The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
The Neural Coding of Stimulus Intensity: Linking the Population Response of Mechanoreceptive Afferents with Psychophysical Behavior
Open accessAbstract
How specific aspects of a stimulus are encoded at different stages of neural processing is a critical question in sensory neuroscience. In the present study, we investigated the neural code underlying the perception of stimulus intensity in the somatosensory system. We first characterized the responses of SA1 (slowly adapting type 1), RA (rapidly adapting), and PC (Pacinian) afferents of macaque monkeys to sinusoidal, diharmonic, and bandpass noise stimuli. We then had human subjects rate the perceived intensity of a subset of these stimuli. On the basis of these neurophysiological and psychophysical measurements, we evaluated a series of hypotheses about which aspect(s) of the neural activity evoked at the somatosensory periphery account for perception. We evaluated three types of neural codes. The first consisted of population codes based on the firing rate of neurons located directly under the probe. The second included population codes based on the firing rate of the entire population of active neurons. The third included codes based on the number of active afferents. We found that the response evoked in the localized population is logarithmic with stimulus amplitude (given a constant frequency composition), whereas the population response across all neurons is linear with stimulus amplitude. We conclude that stimulus intensity is best accounted for by the firing rate evoked in afferents located under or near the locus of stimulation, weighted by afferent type.
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“In the intact nerve, increases in pressure result in both an increase in the number of recruited fibers and an increase in the firing rates of those fibers already recruited (Muniak et al., 2007), which explains why changes in either the delivered charge or the stimulation frequencies result in changes in perceived pressure.”
From Biomimetic approaches to bionic touch through a peripheral nerve interface (2015) · cites this paper as Muniak et al., 2007
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Citations
Cites
The Logic of Scientific Discovery.
Hutchison, T. W., & Popper, K. R. (1959) · Economica · doi:10.2307/2550489 · Cited by 7,629
The Logic of Scientific Discovery
Popper, K. R., & Weiss, G. (1959) · Physics Today · doi:10.1063/1.3060577 · Cited by 2,717
Johansson, R. S., & Vallbo, A. B. (1979) · The Journal of Physiology · doi:10.1113/jphysiol.1979.sp012619 · Cited by 1,291
The roles and functions of cutaneous mechanoreceptors.
Johnson, K. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00234-8 · Cited by 1,063 · cited 1×
“…flutter and motion perception; and PC in the perception of microtextures (Hollins and Bensmaia, 2007) and of textures explored through a tool (Yoshioka et al., 2007) (for review, see Johnson, 2001)], all three populations of afferents respond to most natural stimuli, albeit to different degrees.”
Talbot, W. H., Darian-Smith, I., Kornhuber, H. H., & Mountcastle, V. B. (1968) · Journal of Neurophysiology · doi:10.1152/jn.1968.31.2.301 · Cited by 993 · cited 10×
“The frequency dependence of threshold parameter conformed with previous measurements of absolute threshold (Talbot et al., 1968; Freeman and Johnson, 1982a; Johansson et al., 1982): PC afferents yielded a characteristic U-shaped threshold-frequency relationship; the RA threshold-frequency function was also U-shaped (f…”
MethodInfluentialFour channels mediate the mechanical aspects of touch
Bolanowski, S. J., Gescheider, G. A., Verrillo, R. T., & Checkosky, C. M. (1988) · The Journal of the Acoustical Society of America · doi:10.1121/1.397184 · Cited by 937 · cited 1×
“However, there is little direct evidence that it contributes to vibrotaction [for a counterargument, see Bolanowski et al. (1988)].”
Mountcastle, V. B., Talbot, W. H., Sakata, H., & Hyvärinen, J. (1969) · Journal of Neurophysiology · doi:10.1152/jn.1969.32.3.452 · Cited by 683 · cited 1×
“The perceived intensity of sinusoids in the low- to intermediatefrequency range has been shown to increase linearly with stimulus intensity (Stevens, 1968; Franzén, 1969; Verrillo et al., 1969) whereas the firing rates evoked in individual peripheral afferents do not (Mountcastle et al., 1969).”
