Synaptic regulation of translation of dendritic mRNAs
Open accessAbstract
The selective localization of protein synthetic machinery at postsynaptic sites makes it possible for the synthesis of particular proteins to be regulated by synaptic signals. Here we consider how the structure of the machinery constrains synthetic capacity and the evidence that mRNA translation is locally controlled by synaptic signals. Since the discovery of protein synthetic machinery at synaptic sites on dendrites (Steward and Levy, 1982), substantial progress has been made in identifying dendritic mRNAs and in showing that dendritic protein synthesis is critical for persistent synaptic modifications like long-term potentiation (LTP) and long-term depression (LTD). Although many pieces of the puzzle have been identified, major questions remain. Here we focus on one of the unknowns: how translational activity at synapses is regulated and whether regulation involves upregulation or downregulation of overall translation or differential regulation of the translation of particular transcripts. It is useful to begin by considering constraints imposed by the nature of the protein synthetic machinery at synapses.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Local dendritic protein translation plays an integral part in synaptic plasticity.
“Decades after local dendritic protein translation was first proposed (Steward and Levy, 1982), there is now wide agreement that it plays an integral part in synaptic plasticity (Schuman et al., 2006).”
From Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops (2016) · cites this paper as Schuman et al., 2006
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,012 · see citing works
Activity-dependent scaling of quantal amplitude in neocortical neurons
Turrigiano, G. G., Leslie, K. R., Desai, N. S., Rutherford, L. C., & Nelson, S. B. (1998) · Nature · doi:10.1038/36103 · Cited by 2,226 · see citing works
Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.
Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenen, H., & Bonhoeffer, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8856 · Cited by 1,426 · see citing works
Long-Lasting Neurotrophin-Induced Enhancement of Synaptic Transmission in the Adult Hippocampus
Kang, H., & Schuman, E. M. (1995) · Science · doi:10.1126/science.7886457 · Cited by 1,354 · see citing works
Self-citationPatterson, S. L., Abel, T., Deuel, T. A. S., Martin, K. C., Rose, J. C., & Kandel, E. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80140-3 · Cited by 1,233 · see citing works
Klivenyi, P., Andreassen, O. A., Ferrante, R. J., Dedeoglu, A., Mueller, G., Lancelot, E., Bogdanov, M., Andersen, J. K., Jiang, D., & Beal, M. F. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00001.2000 · Cited by 1,111 · see citing works
A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity
Kang, H., & Schuman, E. (1996) · Science · doi:10.1126/science.273.5280.1402 · Cited by 1,010 · see citing works
Self-citationTranslational Control by MAPK Signaling in Long-Term Synaptic Plasticity and Memory
Kelleher, R. J., Govindarajan, A., Jung, H.-Y., Kang, H., & Tonegawa, S. (2004) · Cell · doi:10.1016/s0092-8674(04)00115-1 · Cited by 845 · see citing works
Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF
Lohof, A. M., Ip, N. Y., & Poo, M.-M. (1993) · Nature · doi:10.1038/363350a0 · Cited by 755 · see citing works
Steward, O., & Levy, W. (1982) · The Journal of Neuroscience · doi:10.1523/jneurosci.02-03-00284.1982 · Cited by 676 · see citing works
Self-citationSutton, M. A., Ito, H. T., Cressy, P., Kempf, C., Woo, J. C., & Schuman, E. M. (2006) · Cell · doi:10.1016/j.cell.2006.03.040 · Cited by 633 · see citing works
Self-citationDynamic visualization of local protein synthesis in hippocampal neurons
Aakalu, G., Smith, W. B., Nguyen, N., Jiang, C., & Schuman, E. M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00295-1 · Cited by 611 · see citing works
Self-citationActivity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors
