The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Microglia Enhance Neurogenesis and Oligodendrogenesis in the Early Postnatal Subventricular Zone
Open accessAbstract
Although microglia have long been considered as brain resident immune cells, increasing evidence suggests that they also have physiological roles in the development of the normal CNS. In this study, we found large numbers of activated microglia in the forebrain subventricular zone (SVZ) of the rat from P1 to P10. Pharmacological suppression of the activation, which produces a decrease in levels of a number of proinflammatory cytokines (i.e., IL-1β, IL-6, TNF-α, and IFN-γ) significantly inhibited neurogenesis and oligodendrogenesis in the SVZ.In vitro neurosphere assays reproduced the enhancement of neurogenesis and oligodendrogenesis by activated microglia and showed that the cytokines revealed the effects complementarily. These results suggest that activated microglia accumulate in the early postnatal SVZ and that they enhance neurogenesis and oligodendrogenesis via released cytokines.
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Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175
Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
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Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
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M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
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“Recently, Miron et al. (2013) showed that a switch from M1 to M2 occurred in microglia during remyelination, and oligodendrocyte differentiation was enhanced by M2 cell releasing factors.”
Inflammation is detrimental for neurogenesis in adult brain
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Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex
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IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress
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Microglia and macrophages in brain homeostasis and disease
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Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
Gao, C., Jiang, J., Tan, Y., & Chen, S. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01588-0 · Cited by 1,616
Microglial signatures and their role in health and disease
Butovsky, O., & Weiner, H. L. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0057-5 · Cited by 1,046
The Semantics of Microglia Activation: Neuroinflammation, Homeostasis, and Stress
Woodburn, S. C., Bollinger, J. L., & Wohleb, E. S. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02309-6 · Cited by 783
The biphasic function of microglia in ischemic stroke
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Metadata
- Authors
- Shigemoto-Mogami, Y., Hoshikawa, K., Goldman, J. E., Sekino, Y., & Sato, K.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2014-02-05
- Volume
- 34
- Issue
- 6
- Pages
- 2231-2243
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2068022069
- Cited by
- 505
- References
- 16
- FWCI
- 12.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Shigemoto-Mogami, Y., Hoshikawa, K., Goldman, J. E., Sekino, Y., & Sato, K. (2014). Microglia Enhance Neurogenesis and Oligodendrogenesis in the Early Postnatal Subventricular Zone. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.1619-13.2014
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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