antagonists (G2013 & M2000) in Clinical Inflammatory Disease
Taeb, M., Rahmani, M., Sharifi, L., & Mirshafiey, A. (2024) · British journal of healthcare and medical research · doi:10.14738/bjhmr.106.14305
Effect of High Mobility Group Box 1 Pathway Inhibition on Gene Expression in the Prefrontal Cortex of Mice Exposed To AlcoholPreprint
Qiu, S., Dong, S., Fan, J., Wu, C., & Qi, X. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4678355
Effect of High Mobility Group Box 1 Pathway Inhibition on Gene Expression in the Prefrontal Cortex of Mice Exposed To AlcoholPreprint
Qiu, S., Dong, S., Fan, J., Wu, C., & Qi, X. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4761065
Alcohol
Krishnan, J. (2024) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815223828124010010
Sex, Drugs, and TBI: The Effects of Sex Hormones and TrkB Activation on Alcohol-Related Behavior Following a Traumatic Brain Injury
Oliverio, R. (2024) · doi:10.33915/etd.12536
Unravelling the impact of TLR4 and sex on chronic alcohol consumption-induced lipidome dysregulation in extracellular vesiclesPreprint
Perpiñá-Clérigues, C., Mellado, S., Galiana‐Roselló, C., Garcia‐García, F., & Pascual, M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.05.611414
Unveiling the role of miRNAs from MSC-EVs in neuroinflammation and behavioral impairments induced by chronic alcohol consumptionPreprint
Mellado, S., Touahri, N., Montagud‐Romero, S., Perpiñá-Clérigues, C., Garcia‐García, F., Moreno‐Manzano, V., Guerri, C., Rodríguez‐Arias, M., & Pascual, M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.03.616225
Study of gene expression of the Toll-like receptor system in the forebrain cortex of rat pups with prenatal alcohol exposure and pharmacologic correction with rifampicin
Airapetov, M. I., Eresko, S. O., Ignatova, P. D., Ganshina, D., Sukhanova, D., Mikhailova, A., Aa, L., Бычков, Э. Р., & Shabanov, P. D. (2024) · Biological Communications · doi:10.21638/spbu03.2024.301
Effect of rifampicin on Toll-like receptor system gene expression in brain structures of rats with prenatal alcohol exposure
Airapetov, M. I., Eresko, S. O., Михайлова, А. А., Sukhanova, D., Ignatova, P. D., Aa, L., Bychkov, E. R., & Шабанов, П. Д. (2025) · Medical Immunology (Russia) · doi:10.15789/1563-0625-eor-2935
Peripheral blood cell-type and sex-specific signatures of alcohol misuse revealed by single-cell transcriptomicsPreprint
Shetty, A. C., Verma, A., Sivinski, J. M., Fan, X., Doty, C., Hollander, B., Roche, D., & Seneviratne, C. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.21.655347
Neuroinflamación, estrés y consumo de drogas
Malaguarnera, M., Rodríguez‐Arias, M., & Miñarro, J. (2025) · Revista Española de Drogodependencias · doi:10.54108/10112
Ethanol-induced changes in neurotrophic and immune genes are regulated by receptor-type protein tyrosine phosphatase β/ζ (RPTPβ/ζ) and microglial-neuronal interactions
Penedo, M. A., Cañeque‐Rufo, H., Gramage, E., & Herradón, G. (2025) · Frontiers in Genetics · doi:10.3389/fgene.2025.1634202
Peroxisome proliferator-activated receptor pathway and key genes in cerebellar dysfunction induced by chronic intermittent alcohol exposure: a transcriptomic study
Zheng, Y., Sun, G., Wei, S., Kong, L., Guo, J., Pan, W. D., Zhu, X., & Qi, X. (2025) · Neurological Research · doi:10.1080/01616412.2025.2556244
Adolescent intermittent ethanol exacerbates Aβ with age in the dorsal hippocampus of female TgF344-AD ratsPreprint
Day, S. M., Reitz, N. L., & Savage, L. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.20.683498
Additional file 1 of Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation
Banerjee, S., Park, T., Kim, Y. S., & Kim, H.-Y. (2023) · Figshare · doi:10.6084/m9.figshare.23949793
Lipopolysaccharide and imiquimod stimulation of potential immune biomarkers in whole blood predict alcohol use disorder risk based on AUDIT scores
Balan, I., Lopez, A. G., Gilmore, T. A., Bremmer, M. P., O’Buckley, T. K., Xia, K., Hendershot, C. S., & Morrow, A. L. (2026) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.70236
Research Progress on the Role of Microglia in Neuroinflammation Associated with Alcohol Use Disorders
何, 林. (2026) · Open Journal of Natural Science · doi:10.12677/ojns.2026.142028
Mécanismes inflammatoires liés à la consommation chronique d'alcool : de la translocation bactérienne aux monocytes.
Donnadieu‐Rigole, H. (2016) · doi:10.70675/f90f0a83z763ez43e3z9e94z3003045bae48
Rôle de la neuroinflammation dans les atteintes de la plasticité synaptique glutamatergique induites par le binge drinking dans l'hippocampe de rat
Bertrand, C. (2021) · theses.fr (ABES) · doi:10.70675/05df8357z6906z4971za054z1b8e0b0127ee
Immunomodulatory effects of mesenchymal stem cell-derived extracellular vesicles on NLRP3 inflammasome activation in the adult mouse brain after chronic ethanol exposure
Mellado, S., Moreno‐Manzano, V., Guerri, C., & Pascual, M. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-11774-2
Astrocytes and Interleukin‐1β in the Dorsal Hippocampus Contribute to Enhanced Fear Learning Following Ethanol and Stress
Barkell, G. A., McNeill, S. T., Thiele, T. E., & Lysle, D. T. (2026) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.70304
Investigating metabotropic glutamate receptors as molecular targets for next-generation pharmacotherapies for alcohol use disorder
Obraitis, D., Barry, J., & Li, D. (2026) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2026.2675555
Sexually dimorphic roles of toll-like receptors in the central nervous system
Elkabes, S. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106830
Adolescent intermittent ethanol exacerbates amyloid-β with age in the dorsal hippocampus of female TgF344-AD rats
Day, S. M., Reitz, N. L., & Savage, L. M. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261453081 · Cited by 1
Plasma albumin and other indicators as risk factors for delayed neurocognitive recovery in elderly patients undergoing orthopedic surgery
Zhao, G., Fu, H., Liu, F., Duan, M., & Wang, T. (2026) · BMC Surgery · doi:10.1186/s12893-026-03919-8
Heme Oxygenase-1 Contributes to Dampening Proinflammatory Activation in the Human Microglial Cell Line HMC3 and Controls the Transcription Factor IRF5
Furfaro, A. L., Mancini, P., Passalacqua, M., Ortolan, J., Ivaldo, C., Tirendi, S., Vernazza, S., d’Abramo, C., Giliberto, L., & Nitti, M. (2026) · Biomolecules · doi:10.3390/biom16071028
Integrated Network and Transcriptomic Analyses Identify a Candidate Ethanol–ADAM17 Molecular Axis Associated with Glioblastoma Progression
Arumugam, A., Baik, H., Jang, N., Huang, W., & Chang, S. L. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177837
The vagus nerve in alcohol use disorder: Gut-brain mechanisms linking interoception, neuroinflammation, and reward
Lehner, T., Sandoval, D. A., & McCullough, R. L. (2026) · Alcohol · doi:10.1016/j.alcohol.2026.107460
Microglia-mediated extracellular matrix disruption drives neuronal dysfunction, motor impairments, and sedation following alcohol abuse
Paouri, E., Stanko, S., Gasmi, N., Glusauskas, G., Mao, V., Kwak, A., Hsu, S., Sarmadi, S., Huang, E., Das, A., et al. (2026) · Immunity · doi:10.1016/j.immuni.2026.09.011 · Cited by 1
Neuromodulation as a Potential Strategy to Remodel Brain Parenchyma in Addiction
Limens-Pinaque, J., Selim, M. K., Santis, S. D., Camarena, F., & Canals, S. (2026) · Springer eBooks · doi:10.1007/978-3-031-35658-2_18-1

