Differential expression of mRNAs for neuropeptide Y-related peptides in rat nervous tissues: possible evolutionary conservation
Open accessAbstract
Neuropeptide Y (NPY) is the only member of its peptide family that has been isolated from the mammalian CNS. We have recently found that two different NPY-related molecules are present in the CNS of a cyclostome, the river lamprey (Lampetra fluviatilis) (Soderberg et al., 1991). Here we show that this is also true for the rat CNS, by demonstrating expression of peptide YY (PYY) mRNA in brainstem neurons distinct from those neurons that express NPY mRNA. Dissimilar oligonucleotide DNA probes complementary to 3' untranslated regions of the rat PYY, NPY, and pancreatic polypeptide (PP) mRNA were used in in situ hybridization experiments on sections of rat brain and spinal cord, visceral organs, and peripheral nerve ganglia. The PYY probe hybridized with two populations of neurons in the brainstem: one dispersed along the midline in the rostral medulla and another in the lateral caudal medulla (A1 region). No additional labeling was detected in the remainder of the neuraxis. In the periphery, PYY hybridization was seen only in endocrine cells of the colon, and not in sympathetic ganglia or the adrenal gland, suggesting that previous observations of PYY immunoreactivity in these latter structures were due to antibody cross- reactivity with NPY. The NPY probe did not hybridize with cells on the midline region that contains PYY neurons, but it did label large numbers of neurons throughout the neuraxis. No expression of PP mRNA was detected in the CNS. Northern blot analysis failed to detect PYY mRNA in the CNS, further supporting the observation that PYY is only expressed by a discrete collection of CNS neurons. The anatomy of PYY- and NPY-expressing cells in the CNS and gut shows a striking similarity between rat and lamprey (Brodin et al., 1989), vertebrates that diverged evolutionarily about 450 million years ago, suggesting that both peptide systems have been conserved throughout vertebrate evolution.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Pyy is known to be highly expressed in pancreatic islets and endocrine L cells of the lower gastrointestinal tract.
“Pyy is known to be highly expressed in pancreatic islets and endocrine L cells of the lower gastrointestinal tract [39], but its early embryonic expression pattern has not been described.”
From A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE) (2007) · cites this paper as [39]
Cites
Dahlstroem, A., & Fuxé, K. (1964) · PubMed · Cited by 5,143 · see citing works
Tatemoto, K., Carlquist, M., & Mutt, V. (1982) · Nature · doi:10.1038/296659a0 · Cited by 2,254 · see citing works
Immunohistochemical evidence for the existence of adrenaline neurons in the rat brain
Ho¨kfelt, T., Fuxé, K., Goldstein, M., & Johansson, O. (1974) · Brain Research · doi:10.1016/0006-8993(74)90143-7 · Cited by 1,093 · see citing works
Self-citationde Quidt, M. E., & Emson, P. C. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90057-6 · Cited by 569 · see citing works
Isolation and characterization of a new pancreatic polypeptide hormone.
Kimmel, J., Hayden, L. J., & POLLOCK, H. G. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40653-4 · Cited by 449 · see citing works
Lundberg, J. O., Terenius, L. Y., Hökfelt, T. G. M., & Tatemoto, K. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-09-02376.1984 · Cited by 308 · see citing works
Structure and expression of the rat neuropeptide Y gene.
