Changes in the distribution of extracellular matrix components accompany early morphogenetic events of mammalian cortical development.
Open accessAbstract
As a step in defining the molecular environment for development of the mammalian cerebral cortex, we have used immunohistochemistry to analyze the distribution and remodeling of three major extracellular matrix (ECM) components, fibronectin, chondroitin sulfate proteoglycan (CSPG), and tenascin, during embryonic and early postnatal stages in the mouse. Fibronectin and CSPG are distributed throughout the proliferative zone that initially comprises the thin wall of the telencephalic vesicle, but their distribution changes as newly generated cells form the preplate just beneath the pia. Immunolabeling for CSPG becomes most prominent in the preplate, and fibronectin becomes restricted to that layer. Just after this change occurs, processes of preplate neurons, visualized with antibodies to neurofilaments, become evident within the matrix-rich preplate zone. The association of fibronectin and CSPG with preplate cells persists as cortical plate neurons divide the preplate; both ECM components are now most prominent in the marginal zone and subplate, the layers above and below the cortical plate that are preplate derived. Within the preplate and its derivatives, immunolabeling of fibronectin is punctate and closely associated with radial glial processes, while labeling of CSPG is more intense and diffuse. Labeling of fibronectin and CSPG declines rapidly as the cortical plate begins to differentiate into cortex; labeling for tenascin first appears at this stage in the most mature layers, the marginal zone and subplate, then gradually becomes widespread throughout all of cortex and subcortical white matter. In early postnatal life, tenascin is eliminated from the hollows of the vibrissal barrels in the somatosensory region; it then declines rapidly throughout cortex. The association of both fibronectin and CSPG with preplate cells and the distribution of fibronectin along radial glia during early cortical development suggest that one or both of these transient cell types might produce specific ECM components or induce their local deposition. The spatial and temporal distribution of fibronectin and CSPG suggests a role in defining a destination for migrating neurons that form the cortical plate and in delineating the pathway for early axonal extension. In contrast, the relatively late appearance of tenascin correlates best with the formation of astrocytes and their processes rather than with the establishment of cortical layers or major axonal pathways. These events are well underway before labeling of tenascin is evident.
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In the mouse cortex, tenascin immunolabeling is first detected around E16 and tenascin levels increase after birth until the third postnatal week.
“In the mouse cortex, tenascin immunolabeling is first detected around E16 (Sheppard et al., 1991) and tenascin levels increase after birth until the third postnatal week (Brückner et al., 2000).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Sheppard et al., 1991
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Cites
Mode of cell migration to the superficial layers of fetal monkey neocortex
Rakic, P. (1972) · Journal of Comparative Neurology · doi:10.1002/cne.901450105 · Cited by 2,170 · see citing works
A simple method of reducing the fading of immunofluorescence during microscopy
Johnson, G. D., & Araujo, G. M. D. C. N. (1981) · Journal of Immunological Methods · doi:10.1016/0022-1759(81)90183-6 · Cited by 1,884 · see citing works
Autoradiographic Study of Cell Migration during Histogenesis of Cerebral Cortex in the Mouse
ANGEVINE, J. B., & SIDMAN, R. L. (1961) · Nature · doi:10.1038/192766b0 · Cited by 1,530 · see citing works
Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro
Snow, D. M., Lemmon, V., Carrino, D. A., Caplan, A. I., & Silver, J. (1990) · Experimental Neurology · doi:10.1016/s0014-4886(05)80013-5 · Cited by 776 · see citing works
Laminin promotes neuritic regeneration from cultured peripheral and central neurons.
