The DOI matches its Crossref record; 61 of the 63 references it cites were found in a registry or an index.
Locus coeruleus neurons in monkey are selectively activated by attended cues in a vigilance task
Open accessAbstract
Impulse activity was recorded extracellularly from noradrenergic neurons in the nucleus locus coeruleus (LC; 47 single-cell and 126 multicell recordings) of four cynomolgus monkeys performing an oddball visual discrimination task. For juice reward, the subjects were required to release a lever rapidly in response to an infrequent (10– 20% of trials) target cue (CS+) that was randomly intermixed with nontarget (CS-) stimuli presented on a video display. All LC neurons examined were phasically and selectively activated by target cues in this task. Other task events elicited no consistent response from these neurons (juice reward, lever release, fix-spot stimuli, nontarget stimuli). In one animal, nontarget cues phasically inhibited LC neurons. Phasic LC excitatory responses to target cues in this task occurred at a relatively short latency (mean = 90.7 msec), approximately 200 msec prior to the behavioral response (lever release). In addition, LC response magnitudes varied with behavioral performance, being substantially attenuated during epochs of poor performance (high false alarm rate). There was a positive correlation (r = 0.30, p < 0.0001) between the latency of LC responses and the latency of behavioral responses to same target cues, consistent with the possibility that LC responses may have a role in selective attention by facilitating responses to the CS+ stimulus. Analyses of behavioral response latencies to pairs of stimuli indicated that LC responses may facilitate behavioral responses to subsequent sensory cues, consistent with a role of this system in sustained attention/vigilance. Moreover, responses became reduced in magnitude over time during prolonged task performance (> 90 min), in parallel with a behavioral performance decrement. These results show that LC neurons are activated selectively by attended stimuli that demand a rapid response in this task, and that such LC responses may contribute to conditioned behavioral responses.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“One study [51] found that locus coeruleus neurons are selectively activated in a sustained attention task in monkeys.”
From Linking ADHD to the Neural Circuitry of Attention (2017) · cites this paper as [51]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Posner, M. I. (1980) · Quarterly Journal of Experimental Psychology · doi:10.1080/00335558008248231 · Cited by 9,670 · cited 1×
“In the latter, the intensity of attention, or alertness, is assumed to remain constant, and differences in response among trials are sought as a function of different instructions given for different trials (e.g., attend right vs left; Posner, 1980; Johnston and Dark, 1986).”
BackgroundDahlstroem, A., & Fuxé, K. (1964) · PubMed · Cited by 5,133
Stereotaxic mapping of the monoamine pathways in the rat brain
Ungerstedt, U. (1971) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.1971.tb10998.x · Cited by 3,819
Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex
Funahashi, S., Bruce, C. J., & Goldman-Rakic, P. S. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.2.331 · Cited by 2,685
Biogenic Amines and the States of Sleep
Jouvet, M. (1969) · Science · doi:10.1126/science.163.3862.32 · Cited by 1,284
Aston‐Jones, G., & Bloom, F. E. (1981) · Journal of Neuroscience · doi:10.1523/jneurosci.01-08-00887.1981 · Cited by 1,072
Self-citationThe Breakdown of Vigilance during Prolonged Visual Search
Mackworth, N. H. (1948) · Quarterly Journal of Experimental Psychology · doi:10.1080/17470214808416738 · Cited by 1,040
Svensson, T. H., Bunney, B. S., & Aghajanian, G. K. (1975) · Brain Research · doi:10.1016/0006-8993(75)90276-0 · Cited by 1,015
A Dynamic Model of Stress and Sustained Attention
Hancock, P. A. (1989) · Human Factors: The Journal of the Human Factors and Ergonomics Society · doi:10.1177/001872088903100503 · Cited by 874
Bushnell, M., Goldberg, M. E., & Robinson, D. L. (1981) · Journal of Neurophysiology · doi:10.1152/jn.1981.46.4.755 · Cited by 868
Research works printed but not linked: 1
- Parasuraman R (1984) The psychobiology of sustained attention. In: Sustained attention in human performance (Warm JS, ed), pp 61- 10 1. New York: Wiley.