Larhammar, D., Ericsson, A. B., & PERSSON, H. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.7.2068 · Cited by 301 · see citing works
Self-citationNeuropeptide Y modulates neurotransmitter release and Ca2+ currents in rat sensory neurons
Walker, M., Ewald, D. A., Perney, T. M., & Miller, R. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02438.1988 · Cited by 207 · see citing works
Localization and identification of Neuropeptide Y (NPY)-like immunoreactivity in the frog brain
Danger, J., Guy, J., Benyamina, M., Jégou, S., Leboulenger, F., Coté, J., Tonon, M., Peplletier, G., & Vaudry, H. (1985) · Peptides · doi:10.1016/0196-9781(85)90455-3 · Cited by 150 · see citing works
Peptide YY-like immunoreactivity in the central nervous system of the rat
Ekman, R., Wahlestedt, C., Böttcher, G., Sundler, F., Håkanson, R., & Panula, P. (1986) · Regulatory Peptides · doi:10.1016/0167-0115(86)90059-5 · Cited by 133 · see citing works
Pancreatic polypeptide immunoreactivity in rat brain is actually neuropeptide Y
DiMaggio, D. A., Chronwall, B. M., Buchanan, K. D., & O'Donohoue, T. L. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90259-3 · Cited by 131 · see citing works
Lin, T. M., & Chance, R. E. (1974) · PubMed · Cited by 89 · see citing works
Peptide YY (PYY)‐immunoreactive neurons in the lower brain stem and spinal cord of rat
Broomé, M., Hökfelt, T. G. M., & Terenius, L. Y. (1985) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1985.tb07728.x · Cited by 88 · see citing works
Peptide YY. Structure of the precursor and expression in exocrine pancreas.
Leiter, A. B., Toder, A. E., Wolfe, H. J., Taylor, I. L., Cooperman, S. S., Mandel, G., & Goodman, R. H. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45154-x · Cited by 80 · see citing works
Krstenansky, J. L., Owen, T. J., Buck, S. H., Hagaman, K. A., & McLean, L. R. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.12.4377 · Cited by 79 · see citing works
Schalling, M., Hökfelt, T. G. M., Wallace, B., Goldstein, M., Filer, D., Yamin, C., & Schlesinger, D. H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.16.6208 · Cited by 59 · see citing works
Leslie, R. A., McDonald, T. J., & Robertson, H. A. (1988) · Peptides · doi:10.1016/0196-9781(88)90091-5 · Cited by 49 · see citing works
Brodin, L., Rawitch, A. B., Taylor, T., Ohta, Y., Ring, H., Hökfelt, T., Grillner, S. E., & Terenius, L. Y. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-10-03428.1989 · Cited by 45 · see citing works
Self-citationYonekura, H., Nata, K., Watanabe, T., Kurashina, Y., Yamamoto, H., & Okamoto, H. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69165-3 · Cited by 37 · see citing works
Peptide YY receptors in the brain
Inui, A., Oya, M., Okita, M., Inoue, T., Sakatani, N., Morioka, H., Shii, K., Yokono, K., Mizuno, N., & Baba, S. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(88)90481-0 · Cited by 34 · see citing works
Adrenal vein catecholamines and neuropeptides during splanchnic nerve stimulation in cats
Gaumann, D. M., Yaksh, T. L., Tyce, G. M., & Stoddard, S. L. (1989) · Peptides · doi:10.1016/0196-9781(89)90147-2 · Cited by 26 · see citing works
Peptide YY-like immunoreactivity in sympathetic neurons of the rat
Häppölä, O., Wahlestedt, C., Ekman, R., Soinila, S. O., Panula, P., & Håkanson, R. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90235-v · Cited by 24 · see citing works
Olschowka, J. A., & Jacobowitz, D. M. (1983) · Peptides · doi:10.1016/0196-9781(83)90120-1 · Cited by 16 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Charney, D. S. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.2.195 · Cited by 1,605 · see citing works
Evolution of neuropeptide Y, peptide YY and pancreatic polypeptide
Larhammar, D. (1996) · Regulatory Peptides · doi:10.1016/0167-0115(95)00169-7 · Cited by 388 · see citing works
Self-citationThe neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y
Kask, A., Harro, J., von Hörsten, S., Redrobe, J. P., Dumont, Y., & Quirion, R. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00066-5 · Cited by 358 · see citing works