Ochoa, J., & Torebjörk, E. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014873 · Cited by 467 · cited 2×
“For instance, microstimulation of single SA2 afferents does not produce any conscious sensation, much less a vibratory percept, whereas microstimulation of the other three afferent types yields sensations ranging from pressure, to taps, to vibrations, the nature of which depends both on the frequency of the electrical…”
Johansson, R. S., Landstro¨m, U., & Lundström, R. (1982) · Brain Research · doi:10.1016/0006-8993(82)90899-x · Cited by 442 · cited 1×
“The frequency dependence of threshold parameter conformed with previous measurements of absolute threshold (Talbot et al., 1968; Freeman and Johnson, 1982a; Johansson et al., 1982): PC afferents yielded a characteristic U-shaped threshold-frequency relationship; the RA threshold-frequency function was also U-shaped (f…”
Johansson, R. S. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012411 · Cited by 430 · cited 3×
“The coarse spatial structure of SA1 and RA RFs is similar (Johansson, 1978), and the model is likely applicable to both afferent types.”
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Spatial and temporal codes mediate the tactile perception of natural textures
Weber, A. I., Saal, H. P., Lieber, J. D., Cheng, J.-W., Manfredi, L. R., Dammann, J. F., & Bensmaia, S. J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305509110 · Cited by 421
“Extracellular single-unit recordings were collected from the median and ulnar nerves innervating the distal fingertips of six Rhesus macaques (Macaca mulatta) using established procedures (11, 12).”
BackgroundMethodValle, G., Mazzoni, A., Iberite, F., D’Anna, E., Strauss, I., Granata, G., Controzzi, M., Clemente, F., Rognini, G., Cipriani, C., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.08.033 · Cited by 355
Restoring the sense of touch with a prosthetic hand through a brain interface
Tabot, G. A., Dammann, J. F., Berg, J. A., Tenore, F. V., Boback, J. L., Vogelstein, R. J., & Bensmaia, S. J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221113110 · Cited by 320
Quantitative assessment of pleasant touch
Essick, G. K., McGlone, F. P., Dancer, C., Fabricant, D., Ragin, Y., Phillips, N., Jones, T., & Guest, S. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.02.003 · Cited by 328
“…in populations of slowly adapting mechanoreceptors (SAI units: Blake et al., 1997; Connor et al., 1990; Connor and Johnson, 1992; see also Muniak et al., 2007, for vibrotactile intensity coding) except for very smooth surfaces, where activity in the Pacinian (RAII) channel appears more…”
Sensory feedback for limb prostheses in amputees
Raspopovic, S., Valle, G., & Petrini, F. M. (2021) · Nature Materials · doi:10.1038/s41563-021-00966-9 · Cited by 308
Metadata
- Authors
- Muniak, M. A., Ray, S., Hsiao, S. S., Dammann, J. F., & Bensmaia, S. J.
- Affiliations
- Johns Hopkins University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-10-24
- Volume
- 27
- Issue
- 43
- Pages
- 11687-11699
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6673240
- OpenAlex
- W1989489753
- Cited by
- 235
- References
- 42
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 18 · 2023: 14 · 2022: 18 · 2021: 26 · 2020: 16 · 2019: 16 · 2018: 15 · 2017: 14 · 2016: 13 · 2015: 11 · 2014: 14 · 2013: 10 · 2012: 8
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (NS-38034)
- National Institute on Deafness and Other Communication Disorders (R01DC000095, DC-00023, DC-00095, T32DC000023)
- National Institute of Neurological Disorders and Stroke (NS 38034, NS-18787, R01NS018787, P01NS038034)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- neural coding, somatosensory system, rapidly adapting afferents, Pacinian corpuscles, population coding, firing rate, psychophysics, macaque, sinusoidal stimuli, bandpass noise
- MeSH terms
- Action Potentials, Adult, Animals, Differential Threshold, Female, Humans, Macaca mulatta, Male, Mechanoreceptors, Neurons, Afferent, Physical Stimulation, Psychomotor Performance, Touch, Vibration
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