Manthorpe, M., Engvall, E., Ruoslahti, E. I., Longo, F. M., Davis, G. E., & Varon, S. S. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.6.1882 · Cited by 717 · see citing works
Three different fibronectin mRNAs arise by alternative splicing within the coding region
Schwarzbauer, J. E., Tamkun, J. W., Lemischka, I. R., & Hynes, R. O. (1983) · Cell · doi:10.1016/0092-8674(83)90175-7 · Cited by 706 · see citing works
Schmechel, D. E., & RAKIC, P. T. (1979) · Anatomy and Embryology · doi:10.1007/bf00300010 · Cited by 676 · see citing works
Rogers, S. L., Letourneau, P. C., Palm, S. L., McCarthy, J. B., & Furcht, L. T. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90350-0 · Cited by 667 · see citing works
Subplate Neurons Pioneer the First Axon Pathway from the Cerebral Cortex
McConnell, S. K., Ghosh, A., & Shatz, C. J. (1989) · Science · doi:10.1126/science.2475909 · Cited by 647 · see citing works
Voigt, T. B. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902890106 · Cited by 549 · see citing works
Pixley, S. K., & de Vellis, J. (1984) · Developmental Brain Research · doi:10.1016/0165-3806(84)90097-x · Cited by 534 · see citing works
Dual origin of the mammalian neocortex and evolution of the cortical plate
Marín‐Padilla, M. (1978) · Anatomy and Embryology · doi:10.1007/bf00315920 · Cited by 508 · see citing works
Kostović, I., & RAKIC, P. T. (1980) · Journal of Neurocytology · doi:10.1007/bf01205159 · Cited by 499 · see citing works
Misson, J., Edwards, M. A., Yamamoto, M., & Caviness, V. S. (1988) · Developmental Brain Research · doi:10.1016/0165-3806(88)90121-6 · Cited by 422 · see citing works
Levitt, P. R., Cooper, M., & RAKIC, P. T. (1981) · Journal of Neuroscience · doi:10.1523/jneurosci.01-01-00027.1981 · Cited by 395 · see citing works
Grumet, M., Hoffman, S., Crossin, K. L., & Edelman, G. M. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.23.8075 · Cited by 391 · see citing works
Snow, D. M., Steindler, D. A., & Silver, J. (1990) · Developmental Biology · doi:10.1016/0012-1606(90)90203-u · Cited by 390 · see citing works
Immunohistochemical study of the development of serotonergic neurons in the rat CNS
Lidov, H. G. W., & Molliver, M. E. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90164-2 · Cited by 376 · see citing works
N-cadherin, NCAM, and integrins promote retinal neurite outgrowth on astrocytes in vitro.
Neugebauer, K. M., Tomaselli, K. J., Lilien, J. E., et al. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.107.3.1177 · Cited by 323 · see citing works
Chiquet, M., & Fambrough, D. M. (1984) · The Journal of Cell Biology · doi:10.1083/jcb.98.6.1937 · Cited by 317 · see citing works
Bronner-Fraser, M. E. (1986) · Developmental Biology · doi:10.1016/0012-1606(86)90320-9 · Cited by 303 · see citing works
The extended family of proteoglycans: social residents of the pericellular zone
Gallagher, J. T. (1989) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(89)80072-9 · Cited by 294 · see citing works
A study of neurogenesis in the forebrain of opossum pouch young
Morest, D. K. (1970) · Anatomy and Embryology · doi:10.1007/bf00520999 · Cited by 292 · see citing works
A six-armed oligomer isolated from cell surface fibronectin preparations
Erickson, H., & Inglesias, J. L. (1984) · Nature · doi:10.1038/311267a0 · Cited by 275 · see citing works
Development of the major pathways for neurite outgrowth in the chick hindlimb
Tosney, K. W., & Landmesser, L. T. (1985) · Developmental Biology · doi:10.1016/0012-1606(85)90360-4 · Cited by 272 · see citing works
Margolis, R. K., & Margolis, R. U. (1993) · Cellular and Molecular Life Sciences · doi:10.1007/bf01923587 · Cited by 265 · see citing works
Chuong, C., Crossin, K. L., & Edelman, G. M. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.104.2.331 · Cited by 262 · see citing works
Tan, S. S., Crossin, K. L., Hoffman, S., & Edelman, G. M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.22.7977 · Cited by 254 · see citing works
Guidance of neurite outgrowth by pathways of substratum‐adsorbed laminin
Hammarback, J. A., Palm, S. L., Furcht, L. T., et al. (1985) · Journal of Neuroscience Research · doi:10.1002/jnr.490130115 · Cited by 251 · see citing works
Edwards, M. A., Yamamoto, M., & Caviness, V. S. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90356-9 · Cited by 249 · see citing works
Do neurons in the vertebrate CNS migrate on laminin?