Haglund, M., Nestadt, P. S., Cooper, N. S., Southwick, S. M., & Charney, D. S. (2007) · Development and Psychopathology · doi:10.1017/s0954579407000430 · Cited by 315 · see citing works
Distribution of pancreatic polypeptide and peptide YY
Ekblad, E., & Sundler, F. (2002) · Peptides · doi:10.1016/s0196-9781(01)00601-5 · Cited by 257 · see citing works
Pieribone, V., Nicholas, A., Dagerlind, A., & Hokfelt, T. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-07-04252.1994 · Cited by 243 · see citing works
Self-citationKopp, J., Xu, Q., Zhang, X.-Q., Pedrazzini, T., Herzog, H., Kresse, A. E., Wong, H. C., Walsh, J. H., & Hökfelt, T. G. M. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00463-8 · Cited by 196 · see citing works
Ontogeny of the hypothalamic neuropeptide Y system
Grove, K. L., & Smith, M. S. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00104-5 · Cited by 190 · see citing works
Peptide YY ablation in mice leads to the development of hyperinsulinaemia and obesity
Boey, D., Lin, S., Karl, T., Baldock, P., Lee, N., Enriquez, R., Couzens, M., Slack, K., Dallmann, R., Sainsbury, A., et al. (2006) · Diabetologia · doi:10.1007/s00125-006-0237-0 · Cited by 186 · see citing works
The orexin/hypocretin system: a critical regulator of neuroendocrine and autonomic function
Ferguson, A. V., & Samson, W. K. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/s0091-3022(03)00028-1 · Cited by 172 · see citing works
Roles of pancreatic polypeptide in regulation of food intake
Katsuura, G., Asakawa, A., & Inui, A. (2002) · Peptides · doi:10.1016/s0196-9781(01)00604-0 · Cited by 155 · see citing works
The electrophysiology of feeding circuits
Jobst, E. E., Enriori, P. J., & Cowley, M. A. (2004) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2004.10.007 · Cited by 139 · see citing works
Multiple regulation of peptide YY secretion in the digestive tract
Onaga, T., Zabielski, R., & Kato, S. (2002) · Peptides · doi:10.1016/s0196-9781(01)00609-x · Cited by 120 · see citing works
Passage of peptides across the blood-brain barrier: Pathophysiological perspectives
Banks, W. A., & Kastin, A. J. (1996) · Life Sciences · doi:10.1016/s0024-3205(96)00380-3 · Cited by 120 · see citing works
Kishi, T., Aschkenasi, C. J., Choi, B. J., Lopez, M. E., Lee, C. E., Liu, H., Hollenberg, A. N., Friedman, J. M., & Elmquist, J. K. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20432 · Cited by 119 · see citing works
Sundström, G., Larsson, T., Brenner, S., Venkatesh, B., & Larhammar, D. (2007) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2007.08.016 · Cited by 115 · see citing works
Self-citationDistribution of NPY receptors in the hypothalamus
Fetissov, S. O., Kopp, J., & Hökfelt, T. G. M. (2004) · Neuropeptides · doi:10.1016/j.npep.2004.05.009 · Cited by 110 · see citing works
Lundell, I., Statnick, M. A., Johnson, D., Schober, D. A., Starbäck, P., Gehlert, D. R., & Larhammar, D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.5111 · Cited by 110 · see citing works
Self-citationPsychobiological Mechanisms of Resilience and Vulnerability
Charney, D. S. (2004) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/foc.2.3.368 · Cited by 109 · see citing works
Orexin Neurons Express a Functional Pancreatic Polypeptide Y4 Receptor
Campbell, R. E., Smith, M. S., Allen, S. E., Grayson, B. E., ffrench‐Mullen, J. M. H., & Grove, K. L. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-04-01487.2003 · Cited by 108 · see citing works
Evolution of neuropeptide Y and its related peptides
Larhammar, D., Blomqvist, A. G., & Söderberg, C. (1993) · Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology · doi:10.1016/0742-8413(93)90236-e · Cited by 102 · see citing works
Self-citationGuthmann, A., & Herbert, H. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19991227)415:4 · Cited by 1 · see citing works
PYY transgenic mice are protected against diet-induced and genetic obesity
Boey, D., Lin, S., Enriquez, R. F., Lee, N. J., Slack, K., Couzens, M., Baldock, P. A. J., Herzog, H., & Sainsbury, A. (2008) · Neuropeptides · doi:10.1016/j.npep.2007.11.003 · Cited by 95 · see citing works
