Cited by 3,819Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Stereotaxic mapping of the monoamine pathways in the rat brain

Ungerstedt, Urban·1971·Acta Physiologica Scandinavica

Abstract

Abstract The ascending monoamine pathways in the rat brain are demonstrated by the pile up of fluorescent material occurring in the axons after various types of lesions. The anatomy of the pathways is outlined in drawings of frontal sections of the brain and the origin and termination of several pathways is determined by studying the anterograde and retrograde degeneration occurring after well localised lesions. It is possible to separate the ascending NA pathways into a dorsal and a ventral bundle of axons. The dorsal bundle innervates the cortex and the hippocampus and the ventral bundle supplies NA nerve terminals to the medulla, the pons, the mesencephalon and the diencephalon. The dorsal bundle is found to originate in the locus coeruleus. Lesions of this nucleus abolish the nerve terminals in all cortical areas and in several other areas of the brain indicating a unique role for the locus coeruleus in influencing the activity of the entire brain. The 5‐HT pathways have a distribution similar to the ventral NA pathyway. The course of the nigro‐striatal and the meso‐limbic DA pathways is presented in detail.

Integrity signals

Registry

Crossref · 10.1111/j.1365-201x.1971.tb10998.x

Cites

138 of 138 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Ungerstedt, U.
Affiliations
Karolinska Institutet (SE)
Corresponding author
Ungerstedt, Urban
Venue
Acta Physiologica Scandinavica
Publisher
Wiley
Published
1971-12
Volume
82
Issue
S367
Pages
1-48
ISSN
  • 0001-6772 (ISSN-L)
  • 1365-201X
OpenAlex
W2113449040
Cited by
3,819
References
138
Citations by year
2026: 1 · 2025: 6 · 2024: 11 · 2023: 9 · 2022: 10 · 2021: 16 · 2020: 17 · 2019: 17 · 2018: 14 · 2017: 20 · 2016: 22 · 2015: 12 · 2014: 22 · 2013: 19 · 2012: 25
FWCI
58.62
Type
journal article
Language
en
Open access
closed
Locations
  • Acta Physiologica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
Funders
Vetenskapsrådet
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
norepinephrine, serotonin, dopamine, locus coeruleus, nigrostriatal pathway, mesolimbic system, Wallerian degeneration, retrograde degeneration, axon tracing, rat brain, hippocampus, medulla
MeSH terms
Amines, Animals, Axons, Brain, Brain Chemistry, Brain Injuries, Brain Mapping, Diencephalon, Dopamine, Electrocoagulation, Fluoresceins, Hippocampus, Histocytochemistry, Medulla Oblongata, Mesencephalon, Microscopy, Fluorescence, Synaptic Transmission, Neurons, Norepinephrine, Pons, Serotonin, Staining and Labeling, Stereotaxic Techniques, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review