Liesi, P. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03755.x · Cited by 245 · see citing works
Herndon, M. E., & Lander, A. D. (1990) · Neuron · doi:10.1016/0896-6273(90)90148-9 · Cited by 245 · see citing works
Culican, S., Baumrind, N., Yamamoto, M., et al. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-02-00684.1990 · Cited by 221 · see citing works
Promotion of retinal neurite outgrowth by substratum-bound fibronectin
Akers, R. M., Mosher, D. F., & Lilien, J. E. (1981) · Developmental Biology · doi:10.1016/0012-1606(81)90328-6 · Cited by 219 · see citing works
Is astrocyte laminin involved in axon guidance in the mammalian CNS?
Liesi, P., & Silver, J. (1988) · Developmental Biology · doi:10.1016/0012-1606(88)90366-1 · Cited by 218 · see citing works
Distribution of laminin in the developing peripheral nervous system of the chick
Rogers, S. L., Edson, K. J., Letourneau, P. C., et al. (1986) · Developmental Biology · doi:10.1016/0012-1606(86)90177-6 · Cited by 207 · see citing works
Autoradiographic study of early neurogenesis in rat neocortex
Raedler, E., & Raedler, A. (1978) · Anatomy and Embryology · doi:10.1007/bf00345657 · Cited by 206 · see citing works
Chun, J. J. M., & Shatz, C. J. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-05-01648.1989 · Cited by 196 · see citing works
Crossin, K. L., Hoffman, S., Tan, S., & Edelman, G. M. (1989) · Developmental Biology · doi:10.1016/0012-1606(89)90264-9 · Cited by 182 · see citing works
Valverde, F., Facal‐valverde, M. V., Santacana, M., & Heredia, M. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902900108 · Cited by 173 · see citing works
Tomaselli, K. J., Damsky, C. H., & Reichardt, L. F. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.107.3.1241 · Cited by 166 · see citing works
Fibronectin-like immunoreactivity in the developing cerebral cortex
Gr, S., & Pearlman, A. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-10-03325.1987 · Cited by 161 · see citing works
Self-citationMjaatvedt, C. H., Lepera, R. C., & Markwald, R. R. (1987) · Developmental Biology · doi:10.1016/0012-1606(87)90206-5 · Cited by 157 · see citing works
Laminin as a substrate for retinal axons in vitro
Smalheiser, N. R., Crain, S. M., & Reid, L. M. (1984) · Developmental Brain Research · doi:10.1016/0165-3806(84)90184-6 · Cited by 150 · see citing works
Immunoreactivity for laminin in the developing ventral longitudinal pathway of the brain
Letourneau, P. C., Madsen, A. M., Palm, S. L., et al. (1988) · Developmental Biology · doi:10.1016/0012-1606(88)90066-8 · Cited by 148 · see citing works
Verney, C., Berger, B., Adrien, J., Vigny, A., & Gay, M. (1982) · Developmental Brain Research · doi:10.1016/0165-3806(82)90111-0 · Cited by 147 · see citing works
Distribution and function of tenascin during cranial neural crest development in the chick
Bronner-Fraser, M. E. (1988) · Journal of Neuroscience Research · doi:10.1002/jnr.490210206 · Cited by 139 · see citing works
Chun, J. J. M., & Shatz, C. J. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.106.3.857 · Cited by 137 · see citing works
Humphries, M. J., Akiyama, S. K., Komoriya, A., Olden, K., & Yamada, K. M. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.106.4.1289 · Cited by 135 · see citing works
Smart, I. H. M., & Smart, M. (1982) · PubMed · Cited by 133 · see citing works
Innervation of embryonic rat cerebral cortex by catecholamine‐containing fibers
