Regulation of Amyloid Precursor Protein Catabolism Involves the Mitogen-Activated Protein Kinase Signal Transduction Pathway
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Catabolic processing of the amyloid precursor protein (APP) is subject to regulatory control by protein kinases. We hypothesized that this regulation involves sequential activation of the enzymes mitogen-activated protein kinase kinase (MEK) and extracellular signal-regulated protein kinase (ERK). In the present investigation, we provide evidence that MEK is critically involved in regulating APP processing by both nerve growth factor and phorbol esters. Western blot analysis of the soluble N-terminal APP derivative APP s demonstrated that the synthetic MEK inhibitor PD 98059 antagonized nerve growth factor stimulation of both APP s production and ERK activation in PC12 cells. Moreover, PD 98059 inhibited phorbol ester stimulation of APP s production and activation of ERK in both human embryonic kidney cells and cortical neurons. Furthermore, overexpression of a kinase-inactive MEK mutant inhibited phorbol ester stimulation of APP secretion and activation of ERK in human embryonic kidney cell lines. Most important, PD 98059 antagonized phorbol ester-mediated inhibition of Aβ secretion from cells overexpressing human APP 695 carrying the “Swedish mutation.” Taken together, these data indicate that MEK and ERK may be critically involved in protein kinase C and nerve growth factor regulation of APP processing. The mitogen-activated protein kinase cascade may provide a novel target for altering catabolic processing of APP.
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ERK activation modulates APP processing and Aβ generation.
“ERK activation has been shown to modulate APP processing and Aβ generation (24, 25, 36).”
From Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans (2011) · cites this paper as [36]
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High-Efficiency Transformation of Mammalian Cells by Plasmid DNA
Chen, C., & Okayama, H. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.8.2745 · Cited by 5,374 · see citing works
Alessi, D. R., Cuenda, A., Cohen, P., Dudley, D. T., & Saltiel, A. R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.46.27489 · Cited by 3,396 · see citing works
A synthetic inhibitor of the mitogen-activated protein kinase cascade.
Dudley, D. T., Pang, L., Decker, S. J., Bridges, A. J., & Saltiel, A. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7686 · Cited by 2,679 · see citing works
Amyloid β-peptide is produced by cultured cells during normal metabolism
Haass, C., Schlossmacher, M. G., Hung, A. Y., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B. L., Lieberburg, I., Koo, E. H., Schenk, D., Teplow, D. B., et al. (1992) · Nature · doi:10.1038/359322a0 · Cited by 1,921 · see citing works
Cobb, M. H., & Goldsmith, E. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.25.14843 · Cited by 1,718 · see citing works
Borchelt, D. R., Thinakaran, G., Eckman, C. B., Lee, M. K., Davenport, F., Ratovitsky, T., Prada, C.-M., Kim, G., Seekins, S., Yager, D., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80230-5 · Cited by 1,478 · see citing works
Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing
Shoji, M., Golde, T. E., Ghiso, J., Cheung, T. T., Estus, S., Shaffer, L. M., Cai, X.-D., McKay, D. M., Tintner, R., Frangione, B., et al. (1992) · Science · doi:10.1126/science.1439760 · Cited by 1,447 · see citing works
Amyloid, the presenilins and Alzheimer’s disease
Hardy, J. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01030-2 · Cited by 1,370 · see citing works
Citron, M., Westaway, D., Xia, W., Carlson, G., Diehl, T., Levesque, G., Johnson-wood, K., Lee, M., Seubert, P., Davis, A., et al. (1997) · Nature Medicine · doi:10.1038/nm0197-67 · Cited by 1,271 · see citing works
Gel electrophoresis of proteins: a practical approach
HAMES, B. D., & RICKWOOD, D. (1981) · Cited by 1,088 · see citing works
Anderson, N. G., Maller, J. L., Tonks, N. K., & Sturgill, T. W. (1990) · Nature · doi:10.1038/343651a0 · Cited by 1,064 · see citing works
Payne, D. M., Rossomando, A. J., Martino, P. A., Erickson, A. K., Her, J. H., Shabanowitz, J., Hunt, D. F., Weber, M. J., & Sturgill, T. W. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb08021.x · Cited by 1,041 · see citing works