Ju, W. H., Morishita, W., Tsui, J., Gaietta, G. M., Deerinck, T. J., Adams, S., Garner, C. C., Tsien, R. Y., Ellisman, M. H., & Malenka, R. C. (2004) · Nature Neuroscience · doi:10.1038/nn1189 · Cited by 524 · see citing works
Ostroff, L. E., Fiala, J. C., Allwardt, B., & Harris, K. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00785-7 · Cited by 461 · see citing works
Takei, N., Inamura, N., Kawamura, M., Namba, H., Hara, K., Yonezawa, K., & Nawa, H. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1427-04.2004 · Cited by 442 · see citing works
Schratt, G., Nigh, E., Chen, W. G., Hu, L. S., & Greenberg, M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1739-04.2004 · Cited by 425 · see citing works
NMDA receptor-mediated control of protein synthesis at developing synapses
Scheetz, A., Nairn, A., & Constantine-Paton, M. (2000) · Nature Neuroscience · doi:10.1038/72915 · Cited by 382 · see citing works
Bagni, C., Mannucci, L., Dotti, C. G., & Amaldi, F. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-10-j0004.2000 · Cited by 357 · see citing works
Ouyang, Y., Rosenstein, A. J., Kreiman, G., Schuman, E., & Kennedy, M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-18-07823.1999 · Cited by 310 · see citing works
Self-citationRegulation of Dendritic Protein Synthesis by Miniature Synaptic Events
Sutton, M. A., Wall, N. R., Aakalu, G., & Schuman, E. (2004) · Science · doi:10.1126/science.1096202 · Cited by 286 · see citing works
Self-citationMetabotropic glutamate receptors trigger postsynaptic protein synthesis.
Weiler, I., & Greenough, W. (1993) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.90.15.7168 · Cited by 260 · see citing works
Tsokas, P., Grace, E., Chan, P., Ma, T., Sealfon, S., Iyengar, R., Landau, E., & Blitzer, R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0599-05.2005 · Cited by 259 · see citing works
Smith, W. B., Starck, S. R., Roberts, R. W., & Schuman, E. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.015 · Cited by 252 · see citing works
Self-citationMessaoudi, E., Bårdsen, K., Srebro, B., & Bramham, C. R. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.1.496 · Cited by 208 · see citing works
Marin, P., Nastiuk, K. L., Daniel, N., Girault, J., Czernik, A. J., Glowinski, J., Nairn, A. C., & Prémont, J. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-10-03445.1997 · Cited by 174 · see citing works
Moccia, R., Chen, D., Lyles, V., Kapuya, E., Yaping, E., Kalachikov, S. M., Spahn, C. M. T., Frank, J., Kandel, E. R., Barad, M., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-28-09409.2003 · Cited by 172 · see citing works
Current advances in local protein synthesis and synaptic plasticity
Pfeiffer, B. E., & Huber, K. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1797-06.2006 · Cited by 168 · see citing works
Dendritic mRNAs encode diversified functionalities in hippocampal pyramidal neurons
Zhong, J. W., Zhang, T., & Bloch, L. M. (2006) · BMC Neuroscience · doi:10.1186/1471-2202-7-17 · Cited by 162 · see citing works
Feig, S., & Lipton, P. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-03-01010.1993 · Cited by 150 · see citing works
Steward, O., & Reeves, T. M. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-01-00176.1988 · Cited by 144 · see citing works
Self-citationIdentification of sites for exponential translation in living dendrites
Job, C., & Eberwine, J. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.231485698 · Cited by 135 · see citing works
Huang, F.-S., Chotiner, J. K., & Steward, O. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1779-05.2005 · Cited by 112 · see citing works
Self-citationSteward, O., & Halpain, S. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-18-07834.1999 · Cited by 99 · see citing works
Self-citationHåvik, B., Røkke, H., Bårdsen, K., Davanger, S., & Bramham, C. R. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02712.x · Cited by 84 · see citing works
RNA-Binding Proteins: A Lesson in Repression
Wells, D. G. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1795-06.2006 · Cited by 73 · see citing works