Cerdá‐Reverter, J. M., Anglade, I., Martı́nez-Rodrı́guez, G., Mazurais, D., Muñoz‐Cueto, J. A., Carrillo, M., Kah, O., & Zanuy, S. (2000) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(00)00063-6 · Cited by 88 · see citing works
Cerdá‐Reverter, J. M., Martı́nez-Rodrı́guez, G., Zanuy, S., Carrillo, M., & Larhammar, D. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00132-4 · Cited by 83 · see citing works
Self-citationPeptide YY Regulates Bone Turnover in Rodents
Wortley, K. E., García, K., Okamoto, H., Thabet, K., Anderson, K. D., Shen, V., Herman, J. P., Valenzuela, D. M., Yancopoulos, G. D., Tschöp, M. H., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.08.024 · Cited by 82 · see citing works
Söderberg, C., Kijas, A. W., Ringvall, M., Yan, Y., Postlethwait, J. H., Brodin, L., & Larhammar, D. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750908.x · Cited by 80 · see citing works
Self-citationSöderberg, C., Pieribone, V. A., Dahlstrand, J., Brodin, L., & Larhammar, D. (1994) · Journal of Neuroscience Research · doi:10.1002/jnr.490370510 · Cited by 78 · see citing works
Self-citationThe role of peptide YY in regulating glucose homeostasis
Boey, D., Sainsbury, A., & Herzog, H. (2007) · Peptides · doi:10.1016/j.peptides.2006.07.031 · Cited by 77 · see citing works
Characterization of two forms of peptide YY, PYY(1–36) and PYY(3–36), in the rabbit
Grandt, D., Schimiczek, M., Struk, K., Shively, J. E., Eysselein, V. E., Goebell, H., & Reeve, J. R. (1994) · Peptides · doi:10.1016/0196-9781(94)90035-3 · Cited by 77 · see citing works
The effects of short-chain fatty acids on the cardiovascular system
Richards, L. B., Li, M., van Esch, B. C. A. M., Garssen, J., & Folkerts, G. (2016) · PharmaNutrition · doi:10.1016/j.phanu.2016.02.001 · Cited by 74 · see citing works
Distribution of pancreatic polypeptide receptors in the rat brain
Whitcomb, D. C., Puccio, A. M., Vigna, S. R., Taylor, I. L., & Hoffman, G. E. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00295-3 · Cited by 70 · see citing works
Neuroendocrine regulation of eating behavior
Vettor, R., Fabris, R., Pagano, C., & Federspil, G. (2002) · Journal of Endocrinological Investigation · doi:10.1007/bf03344047 · Cited by 66 · see citing works
Risinger, C., Blomqvist, A. G., Lundell, I., Lambertsson, A., Nässel, D. R., Pieribone, V. A., Brodin, L., & Larhammar, D. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80540-7 · Cited by 62 · see citing works
Self-citationEvolution of the Neuropeptide Y Family of Peptides
Larhammar, D., Söderberg, C., & Blomquist, A. G. (1993) · Humana Press eBooks · doi:10.1007/978-1-59259-465-8_1 · Cited by 60 · see citing works
Self-citationCloning and Characterization of a Novel Neuropeptide Y Receptor Subtype in the Zebrafish
Lundell, I., BERGLUND, M. M., Starbäck, P., Salaneck, E., Gehlert, D. R., & Larhammar, D. (1997) · DNA and Cell Biology · doi:10.1089/dna.1997.16.1357 · Cited by 60 · see citing works
Self-citationCharacterization of brainstem peptide YY (PYY) neurons
Glavas, M. M., Grayson, B. E., Allen, S. E., Copp, D. R., Smith, M. S., Cowley, M. A., & Grove, K. L. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21543 · Cited by 57 · see citing works
Ghrelin and PYY in the regulation of energy balance and metabolism: lessons from mouse mutants
Kirchner, H., Tong, J., Tschöp, M. H., & Pfluger, P. T. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00191.2009 · Cited by 57 · see citing works
Aragon, F. C., Karaca, M., Novials, A., Maldonado, R. J., Maechler, P., & Rubı́, B. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.11.005 · Cited by 57 · see citing works
Peptide YY: A neuropeptide in the gut. Immunocytochemical and immunochemical evidence
Böttcher, G., Ekblad, E., Ekman, R., Håkanson, R., & Sundler, F. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90472-r · Cited by 57 · see citing works
Hou, J., Charters, A. M., Lee, S. C., Zhao, Y., Wu, M. K., Jones, S. J., Marra, M. A., & Hoodless, P. A. (2007) · BMC Developmental Biology · doi:10.1186/1471-213x-7-92 · Cited by 56 · see citing works
“Pyy is known to be highly expressed in pancreatic islets and endocrine L cells of the lower gastrointestinal tract [39], but its early embryonic expression pattern has not been described.”