Meisenhelder, J., Suh, P., Rhee, S. G., & Hunter, T. R. (1989) · Cell · doi:10.1016/0092-8674(89)90048-2 · Cited by 955 · see citing works
Nitsch, R. M., Slack, B. E., Wurtman, R. J., & Growdon, J. H. (1992) · Science · doi:10.1126/science.1411529 · Cited by 898 · see citing works
Pang, L., Sawada, T., Decker, S. J., & Saltiel, A. R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.23.13585 · Cited by 896 · see citing works
Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing
Sisodia, S. S., Koo, E. H., Beyreuther, K. T., Unterbeck, A., & Price, D. L. (1990) · Science · doi:10.1126/science.1691865 · Cited by 894 · see citing works
Self-citationAlzheimer's Disease--Genotypes, Phenotype, and Treatments
Selkoe, D. J. (1997) · Science · doi:10.1126/science.275.5300.630 · Cited by 871 · see citing works
(1997) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(97)88594-9 · Cited by 709 · see citing works
Selkoe, D. J., Podlisny, M. B., Joachim, C. L., Vickers, E., Lee, G. S., Fritz, L. C., & Oltersdorf, T. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.19.7341 · Cited by 579 · see citing works
Buxbaum, J. D., Oishi, M., Chen, H. I., Pinkas‐Kramarski, R., JAFFE, E. A., Gandy, S., & Greengard, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10075 · Cited by 558 · see citing works
Lemere, C. A., Lopera, F., Kosik, K. S., Lendon, C. L., Ossa, J., Saido, T. C., Yamaguchi, H., Ruiz, A., Martinez, A., Madrigal, L., et al. (1996) · Nature Medicine · doi:10.1038/nm1096-1146 · Cited by 487 · see citing works
Ida, N., Hartmann, T., Pantel, J., Schrüder, J., Zerfaß, R., Fürstl, H., Sandbrink, R., Masters, C. L., & Beyreuther, K. T. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.37.22908 · Cited by 476 · see citing works
Self-citationBuxbaum, J. D., Gandy, S., Cicchetti, P., Ehrlich, M. E., Czernik, A. J., Fracasso, R. P., Ramabhadran, T. V., Unterbeck, A., & Greengard, P. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.15.6003 · Cited by 450 · see citing works
Furukawa, K., Sopher, B. L., Rydel, R. E., Begley, J. G., Pham, D. G., Martin, G. M., Fox, M., & Mattson, M. P. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67051882.x · Cited by 414 · see citing works
Activation of protein kinase C inhibits cellular production of the amyloid beta-protein.
Hung, A. Y., Haass, C., Nitsch, R. M., Qiu, W. Q., Citron, M., Wurtman, R. J., Growdon, J. H., & Selkoe, D. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49409-x · Cited by 399 · see citing works
Lazar, D. F., Wiese, R. J., Brady, M. J., Mastick, C. C., Waters, S. B., Yamauchi, K., Pessin, J. E., Cuatrecasas, P., & Saltiel, A. R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.35.20801 · Cited by 396 · see citing works
MAP Kinases: Charting the Regulatory Pathways
Pelech, S., & Sanghera, J. S. (1992) · Science · doi:10.1126/science.1382311 · Cited by 364 · see citing works
Self-citationEstrogen regulates metabolism of Alzheimer amyloid beta precursor protein.
Jaffe, A. B., Toran‐Allerand, C. D., Greengard, P., & Gandy, S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36796-0 · Cited by 363 · see citing works
The regulation of amyloid β protein precursor secretion and its modulatory role in cell adhesion
Schubert, D. A., Jin, L.-W., Saitoh, T., & Cole, G. M. (1989) · Neuron · doi:10.1016/0896-6273(89)90237-7 · Cited by 353 · see citing works
Slunt, H. H., Thinakaran, G., von Koch, C., Lo, A., Tanzi, R. E., & Sisodia, S. S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41992-2 · Cited by 346 · see citing works
Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein.
Caporaso, G. L., Gandy, S., Buxbaum, J. D., Ramabhadran, T. V., & Greengard, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.7.3055 · Cited by 338 · see citing works
Requirements for Phosphorylation of Map Kinase During Meiosis in Xenopus Oocytes
Posada, J. A., & Cooper, J. A. (1992) · Science · doi:10.1126/science.1313186 · Cited by 316 · see citing works
Citron, M., Diehl, T. S., Gordon, G., Biere, A. L., Seubert, P. A., & Selkoe, D. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13170 · Cited by 287 · see citing works
Ehlers, M. R., & Riordan, J. F. (1991) · Biochemistry · doi:10.1021/bi00106a001 · Cited by 281 · see citing works
Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide.