Leski, M. L., & Steward, O. (1996) · Neurochemical Research · doi:10.1007/bf02527725 · Cited by 29 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms
Citri, A., & Malenka, R. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301559 · Cited by 2,323 · see citing works
Mechanisms of CaMKII action in long-term potentiation
Lisman, J., Yasuda, R., & Raghavachari, S. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3192 · Cited by 1,134 · see citing works
The Postsynaptic Architecture of Excitatory Synapses: A More Quantitative View
Sheng, M., & Hoogenraad, C. C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.060805.160029 · Cited by 1,003 · see citing works
Regulatory mechanisms of AMPA receptors in synaptic plasticity
Derkach, V. A., Oh, M. C., Guire, E. S., & Soderling, T. R. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2055 · Cited by 708 · see citing works
New insights into brain BDNF function in normal aging and Alzheimer disease
Tapia‐Arancibia, L., Aliaga, E., Silhol, M., & Arancibia, S. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.07.007 · Cited by 571 · see citing works
Richter, J. D. (2007) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2007.04.004 · Cited by 526 · see citing works
Muddashetty, R. S., Kelić, S., Gross, C., Xu, M., & Bassell, G. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0937-07.2007 · Cited by 421 · see citing works
Synaptic Signaling by All-Trans Retinoic Acid in Homeostatic Synaptic Plasticity
Aoto, J., Nam, C. I., Poon, M. M., Ting, P., & Chen, L. (2008) · Neuron · doi:10.1016/j.neuron.2008.08.012 · Cited by 397 · see citing works
Pathogenetic mechanisms of hepatic encephalopathy
Häussinger, D., & Schliess, F. (2008) · Gut · doi:10.1136/gut.2007.122176 · Cited by 391 · see citing works
The Dendritic Branch Is the Preferred Integrative Unit for Protein Synthesis-Dependent LTP
Govindarajan, A., Israely, I., Huang, S.-Y., & Tonegawa, S. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.008 · Cited by 349 · see citing works
New insights into the role of brain-derived neurotrophic factor in synaptic plasticity
Waterhouse, E. G., & Xu, B. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.06.009 · Cited by 341 · see citing works
Dendritic spines: from structure to in vivo function
Rochefort, N. L., & Konnerth, A. (2012) · The EMBO Reports · doi:10.1038/embor.2012.102 · Cited by 299 · see citing works
Patterson, S. L. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.12.020 · Cited by 281 · see citing works
RNA granules: The good, the bad and the ugly
Thomas, M. G., Loschi, M., Desbats, M. A., & Boccaccio, G. L. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.08.011 · Cited by 262 · see citing works
Exosomal transfer of proteins and RNAs at synapses in the nervous system
Smalheiser, N. R. (2007) · Biology Direct · doi:10.1186/1745-6150-2-35 · Cited by 251 · see citing works
BDNF activates mTOR to regulate GluR1 expression required for memory formation
Slipczuk, L., Bekinschtein, P., Katche, C., Cammarota, M., Izquierdo, I., & Medina, J. H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006007 · Cited by 246 · see citing works
Identification of Process-Localized mRNAs from Cultured Rodent Hippocampal Neurons
Poon, M. M., Choi, S.-H., Jamieson, C. A. M., Geschwind, D. H., & Martin, K. C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3432-06.2006 · Cited by 225 · see citing works
SAP97 and CASK mediate sorting of NMDA receptors through a previously unknown secretory pathway
Jeyifous, O., Waites, C. L., Specht, C. G., Fujisawa, S., Schubert, M., Lin, E. I., Marshall, J. J., Aoki, C. J., de Silva, T., Montgomery, J. M., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2362 · Cited by 219 · see citing works
RNA Trafficking and Local Protein Synthesis in Dendrites: An Overview
Martin, K. C., & Zukin, R. S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1801-06.2006 · Cited by 218 · see citing works
Cohen, L. D., Zuchman, R., Sorokina, O., Müller, A., Dieterich, D. C., Armstrong, J. D., Ziv, T., & Ziv, N. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063191 · Cited by 215 · see citing works
