The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Synaptic Regulation of Translation of Dendritic mRNAs
Open accessAbstract
The selective localization of protein synthetic machinery at postsynaptic sites makes it possible for the synthesis of particular proteins to be regulated by synaptic signals. Here we consider how the structure of the machinery constrains synthetic capacity and the evidence that mRNA translation is locally controlled by synaptic signals. Since the discovery of protein synthetic machinery at synaptic sites on dendrites (Steward and Levy, 1982), substantial progress has been made in identifying dendritic mRNAs and in showing that dendritic protein synthesis is critical for persistent synaptic modifications like long-term potentiation (LTP) and long-term depression (LTD). Although many pieces of the puzzle have been identified, major questions remain. Here we focus on one of the unknowns: how translational activity at synapses is regulated and whether regulation involves upregulation or downregulation of overall translation or differential regulation of the translation of particular transcripts. It is useful to begin by considering constraints imposed by the nature of the protein synthetic machinery at synapses.
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“Decades after local dendritic protein translation was first proposed (Steward and Levy, 1982), there is now wide agreement that it plays an integral part in synaptic plasticity (Schuman et al., 2006).”
From Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops (2016) · cites this paper as Schuman et al., 2006
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Metadata
- Authors
- Schuman, E. M., Dynes, J. L., & Steward, O.
- Affiliations
- California Institute of Technology (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-07-05
- Volume
- 26
- Issue
- 27
- Pages
- 7143-7146
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6673937
- OpenAlex
- W1985362922
- Cited by
- 230
- References
- 36
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 12 · 2016: 14 · 2015: 10 · 2014: 10 · 2013: 20 · 2012: 14
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- National Institutes of Health (NS12333)
- National Institute of Mental Health (R01MH065537, MH65537)
- National Institute of Neurological Disorders and Stroke (NS-12333)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- long-term potentiation, long-term depression, synaptic plasticity, translational regulation, dendritic mRNA
- MeSH terms
- Animals, Dendrites, Gene Expression Regulation, Humans, Neuronal Plasticity, RNA, Messenger, Synapses, Protein Biosynthesis
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