Buxbaum, J. D., Koo, E. H., & Greengard, P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.9195 · Cited by 272 · see citing works
Malarkey, K., BELHAM, C. M., Paul, A., Graham, A. M., McLees, A., Scott, P., & Plevin, R. J. (1995) · Biochemical Journal · doi:10.1042/bj3090361 · Cited by 268 · see citing works
Calcium Ionophore Increases Amyloid .beta. Peptide Production by Cultured Cells
Querfurth, H. W., & Selkoe, D. J. (1994) · Biochemistry · doi:10.1021/bi00181a016 · Cited by 243 · see citing works
Cellular signaling roles of TGFβ, TNFα and βAPP in brain injury responses and Alzheimer's disease
Mattson, M. P., Barger, S. W., Furukawa, K., Bruce‐Keller, A. J., Wyss‐Coray, T., Mark, R. J., & Mucke, L. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00014-8 · Cited by 243 · see citing works
Rönnstrand, L., Mori, S., Arridsson, A. K., Eriksson, A. B., Wernstedt, C., Hellman, U., Claesson, L., & Heldin, C. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05484.x · Cited by 229 · see citing works
Downing, J. R., Roussel, M. F., & Sherr, C. J. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.7.2890 · Cited by 227 · see citing works
Frödin, M., Sekine, N., Roche, E., Filloux, C., Prentki, M., Wollheim, C. B., & OBBERGHEN, E. V. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.14.7882 · Cited by 220 · see citing works
Serotonin 5-HT2a and 5-HT2c Receptors Stimulate Amyloid Precursor Protein Ectodomain Secretion
Nitsch, R. M., Deng, M., Growdon, J. H., & Wurtman, R. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.8.4188 · Cited by 219 · see citing works
Seger, R., Seger, D., Reszka, A. A., Munar, E., Eldar-Finkelman, H., Dobrowolska, G., Jensen, A., Campbell, J. S., Fischer, E. H., & Krebs, E. G. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47305-x · Cited by 216 · see citing works
Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells
Anderson, J. P., Esch, F. S., Keim, P. S., Sambamurti, K., Lieberburg, I. M., & Robakis, N. K. R. K. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90775-o · Cited by 212 · see citing works
Weidemann, A., Paliga, K., Dürrwang, U., Czech, C., Evin, G. M., Masters, C. L., & Beyreuther, K. T. (1997) · Nature Medicine · doi:10.1038/nm0397-328 · Cited by 211 · see citing works
Self-citationAplin, A. E., Gibb, G. M., Jacobsen, J. S., Gallo, J., & Anderton, B. H. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67020699.x · Cited by 201 · see citing works
Wolf, B. A., Wertkin, A. M., Jolly, Y. C., Yasuda, R. P., Wolfe, B. B., Konrad, R. J., Manning, D. R., Ravi, S., WILLIAMSON, J. R., & Lee, V. M. ‐. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.9.4916 · Cited by 190 · see citing works
Buxbaum, J. D., Ruefli, A. A., Parker, C. A., Cypess, A. M., & Greengard, P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.10.4489 · Cited by 184 · see citing works
Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors.
Lee, R. K., Wurtman, R. J., Cox, A. J., & Nitsch, R. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.8083 · Cited by 179 · see citing works
Wang, R., Meschia, J. F., Cotter, R. J., & Sisodia, S. S. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55397-7 · Cited by 178 · see citing works
Greenberg, S. M., Koo, E. H., Selkoe, D. J., Qiu, W. Q., & Kosik, K. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.7104 · Cited by 161 · see citing works
Regulated secretion of beta-amyloid precursor protein in rat brain
Farber, S., Nitsch, R. M., Schulz, J., & Wurtman, R. J. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07442.1995 · Cited by 155 · see citing works
Transforming growth factor-alpha and beta-amyloid precursor protein share a secretory mechanism.
Arribas, J., & Massagué, J. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.128.3.433 · Cited by 153 · see citing works
Evidence for phosphorylation and oligomeric assembly of presenilin 1
Seeger, M., Nordstedt, C., Petanceska, S. S., Kovacs, D. M., Gouras, G. K., Hahne, S., Fraser, P., Lévesque, L., Czernik, A. J., George‐Hyslop, P. S., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5090 · Cited by 145 · see citing works
Selective ectodomain phosphorylation and regulated cleavage of beta‐amyloid precursor protein.
Hung, A. Y., & Selkoe, D. J. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06291.x · Cited by 141 · see citing works
Fiore, R. S., Murphy, T. H., Sanghera, J. S., Pelech, S., & Baraban, J. M. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb09796.x · Cited by 140 · see citing works
Self-citationActivation of mitogen-activating protein kinase by glucose is not required for insulin secretion
Khoo, S., & Cobb, M. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.11.5599 · Cited by 139 · see citing works
Inhibition of β‐Amyloid Production by Activation of Protein Kinase C
Gabuzda, D. H., Busciglio, J. A., & Yankner, B. A. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb07479.x · Cited by 138 · see citing works
Multiple signals activate cleavage of the membrane transforming growth factor-alpha precursor.
Pandiella, A., & Massagué, J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)67662-3 · Cited by 130 · see citing works
Refolo, L. M., Salton, S. R., Anderson, J. P., Mehta, P. D., & Robakis, N. K. R. K. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)91511-8 · Cited by 129 · see citing works
Bardwell, L., & Thorner, J. W. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)30032-7 · Cited by 127 · see citing works
Middlemas, D. S., Meisenhelder, J., & Hunter, T. R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37708-6 · Cited by 123 · see citing works
Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor
Müllberg, J., Schooltink, H., Stoyan, T., Heinrich, P. C., & Rose‐John, S. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)92272-y · Cited by 116 · see citing works
Walter, J., Grünberg, J., Capell, A., Pesold, B., Schindzielorz, A., Citron, M., Mendla, K. D., George‐Hyslop, P. S., Multhaup, G., Selkoe, D. J., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5349 · Cited by 107 · see citing works
Electrophoretic Separation of βA4 Peptides (1–40) and (1–42)
Klafki, H.-W., Wiltfang, J., & Staufenbiel, M. (1996) · Analytical Biochemistry · doi:10.1006/abio.1996.0195 · Cited by 99 · see citing works
Role of neurotransmission in the regulation of amyloid β-protein precursor processing
Nitsch, R. M., & Growdon, J. H. (1994) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)90325-5 · Cited by 98 · see citing works
Bardwell, L. (1996) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(96)30032-7 · Cited by 95 · see citing works
The release of Alzheimer's disease beta amyloid peptide is reduced by phorbol treatment.
