The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
Basal cortisol levels and cognitive deficits in human aging
Open accessAbstract
A group of 19 healthy elderly subjects previously shown to differ in terms of their cortisol levels over a 4 year period were administered a neuropsychological test battery assessing memory, attention, and language. Correlational analyses performed on various corticosteroid measures showed that the slope of the change in cortisol levels over time predicted cognitive deficits in this elderly population. Aged subjects showing a significant increase in cortisol levels with years and with high current basal cortisol levels were impaired on tasks measuring explicit memory and selective attention when compared to aged subjects presenting either decreasing cortisol levels with years or increasing cortisol levels with moderate current basal cortisol levels. We further showed that subjects presenting a decrease in cortisol levels with years performed as well as young healthy subjects with regard to cognitive performance. Thus, impaired cognitive performance was associated with recent evidence of hypothalamic-pituitary-adrenal (HPA) dysregulation and elevated basal cortisol levels. These results are consistent with recent animal studies showing the existence of subpopulations of aged rats that differ in HPA activity and cognitive performance. Finally, the pattern of cognitive results related to the cortisol history of subjects is in agreement with a role played by the hippocampus in age-related HPA dysfunction and cognitive performance.
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“Elevated HPA and cardiovascular parameters have also been linked to poor cognitive functioning in many studies.29,31,[49][50][51][52][53][54]”
From Socio‐economic differentials in peripheral biology: Cumulative allostatic load (2010) · cites this paper as [29]
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Protective and Damaging Effects of Stress Mediators
McEwen, B. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801153380307 · Cited by 6,733
Brain corticosteroid receptor balance in health and disease
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Metadata
- Authors
- Lupien, S., Lecours, A., Lussier, I., Schwartz, G., Nair, N., & Meaney, M.
- ORCID
- Lupien, S
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1994-05-01
- Volume
- 14
- Issue
- 5
- Pages
- 2893-2903
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6577490
- OpenAlex
- W1920785023
- Cited by
- 566
- References
- 92
- Citations by year
- 2025: 3 · 2024: 10 · 2023: 7 · 2022: 8 · 2021: 16 · 2020: 12 · 2019: 14 · 2018: 10 · 2017: 7 · 2016: 23 · 2015: 29 · 2014: 18 · 2013: 14 · 2012: 17
- FWCI
- 10.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alzheimer's Association
- Medical Research Council Canada
- National Institutes of Health (5r01ag009488-05)
- Medical Research Council
- National Institute on Aging (AG 09488)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- basal cortisol, cognitive aging, HPA axis dysregulation, declarative memory, selective attention, hippocampus, corticosteroids
- MeSH terms
- Aged, Aging, Attention, Cognition Disorders, Electrocardiography, Electroencephalography, Female, Humans, Hydrocortisone, Intelligence, Intelligence Tests, Language, Learning, Longitudinal Studies, Male, Memory, Middle Aged, Neuropsychological Tests
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