Dopamine-Regulated MicroRNA MiR-181a Controls GluA2 Surface Expression in Hippocampal Neurons
Saba, R., Störchel, P. H., Aksoy-Aksel, A., Kepura, F., Lippi, G., Plant, T. D., & Schratt, G. M. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.05896-11 · Cited by 196 · see citing works
Price, T. J., Rashid, M. H., Millecamps, M., Sanoja, R., Entrena, J. M., & Cerveró, F. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4383-07.2007 · Cited by 210 · see citing works
RNA Protein Interaction in Neurons
Darnell, R. B. (2013) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062912-114322 · Cited by 181 · see citing works
Cougot, N., Bhattacharyya, S. N., Tapia-Arancibia, L., Bordonné, R., Filipowicz, W., Bertrand, E., & Rage, F. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4155-08.2008 · Cited by 165 · see citing works
Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond
Grossman, A. W., Aldridge, G. M., Weiler, I. J., & Greenough, W. T. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1790-06.2006 · Cited by 178 · see citing works
mRNA Transport in Dendrites: RNA Granules, Motors, and Tracks
Hirokawa, N. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1821-06.2006 · Cited by 171 · see citing works
Current advances in local protein synthesis and synaptic plasticity
Pfeiffer, B. E., & Huber, K. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1797-06.2006 · Cited by 168 · see citing works
Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops
Mullins, C., Fishell, G., & Tsien, R. W. (2016) · Neuron · doi:10.1016/j.neuron.2016.02.017 · Cited by 167 · see citing works
Synaptic Activity Controls Dendritic Spine Morphology by Modulating eEF2-Dependent BDNF Synthesis
Verpelli, C., Piccoli, G., Zibetti, C., Zanchi, A., Gardoni, F., Huang, K., Brambilla, D., Luca, M. D., Battaglioli, E., & Sala, C. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0119-10.2010 · Cited by 154 · see citing works
Lee, H. Y., Ge, W., Huang, W. C., He, Y., Wang, G. X., Rowson-Baldwin, A., Smith, S. J., Jan, Y. N., & Jan, L. Y. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.033 · Cited by 149 · see citing works
Long-term potentiation: Peeling the onion
Nicoll, R. A., & Roche, K. W. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.02.010 · Cited by 146 · see citing works
Regulation of AMPA receptors and synaptic plasticity
Santos, S. D., Carvalho, A. L., Caldeira, M. V., & Duarte, C. B. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.037 · Cited by 139 · see citing works
Ammonia induces RNA oxidation in cultured astrocytes and brain in vivo†
Görg, B., Qvartskhava, N., Keitel, V., Bidmon, H. J., Selbach, O., Schliess, F., & Häussinger, D. (2008) · Hepatology · doi:10.1002/hep.22345 · Cited by 136 · see citing works
Minis, A., Dahary, D., Manor, O., Leshkowitz, D., Pilpel, Y., & Yaron, A. (2013) · Developmental Neurobiology · doi:10.1002/dneu.22140 · Cited by 128 · see citing works
Synaptic retinoic acid signaling and homeostatic synaptic plasticity
Chen, L., Lau, A. G., & Sarti, F. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.12.004 · Cited by 128 · see citing works
Nicoll, R. A., & Schulman, H. (2023) · Physiological Reviews · doi:10.1152/physrev.00034.2022 · Cited by 126 · see citing works
Interaction of oxidative stress, astrocyte swelling and cerebral ammonia toxicity
Häussinger, D., & Görg, B. (2009) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328333b829 · Cited by 124 · see citing works
The DEAH-box helicase DHX36 mediates dendritic localization of the neuronal precursor-microRNA-134Preprint
Bicker, S., Khudayberdiev, S., Weiß, K., Zocher, K., Baumeister, S., & Schratt, G. M. (2013) · Genes & Development · doi:10.1101/gad.211243.112 · Cited by 118 · see citing works
Expression mechanisms underlying long-term potentiation: a postsynaptic view, 10 years on
Granger, A. J., & Nicoll, R. A. (2013) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0136 · Cited by 120 · see citing works
Abnormal mGlu 5 Receptor/Endocannabinoid Coupling in Mice Lacking FMRP and BC1 RNA