Jacobsen, J. S., Spruyt, M. A., Brown, A. M., Sahasrabudhe, S. R., Blume, A. J., Vitek, M. P., Muenkel, H. A., & Sonnenberg‐Reines, J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37204-6 · Cited by 91 · see citing works
Protein Serine/Threonine Kinases of the MAPK Cascade
Graves, J. D., Campbell, J. S., & Krebs, E. G. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb26684.x · Cited by 86 · see citing works
Xu, H., Sweeney, D. A., Greengard, P., & Gandy, S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.4081 · Cited by 84 · see citing works
Ectodomain Phosphorylation of β-Amyloid Precursor Protein at Two Distinct Cellular Locations
Walter, J., Capell, A., Hung, A. Y., Langen, H., Schnölzer, M., Thinakaran, G., Sisodia, S. S., Selkoe, D. J., & Haass, C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.3.1896 · Cited by 82 · see citing works
Slack, B. E., Breu, J., Petryniak, M. A., Srivastava, K., & Wurtman, R. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.14.8337 · Cited by 78 · see citing works
Networking with mitogen-activated protein kinases
Pelech, S., Charest, D. L., Mordret, G. P., Siow, Y. L., Palaty, C., Campbell, D., Charlton, L., Samiei, M., & Sanghera, J. S. (1993) · Molecular and Cellular Biochemistry · doi:10.1007/bf01076767 · Cited by 71 · see citing works
Self-citationRegulated cleavage of alzheimer β-amyloid precursor protein in the absence of the cytoplasmic tail
Silva, O. A. B. D. C. E., Iverfeldt, K., Oltersdorf, T., Sinha, S., Lieberburg, I. M., Ramabhadran, T. V., Suzuki, T., Sisodia, S. S., Gandy, S., & Greengard, P. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90031-a · Cited by 70 · see citing works
Stratton, K. R., Worley, P. F., Litz, J. S., Parsons, S. J., Huganir, R. L., & Baraban, J. M. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb02574.x · Cited by 58 · see citing works
MAP kinase-dependent pathways in cell cycle control
Pelech, S., & Charest, D. L. (1995) · Springer eBooks · doi:10.1007/978-1-4615-1809-9_4 · Cited by 55 · see citing works
Self-citationFukuyama, R., Chandrasekaran, K., & Rapoport, S. I. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90067-y · Cited by 55 · see citing works
Nånberg, E., Rupp, E., Carpenter, G. F., Eriksson, A. B., Rönnstrand, L., Engström, U., Hellman, U., Heldin, C., & Claesson, L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7773 · Cited by 54 · see citing works
Raymond, L. A., Moshaver, A., Tingley, W. G., Shalaby, I., & Huganir, R. L. (1996) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1996.0008 · Cited by 48 · see citing works
Cox, M., Ely, C. M., Catling, A. D., Weber, M. J., & Parsons, S. J. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66031103.x · Cited by 46 · see citing works
Amino-terminal region of the β-amyloid precursor protein activates mitogen-activated protein kinase
Greenberg, S. M., Qiu, W. Q., Selkoe, D. J., Ben-Itzhak, A., & Kosik, K. S. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11944-r · Cited by 42 · see citing works
Stein, J. A., & Rettenmier, C. W. (1991) · PubMed · Cited by 38 · see citing works
Regulation of APP Expression, Biogenesis and Metabolism by Extracellular Matrix and Cytokinesa
Beyreuther, K. T., Multhaup, G., Mönning, U., Sandbrink, R., Beher, D., Hesse, L., Small, D. H., & Masters, C. L. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb34403.x · Cited by 33 · see citing works
Self-citationRegulation of APP Processing Potential for the Therapeutical Reduction of Brain Amyloid Burdena
Nitsch, R. M., Wurtman, R. J., & Growdon, J. H. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb34416.x · Cited by 29 · see citing works
Regulation of APP Processing by Intra‐ and Intercellular Signalsa
Buxbaum, J. D., & Greengard, P. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb34441.x · Cited by 20 · see citing works
Phosphoinositide Turnover Associated with Synaptic Transmission
Murphy, T. H., Wright, D. D., & Baraban, J. M. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10130.x · Cited by 13 · see citing works
Mills, J., & Reiner, P. B. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67041511.x · Cited by 9 · see citing works
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Buxbaum, J. D., Liu, K.-N., Luo, Y., Slack, J. L., Stocking, K. L., Peschon, J. J., Johnson, R. S., Castner, B. J., Cerretti, D. P., & Black, R. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.43.27765 · Cited by 933 · see citing works
Dineley, K. T., Westerman, M., Bui, D., Bell, K., Ashe, K. H., & Sweatt, J. D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-12-04125.2001 · Cited by 462 · see citing works
The Role of Mitogen-Activated Protein Kinase Pathways in Alzheimer’s Disease
Zhu, X., Lee, H., Raina, A. K., Perry, G. L., & Smith, M. A. (2002) · Neurosignals · doi:10.1159/000067426 · Cited by 392 · see citing works
The role of cerebral amyloid accumulation in common forms of Alzheimer disease
Gandy, S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25100 · Cited by 394 · see citing works
β‐Amyloid efflux mediated by p‐glycoprotein
Lam, F. C., Liu, R., Lu, P., Shapiro, A. B., Renoir, J., Sharom, F. J., & Reiner, P. B. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00113.x · Cited by 379 · see citing works
Self-citationAluminum and Alzheimer's Disease: After a Century of Controversy, Is there a Plausible Link?