Schlumpf, M., Shoemaker, W. J., & Bloom, F. E. (1980) · The Journal of Comparative Neurology · doi:10.1002/cne.901920210 · Cited by 132 · see citing works
Adler, R., Jerdan, J. A., & Hewitt, A. T. (1985) · Developmental Biology · doi:10.1016/0012-1606(85)90124-1 · Cited by 128 · see citing works
Aquino, D. A., Margolis, R. U., & Margolis, R. K. (1984) · The Journal of Cell Biology · doi:10.1083/jcb.99.3.1130 · Cited by 126 · see citing works
Neurons cultured from developing rat brain attach and spread preferentially to laminin
Liesi, P., Dahl, D. R., & Vaheri, A. I. (1984) · Journal of Neuroscience Research · doi:10.1002/jnr.490110304 · Cited by 126 · see citing works
Transient expression of laminin in the optic nerve of the developing rat
McLoon, S., McLoon, L. K., Palm, S., et al. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-06-01981.1988 · Cited by 125 · see citing works
Perris, R., & Johansson, S. (1990) · Developmental Biology · doi:10.1016/0012-1606(90)90002-z · Cited by 123 · see citing works
Hagg, T., Muir, D., Engvall, E., Varon, S. S., & Manthorpe, M. (1989) · Neuron · doi:10.1016/0896-6273(89)90241-9 · Cited by 121 · see citing works
Tucker, R. P., & Erickson, C. A. (1984) · Developmental Biology · doi:10.1016/0012-1606(84)90094-0 · Cited by 118 · see citing works
Transitory population of cells in the temporal cortex of kittens
Valverde, F., & Facal‐valverde, M. V. (1987) · Developmental Brain Research · doi:10.1016/0165-3806(87)90108-8 · Cited by 112 · see citing works
Takahashi, T., Misson, J., & Caviness, V. S. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.903020103 · Cited by 108 · see citing works
Oohira, A., Matsui, F., Matsuda, M., Takida, Y., & Kuboki, Y. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)81505-3 · Cited by 106 · see citing works
Dual Fate of Subplate Neurons in a Rodent
Woo, T., Beale, J. M., & Finlay, B. L. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.5.433 · Cited by 105 · see citing works
Hatten, M., Furie, M. B., & Rifkin, D. B. (1982) · Journal of Neuroscience · doi:10.1523/jneurosci.02-09-01195.1982 · Cited by 89 · see citing works
Rogers, S. L., Letourneau, P. C., Peterson, B. A., Furcht, L. T., & McCarthy, J. B. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.105.3.1435 · Cited by 79 · see citing works
Axon strata of the cerebral wall in embryonic mice
Crandall, J. E., & Caviness, V. S. (1984) · Developmental Brain Research · doi:10.1016/0165-3806(84)90305-5 · Cited by 75 · see citing works
Extracellular matrix during laminar pattern formation of neocortex in normal and reeler mutant mice
Nakanishi, S. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90031-3 · Cited by 68 · see citing works
Chromatin Proteins Share Antigenic Determinants with Neurofilaments
Wood, J. N., LaThangue, N. B., McLachlan, D. R. C., et al. (1985) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1985.tb07124.x · Cited by 67 · see citing works
Caviness, V. S., & Korde, M. G. (1981) · Brain Research · doi:10.1016/0006-8993(81)91167-7 · Cited by 51 · see citing works
Stallcup, W. B., Pytela, R., & Ruoslahti, E. I. (1989) · Developmental Biology · doi:10.1016/0012-1606(89)90218-2 · Cited by 50 · see citing works
Prenatal gliogenesis in the developing cerebrum of the mouse
Choi, B. H. (1988) · Glia · doi:10.1002/glia.440010503 · Cited by 44 · see citing works
Extracellular matrix distribution during neocortical wall ontogenesis in "normal" and "Reeler" mice.