Maccarrone, M., Rossi, S., Bari, M., Chiara, V. D., Rapino, C., Musella, A., Bernardi, G., Bagni, C., & Centonze, D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.19 · Cited by 119 · see citing works
Tongiorgi, E. (2008) · Neuroscience Research · doi:10.1016/j.neures.2008.04.013 · Cited by 116 · see citing works
Jordan, B. A., Fernholz, B. D., Khatri, L., & Ziff, E. B. (2007) · Nature Neuroscience · doi:10.1038/nn1867 · Cited by 112 · see citing works
Davidkova, G., & Carroll, R. C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3334-07.2007 · Cited by 112 · see citing works
González, A., Huerta-Salgado, C., Orozco-Aguilar, J., Aguirre, F. S., Tacchi, F., Simón, F., & Cabello‐Verrugio, C. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1617805 · Cited by 113 · see citing works
Fatimy, R. E., Davidovic, L., Tremblay, S., Jaglin, X. H., Dury, A. Y., Robert, C., Koninck, P. D., & Khandjian, É. W. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006192 · Cited by 107 · see citing works
AMPA Receptor Trafficking for Postsynaptic Potentiation
Park, M. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00361 · Cited by 102 · see citing works
Hillefors, M., Gioio, A. E., Mameza, M. G., & Kaplan, B. B. (2007) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-007-9148-y · Cited by 101 · see citing works
Ide, M., & Lewis, D. A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.02.016 · Cited by 101 · see citing works
Osmotic and oxidative/nitrosative stress in ammonia toxicity and hepatic encephalopathy
Görg, B., Schliess, F., & Häussinger, D. (2013) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2013.03.010 · Cited by 97 · see citing works
Localization and local translation of Arc/Arg3.1 mRNA at synapses: some observations and paradoxes
Steward, O., Farris, S., Pirbhoy, P. S., Darnell, J. C., & Driesche, S. J. V. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00101 · Cited by 98 · see citing works
Self-citationGlutamate receptor dynamics and protein interaction: Lessons from the NMDA receptor
Bard, L., & Groc, L. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.05.009 · Cited by 94 · see citing works
Repair of spinal cord injury with neuronal relays: From fetal grafts to neural stem cells
Bonner, J. F., & Steward, O. (2015) · Brain Research · doi:10.1016/j.brainres.2015.01.006 · Cited by 92 · see citing works
Self-citationRNA transport and localized protein synthesis in neurological disorders and neural repair
Wang, W., van Niekerk, E. A., Willis, D. E., & Twiss, J. L. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20511 · Cited by 90 · see citing works
Hoffman, M. S., Nichols, N. L., MacFarlane, P. M., & Mitchell, G. S. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00098.2012 · Cited by 88 · see citing works
Sakagami, H., Sanda, M., Fukaya, M., Miyazaki, T., Sukegawa, J., Yanagisawa, T., Suzuki, T., Fukunaga, K., Watanabe, M., & Kondo, H. (2008) · Neuroscience Research · doi:10.1016/j.neures.2007.10.013 · Cited by 83 · see citing works
Translating nociceptor sensitivity: the role of axonal protein synthesis in nociceptor physiology
Price, T. J., & Géranton, S. M. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06786.x · Cited by 76 · see citing works
Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light and electron microscopy
Butko, M. T., Yang, J. Y., Yang, G., Kim, H. J., Jeon, N. L., Shu, X., Mackey, M. R., Ellisman, M. H., Tsien, R. Y., & Lin, M. Z. (2012) · Nature Neuroscience · doi:10.1038/nn.3246 · Cited by 72 · see citing works
Most, D., Ferguson, L. B., & Harris, R. A. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-62619-6.00006-9 · Cited by 70 · see citing works
The neuronal splicing factor Nova co-localizes with target RNAs in the dendrite
Racca, C. (2010) · Frontiers in Neural Circuits · doi:10.3389/neuro.04.005.2010 · Cited by 69 · see citing works
SAP97-mediated ADAM10 trafficking from Golgi outposts depends on PKC phosphorylation
Saraceno, C., Marcello, E. E., Marino, D. D., Borroni, B., Claeysen, S., Perroy, J., Padovani, A., Tramontano, A. L., Gardoni, F., & Luca, M. D. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.492 · Cited by 69 · see citing works