Tomljenovic, L. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101494 · Cited by 371 · see citing works
Cirrito, J. R., Disabato, B. M., Restivo, J. L., Verges, D. K., Goebel, W. D., Sathyan, A., Hayreh, D., D'Angelo, G., Benzinger, T., Yoon, H., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107411108 · Cited by 370 · see citing works
Skovronsky, D., Moore, D. B., Milla, M. E., Doms, R. W., & Lee, V. M. ‐. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.4.2568 · Cited by 325 · see citing works
The role of G protein-coupled receptors in the pathology of Alzheimer's disease
Thathiah, A., & De Strooper, B. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2977 · Cited by 288 · see citing works
Stein, T. D., & Johnson, J. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07380.2002 · Cited by 288 · see citing works
Ferrer, I., Blanco, R., Carmona, M., Ribera, R., Goutan, E., Puig, B., Rey, M. J., Cardozo, A., Viñals, F., & Ribalta, T. (2001) · Brain Pathology · doi:10.1111/j.1750-3639.2001.tb00387.x · Cited by 239 · see citing works
Regulation of Amyloid Precursor Protein Cleavage
Mills, J., & Reiner, P. B. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0720443.x · Cited by 221 · see citing works
Self-citationSingh, M., Sétáló, G., Guan, X., Frail, D. E., & Toran‐Allerand, C. D. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-05-01694.2000 · Cited by 247 · see citing works
Roßner, S. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00044-6 · Cited by 195 · see citing works
Singh, M. (2001) · Endocrine · doi:10.1385/endo:14:3:407 · Cited by 194 · see citing works
Arendt, T. (2003) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2003.09.007 · Cited by 188 · see citing works
The Identification and Characterization of Oxidized RNAs in Alzheimer's Disease
Shan, X., Tashiro, H., & Lin, C. G. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-12-04913.2003 · Cited by 185 · see citing works
Solano, D. C., Sironi, M., Bonfini, C., Solerte, S. B., Govoni, S. M., & Racchi, M. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.7.1015 · Cited by 175 · see citing works
Borchardt, T., Camakaris, J., Cappai, R., Masters, C. L., Beyreuther, K. T., & Multhaup, G. (1999) · Biochemical Journal · doi:10.1042/bj3440461 · Cited by 174 · see citing works
Self-citationAlzheimer's disease as a disorder of mechanisms underlying structural brain self-organization
Arendt, T. (2001) · Neuroscience · doi:10.1016/s0306-4522(00)00516-9 · Cited by 168 · see citing works
The amyloid precursor protein of Alzheimer’s disease and the Aβ peptide
Storey, & Cappai, R. (1999) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.1999.00164.x · Cited by 167 · see citing works
Kaur, P., Jodhka, P. K., Underwood, W., Bowles, C. A., de Fiebre, N. C., de Fiebre, C. M., & Singh, M. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21370 · Cited by 163 · see citing works
Modulation of Statin-Activated Shedding of Alzheimer APP Ectodomain by ROCK
Pedrini, S., Carter, T. L., Prendergast, G., Petanceska, S., Ehrlich, M. E., & Gandy, S. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020018 · Cited by 154 · see citing works
Synaptic Therapy in Alzheimer's Disease: A CREB-centric Approach
Teich, A. F., Nicholls, R. E., Puzzo, D., Fiorito, J., Purgatorio, R., Fà, M., & Arancio, O. (2015) · Neurotherapeutics · doi:10.1007/s13311-014-0327-5 · Cited by 147 · see citing works
Dietary fatty acids intake: possible role in cognitive decline and dementia
Solfrizzi, V., D’Introno, A., Colacicco, A. M., Capurso, C. A., DelParigi, A., Capurso, S. A., Gadaleta, A., Capurso, A., & Panza, F. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.01.001 · Cited by 132 · see citing works
Obesity, leptin, and Alzheimer's disease
Lee, E. B. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06274.x · Cited by 126 · see citing works
Manthey, D., Heck, S., Engert, S., & Behl, C. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02346.x · Cited by 122 · see citing works
Yogev‐Falach, M., Amit, T., Bar‐Am, O., Weinstock, M., & Youdim, M. B. H. (2002) · The FASEB Journal · doi:10.1096/fj.02-0198fje · Cited by 104 · see citing works
Estrogen and the brain: beyond ER-α and ER-β
Toran‐Allerand, C. D. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.05.006 · Cited by 101 · see citing works
Hamilton, S. E., & Nathanson, N. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011563200 · Cited by 99 · see citing works
Mediators of tau phosphorylation in the pathogenesis of Alzheimer’s disease
Hanger, D. P., Seereeram, A., & Noble, W. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.104 · Cited by 98 · see citing works
Gärtner, U., Holzer, M., & Arendt, T. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00059-7 · Cited by 95 · see citing works