Authors: Alfonso-Loeches, S., Pascual-Lucas, M., Blanco, A. M., Sanchez-Vera, I., & Guerri, C.
Affiliations: Centro de Investigacion Principe Felipe (ES)
Corresponding author: Guerri, C.
ORCID: Blanco, A. M.
Guerri, C.
Venue: Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2010-06-16
Volume: 30
Issue: 24
Pages: 8285-8295
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.0976-10.2010
PMC: PMC6634595
OpenAlex: W1975931952
Cited by: 579
References: 66
Citations by year: 2026: 17 · 2025: 35 · 2024: 41 · 2023: 39 · 2022: 41 · 2021: 46 · 2020: 44 · 2019: 41 · 2018: 30 · 2017: 56 · 2016: 46 · 2015: 24 · 2014: 36 · 2013: 23 · 2012: 35
FWCI: 16.09
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Ministerio de Ciencia e Innovación
Plan Nacional sobre Drogas
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: TLR4, ethanol, glial activation, astrocytes, microglia, neurodegeneration, brain injury, MAPK signaling, NF-κB signaling, inflammatory mediators, apoptosis, caspase-3, inducible nitric oxide synthase, cyclooxygenase-2, cytokines, female mice, cerebral cortex
MeSH terms: Ethanol, Animals, Astrocytes, Brain Injuries, Calcium-Binding Proteins, Central Nervous System Depressants, Disease Models, Animal, Encephalitis, Female, Gene Expression Regulation, Lipopolysaccharides, Mice, Inbred C57BL, Microfilament Proteins, Nerve Tissue Proteins, RNA, Messenger, Time Factors, Tumor Necrosis Factor-alpha, Rats, Wistar, Mice, Knockout, Statistics, Nonparametric, Lipopolysaccharide Receptors, RNA, Small Interfering, Green Fluorescent Proteins, Toll-Like Receptor 4, Lymphocyte Antigen 96, Mice, Rats, Cyclooxygenase 2, Caspase 3, Interleukin-1beta

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pivotal Role of TLR4 Receptors in Alcohol-Induced Neuroinflammation and Brain Damage

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks