The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Sex differences in aging of the human frontal and temporal lobes
Open accessAbstract
This study investigated effects of age and sex on regional brain structure in humans, focusing on the frontal and temporal lobes. Hemispheric volumes were obtained from magnetic resonance images (MRIs) of 96 young (53 men, 43 women; aged 18–40 years) and 34 older (17 men, 17 women; aged 41–80) healthy volunteers. Images (5 mm axial spin-echo, repetition time of 3000 msec and echo times of 30 and 80 msec) were resliced along the anterior commissure-posterior commissure (AC-PC) axis to standardize for difference in head tilt, and imported into a computer program where borders of the frontal and temporal lobes were delineated. The program calculated regional brain volumes based on slice data from which CSF was segmented out. An age x sex x hemisphere x region interaction indicated that age-related reductions in brain volume were sexually dimorphic, lateralized, and region specific. Greater decrements in brain volume occurred with age in the frontal lobe than in the temporal lobe. Age-related reductions in both regions were greater in men than in women, demonstrating that sexual dimorphisms in human neuroanatomy are not fixed, but continue to change throughout adulthood. The possibility that gonadal hormones play a role in the promotion and/or prevention of neural atrophy with aging is discussed.
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Citations
Cites
Decreases in regional cerebral blood flow with normal aging
Martin, A. J., Friston, K. J., Colebatch, J. G., & Frackowiak, R. S. J. (1991) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1991.121 · Cited by 393
Regional cerebral blood flow and oxygen consumption in human aging
Pantano, P., Baron, J. C., Lebrun-Grandié, P., Duquesnoy, N., Bousser, M. G., & Comar, D. (1984) · Stroke · doi:10.1161/01.str.15.4.635 · Cited by 341
Kuhl, D. E., Metter, E. J., Riege, W. H., & Phelps, M. E. (1982) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1982.15 · Cited by 338
Sex difference in the bed nucleus of the stria terminalis of the human brain
Allen, L. S., & Gorski, R. A. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.903020402 · Cited by 281
Cited by
A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains
Good, C. D., Johnsrude, I. S., Ashburner, J., Henson, R. N. A., Friston, K. J., & Frackowiak, R. S. J. (2001) · NeuroImage · doi:10.1006/nimg.2001.0786 · Cited by 4,561
Structural and functional brain development and its relation to cognitive development
Casey, B. J., Giedd, J. N., & Thomas, K. M. (2000) · Biological Psychology · doi:10.1016/s0301-0511(00)00058-2 · Cited by 1,506
Gur, R. C., Turetsky, B. I., Matsui, M., Yan, M., Bilker, W., Hughett, P., & Gur, R. E. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-10-04065.1999 · Cited by 909
Self-citationSex Differences in Brain Maturation during Childhood and Adolescence
De Bellis, M. D. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.6.552 · Cited by 728
DeCarli, C., Massaro, J., Harvey, D., Hald, J., Tullberg, M., Au, R., Beiser, A., D’Agostino, R., & Wolf, P. A. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.05.004 · Cited by 680
Metadata
- Authors
- Cowell, P., Turetsky, B., Gur, R., Grossman, R., Shtasel, D., & Gur, R.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1994-08-01
- Volume
- 14
- Issue
- 8
- Pages
- 4748-4755
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2134591652
- Cited by
- 336
- References
- 4
- FWCI
- 8.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Cowell, P., Turetsky, B., Gur, R., Grossman, R., Shtasel, D., & Gur, R. (1994). Sex differences in aging of the human frontal and temporal lobes. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.14-08-04748.1994
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
