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Cited by 116

The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.

Parallel ON and OFF cone bipolar inputs establish spatially coextensive receptive field structure of blue–yellow ganglion cells in primate retina

Crook, J. D., Davenport, C. M., Peterson, B. B., Packer, O. S., Detwiler, P. B., Dacey, D. M.·2009·Journal of Neuroscience
DOI 10.1523/jneurosci.1218-09.2009PMC PMC2733872
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Abstract

In the primate retina the small bistratified, "blue-yellow" color-opponent ganglion cell receives parallel ON-depolarizing and OFF-hyperpolarizing inputs from short (S)-wavelength sensitive and combined long (L)- and middle (M)-wavelength sensitive cone photoreceptors, respectively. However, the synaptic pathways that create S versus LM cone-opponent receptive field structure remain controversial. Here, we show in the macaque monkey retina in vitro that at photopic light levels, when an identified rod input is excluded, the small bistratified cell displays a spatially coextensive receptive field in which the S-ON-input is in spatial, temporal, and chromatic balance with the LM-OFF-input. ON pathway block with l-AP-4, the mGluR6 receptor agonist, abolished the S-ON response but spared the LM-OFF response. The isolated LM component showed a center-surround receptive field structure consistent with an input from OFF-center, ON-surround "diffuse" cone bipolar cells. Increasing retinal buffering capacity with HEPES attenuated the LM-ON surround component, consistent with a non-GABAergic outer retina feedback mechanism for the bipolar surround. The GABAa/c receptor antagonist picrotoxin and the glycine receptor antagonist strychnine did not affect chromatic balance or the basic coextensive receptive field structure, suggesting that the LM-OFF field is not generated by an inner retinal inhibitory pathway. We conclude that the opponent S-ON and LM-OFF responses originate from the excitatory receptive field centers of S-ON and LM-OFF cone bipolar cells, and that the LM-OFF- and ON-surrounds of these parallel bipolar inputs largely cancel, explaining the small, spatially coextensive but spectrally antagonistic receptive field structure of the blue-ON ganglion cell.

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Research works printed but not linked: 3

  1. Dartnall HJA Dartnall HJA 1972 Photosensitivity Photochemistry of Vision 122 145 New York Springer Verlag
  2. Ghosh KK Grunert U 1999 Synaptic input to small bistratified (blue-ON) ganglion cells in the retina of a new world monkey, the marmoset Callithrix jacchus J Comp Neurol 413 417 428 10502249
  3. Ghosh KK Martin PR Grunert U 1997 Morphological analysis of the blue cone pathway in the retina of a new world monkey, the marmoset Callithrix jacchus J CompNeurol 379 211 225 9050786

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Metadata

Authors
Crook, J. D., Davenport, C. M., Peterson, B. B., Packer, O. S., Detwiler, P. B., & Dacey, D. M.
Venue
Journal of Neuroscience
Publisher
Society for Neuroscience
Published
2009-07-01
Volume
29
Issue
26
Pages
8372-8387
ISSN
  • 0270-6474
  • 1529-2401
DOI
10.1523/jneurosci.1218-09.2009
PMC
PMC2733872
Cited by
116
References
83
Language
en

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