The DOI matches its Crossref record; 61 of the 63 references it cites were found in a registry or an index.
Locus coeruleus neurons in monkey are selectively activated by attended cues in a vigilance task
Open accessAbstract
Impulse activity was recorded extracellularly from noradrenergic neurons in the nucleus locus coeruleus (LC; 47 single-cell and 126 multicell recordings) of four cynomolgus monkeys performing an oddball visual discrimination task. For juice reward, the subjects were required to release a lever rapidly in response to an infrequent (10– 20% of trials) target cue (CS+) that was randomly intermixed with nontarget (CS-) stimuli presented on a video display. All LC neurons examined were phasically and selectively activated by target cues in this task. Other task events elicited no consistent response from these neurons (juice reward, lever release, fix-spot stimuli, nontarget stimuli). In one animal, nontarget cues phasically inhibited LC neurons. Phasic LC excitatory responses to target cues in this task occurred at a relatively short latency (mean = 90.7 msec), approximately 200 msec prior to the behavioral response (lever release). In addition, LC response magnitudes varied with behavioral performance, being substantially attenuated during epochs of poor performance (high false alarm rate). There was a positive correlation (r = 0.30, p < 0.0001) between the latency of LC responses and the latency of behavioral responses to same target cues, consistent with the possibility that LC responses may have a role in selective attention by facilitating responses to the CS+ stimulus. Analyses of behavioral response latencies to pairs of stimuli indicated that LC responses may facilitate behavioral responses to subsequent sensory cues, consistent with a role of this system in sustained attention/vigilance. Moreover, responses became reduced in magnitude over time during prolonged task performance (> 90 min), in parallel with a behavioral performance decrement. These results show that LC neurons are activated selectively by attended stimuli that demand a rapid response in this task, and that such LC responses may contribute to conditioned behavioral responses.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“One study [51] found that locus coeruleus neurons are selectively activated in a sustained attention task in monkeys.”
From Linking ADHD to the Neural Circuitry of Attention (2017) · cites this paper as [51]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Posner, M. I. (1980) · Quarterly Journal of Experimental Psychology · doi:10.1080/00335558008248231 · Cited by 9,670 · cited 1×
“In the latter, the intensity of attention, or alertness, is assumed to remain constant, and differences in response among trials are sought as a function of different instructions given for different trials (e.g., attend right vs left; Posner, 1980; Johnston and Dark, 1986).”
BackgroundDahlstroem, A., & Fuxé, K. (1964) · PubMed · Cited by 5,133
Stereotaxic mapping of the monoamine pathways in the rat brain
Ungerstedt, U. (1971) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.1971.tb10998.x · Cited by 3,819
Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex
Funahashi, S., Bruce, C. J., & Goldman-Rakic, P. S. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.2.331 · Cited by 2,685
Biogenic Amines and the States of Sleep
Jouvet, M. (1969) · Science · doi:10.1126/science.163.3862.32 · Cited by 1,284
Aston‐Jones, G., & Bloom, F. E. (1981) · Journal of Neuroscience · doi:10.1523/jneurosci.01-08-00887.1981 · Cited by 1,072
Self-citationThe Breakdown of Vigilance during Prolonged Visual Search
Mackworth, N. H. (1948) · Quarterly Journal of Experimental Psychology · doi:10.1080/17470214808416738 · Cited by 1,040
Svensson, T. H., Bunney, B. S., & Aghajanian, G. K. (1975) · Brain Research · doi:10.1016/0006-8993(75)90276-0 · Cited by 1,015
A Dynamic Model of Stress and Sustained Attention
Hancock, P. A. (1989) · Human Factors: The Journal of the Human Factors and Ergonomics Society · doi:10.1177/001872088903100503 · Cited by 874
Bushnell, M., Goldberg, M. E., & Robinson, D. L. (1981) · Journal of Neurophysiology · doi:10.1152/jn.1981.46.4.755 · Cited by 868
Research works printed but not linked: 1
- Parasuraman R (1984) The psychobiology of sustained attention. In: Sustained attention in human performance (Warm JS, ed), pp 61- 10 1. New York: Wiley.