BackgroundEffects of olfactory bulbectomy on neuropeptide gene expression in the rat olfactory/limbic system
Holmes, P. V., Davis, R. C., Masini, C. V., & Primeaux, S. D. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00029-3 · Cited by 53 · see citing works
Eriksson, H., Berglund, M. M., Holmberg, S. K. S., Kahl, U., Gehlert, D. R., & Larhammar, D. (1998) · Regulatory Peptides · doi:10.1016/s0167-0115(98)00050-0 · Cited by 53 · see citing works
Self-citationRegional variation in transport of pancreatic polypeptide across the blood-brain barrier of mice
Banks, W. A. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)00412-c · Cited by 50 · see citing works
Central and peripheral regulation of gastric acid secretion by peptide YY
Yang, H. (2002) · Peptides · doi:10.1016/s0196-9781(01)00611-8 · Cited by 48 · see citing works
Li, X., Glazewski, S., Lin, X., Elde, R. P., & Fox, K. D. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903570310 · Cited by 48 · see citing works
Pharmacological characterization of cloned chicken neuropeptide Y receptors Y1 and Y5
Holmberg, S. K. S., Mikko, S., Boswell, T., Zoorob, R., & Larhammar, D. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00817.x · Cited by 47 · see citing works
Self-citationJAZIN, E. E., Zhang, X., Söderström, S., Williams, R., Hökfelt, T., Ebendal, T., & Larhammar, D. (1993) · Developmental Brain Research · doi:10.1016/0165-3806(93)90128-w · Cited by 47 · see citing works
Self-citationSalmon, A. L., Johnsen, A. H., Bienert, M., McMurray, G., Nandha, K. A., Bloom, S. R., & Shaw, C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.7.4549 · Cited by 42 · see citing works
Muriel, M., Lambeng, N., Darios, F. D., Michel, P. P., Hirsch, É. C., Agid, Y., & Ruberg, M. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20001016)426:2 · Cited by 46 · see citing works
Charney, D. S. (2003) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2003.5.3/dcharney · Cited by 40 · see citing works
Boswell, T., Millam, J. R., Li, Q., & Dunn, I. (1998) · Cell and Tissue Research · doi:10.1007/s004410051095 · Cited by 42 · see citing works
Chen, Y., Shen, Y., Pandit, N. P., Fu, J., Li, D., & Li, J. (2013) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2013.03.029 · Cited by 41 · see citing works
Mor, A., Chartrel, N., Vaudry, H., & Nicolas, P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10295 · Cited by 40 · see citing works
Evolution of the Neuropeptide Y Family and Its Receptorsa
Larhammar, D., Söderberg, C., & Lundell, I. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb10729.x · Cited by 39 · see citing works
Self-citationSweerts, B., Jarrott, B., & Lawrence, A. J. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00674.x · Cited by 38 · see citing works
Olfactory bulbectomy increases prepro-galanin mRNA levels in the rat locus coeruleus
Holmes, P. V., & Crawley, J. N. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00295-4 · Cited by 36 · see citing works
Glaum, S. R., Miller, R. J., Rhim, H., Maclean, D., Georgic, Y. M., MacKenzie, R. G., & Grundemar, L. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0700883 · Cited by 35 · see citing works