SYNCRIP, a component of dendritically localized mRNPs, binds to the translation regulator BC200 RNA
Duning, K., Buck, F., Barnekow, A., & Kremerskothen, J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05138.x · Cited by 68 · see citing works
Ethanol Sensitivity and Tolerance in Long‐Term Memory Mutants of Drosophila melanogaster
Berger, K. H., Kong, E. C., Dubnau, J., Tully, T., Moore, M. S., & Heberlein, U. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00659.x · Cited by 68 · see citing works
Insights into lncRNAs in Alzheimer’s disease mechanisms
Li, D., Zhang, J., Li, X., Chen, Y., Feng, Y., & Liu, Q. (2020) · RNA Biology · doi:10.1080/15476286.2020.1788848 · Cited by 66 · see citing works
Smaug1 mRNA-silencing foci respond to NMDA and modulate synapse formation
Báez, M. V., Luchelli, L., Maschi, D., Habif, M., Pascual, M. L., Thomas, M. G., & Boccaccio, G. L. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201108159 · Cited by 64 · see citing works
RNA Binding Proteins Accumulate at the Postsynaptic Density with Synaptic Activity
Zhang, G., Neubert, T. A., & Jordan, B. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2463-11.2012 · Cited by 60 · see citing works
A Simple Method for Combined Fluorescence In Situ Hybridization and Immunocytochemistry
Moon, I. S., Cho, S., Jin, I., & Walikonis, R. S. (2007) · Molecules and Cells · doi:10.1016/s1016-8478(23)10758-8 · Cited by 63 · see citing works
Functional Characterization of the Dendritically Localized mRNA Neuronatin in Hippocampal Neurons
Oyang, E. L., Davidson, B. C., Lee, W., & Poon, M. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024879 · Cited by 60 · see citing works
Price, T. J., Das, V., & Dussor, G. O. (2016) · Current Drug Targets · doi:10.2174/1389450116666151102095046 · Cited by 60 · see citing works
Regulation of glutamate receptor subunit availability by microRNAs
Karr, J. E., Vagin, V. V., Chen, K., Ganesan, S., Olenkina, O. M., Gvozdev, V. A., & Featherstone, D. E. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200902062 · Cited by 59 · see citing works
Gogliotti, R. G., Senter, R. K., Rook, J. M., Ghoshal, A., Zamorano, R., Malosh, C., Stauffer, S. R., Bridges, T. M., Bartolomé, J. M., Daniels, J. S., et al. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw074 · Cited by 57 · see citing works
Chapter 5 Translational Control of Gene Expression
Lackner, D. H., & Bähler, J. (2008) · International review of cytology · doi:10.1016/s1937-6448(08)01205-7 · Cited by 58 · see citing works
Translational control at the synapse: role of RNA regulators
Iacoangeli, A., & Tiedge, H. (2012) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2012.11.001 · Cited by 56 · see citing works
Targeting AMPK for the Alleviation of Pathological Pain
Asiedu, M. N., Dussor, G. O., & Price, T. J. (2016) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-319-43589-3_11 · Cited by 56 · see citing works
Targeting calpain in synaptic plasticity
Baudry, M., Chou, M. M., & Bi, X. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.766169 · Cited by 55 · see citing works
RNA localisation in the nervous system
Dahm, R., Kiebler, M. A., & Macchi, P. (2007) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2007.01.009 · Cited by 54 · see citing works
Pathophysiological Mechanisms for Actions of the Neurotrophins
Twiss, J. L., Chang, J., & Schanen, N. C. (2006) · Brain Pathology · doi:10.1111/j.1750-3639.2006.00039.x · Cited by 53 · see citing works
Cohen, J. E., Lee, P. R., & Fields, R. D. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0509 · Cited by 51 · see citing works
Evans, A. J., Gurung, S., Wilkinson, K. A., Stephens, D. J., & Henley, J. M. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.06.001 · Cited by 49 · see citing works
Lu, W.-H., Yeh, N.-H., & Huang, Y. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.073 · Cited by 49 · see citing works
Striatal Proteomic Analysis Suggests that First L-Dopa Dose Equates to Chronic Exposure