Cited by
Sorted by citations
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564
Aston-Jones, G., & Cohen, J. D. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135709 · Cited by 4,472
Self-citationGetting formal with dopamine and reward
Schultz, W. (2002) · Neuron · doi:10.1016/s0896-6273(02)00967-4 · Cited by 2,574
Berridge, C. W., & Waterhouse, B. D. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00143-7 · Cited by 2,529
Decision making, the P3, and the locus coeruleus–norepinephrine system
Nieuwenhuis, S., Aston-Jones, G., & Cohen, J. D. (2005) · Psychological Bulletin · doi:10.1037/0033-2909.131.4.510 · Cited by 1,678
Self-citationNeuronal Coding of Prediction Errors
Schultz, W., & Dickinson, A. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.473 · Cited by 1,427
Joshi, S., Li, Y., Kalwani, R. M., & Gold, J. I. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.028 · Cited by 1,387
Neuronal Reward and Decision Signals: From Theories to Data
Schultz, W. (2015) · Physiological Reviews · doi:10.1152/physrev.00023.2014 · Cited by 1,126
Cohen, J. D., McClure, S. M., & Yu, A. J. (2007) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2007.2098 · Cited by 1,121
Dopamine neurons report an error in the temporal prediction of reward during learning
Hollerman, J. R., & Schultz, W. (1998) · Nature Neuroscience · doi:10.1038/1124 · Cited by 1,161
Orienting and reorienting: the locus coeruleus mediates cognition through arousal
Sara, S. J., & Bouret, S. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.011 · Cited by 1,056
Meerlo, P., Sgoifo, A., & Suchecki, D. (2008) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.07.007 · Cited by 948
Pupillometry: A Window to the Preconscious?
Laeng, B., Sirois, S., & Gredebäck, G. (2012) · Perspectives on Psychological Science · doi:10.1177/1745691611427305 · Cited by 921
Role of locus coeruleus in attention and behavioral flexibility
Aston-Jones, G., Rajkowski, J., & Cohen, J. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00140-7 · Cited by 900
Self-citationVigilance, alertness, or sustained attention: physiological basis and measurement
Oken, B. S., Salinsky, M. C., & Elsas, S. M. (2006) · Clinical Neurophysiology · doi:10.1016/j.clinph.2006.01.017 · Cited by 887
Behavioral Correlates of Activity in Identified Hypocretin/Orexin Neurons
Mileykovskiy, B. Y., Kiyashchenko, L. I., & Siegel, J. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.035 · Cited by 841
Pupil diameter covaries with BOLD activity in human locus coeruleus
Murphy, P. R., O'Connell, R. G., O'Sullivan, M., Robertson, I. H., & Balsters, J. H. (2014) · Human Brain Mapping · doi:10.1002/hbm.22466 · Cited by 819
Network reset: a simplified overarching theory of locus coeruleus noradrenaline function
Bouret, S., & Sara, S. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.09.002 · Cited by 862
Gilzenrat, M. S., Nieuwenhuis, S., Jepma, M., & Cohen, J. D. (2010) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.10.2.252 · Cited by 873
The role of locus coeruleus in the regulation of cognitive performance
Usher, M., Cohen, J. D., Servan-Schreiber, D., Rajkowski, J., & Aston-Jones, G. (1999) · Science · doi:10.1126/science.283.5401.549 · Cited by 715
Self-citationModafinil: a review of neurochemical actions and effects on cognition
Minzenberg, M. J., & Carter, C. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301534 · Cited by 713
The regulation of sleep and arousal: development and psychopathology
Dahl, R. E. (1996) · Development and Psychopathology · doi:10.1017/s0954579400006945 · Cited by 707
Metalearning and neuromodulation
Doya, K. (2002) · Neural Networks · doi:10.1016/s0893-6080(02)00044-8 · Cited by 704
Solanto, M. V. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00175-7 · Cited by 677
Very Slow Activity Fluctuations in Monkey Visual Cortex: Implications for Functional Brain Imaging
Leopold, D. A. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.4.422 · Cited by 675
The Development of Visual Attention in Infancy
Colombo, J. (2001) · Annual Review of Psychology · doi:10.1146/annurev.psych.52.1.337 · Cited by 673
Cognitive functions of cortical acetylcholine: toward a unifying hypothesis
Sarter, M. F., & Bruno, J. P. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00009-4 · Cited by 675
Adaptive gain and the role of the locus coeruleus–norepinephrine system in optimal performance
Aston‐Jones, G., & Cohen, J. D. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20723 · Cited by 671
Self-citationPupil Size as a Window on Neural Substrates of Cognition
