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Cited by 566Stress Responses and CortisolAdrenal Hormones and DisordersDementia and Cognitive Impairment Research

The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.

Basal cortisol levels and cognitive deficits in human aging

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Lupien, S, Lecours, AR, Lussier, I, Schwartz, G, Nair, NP, Meaney, MJ·1994·The Journal of Neuroscience
DOI 10.1523/jneurosci.14-05-02893.1994PMC PMC6577490
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Abstract

A group of 19 healthy elderly subjects previously shown to differ in terms of their cortisol levels over a 4 year period were administered a neuropsychological test battery assessing memory, attention, and language. Correlational analyses performed on various corticosteroid measures showed that the slope of the change in cortisol levels over time predicted cognitive deficits in this elderly population. Aged subjects showing a significant increase in cortisol levels with years and with high current basal cortisol levels were impaired on tasks measuring explicit memory and selective attention when compared to aged subjects presenting either decreasing cortisol levels with years or increasing cortisol levels with moderate current basal cortisol levels. We further showed that subjects presenting a decrease in cortisol levels with years performed as well as young healthy subjects with regard to cognitive performance. Thus, impaired cognitive performance was associated with recent evidence of hypothalamic-pituitary-adrenal (HPA) dysregulation and elevated basal cortisol levels. These results are consistent with recent animal studies showing the existence of subpopulations of aged rats that differ in HPA activity and cognitive performance. Finally, the pattern of cognitive results related to the cortisol history of subjects is in agreement with a role played by the hippocampus in age-related HPA dysfunction and cognitive performance.

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Research works printed but not linked: 4

  1. Lyons J (1976) Semantics, 12. Cambridge: Cambridge UP.
  2. Meanev MJ. Bodnoff SR. O'Donnell D. Rowe W. Sanieau A. Rose GM,'Poi&r J, Seckl J (1993) Glucocorticoids as regulators ofneuron survival and repair in the aged brain. In: Restorative neurology, Vol 6 (Cue110 AC, ed), pp 185-210. Amsterdam: Elsevier.
  3. Squire LR (1987) Memory and brain. New York: Oxford UP.
  4. Treisman A (1983) The role of attention in obiect nercention. In: Physical and biological processing of images (BraddickOJ, Sleigh AC, eds), pp 3 16-325. New York: Springer.

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Metadata

Authors
Lupien, S., Lecours, A., Lussier, I., Schwartz, G., Nair, N., & Meaney, M.
ORCID
Lupien, S
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
1994-05-01
Volume
14
Issue
5
Pages
2893-2903
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
DOI
10.1523/jneurosci.14-05-02893.1994
PMC
PMC6577490
OpenAlex
W1920785023
Cited by
566
References
92
Citations by year
2025: 3 · 2024: 10 · 2023: 7 · 2022: 8 · 2021: 16 · 2020: 12 · 2019: 14 · 2018: 10 · 2017: 7 · 2016: 23 · 2015: 29 · 2014: 18 · 2013: 14 · 2012: 17
FWCI
10.54
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Alzheimer's Association
  • Medical Research Council Canada
  • National Institutes of Health (5r01ag009488-05)
  • Medical Research Council
  • National Institute on Aging (AG 09488)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
basal cortisol, cognitive aging, HPA axis dysregulation, declarative memory, selective attention, hippocampus, corticosteroids
MeSH terms
Aged, Aging, Attention, Cognition Disorders, Electrocardiography, Electroencephalography, Female, Humans, Hydrocortisone, Intelligence, Intelligence Tests, Language, Learning, Longitudinal Studies, Male, Memory, Middle Aged, Neuropsychological Tests

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