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Current Advances in Local Protein Synthesis and Synaptic Plasticity
Open accessAbstract
Local or dendritic protein synthesis is required for long-term functional synaptic change, such as long-term potentiation (LTP) and long-term depression (LTD). LTP and LTD both rely on similar signal transduction cascades, which regulate translation initiation. Current research indicates that the specificity by which new proteins participate in either LTP or LTD may be determined in part by specific RNA-binding proteins as well as activity-dependent capture.
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“This local translation of messenger RNAs (mRNAs) at or near synapses is a critical mechanism for maintaining persistent changes in synaptic strength and for memory consolidation (Figure 5).”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [72]
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“While early phases of LTP (E-LTP) are mediated by post-translational modifications in existing proteins and occur independently of protein synthesis, the long-lasting forms of synaptic plasticity, including late-phase LTP (L-LTP) and LTD, require new local protein synthesis within dendrites, a process where specificity is determined by RNA-binding proteins and activity-dependent capture [71,72].”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [72]
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“While early phases of LTP (E-LTP) are mediated by post-translational modifications in existing proteins and occur independently of protein synthesis, the long-lasting forms of synaptic plasticity, including late-phase LTP (L-LTP) and LTD, require new local protein synthesis within dendrites, a process where specificity is determined by RNA-binding proteins and activity-dependent capture [71,72].”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [72]
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Citations
Cites
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“Interestingly, the mRNA for FMRP is present in dendrites, and FMRP is synthesized in response to mGluR activation (Weiler et al., 1997; Antar et al., 2004).”
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Metadata
- Authors
- Pfeiffer, B. E., & Huber, K. M.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-07-05
- Volume
- 26
- Issue
- 27
- Pages
- 7147-7150
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6673933
- OpenAlex
- W2011356607
- Cited by
- 168
- References
- 50
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 3 · 2023: 6 · 2022: 5 · 2021: 2 · 2020: 7 · 2019: 6 · 2018: 3 · 2017: 6 · 2016: 9 · 2015: 8 · 2014: 8 · 2013: 7 · 2012: 5
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- local protein synthesis, dendritic translation, synaptic plasticity, long-term potentiation, long-term depression, translation initiation, signal transduction, RNA-binding proteins
- MeSH terms
- Animals, Humans, Neuronal Plasticity, Synapses, Protein Biosynthesis, Long-Term Potentiation, Long-Term Synaptic Depression
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