Derer, P., & Nakanishi, S. (1983) · PubMed · Cited by 37 · see citing works
Extracellular Matrix Molecules That Influence Neural Development
Sanes, J. (1989) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.12.1.491 · Cited by 37 · see citing works
Brauer, P. R., & Markwald, R. R. (1988) · The Anatomical Record · doi:10.1002/ar.1092220111 · Cited by 29 · see citing works
Studies on The Migration of Mouse Germ Cells
Donovan, P. J., Stott, D., Godin, I., et al. (1987) · Journal of Cell Science · doi:10.1242/jcs.1987.supplement_8.20 · Cited by 29 · see citing works
Tenascin: An Extracellular Matrix Protein Prominent In Specialized Embryonic Tissues And Tumors
Erickson, H. (1989) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.5.1.71 · Cited by 27 · see citing works
Structure and orientation of extracellular matrix in developing chick optic tectum
Krayanek, S. R. (1980) · The Anatomical Record · doi:10.1002/ar.1091970109 · Cited by 26 · see citing works
Brückner, G., Müller, L., Wollweber, L., et al. (1985) · PubMed · Cited by 22 · see citing works
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Allendoerfer, K. L., & Shatz, C. J. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.001153 · Cited by 653 · see citing works
Oligodendrocyte development and the onset of myelination in the human fetal brain
Jakovcevski, I. (2009) · Frontiers in Neuroanatomy · doi:10.3389/neuro.05.005.2009 · Cited by 323 · see citing works
Cortical development: View from neurological mutants two decades later
Rakic, P., & Caviness, V. S. (1995) · Neuron · doi:10.1016/0896-6273(95)90258-9 · Cited by 287 · see citing works
Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons
Sugitani, Y., Nakai, S., Minowa, O., Nishi, M., Jishage, K.-I., Kawano, H., Mori, K., Ogawa, M., & Noda, T. (2002) · Genes & Development · doi:10.1101/gad.978002 · Cited by 259 · see citing works
Venstrom, K. A., & Reichardt, L. F. (1993) · The FASEB Journal · doi:10.1096/fasebj.7.11.8370483 · Cited by 269 · see citing works
The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders
Wen, T. H., Binder, D. K., Ethell, I. M., & Razak, K. A. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00270 · Cited by 170 · see citing works
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Quattrocchi, C. C., Wannenes, F., Persico, A. M., Ciafré, S. A., D'Arcangelo, G., Farace, M. G., & Keller, F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106996200 · Cited by 154 · see citing works
Köppe, G., Brückner, G., Brauer, K., Härtig, W., & Bigl, V. (1997) · Cell and Tissue Research · doi:10.1007/s004410050790 · Cited by 129 · see citing works
Miller, B., Sheppard, A. M., Bicknese, A. R., & Pearlman, A. L. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903550410 · Cited by 114 · see citing works
Self-citationOkamoto, M., Mori, S., & Endo, H. (1994) · Brain Research · doi:10.1016/0006-8993(94)91217-3 · Cited by 59 · see citing works
Harrison, S. J., Nishinakamura, R., Jones, K. R., & Monaghan, A. P. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.002873 · Cited by 42 · see citing works
Friauf, E. (2000) · Audiology and Neurotology · doi:10.1159/000013889 · Cited by 33 · see citing works
Reelin-Nrp1 Interaction Regulates Neocortical Dendrite Development in a Context-Specific Manner
Kohno, T., Ishii, K., Hirota, Y., Honda, T., Makino, M., Kawasaki, T., Nakajima, K., & Hattori, M. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.1907-20.2020 · Cited by 30 · see citing works
- Authors
- Sheppard, A., Hamilton, S., & Pearlman, A.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1991-12-01
- Volume
- 11
- Issue
- 12
- Pages
- 3928-3942
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6575290
- OpenAlex
- W1879100080
- Cited by
- 249
- References
- 77
- Citations by year
- 2025: 1 · 2024: 4 · 2022: 2 · 2021: 1 · 2020: 6 · 2019: 3 · 2018: 1 · 2017: 5 · 2016: 6 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 3
- FWCI
- 5.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- National Institutes of Health (5r01ey000621-27)
- National Eye Institute (R01-EY00621)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- extracellular matrix, cortical development, fibronectin, chondroitin sulfate proteoglycans, tenascin, preplate, radial glia, cortical plate, subplate, marginal zone, neuronal migration, axonal extension, mouse embryo, postnatal development
- MeSH terms
- Animals, Animals, Newborn, Cerebral Cortex, Extracellular Matrix, Embryonic and Fetal Development, Fibronectins, Immunohistochemistry, Neuroglia, Chondroitin Sulfate Proteoglycans, Tissue Distribution, Cell Adhesion Molecules, Neuronal, Extracellular Matrix Proteins, Tenascin, Mice
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