Cited by 566Stress Responses and CortisolAdrenal Hormones and DisordersDementia and Cognitive Impairment Research

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Basal cortisol levels and cognitive deficits in human aging

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Lupien, S, Lecours, AR, Lussier, I, Schwartz, G, Nair, NP, Meaney, MJ·1994·The Journal of Neuroscience

DOI 10.1523/jneurosci.14-05-02893.1994PMC PMC6577490

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Abstract

A group of 19 healthy elderly subjects previously shown to differ in terms of their cortisol levels over a 4 year period were administered a neuropsychological test battery assessing memory, attention, and language. Correlational analyses performed on various corticosteroid measures showed that the slope of the change in cortisol levels over time predicted cognitive deficits in this elderly population. Aged subjects showing a significant increase in cortisol levels with years and with high current basal cortisol levels were impaired on tasks measuring explicit memory and selective attention when compared to aged subjects presenting either decreasing cortisol levels with years or increasing cortisol levels with moderate current basal cortisol levels. We further showed that subjects presenting a decrease in cortisol levels with years performed as well as young healthy subjects with regard to cognitive performance. Thus, impaired cognitive performance was associated with recent evidence of hypothalamic-pituitary-adrenal (HPA) dysregulation and elevated basal cortisol levels. These results are consistent with recent animal studies showing the existence of subpopulations of aged rats that differ in HPA activity and cognitive performance. Finally, the pattern of cognitive results related to the cortisol history of subjects is in agreement with a role played by the hippocampus in age-related HPA dysfunction and cognitive performance.

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A feature-integration theory of attention.
Treisman, A. M., & Gelade, G. (1980) · Cognitive Psychology · doi:10.1016/0010-0285(80)90005-5 · Cited by 12,366
LOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONS
Scoville, W. B., & Milner, B. (1957) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.20.1.11 · Cited by 7,322
Applied Multiple Regression/Correlation Analysis for the Behavioral Sciences.
Henry, N. W., Cohen, J., & Cohen, P. R. (1977) · Contemporary Sociology A Journal of Reviews · doi:10.2307/2064799 · Cited by 7,242
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376
Preserved Learning and Retention of Pattern-Analyzing Skill in Amnesia: Dissociation of Knowing How and Knowing That
Cohen, N. J., & Squire, L. R. (1980) · Science · doi:10.1126/science.7414331 · Cited by 2,296
Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus
Zola-Morgan, S., Squire, L., & Amaral, D. (1986) · The Journal of Neuroscience · doi:10.1523/jneurosci.06-10-02950.1986 · Cited by 1,997
Memory and the Brain
Squire, L. R. (1986) · Elsevier eBooks · doi:10.1016/b978-0-12-268330-5.50013-5 · Cited by 1,932
Evolving conceptions of memory storage, selective attention, and their mutual constraints within the human information-processing system.
Cowan, N. (1988) · Psychological Bulletin · doi:10.1037/0033-2909.104.2.163 · Cited by 1,918
Implicit and explicit memory for new associations in normal and amnesic subjects.
Graf, P., & Schacter, D. L. (1985) · Journal of Experimental Psychology: Learning, Memory, and Cognition · doi:10.1037//0278-7393.11.3.501 · Cited by 1,872
The Role of the Hippocampus in Feedback Regulation of the Hypothalamic-Pituitary-Adrenocortical Axis*
JACOBSON, L., & SAPOLSKY, R. (1991) · Endocrine Reviews · doi:10.1210/edrv-12-2-118 · Cited by 1,739

Show all 92 references

Research works printed but not linked: 4

Lyons J (1976) Semantics, 12. Cambridge: Cambridge UP.
Meanev MJ. Bodnoff SR. O'Donnell D. Rowe W. Sanieau A. Rose GM,'Poi&r J, Seckl J (1993) Glucocorticoids as regulators ofneuron survival and repair in the aged brain. In: Restorative neurology, Vol 6 (Cue110 AC, ed), pp 185-210. Amsterdam: Elsevier.
Squire LR (1987) Memory and brain. New York: Oxford UP.
Treisman A (1983) The role of attention in obiect nercention. In: Physical and biological processing of images (BraddickOJ, Sleigh AC, eds), pp 3 16-325. New York: Springer.

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Self-citation
Cortisol Reduces Hippocampal Glucose Metabolism in Normal Elderly, but Not in Alzheimer's Disease
de Leon, M. J., McRae, T., Rusinek, H., Convit, A. J., Santi, S. D., Tarshish, C. Y., Golomb, J. B., Volkow, N. D., Daisley, K., Orentreich∥, N., et al. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.10.4305 · Cited by 176

Authors: Lupien, S., Lecours, A., Lussier, I., Schwartz, G., Nair, N., & Meaney, M.
ORCID: Lupien, S
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 1994-05-01
Volume: 14
Issue: 5
Pages: 2893-2903
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.14-05-02893.1994
PMC: PMC6577490
OpenAlex: W1920785023
Cited by: 566
References: 92
Citations by year: 2025: 3 · 2024: 10 · 2023: 7 · 2022: 8 · 2021: 16 · 2020: 12 · 2019: 14 · 2018: 10 · 2017: 7 · 2016: 23 · 2015: 29 · 2014: 18 · 2013: 14 · 2012: 17
FWCI: 10.54
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 184 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Alzheimer's Association
Medical Research Council Canada
National Institutes of Health (5r01ag009488-05)
Medical Research Council
National Institute on Aging (AG 09488)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: basal cortisol, cognitive aging, HPA axis dysregulation, declarative memory, selective attention, hippocampus, corticosteroids
MeSH terms: Aged, Aging, Attention, Cognition Disorders, Electrocardiography, Electroencephalography, Female, Humans, Hydrocortisone, Intelligence, Intelligence Tests, Language, Learning, Longitudinal Studies, Male, Memory, Middle Aged, Neuropsychological Tests

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Basal cortisol levels and cognitive deficits in human aging

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