Joshi, S., & Gold, J. I. (2020) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2020.03.005 · Cited by 620
Psychological entropy: a framework for understanding uncertainty-related anxiety
Hirsh, J. B., Mar, R. A., & Peterson, J. B. (2012) · Psychological Review · doi:10.1037/a0026767 · Cited by 606
Pupillometry and P3 index the locus coeruleus-noradrenergic arousal function in humans
Murphy, P. R., Robertson, I. H., Balsters, J. H., & O'connell, R. G. (2011) · Psychophysiology · doi:10.1111/j.1469-8986.2011.01226.x · Cited by 519
On the Phase Reduction and Response Dynamics of Neural Oscillator Populations
Brown, E., Moehlis, J., & Holmes, P. J. (2004) · Neural Computation · doi:10.1162/089976604322860668 · Cited by 507
Nicotine-Induced Limbic Cortical Activation in the Human Brain: A Functional MRI Study
Stein, E. A., Pankiewicz, J., Harsch, H. H., Cho, J.-K., Fuller, S. A., Hoffmann, R. G., Hawkins, M., Rao, S. M., Bandettini, P. A., & Bloom, A. S. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.8.1009 · Cited by 483
Nieuwenhuis, S., de Geus, E. J. C., & Aston‐Jones, G. (2010) · Psychophysiology · doi:10.1111/j.1469-8986.2010.01057.x · Cited by 479
Self-citationSnakes as agents of evolutionary change in primate brains
Isbell, L. A. (2006) · Journal of Human Evolution · doi:10.1016/j.jhevol.2005.12.012 · Cited by 451
Varazzani, C., San‐Galli, A., Gilardeau, S., & Bouret, S. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0454-15.2015 · Cited by 482
Noradrenergic mechanisms in neurodegenerative diseases: a theory
Marien, M. R., Colpaert, F. C., & Rosenquist, A. C. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.02.002 · Cited by 425
Locus coeruleus and regulation of behavioral flexibility and attention
(2000) · Progress in Brain Research · doi:10.1016/s0079-6123(00)26013-5 · Cited by 400
Self-citationGoldstein, D. S. (1976) · Elsevier eBooks · doi:10.1016/c2013-0-05741-6 · Cited by 392
Evolution of concepts of stress
Goldstein, D. S., & Kopin, I. J. (2007) · Stress · doi:10.1080/10253890701288935 · Cited by 462
The functional role of the inferior parietal lobe in the dorsal and ventral stream dichotomy
Singh‐Curry, V., & Husain, M. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2008.11.033 · Cited by 399
Hayden, B. Y., Heilbronner, S. R., Pearson, J. M., & Platt, M. L. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4652-10.2011 · Cited by 379
Sirois, S., & Brisson, J. (2014) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1323 · Cited by 375
Bouret, S., & Sara, S. J. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03526.x · Cited by 371
IMAGING VALUATION MODELS IN HUMAN CHOICE
Montague, P. R., King‐Casas, B., & Cohen, J. D. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112903 · Cited by 382
The reticular-activating hypofrontality (RAH) model of acute exercise
Dietrich, A., & Audiffren, M. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.02.001 · Cited by 365
Locus coeruleus activity in monkey: Phasic and tonic changes are associated with altered vigilance
Rajkowski, J., Kubiak, P., & Aston‐Jones, G. (1994) · Brain Research Bulletin · doi:10.1016/0361-9230(94)90175-9 · Cited by 359
Self-citationThe neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y
Kask, A., Harro, J., von Hörsten, S., Redrobe, J. P., Dumont, Y., & Quirion, R. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00066-5 · Cited by 358
Event-related potential studies of outcome processing and feedback-guided learning
San Martín, R. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00304 · Cited by 354
Thiele, A., & Bellgrove, M. A. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.008 · Cited by 350
Redish, A. D., Jensen, S., Johnson, A., & Kurth-Nelson, Z. (2007) · Psychological Review · doi:10.1037/0033-295x.114.3.784 · Cited by 346
Potent excitatory influence of prefrontal cortex activity on noradrenergic locus coeruleus neurons
Jodoj, E., Chiang, C., & Aston-Jones, G. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00372-2 · Cited by 321
Self-citationCognitive Mechanisms of Nicotine on Visual Attention
Lawrence, N., Ross, T. J., & Stein, E. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)01004-8 · Cited by 321
Hulsey, D. R., Riley, J. R., Loerwald, K. W., Rennaker, R. L., Kilgard, M. P., & Hays, S. A. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.12.005 · Cited by 334
McGaughy, J., Dalley, J. W., Morrison, C. H., Everitt, B. J., & Robbins, T. W. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01905.2002 · Cited by 311