ERK1/2 is an endogenous negative regulator of the γsecretase activity
Kim, S., Park, H., Hong, H. S., Baik, E. J., Jung, M. W., & Mook‐Jung, I. (2006) · The FASEB Journal · doi:10.1096/fj.05-4055fje · Cited by 92 · see citing works
Goodenough, S., Engert, S., & Behl, C. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01622-0 · Cited by 91 · see citing works
Arendt, T. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00216-5 · Cited by 89 · see citing works
Wang, J., Al‐Lamki, R. S., Zhang, H., Kirkiles-Smith, N. C., Gaeta, M. L., Thiru, S., Pober, J. S., & Bradley, J. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212662200 · Cited by 88 · see citing works
Taru, H., Kirino, Y., & Suzuki, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203713200 · Cited by 85 · see citing works
JNK and ERK1/2 pathways have a dual opposite effect on the expression of BACE1
Tamagno, E., Guglielmotto, M., Giliberto, L., Vitali, A., Borghi, R., Autelli, R., Danni, O., & Tabaton, M. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.12.015 · Cited by 84 · see citing works
Modulation of Amyloid Precursor Protein Cleavage by Cellular Sphingolipids*
Sawamura, N., Ko, M., Yu, W., Zou, K., Hanada, K., Suzuki, T., Gong, J., Yanagisawa, K., & Michikawa, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309832200 · Cited by 88 · see citing works
Shi, C., Zheng, D., Li, F., Wu, F., Kwong, W. H., & Xu, J. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.12.005 · Cited by 81 · see citing works
Non-steroidal Anti-inflammatory Drugs Stimulate Secretion of Non-amyloidogenic Precursor Protein
Avramovich‐Tirosh, Y., Amit, T., & Youdim, M. B. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201308200 · Cited by 81 · see citing works
Alzheimer culprits: Cellular crossroads and interplay
Claeysen, S., Cochet, M., Donneger, R., Dumuis, A., Bockaert, J., & Giannoni, P. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.05.008 · Cited by 79 · see citing works
TRPM7 Activates m-Calpain by Stress-Dependent Stimulation of p38 MAPK and c-Jun N-Terminal Kinase
Su, L.-T., Chen, H.-C., González-Pagán, O., Overton, J. D., Xie, J., Yue, L., & Runnels, L. W. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.01.014 · Cited by 78 · see citing works
Qin, W., Ho, L., Wang, J., Peskind, E. R., & Pasinetti, G. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004183 · Cited by 75 · see citing works
Parvathy, S., Ehrlich, M. E., Pedrini, S., Diaz, N. S., Refolo, L. M., Buxbaum, J. D., Bogush, A. I., Petanceska, S. S., & Gandy, S. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02521.x · Cited by 74 · see citing works
Arendt, T., Holzer, M., Stöbe, A., GÄRTNER, U., Lüth, H., Brückner, M. K., & Ueberham, U. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06931.x · Cited by 72 · see citing works
Kong, Q., Peterson, T. S., Baker, O. J., Stanley, E., Camden, J. M., Seye, C. I., Erb, L., Simonyi, Á., Wood, W. G., Sun, G. Y., et al. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06048.x · Cited by 69 · see citing works
Oxidative stress affects processing of amyloid precursor protein in vascular endothelial cells
Muche, A., Arendt, T., & Schliebs, R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178127 · Cited by 68 · see citing works
Disturbance of neuronal plasticity is a critical pathogenetic event in Alzheimer's disease
Arendt, T. (2001) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(01)00007-7 · Cited by 66 · see citing works
Association of ABCA2 expression with determinants of Alzheimer's disease
Chen, Z. J., Vulevic, B., Ile, K. E., Soulika, A. M., Davis, W., Reiner, P. B., Connop, B. P., Nathwan, P., Trojanowski, J. Q., & Tew, K. D. (2004) · The FASEB Journal · doi:10.1096/fj.03-1490fje · Cited by 66 · see citing works
Self-citationImpact of HMG-CoA reductase inhibition on brain pathology
Zipp, F., Waiczies, S., Aktaş, O., Neuhaus, O., Hemmer, B., Schraven, B., Nitsch, R., & Hartung, H. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.05.001 · Cited by 65 · see citing works
The pharmacology of amyloid precursor protein processing
Racchi, M. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00158-4 · Cited by 62 · see citing works
Aliev, G. M., Obrenovich, M. E., Tabrez, S. S. M., Jabir, N. R., Reddy, V. P., Li, Y., Burnstock, G., Cacabelos, R., & Kamal, M. A. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/962984 · Cited by 62 · see citing works
Distribution, levels, and activation of MEK1 in Alzheimer's disease
Zhu, X.-W., Sun, Z., Lee, H.-G., Siedlak, S., Perry, G., & Smith, M. A. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01820.x · Cited by 60 · see citing works
Nicotinic receptors and Alzheimer's disease
Bourin, M., Ripoll, N., & Dailly, É. (2003) · Current Medical Research and Opinion · doi:10.1185/030079903125001631 · Cited by 61 · see citing works
