The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Extracellular glucose concentration in mammalian brain: continuous monitoring of changes during increased neuronal activity and upon limitation in oxygen supply in normo-, hypo-, and hyperglycemic animals
Open accessAbstract
The concentration of extracellular glucose in anesthetized rat brain was measured continuously with two types of substrate-specific microelectrodes in a number of physiological and pathological conditions. Extracellular glucose level increased in hyperglycemia and decreased in hypoglycemia, paralleling the changes in blood sugar. Increased neuronal activity and in particular spreading depression, evoked triphasic alterations in extracellular glucose concentration: an initial rapid fall was followed by an equally swift overshoot above the baseline and a subsequent return to it. Limitation in O2 supply led to a decline in extracellular content of glucose: respiration with 5% O2 reduced the level by 7–20% and that with 3% O2 by 75–85%. Decreases to undetectable concentrations were seen in ischemia despite the use of an oxygen-insensitive microglucose sensor. Restoration of oxygen supply to the brain was accompanied by increases in extracellular glucose content above the original normoxic level, which returned to baseline values after 10–15 min. In hyperglycemic animals ischemia-induced leakage of K+ was delayed while the rate of recovery to control levels after restitution of blood flow was enhanced. It is concluded that continuous monitoring of glucose with glucose-specific microelectrodes provides a new and important insight into brain energy metabolism.
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Cites
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Ferrocene-mediated enzyme electrode for amperometric determination of glucose
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Cited by
Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
Parton, L. E., Ye, C. P., Coppari, R., Enriori, P. J., Choi, B., Zhang, C.-Y., Xu, C., Vianna, C. R., Balthasar, N., Lee, C. E., et al. (2007) · Nature · doi:10.1038/nature06098 · Cited by 700
Tissue oxygen tension and brain sensitivity to hypoxia
Erecińska, M., & Silver, I. A. (2001) · Respiration Physiology · doi:10.1016/s0034-5687(01)00306-1 · Cited by 615
Self-citationGlucose transporters in brain in health and disease
Koepsell, H. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02441-x · Cited by 558
Impact of postprandial glycaemia on health and prevention of disease
Blaak, E. E., Antoine, J. ‐., Benton, D., Björck, I., Bozzetto, L., Brouns, F., Diamant, M., Dye, L., Hulshof, T., Holst, J. J., et al. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01011.x · Cited by 477
Enzyme-Based Biosensors for in Vivo Measurements
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Metadata
- Authors
- Silver, I., & Erecinska, M.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1994-08-01
- Volume
- 14
- Issue
- 8
- Pages
- 5068-5076
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2127575529
- Cited by
- 477
- References
- 45
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Silver, I., & Erecinska, M. (1994). Extracellular glucose concentration in mammalian brain: continuous monitoring of changes during increased neuronal activity and upon limitation in oxygen supply in normo-, hypo-, and hyperglycemic animals. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.14-08-05068.1994
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