Brain and Pituitary Hormones of Lampreys, Recent Findings and their Evolutionary Significance
Sower, S. A. (1998) · American Zoologist · doi:10.1093/icb/38.1.15 · Cited by 34 · see citing works
Intracisternal PYY increases gastric mucosal resistance: role of cholinergic, CGRP, and NO pathways
Yang, H., Kawakubo, K., & Taché, Y. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.277.3.g555 · Cited by 31 · see citing works
McLean, K. J., Jarrott, B., & Lawrence, A. J. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00219-i · Cited by 30 · see citing works
Eating disorders and gastrointestinal peptides
Tong, J., & D’Alessio, D. D. (2011) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e328341e12b · Cited by 27 · see citing works
Sundström, G., Larsson, T., Brenner, S., Venkatesh, B., & Larhammar, D. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1327.095 · Cited by 28 · see citing works
Self-citationNeuropeptide Y Has a Protective Role during Murine Retrovirus-Induced Neurological Disease
Du, M., Butchi, N. B., Woods, T. A., Morgan, T. W., & Peterson, K. E. (2010) · Journal of Virology · doi:10.1128/jvi.01022-10 · Cited by 26 · see citing works
Differential gene expression in WKY and SHR brain following acute and chronic air-puff stress
McDougall, S. J., Widdop, R. E., & Lawrence, A. J. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.10.010 · Cited by 23 · see citing works
Phylogeny of NPY-Family Peptides and Their Receptors
Larhammar, D., Fredriksson, R., Larson, E. T., & Salaneck, E. (2004) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-18764-3_4 · Cited by 22 · see citing works
Self-citationHolmes, P. V., de Bartolomeis, A., Koprivica, V., & Crawley, J. N. (1995) · Synapse · doi:10.1002/syn.890190307 · Cited by 21 · see citing works
Neuropeptide Y and Pain: Insights from Brain Research
Nelson, T. S., Allen, H. N., & Khanna, R. (2024) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00333 · Cited by 20 · see citing works
Silva, T., da Silveira, G. A., Fior-Chadi, D. R., & Chadi, G. (2004) · Alcohol · doi:10.1016/j.alcohol.2004.02.003 · Cited by 20 · see citing works
Verma, D., Hörmer, B. A., Bellmann‐Sickert, K., Thieme, V., Beck‐Sickinger, A. G., Herzog, H., Sperk, G., & Tasan, R. O. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13456 · Cited by 19 · see citing works
Gelegen, Ç., Chandarana, K., Choudhury, A. I., Al‐Qassab, H., Evans, I. M., Irvine, E. E., Hyde, C., Claret, M., Andréelli, F., Sloan, S. E., et al. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00033.2012 · Cited by 16 · see citing works
Castro, A., Manso, M. J., & Anadón, R. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10694 · Cited by 16 · see citing works
Ferrari, M., Coelho, E. F., Farizatto, K. L. G., Chadi, G., & Fior-Chadi, D. R. (2011) · International Journal of Hypertension · doi:10.4061/2011/216464 · Cited by 13 · see citing works
Pieribone, V. A., Brodin, L., & Hökfelt, T. G. M. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903410406 · Cited by 13 · see citing works
Self-citationChen, Z., Travers, S. P., & Travers, J. B. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00536.2011 · Cited by 10 · see citing works
Bariatric Surgery and Bone Loss: Do We Need to Be Concerned?
