The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Naturally Occurring Truncated trkB Receptors Have Dominant Inhibitory Effects on Brain-Derived Neurotrophic Factor Signaling
Open accessAbstract
trkB encodes a receptor tyrosine kinase activated by three neurotrophins—brain-derived neurotrophic factor (BDNF), neurotrophin-3, and neurotrophin-4/5.In vivo, three isoforms of the receptor are generated by differential splicing—gp145 trkB or the full-length trkB receptor, and trkB.T1 and trkB.T2, two cytoplasmically truncated receptors that lack kinases, but contain unique C termini. Although the truncated receptors appear to be precisely regulated during nervous system development and regeneration, their role in neurotrophin signaling has not been directly tested. In this paper, we studied the signaling properties and interactions of gp145 trkB, trkB.T1, and trkB.T2 by expressing the receptors in a Xenopus oocyte microinjection assay. We found that oocytes expressing gp145 trkB, but not trkB.T1 or trkB.T2, were capable of eliciting 45 Ca efflux responses (a phospholipase C-γ-mediated mechanism) after stimulation by BDNF. When trkB.T1 and trkB.T2 were coexpressed with gp145 trkB, they acted as dominant negative receptors, inhibiting the BDNF signal by forming nonfunctional heterodimers with the full-length receptors. An ATP-binding mutant of gp145 trkB had similar dominant inhibitory effects. Our data suggest that naturally occurring truncated trkB receptors function as inhibitory modulators of neurotrophin responsiveness. Furthermore, the homodimerization of gp145 trkB appears to be an essential step in activation of the BDNF signaling cascade.
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Raza, H., John, A., & Nemmar, A. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350087 · Cited by 47,221
Domingos da Silveira da Luz, A. C., Pereira Dias, G., do Nascimento Bevilaqua, M. C., Cocks, G., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 3,995
Purification of a new neurotrophic factor from mammalian brain.
Barde, Y. A., Edgar, D., & Thoenen, H. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01207.x · Cited by 1,822
Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs
Krieg, P. A., & Melton, D. A. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.18.7057 · Cited by 1,533
Molecular cloning and expression of brain-derived neurotrophic factor
Leibrock, J., Lottspeich, F., Hohn, A., Hofer, M., Hengerer, B., Masiakowski, P., Thoenen, H., & Barde, Y.-A. (1989) · Nature · doi:10.1038/341149a0 · Cited by 1,457
Squinto, S. P., Stitt, T. N., Aldrich, T. H., Davis, S., Blanco, S. M., RadzieJewski, C., Glass, D. J., Masiakowski, P., Furth, M. E., Valenzuela, D. M., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90395-f · Cited by 834
Soppet, D., Escandon, E., Maragos, J., Middlemas, D. S., Raid, S. W., Blair, J., Burton, L. E., Stanton, B. R., Kaplan, D. R., Hunter, T., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90396-g · Cited by 820
Isolation of Monoclonal Antibodies Specific for Human c-myc Proto-Oncogene Product
Evan, G. I., Lewis, G. K., Ramsay, G., & Bishop, J. M. (1985) · Molecular and Cellular Biology · doi:10.1128/mcb.5.12.3610-3616.1985 · Cited by 794
Middlemas, D. S., Lindberg, R. A., & Hunter, T. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.1.143 · Cited by 775
Cited by
Neurotrophins: Roles in Neuronal Development and Function
Huang, E. J., & Reichardt, L. F. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.677 · Cited by 4,394
Self-citationTrk Receptors: Roles in Neuronal Signal Transduction
Huang, E. J., & Reichardt, L. F. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161629 · Cited by 2,537
Self-citationNeurotrophin-regulated signalling pathways
Reichardt, L. F. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1894 · Cited by 2,195
Self-citationNeurotrophin regulation of neural circuit development and function
Park, H., & Poo, M.-M. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3379 · Cited by 2,060
Binder (2004) · doi:10.1080/08977190410001723308 · Cited by 1,481
Metadata
- Authors
- Eide, F. F., Vining, E. R., Eide, B. L., Zang, K., Wang, X.-Y., & Reichardt, L. F.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1996-05-15
- Volume
- 16
- Issue
- 10
- Pages
- 3123-3129
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2157001082
- Cited by
- 474
- References
- 32
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Naturally Occurring Truncated trkB Receptors Have Dominant Inhibitory Effects on Brain-Derived Neurotrophic Factor Signaling. https://app.cochat.ai/papers/10.1523/jneurosci.16-10-03123.1996
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- Eide, F. F., Vining, E. R., Eide, B. L., Zang, K., Wang, X.-Y., & Reichardt, L. F. (1996). Naturally Occurring Truncated trkB Receptors Have Dominant Inhibitory Effects on Brain-Derived Neurotrophic Factor Signaling. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.16-10-03123.1996
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