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Current Advances in Local Protein Synthesis and Synaptic Plasticity
Open accessAbstract
Local or dendritic protein synthesis is required for long-term functional synaptic change, such as long-term potentiation (LTP) and long-term depression (LTD). LTP and LTD both rely on similar signal transduction cascades, which regulate translation initiation. Current research indicates that the specificity by which new proteins participate in either LTP or LTD may be determined in part by specific RNA-binding proteins as well as activity-dependent capture.
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“This local translation of messenger RNAs (mRNAs) at or near synapses is a critical mechanism for maintaining persistent changes in synaptic strength and for memory consolidation (Figure 5).”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [72]
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“While early phases of LTP (E-LTP) are mediated by post-translational modifications in existing proteins and occur independently of protein synthesis, the long-lasting forms of synaptic plasticity, including late-phase LTP (L-LTP) and LTD, require new local protein synthesis within dendrites, a process where specificity is determined by RNA-binding proteins and activity-dependent capture [71,72].”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [72]
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In the citing paper
“While early phases of LTP (E-LTP) are mediated by post-translational modifications in existing proteins and occur independently of protein synthesis, the long-lasting forms of synaptic plasticity, including late-phase LTP (L-LTP) and LTD, require new local protein synthesis within dendrites, a process where specificity is determined by RNA-binding proteins and activity-dependent capture [71,72].”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [72]
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Citations
Cites
The molecular biology of memory storage: a dialogue between genes and synapses
Kandel, E. R. (2001) · Science · doi:10.1126/science.1067020 · Cited by 3,917
Synaptic tagging and long-term potentiation
Frey, U., & Morris, R. G. M. (1997) · Nature · doi:10.1038/385533a0 · Cited by 1,736 · cited 2×
“Frey and Morris (1997) observed that L-LTP induction at a subset of synapses stimulated the synthesis of new proteins that could be subsequently captured at a second independent set of synapses by a single tetanus, converting E-LTP to L-LTP (Frey and Morris, 1997).”
The mGluR theory of fragile X mental retardation
Bear, M. F., Huber, K. M., & Warren, S. T. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.04.009 · Cited by 1,580
Self-citationAltered synaptic plasticity in a mouse model of fragile X mental retardation
Huber, K. M., Gallagher, S. M., Warren, S. T., & Bear, M. F. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122205699 · Cited by 1,349
Self-citationCleavage of proBDNF by tPA/Plasmin Is Essential for Long-Term Hippocampal Plasticity
Pang, P. T., Teng, H. K., Zaitsev, E., Woo, N. T., Sakata, K., Zhen, S., Teng, K. K., Yung, W.-H., Hempstead, B. L., & Lu, B. (2004) · Science · doi:10.1126/science.1100135 · Cited by 1,136
Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.
Huber, K., Kayser, M., & Bear, M. (2000) · Science · doi:10.1126/science.288.5469.1254 · Cited by 1,015
Self-citationA Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity
Kang, H., & Schuman, E. M. (1996) · Science · doi:10.1126/science.273.5280.1402 · Cited by 996
Translational Control by MAPK Signaling in Long-Term Synaptic Plasticity and Memory
Kelleher, R. J., Govindarajan, A., Jung, H.-Y., Kang, H., & Tonegawa, S. (2004) · Cell · doi:10.1016/s0092-8674(04)00115-1 · Cited by 845
Tang, S. J., Reis, G., Kang, H., Gingras, A.-C., Sonenberg, N., & Schuman, E. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012605299 · Cited by 734
Weiler, I. J., Irwin, S. A., Klintsova, A. Y., Spencer, C. M., Brazelton, A. D., Miyashiro, K., Comery, T. A., Patel, B., Eberwine, J., & Greenough, W. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5395 · Cited by 644 · cited 1×
“Interestingly, the mRNA for FMRP is present in dendrites, and FMRP is synthesized in response to mGluR activation (Weiler et al., 1997; Antar et al., 2004).”
Research works printed but not linked: 1
- (2000), J Neurosci, 20, 8572
Cited by
Sorted by citations
Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms
Citri, A., & Malenka, R. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301559 · Cited by 2,323
Synaptic plasticity and addiction
Kauer, J. A., & Malenka, R. C. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2234 · Cited by 1,397
Hippocampal GABAergic Inhibitory Interneurons
Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., & McBain, C. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00007.2017 · Cited by 889
Hagerman, R. J., Berry-Kravis, E., Hazlett, H. C., Bailey, D. B., Moine, H., Kooy, R. F., Tassone, F., Gantois, I., Sonenberg, N., Mandel, J. L., et al. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.65 · Cited by 838
Physiology of repetitive transcranial magnetic stimulation of the human brain
Hoogendam, J. M., Ramakers, G. M. J., & Di Lazzaro, V. (2010) · Brain Stimulation · doi:10.1016/j.brs.2009.10.005 · Cited by 669
Metadata
- Authors
- Pfeiffer, B. E., & Huber, K. M.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-07-05
- Volume
- 26
- Issue
- 27
- Pages
- 7147-7150
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6673933
- OpenAlex
- W2011356607
- Cited by
- 168
- References
- 50
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 3 · 2023: 6 · 2022: 5 · 2021: 2 · 2020: 7 · 2019: 6 · 2018: 3 · 2017: 6 · 2016: 9 · 2015: 8 · 2014: 8 · 2013: 7 · 2012: 5
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- local protein synthesis, dendritic translation, synaptic plasticity, long-term potentiation, long-term depression, translation initiation, signal transduction, RNA-binding proteins
- MeSH terms
- Animals, Humans, Neuronal Plasticity, Synapses, Protein Biosynthesis, Long-Term Potentiation, Long-Term Synaptic Depression
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