Response to Novelty and its Rapid Habituation in Locus Coeruleus Neurons of the Freely Exploring Rat
Vankov, A., Hervé‐Minvielle, A., & Sara, S. J. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb01108.x · Cited by 309
Phasic norepinephrine: A neural interrupt signal for unexpected events
Dayan, P., & Yu, A. J. (2006) · Network Computation in Neural Systems · doi:10.1080/09548980601004024 · Cited by 319
Hajós, M., Richards, C. D., Székely, A. D., & Sharp, T. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00157-2 · Cited by 311
Pupillary correlates of lapses of sustained attention
Nash Unsworth, A., & Robison, M. K. (2016) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-016-0417-4 · Cited by 315
Monoaminergic neuropathology in Alzheimer’s disease
Šimić, G., Leko, M. B., Wray, S., Harrington, C. R., Delalle, I., Milošević, N. J., Bažadona, D., Buée, L., de Silva, R., Giovanni, G. D., et al. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.04.001 · Cited by 296
Sleep Neurobiology from a Clinical Perspective
España, R. A., & Scammell, T. E. (2011) · SLEEP · doi:10.5665/sleep.1112 · Cited by 294
Monitoring and Control of Action by the Frontal Lobes
Schall, J. D., Stuphorn, V., & Brown, J. W. (2002) · Neuron · doi:10.1016/s0896-6273(02)00964-9 · Cited by 286
Karalunas, S. L., Geurts, H. M., Konrad, K., Bender, S., & Nigg, J. T. (2014) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12217 · Cited by 278
Peckys, D. B., & Landwehrmeyer, G. B. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00251-6 · Cited by 273
Neuronal Gene Expression in the Waking State: A Role for the Locus Coeruleus
Cirelli, C., Pompeiano, M., & Tononi, G. (1996) · Science · doi:10.1126/science.274.5290.1211 · Cited by 270
Relating the mechanisms of orienting and alerting
Fernandez‐Duque, D., & Posner, M. I. (1997) · Neuropsychologia · doi:10.1016/s0028-3932(96)00103-0 · Cited by 262
The neural representation of unexpected uncertainty during value-based decision making
Payzan-LeNestour, E., Dunne, S., Bossaerts, P., & O’Doherty, J. P. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.037 · Cited by 257
Chapter 23 Role of the locus coeruleus in emotional activation
Aston‐Jones, G., Rajkowski, J., Kubiak, P., Valentino, R. J., & Shipley, M. T. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)61877-4 · Cited by 256
Self-citationde Kloet, E. R. (2003) · PubMed · Cited by 255
The role of the locus coeruleus in the development of Parkinson's disease
Gesi, M., Soldani, P., Giorgi, F. S., Santinami, A., Bonaccorsi, I., & Fornai, F. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00028-2 · Cited by 254
Hypocretin (OREXIN): Role in Normal Behavior and Neuropathology
Siegel, J. M. (2004) · Annual Review of Psychology · doi:10.1146/annurev.psych.55.090902.141545 · Cited by 247
Neural Circuit Motifs in Valence Processing
Tye, K. M. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.001 · Cited by 268
The Basal Forebrain Corticopetal System Revisited
Záborszky, L., Pang, K. C. H., Somogyi, J., Nádasdy, Z., & Kalló, I. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09276.x · Cited by 244
Brain Imaging of Attentional Networks in Normal and Pathological States
Fernandez‐Duque, D., & Posner, M. I. (2001) · Journal of Clinical and Experimental Neuropsychology · doi:10.1076/jcen.23.1.74.1217 · Cited by 254
Phasic locus coeruleus activity regulates cortical encoding of salience information
Vazey, E. M., Moorman, D. E., & Aston‐Jones, G. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1803716115 · Cited by 241
Self-citationA noradrenergic theory of cognitive reserve: implications for Alzheimer's disease
Robertson, I. H. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.05.019 · Cited by 256
Dreisbach, G. (2005) · Brain and Cognition · doi:10.1016/j.bandc.2005.08.003 · Cited by 257
Pupillometry as an integrated readout of distinct attentional networks
Strauch, C., Wang, C., Einhäuser, W., der Stigchel, S. V., & Naber, M. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.05.003 · Cited by 255
The emergence and basis of endogenous attention in infancy and early childhood
Colombo, J., & Cheatham, C. L. (2006) · Advances in Child Development and Behavior · doi:10.1016/s0065-2407(06)80010-8 · Cited by 238
Animal models of attention-deficit hyperactivity disorder
Russell, V. A., Sagvolden, T., & Johansen, E. B. (2005) · Behavioral and Brain Functions · doi:10.1186/1744-9081-1-9 · Cited by 248
Coordinated forms of noradrenergic plasticity in the locus coeruleus and primary auditory cortex
