The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Single-Channel Properties of Recombinant AMPA Receptors Depend on RNA Editing, Splice Variation, and Subunit Composition
Open accessAbstract
Non-NMDA glutamate receptor subunits of the AMPA-preferring subfamily combine to form ion channels with heterogeneous functional properties. We have investigated the effects of RNA editing at the Q/R site, splice variation of the “flip/flop” cassette, and multimeric subunit assembly on the single-channel conductance and kinetic properties of the recombinant AMPA receptors formed from GluR2 and GluR4 expressed in HEK 293 cells. We found that AMPA receptor single-channel conductance was dependent on the Q/R site editing state of the subunits comprising the channel. Calcium-permeable (unedited) channels had resolvable single-channel events with main conductance states of 7–8 pS, whereas fully edited GluR2 channels had very low conductances of ∼300 fS (estimated from noise analysis). Additionally, the flip splice variant of GluR4 conferred agonist-dependent conductance properties reminiscent of those found for a subset of AMPA receptors in cultured cerebellar granule cells. These results provide a description of the single-channel properties of certain recombinant AMPA receptors and suggest that the single-channel conductance may be determined by the expression of edited GluR2 subunits in neurons.
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Cites
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Control of Kinetic Properties of AMPA Receptor Channels by Nuclear RNA Editing
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Cited by
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Traynelis, S. F., Wollmuth, L. P., McBain, C. J., Menniti, F. S., Vance, K. M., Ogden, K. K., Hansen, K. B., Yuan, H., Myers, S. J., & Dingledine, R. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002451 · Cited by 3,568
The Glutamate Receptor Ion Channels
Dingledine, R., Borges, K., Bowie, D., & Traynelis, S. F. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01394-2 · Cited by 3,554
Glutamate receptors in the mammalian central nervous system
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Mechanisms for Activation and Antagonism of an AMPA-Sensitive Glutamate Receptor
Armstrong, N., & Gouaux, E. (2000) · Neuron · doi:10.1016/s0896-6273(00)00094-5 · Cited by 872
Derkach, V., Barria, A., & Soderling, T. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3269 · Cited by 842
Metadata
- Authors
- Swanson, G. T., Kamboj, S. K., & Cull-Candy, S. G.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1997-01-01
- Volume
- 17
- Issue
- 1
- Pages
- 58-69
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2162520530
- Cited by
- 489
- References
- 36
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Swanson, G. T., Kamboj, S. K., & Cull-Candy, S. G. (1997). Single-Channel Properties of Recombinant AMPA Receptors Depend on RNA Editing, Splice Variation, and Subunit Composition. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.17-01-00058.1997
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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