Cited by
Sorted by citations
Items 601–627 of 627
Exploring a Role for Sleep in Regulating Skeletal Muscle Physiology
Schwarz-Lam, P. (2014) · TSpace (University of Toronto)
Boundaries Between Events Shape Human Memory Organization
Somaini, F. (2023) · doi:10.14418/wes01.1.2791
Wilmot, J. H., Diniz, C. R. A. F., Crestani, A. P., Puhger, K. R., Roshgadol, J., Tian, L., & Wiltgen, B. J. (2024) · eLife · doi:10.7554/elife.91465.2.sa2
Wilmot, J. H., Diniz, C. R. A. F., Crestani, A. P., Puhger, K. R., Roshgadol, J., Tian, L., & Wiltgen, B. J. (2024) · eLife · doi:10.7554/elife.91465.3.sa2
Utility of Pupillometric Methods for Studying Visual Search
Pinto, J. D. G., & Hout, M. C. (2024) · Springer eBooks · doi:10.1007/978-3-031-54896-3_5
The Noradrenergic Modulation of Attention and Memory: The Attentional Boost Effect (ABE)
Gabrielli, G. B., Spataro, P., & Rossi‐Arnaud, C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-822404-5.15001-6
Krauzlis, R. J. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27380-3.00015-4
Catecholamines in the Brain and Responses to Environmental Challenges
Goldstein, D. S., & Pacák, K. (2000) · Comprehensive physiology · doi:10.1002/j.2040-4603.2000.tb01508.x
Preoperative Cholinergic Signatures Drive Segregated Brain Architecture in Postoperative DeliriumPreprint
Taylor, N. L., Munn, B., Gjini, K., Orlando, I. F., Moran, B., Taylor, J., Wehrman, J., Banks, M. I., Nair, V. A., Pearce, R. A., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-7881643/v1
The effect of Escitalopram on tonic and phasic alertness in healthy volunteers
Bätz, J., & Gauggel, S. (2009) · RWTH Publications (RWTH Aachen)
Attention and novelty processing in stroke and Parkinson's disease
Singh‐Curry, V. (2011) · UCL Discovery (University College London)
Dynamic Routing on a Static Structure: Neuromodulatory Gating of Cortical Wave PropagationPreprint
Maran, R., Shine, J. M., Fulcher, B., & Müller, E. J. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.10.705210 · Cited by 1
Toh, Y. N., & Lee, V. G. (2026) · Attention Perception & Psychophysics · doi:10.3758/s13414-025-03221-4
Modulation noradrénergique de l’attention
Guedj, C. (2016) · theses.fr (ABES) · doi:10.70675/d208400cz08cez4a3aza0e5z1816500f60a8
Cortex préfrontal et flexibilité comportementale : implication de la noradrénaline
Cerpa, J.-C. (2019) · theses.fr (ABES) · doi:10.70675/d4f665b9z3943z4c88z9b4bzbf11cd7cf8d1
Borderies, N. (2020) · theses.fr (ABES) · doi:10.70675/03f23bddzae42z426aza9e6z34fb21ff3d9e
Dynamics of attention and arousal in healthy and migraine populations
Masson, R. (2020) · theses.fr (ABES) · doi:10.70675/3bb511a1za582z4458za9d7z2bda595f8108
Implication of the locus coeruleus in effort processing : electrophysiological studies
Bornert, P. (2021) · theses.fr (ABES) · doi:10.70675/665d6bd7ze2f5z41c9z93f8z764be3c6d822
Vreven, A., Chandler, D. J., Fan, W., Jordan, R., Krentzman, O. J., Lüthi, A., McCall, J. G., Sciolino, N. R., Tkaczynski, J., & Totah, N. K. B. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-24078-2.00010-3
Model-based pupil deconvolution reveals latent attentional dynamicsPreprint
Maity, S., Mathôt, S., & Ray, S. B. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.30.755708
The Mechanistic Relationship between NREM Sleep and Anesthesia
Nelson, L. E., Franks, N. P., & Maze, M. (2006) · Springer eBooks · doi:10.1007/0-387-27682-3_6
Ascending Systems Controlling Attentional Functions
Sarter, M. F., & Demeter, E. (2008) · Elsevier eBooks · doi:10.1016/b978-012370509-9.00111-x
Metadata
- Authors
- Aston-Jones, G., Rajkowski, J., Kubiak, P., & Alexinsky, T.
- Affiliations
- Hahnemann University Hospital (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1994-07-01
- Volume
- 14
- Issue
- 7
- Pages
- 4467-4480
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6577022
- OpenAlex
- W1954301870
- Cited by
- 637
- References
- 63
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 25 · 2023: 24 · 2022: 25 · 2021: 20 · 2020: 30 · 2019: 26 · 2018: 31 · 2017: 34 · 2016: 27 · 2015: 21 · 2014: 19 · 2013: 21 · 2012: 20
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Funders
- U.S. Air Force
- Air Force Office of Scientific Research (F49620)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- locus coeruleus, noradrenergic neurons, sustained attention, selective attention, oddball paradigm, response latency, single-unit activity, Macaca fascicularis
- MeSH terms
- Animals, Arousal, Behavior, Animal, Cues, Discrimination, Psychological, Locus Coeruleus, Macaca fascicularis, Neurons, Photic Stimulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