Martins, A. R. O., & Froemke, R. C. (2015) · Nature Neuroscience · doi:10.1038/nn.4090 · Cited by 233
Neuromodulatory Systems and Their Interactions: A Review of Models, Theories, and Experiments
Avery, M. C., & Krichmar, J. L. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00108 · Cited by 250
When the Brain Takes a Break: A Model-Based Analysis of Mind Wandering
Mittner, M., Boekel, W., Tucker, A. M., Turner, B. M., Heathcote, A., & Forstmann, B. U. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.2062-14.2014 · Cited by 228
Aston‐Jones, G., Rajkowski, J., & Kubiak, P. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00060-2 · Cited by 227
Self-citationMcGaughy, J., Ross, R. S., & Eichenbaum, H. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.01.064 · Cited by 226
Phasic Activation of Monkey Locus Ceruleus Neurons by Simple Decisions in a Forced-Choice Task
Clayton, E. C., Rajkowski, J., Cohen, J. D., & Aston‐Jones, G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2446-04.2004 · Cited by 226
Self-citationCoull, J. T., Frackowiak, R. S. J., & Frith, C. (1998) · Neuropsychologia · doi:10.1016/s0028-3932(98)00035-9 · Cited by 225
Ross, J. A., & Bockstaele, E. J. V. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.601519 · Cited by 241
Locus coeruleus neurons: cessation of activity during cataplexy
Wu, M.-F., Gulyani, S., Yau, E., Mignot, E. J.-M., Phan, B., & Siegel, J. M. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00600-9 · Cited by 220
Rajkowski, J., Majczyński, H., Clayton, E. C., & Aston‐Jones, G. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00673.2003 · Cited by 215
Self-citationChandler, D. J., Jensen, P., McCall, J. G., Pickering, A. E., Schwarz, L. A., & Totah, N. K. B. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1164-19.2019 · Cited by 229
What do the basal ganglia do? A modeling perspective
Chakravarthy, V. S., Joseph, D., & Bapi, R. S. (2010) · Biological Cybernetics · doi:10.1007/s00422-010-0401-y · Cited by 214
Altered dopamine function in pathological gambling
Bergh, C. E. K., Eklund, T., Södersten, P., & Nordin, C. (1997) · Psychological Medicine · doi:10.1017/s0033291796003789 · Cited by 212
Liu, Y., Rodenkirch, C., Moskowitz, N., Schriver, B. J., & Wang, Q. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.094 · Cited by 212
Control of exploitation–exploration meta-parameter in reinforcement learning
Ishii, S., Yoshida, W., & Yoshimoto, J. (2002) · Neural Networks · doi:10.1016/s0893-6080(02)00056-4 · Cited by 214
Participation of the thalamic CM-Pf complex in attentional orienting.
Minamimoto, T., & Kimura, M. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.87.6.3090 · Cited by 199
van Leeuwen, T. H., Steinhausen, H. ‐., Overtoom, C. C. E., Pascual-Marqui, R. D., Klooster, B. V., Rothenberger, A., Sergeant, J. A., & Brandeis, D. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00173-3 · Cited by 197
Twenty-Five Lessons from Computational Neuromodulation
Dayan, P. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.027 · Cited by 190
Therapeutic Potential of Kava in the Treatment of Anxiety Disorders
Singh, Y. N., & Singh, N. N. (2002) · CNS Drugs · doi:10.2165/00023210-200216110-00002 · Cited by 188
The Role of the Locus Coeruleus in Mediating the Attentional Blink: A Neurocomputational Theory.
Nieuwenhuis, S., Gilzenrat, M. S., Holmes, B. D., & Cohen, J. D. (2005) · Journal of Experimental Psychology General · doi:10.1037/0096-3445.134.3.291 · Cited by 196
Metadata
- Authors
- Aston-Jones, G., Rajkowski, J., Kubiak, P., & Alexinsky, T.
- Affiliations
- Hahnemann University Hospital (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1994-07-01
- Volume
- 14
- Issue
- 7
- Pages
- 4467-4480
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6577022
- OpenAlex
- W1954301870
- Cited by
- 637
- References
- 63
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 25 · 2023: 24 · 2022: 25 · 2021: 20 · 2020: 30 · 2019: 26 · 2018: 31 · 2017: 34 · 2016: 27 · 2015: 21 · 2014: 19 · 2013: 21 · 2012: 20
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Funders
- U.S. Air Force
- Air Force Office of Scientific Research (F49620)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- locus coeruleus, noradrenergic neurons, sustained attention, selective attention, oddball paradigm, response latency, single-unit activity, Macaca fascicularis
- MeSH terms
- Animals, Arousal, Behavior, Animal, Cues, Discrimination, Psychological, Locus Coeruleus, Macaca fascicularis, Neurons, Photic Stimulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
