Stereotaxic mapping of the monoamine pathways in the rat brain
Abstract
Abstract The ascending monoamine pathways in the rat brain are demonstrated by the pile up of fluorescent material occurring in the axons after various types of lesions. The anatomy of the pathways is outlined in drawings of frontal sections of the brain and the origin and termination of several pathways is determined by studying the anterograde and retrograde degeneration occurring after well localised lesions. It is possible to separate the ascending NA pathways into a dorsal and a ventral bundle of axons. The dorsal bundle innervates the cortex and the hippocampus and the ventral bundle supplies NA nerve terminals to the medulla, the pons, the mesencephalon and the diencephalon. The dorsal bundle is found to originate in the locus coeruleus. Lesions of this nucleus abolish the nerve terminals in all cortical areas and in several other areas of the brain indicating a unique role for the locus coeruleus in influencing the activity of the entire brain. The 5‐HT pathways have a distribution similar to the ventral NA pathyway. The course of the nigro‐striatal and the meso‐limbic DA pathways is presented in detail.
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Ungerstedt (1971) originally reported that the A10 dopamine nucleus projects primarily to the nucleus accumbens and olfactory tubercle.
“Ungerstedt (1971) originally reported the observation that the A10 dopamine nucleus projects primarily to the nucleus accumbens and olfactory tubercle.”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Ungerstedt, 1971
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- Authors
- Ungerstedt, U.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Ungerstedt, Urban
- Venue
- Acta Physiologica Scandinavica
- Publisher
- Wiley
- Published
- 1971-12
- Volume
- 82
- Issue
- S367
- Pages
- 1-48
- ISSN
- 0001-6772 (ISSN-L)
- 1365-201X
- OpenAlex
- W2113449040
- Cited by
- 3,819
- References
- 138
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 11 · 2023: 9 · 2022: 10 · 2021: 16 · 2020: 17 · 2019: 17 · 2018: 14 · 2017: 20 · 2016: 22 · 2015: 12 · 2014: 22 · 2013: 19 · 2012: 25
- FWCI
- 58.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Physiologica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- norepinephrine, serotonin, dopamine, locus coeruleus, nigrostriatal pathway, mesolimbic system, Wallerian degeneration, retrograde degeneration, axon tracing, rat brain, hippocampus, medulla
- MeSH terms
- Amines, Animals, Axons, Brain, Brain Chemistry, Brain Injuries, Brain Mapping, Diencephalon, Dopamine, Electrocoagulation, Fluoresceins, Hippocampus, Histocytochemistry, Medulla Oblongata, Mesencephalon, Microscopy, Fluorescence, Synaptic Transmission, Neurons, Norepinephrine, Pons, Serotonin, Staining and Labeling, Stereotaxic Techniques, Rats
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