Brzozowska, M. M., Sainsbury, A., Eisman, J. A., & Baldock, P. A. J. (2014) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-014-9162-9 · Cited by 10 · see citing works
Organization of thalamostriatal terminals from the ventral motor nuclei in the macaque
McFarland, N. R., & Haber, S. N. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20000108)429:2 · Cited by 109 · see citing works
Developmental Expression of NPY/PYY Receptors zYb and zYc in Zebrafish
MATHIEU, M. U., Trombino, S., Argenton, F., Larhammar, D., & Vallarino, M. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1327.073 · Cited by 8 · see citing works
Self-citationSer13‐phosphorylated PYY from porcine intestine with a potent biological activity
Chen, Z., Eriste, E., Jonsson, P. A., Norberg, Å., Nepomuceno, D. H., Lovenberg, T. W., Bergman, T., Efendic, S., Jörnvall, H., & Sillard, R. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02234-7 · Cited by 8 · see citing works
Karchewski, L. A., Kim, F. A., Johnston, J. M., McKnight, R. M., & Verge, V. M. K. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19991018)413:2 · Cited by 81 · see citing works
Houdeau, É., & Boyer, P. (1994) · Cell and Tissue Research · doi:10.1007/bf00300232 · Cited by 7 · see citing works
Yahya, A., Xiao, C. Y., Chance, W. T., & Sheriff, S. (2006) · Peptides · doi:10.1016/j.peptides.2006.07.003 · Cited by 6 · see citing works
Neuropeptide Y in Hamster Limbic Nuclei: Lack of Colocalization With Substance P
Burroughs, L. F., Fiber, J. M., & Swann, J. M. (1996) · Peptides · doi:10.1016/0196-9781(96)00130-1 · Cited by 4 · see citing works
Chapter 4 Peptidergic neurons in the vertebrate spinal cord: evolutionary trends
Brodin, L., Söderberg, C., Pieribone, V. A., & Larhammar, D. (1995) · Progress in brain research · doi:10.1016/s0079-6123(08)61784-7 · Cited by 4 · see citing works
Self-citationDistinct contribution of spinal neuropeptide Y and NPY1R neurons to morphine analgesia
Wu, Y., Chen, Y., Zeng, Q., Xu, K., Li, Y., Yang, H., Yang, S., Liu, Y., Wu, J., Ji, L., et al. (2026) · Brain · doi:10.1093/brain/awag077 · Cited by 3 · see citing works
Dingemanse, J., Charef, P., Black, J. E., & Gouws, C. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110955 · Cited by 1 · see citing works
Katsuura, G., & Inui, A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801028-0.00167-7 · Cited by 1 · see citing works
Peptide YY: lessons from mouse models
Boey, D., & Herzog, H. (2006) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/01.med.0000200524.26578.3b · Cited by 1 · see citing works
Cloning and characterization of neuropeptide Y receptors of the Y1 subfamily in mammals and fish
Starbäck, P. (2000) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
role of cholinergic, CGRP, and NO pathways Intracisternal PYY increases gastric mucosal resistance:
Yang, H., Kawakubo, K., & Taché, Y. (2016)
Strand, F. L. (2007) · doi:10.1002/9780470101001.hcn015
Inui, A., & Katsuura, G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820649-2.00098-x
Holzer, P. D., & Farzi, A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.65827-0
Holzer, P. D., & Farzi, A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00401-5
BindingDB (2012) · UC San Diego · doi:10.7270/q2t72g1g
Evolutionary perspective on the NPY-PYY-PP peptides and their receptors
Larhammar, D., & Salaneck, E. (2005) · Birkhäuser-Verlag eBooks · doi:10.1007/3-7643-7427-6_1
Self-citation
- Authors
- Pieribone, V., Brodin, L., Friberg, K., Dahlstrand, J., Soderberg, C., Larhammar, D., & Hokfelt, T.
- Affiliations
- Karolinska Institutet (SE)
- ORCID
- Larhammar, D
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1992-09-01
- Volume
- 12
- Issue
- 9
- Pages
- 3361-3371
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6575750
- OpenAlex
- W1499341760
- Cited by
- 96
- References
- 23
- Citations by year
- 2026: 1 · 2024: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fogarty International Center (1F20TWO 158601)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- neuropeptide Y, peptide YY, pancreatic polypeptide, mRNA expression, brainstem neurons, medulla oblongata, evolutionary conservation, lamprey, sympathetic ganglia, antibody cross-reactivity, in situ hybridization
- MeSH terms
- Animals, Base Sequence, Male, Molecular Sequence Data, Nerve Tissue, Neuropeptide Y, Nucleic Acid Hybridization, Pancreatic Polypeptide, Peptides, Rats, Inbred Strains, RNA, Messenger, Tissue Distribution, Blotting, Northern, Oligonucleotide Probes, Peptide YY, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