Wang, Y., Tang, X. C., & Zhang, H. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22775 · Cited by 60 · see citing works
Estrogen and Neurodegeneration
Gandy, S. (2003) · Neurochemical Research · doi:10.1023/a:1023246921127 · Cited by 59 · see citing works
Estrogen-induced cell signalling in a cellular model of Alzheimer’s disease
Goodenough, S., Schäfer, M., & Behl, C. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00043-8 · Cited by 59 · see citing works
Opportunities for Therapeutic Modulation of O-GlcNAc
Cheng, S. S., Mody, A. C., & Woo, C. M. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00417 · Cited by 61 · see citing works
Role of Receptors in Relation to Plaques and Tangles in Alzheimer’s Disease Pathology
Sharma, K., Pradhan, S., Duffy, L. K., Yeasmin, S., Bhattarai, N., & Schulte, M. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312987 · Cited by 59 · see citing works
Canet-Aviles, R., Anderton, M. J., Hooper, N. M., Turner, A. J., & Vaughan, P. F. T. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00184-5 · Cited by 52 · see citing works
Muscarinic Activation of Mitogen‐Activated Protein Kinase in PC12 Cells
Berkeley, J. L., & Levey, A. I. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750487.x · Cited by 52 · see citing works
Rationalizing a pharmacological intervention on the amyloid precursor protein metabolism
Racchi, M., & Govoni, S. M. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01380-2 · Cited by 52 · see citing works
Ratia, M., Giménez‐Llort, L., Camps, P., Muñoz‐Torrero, D., Pérez, B., Clos, M. V., & Badı́a, A. (2012) · Neurodegenerative Diseases · doi:10.1159/000336427 · Cited by 50 · see citing works
Peng, Y., Lee, D. Y. W., Jiang, L., Ma, Z., Schachter, S. C., & Lemere, C. A. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.09.022 · Cited by 47 · see citing works
Palacino, J. J., Berechid, B. E., Alexander, P., Eckman, C. B., Younkin, S. G., Nye, J. S., & Wolozin, B. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.215 · Cited by 45 · see citing works
Yan, X., Hu, G., Yan, W., Chen, T., Yang, F., Zhang, X., Zhao, G., & Liu, J. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.11.002 · Cited by 44 · see citing works
Alzheimer’s disease as a disorder of dynamic brain self-organization
Arendt, T. (2004) · Progress in brain research · doi:10.1016/s0079-6123(04)47025-3 · Cited by 42 · see citing works
Altered hippocampal muscarinic receptors in acetylcholinesterase‐deficient mice
Volpicelli‐Daley, L. A., Duysen, E. G., Lockridge, O., & Levey, A. I. (2003) · Annals of Neurology · doi:10.1002/ana.10589 · Cited by 42 · see citing works
Role of protein kinase Cα in the regulated secretion of the amyloid precursor protein
Racchi, M., Mazzucchelli, M., Pascale, A., Sironi, M., & Govoni, S. M. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001204 · Cited by 40 · see citing works
Coughlan, C. M. (2000) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(00)00036-x · Cited by 39 · see citing works
Extracellular-regulated kinase controls β-amyloid precursor protein mRNA decay
Westmark, C. J., & Malter, J. S. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00112-7 · Cited by 36 · see citing works
Signal Transduction Therapeutics: Relevance for Alzheimer's Disease
Silva, O. A. B. D. C. E., Fardilha, M., Henriques, A. G., Rebelo, S., Vieira, S. I., & Silva, E. F. D. C. E. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:23:1-2:123 · Cited by 34 · see citing works
Post-menopausal estrogen deprivation and Alzheimer's disease
Gandy, S. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00116-9 · Cited by 34 · see citing works
Holzer, M., Gärtner, U., Klinz, F., Narz, F., Heumann, R., & Arendt, T. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00245-7 · Cited by 34 · see citing works
Hoey, S. E., Buonocore, F., Cox, C. J., Hammond, V. J., Perkinton, M. S., & Williams, R. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078155 · Cited by 33 · see citing works
Predicting pathway perturbations in Down syndrome
Gardiner, K. (2003) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6721-2_2 · Cited by 33 · see citing works
Dysregulation of neuronal differentiation and cell cycle control in Alzheimer’s disease
Arendt, T. (2002) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6139-5_8 · Cited by 33 · see citing works
Ma, G., Chen, S., Wang, X., Ba, M., Yang, H., & Lü, G. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20515 · Cited by 30 · see citing works
A role for MAP kinase in regulating ectodomain shedding of APLP2 in corneal epithelial cells
Xu, K., Zoukhri, D., Zieske, J. D., Dartt, D. A., Sergheraert, C., Loing, E., & Yu, F. X. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.281.2.c603 · Cited by 30 · see citing works
Park, S. H., Lee, S., Hong, Y. K., Hwang, S., Lee, J. H., Bang, S. M., Kim, Y., Koo, B., Lee, I., & Cho, K. S. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b12-00792 · Cited by 29 · see citing works
Liu, F. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00152-6 · Cited by 29 · see citing works
Shi, C., Wu, F., Xu, J., & Zou, J. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.03.028 · Cited by 28 · see citing works
McLaughlin, M., & Breen, K. C. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0720273.x · Cited by 28 · see citing works
Lee, S., Bang, S. M., Hong, Y. K., Lee, J. H., Jeong, H., Park, S. H., Liu, Q. F., Lee, I., & Cho, K. S. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.018069 · Cited by 28 · see citing works
Protein Kinase C-Regulated Aβ Production and Clearance
Kim, T., Hinton, D., & Choi, D. (2011) · International Journal of Alzheimer's Disease · doi:10.4061/2011/857368 · Cited by 32 · see citing works
da Rocha, J. F., Bastos, L., Domingues, S. C., Bento, A. R., Konietzko, U., Silva, O. A. B. D. C. E., & Vieira, S. I. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02139-2 · Cited by 26 · see citing works
PI3-K- and PKC-dependent up-regulation of APP processing enzymes by retinoic acid
Holback, S., Adlerz, L., Gatsinzi, T., Jacobsen, K. T., & Iverfeldt, K. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.10.167 · Cited by 26 · see citing works
Seo, H., Ferree, A. W., & Ole Isacson, A. (2002) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01884.x · Cited by 26 · see citing works
Peng, Y., Hu, Y., Xu, S., Feng, N., Wang, L., & Wang, X. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.10.025 · Cited by 24 · see citing works
Mills, J., & Reiner, P. B. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00381-4 · Cited by 24 · see citing works
Self-citationAkar, C. A., & Wallace, W. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00037-0 · Cited by 24 · see citing works
Abnormalities of protein kinases in neurodegenerative diseases
Wagey, R. T. E., & Krieger, C. (1998) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8845-5_4 · Cited by 23 · see citing works
Liu, Q., & Wu, J. (2006) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2006.00430.x · Cited by 23 · see citing works
Behavioural effects and regulation of PKCα and MAPK by huprine X in middle aged mice
Ratia, M., Giménez‐Llort, L., Camps, P., Muñoz‐Torrero, D., Clos, M. V., & Badı́a, A. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.03.013 · Cited by 22 · see citing works
Welt, T., Kulic, L., Hoey, S. E., McAfoose, J., Späni, C. B., Chadha, A. S., Fisher, A., & Nitsch, R. M. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150152 · Cited by 18 · see citing works
Kwak, Y.-D., Choumkina, E., & Sugaya, K. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.03.054 · Cited by 20 · see citing works
Connop, B. P., Thies, R. L., Beyreuther, K., Ida, N., & Reiner, P. B. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.721457.x · Cited by 19 · see citing works
Self-citationPanax ginseng: A modulator of amyloid, tau pathology, and cognitive function in Alzheimer's disease
Hwang, J., Keum, M., Choe, Y. M., Suh, G., Choi, H., Lee, B. C., Kim, S. G., Kim, H. S., Yi, D., & Kim, J. W. (2025) · Journal of Ginseng Research · doi:10.1016/j.jgr.2025.03.011 · Cited by 19 · see citing works
Binnington, J., & Kalisch, B. E. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04378.x · Cited by 19 · see citing works
- Authors
- Mills, J., Laurent Charest, D., Lam, F., Beyreuther, K., Ida, N., Pelech, S. L., & Reiner, P. B.
- Affiliations
- Heidelberg University (DE)
- University of British Columbia (CA)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1997-12-15
- Volume
- 17
- Issue
- 24
- Pages
- 9415-9422
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6573401
- OpenAlex
- W1794943105
- Cited by
- 134
- References
- 87
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 4
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alzheimer Society
- Medical Research Council
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- amyloid precursor protein, mitogen-activated protein kinase, MEK, ERK, PD98059, nerve growth factor, phorbol ester, protein kinase C, amyloid-beta secretion, Swedish mutation, APP695, PC12 cells, cortical neurons
- MeSH terms
- Alzheimer Disease, Animals, Carcinogens, Cells, Cultured, Cerebral Cortex, Enzyme Inhibitors, Female, Flavonoids, Humans, Kidney, Neurons, Phorbol Esters, Pregnancy, Protein Kinase C, Signal Transduction, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, PC12 Cells, Rats, Sprague-Dawley, Receptors, Nerve Growth Factor, Calcium-Calmodulin-Dependent Protein Kinases, Rats
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