Scholz, B., Svensson, M., Alm, H., Sköld, K., Fälth, M., Kultima, K., Guigoni, C., Doudnikoff, É., Li, Q., Crossman, A. R., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001589 · Cited by 47 · see citing works
Life at Low Copy Number: How Dendrites Manage with So Few mRNAs
Kosik, K. S. (2016) · Neuron · doi:10.1016/j.neuron.2016.11.002 · Cited by 44 · see citing works
Chapter 7 Compartmentalizing the Neuronal Plasma Membrane
Lasiecka, Z. M., Yap, C. C., Vakulenko, M., & Winckler, B. (2008) · International review of cytology · doi:10.1016/s1937-6448(08)01607-9 · Cited by 48 · see citing works
Differing Semaphorin 3A Concentrations Trigger Distinct Signaling Mechanisms in Growth Cone Collapse
Manns, R. P. C., Cook, G. M. W., Holt, C. E., & Keynes, R. J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5964-11.2012 · Cited by 46 · see citing works
Shank1 mRNA: Dendritic Transport by Kinesin and Translational Control by the 5′Untranslated Region
Falley, K., Schütt, J., Iglauer, P., Menke, K., Maas, C., Kneussel, M., Kindler, S., Wouters, F. S., Richter, D., & Kreienkamp, H. (2009) · Traffic · doi:10.1111/j.1600-0854.2009.00912.x · Cited by 45 · see citing works
Proteomic Analysis of Activity-Dependent Synaptic Plasticity in Hippocampal Neurons
Piccoli, G., Verpelli, C., Tonna, N., Romorini, S., Alessio, M., Nairn, A. C., Bachi, A., & Sala, C. (2007) · Journal of Proteome Research · doi:10.1021/pr0701308 · Cited by 46 · see citing works
FXR1P Limits Long-Term Memory, Long-Lasting Synaptic Potentiation, and De Novo GluA2 Translation
Cook, D., Nuro, E., Jones, E. V., Altimimi, H. F., Farmer, W. T., Gandin, V., Hanna, E., Zong, R.-T., Barbon, A., Nelson, D. L., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.028 · Cited by 43 · see citing works
Wu, Y., Williamson, R., Li, Z., Vicario, A., Xu, Z., Kasai, M., Chern, Y., Tongiorgi, E., & Baraban, J. M. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07166.x · Cited by 43 · see citing works
Lyu, D., Yu, W., Tang, N., Wang, R., Zhao, Z., Xie, F., He, Y., Du, H., & Chen, J. (2013) · Molecular Pain · doi:10.1186/1744-8069-9-64 · Cited by 44 · see citing works
Mechanisms regulating dendritic arbor patterning
Ledda, F., & Paratcha, G. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2588-8 · Cited by 44 · see citing works
Persistent modifications of hippocampal synaptic function during remote spatial memory
Pavlowsky, A., Wallace, E. J. C., Fenton, A. A., & Alarcón, J. M. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.08.015 · Cited by 45 · see citing works
Sosińska, P., Mikuła‐Pietrasik, J., & Książek, K. (2015) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2015.08.002 · Cited by 42 · see citing works
Rapid regulation of microRNA following induction of long-term potentiation in vivo
Joilin, G., Guévremont, D., Ryan, B., Claudianos, C., Cristino, A. S., Abraham, W. C., & Williams, J. M. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00098 · Cited by 40 · see citing works
Jain, P., & Bhalla, U. S. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000287 · Cited by 40 · see citing works
RNA oxidation and zinc in hepatic encephalopathy and hyperammonemia
Schliess, F., Görg, B., & Häussinger, D. (2009) · Metabolic Brain Disease · doi:10.1007/s11011-008-9125-2 · Cited by 39 · see citing works
Locomotor impairment and cerebrocortical oxidative stress in portal vein ligated rats in vivo
Brück, J., Görg, B., Bidmon, H. J., Zemtsova, I., Qvartskhava, N., Keitel, V., KIRCHEIS, G., & Häussinger, D. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.06.035 · Cited by 38 · see citing works
Synaptic alterations associated with depression and schizophrenia: potential as a therapeutic target
Calabrese, F., Riva, M. A., & Molteni, R. (2016) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2016.1188080 · Cited by 37 · see citing works
Vila‐Porcile, É., Xu, Z. D., Mailly, P., Nagy, F., Calas, A., Hökfelt, T., & Landry, M. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.22105 · Cited by 37 · see citing works
Perturbation of dendritic protrusions in intellectual disability
Levenga, J., & Willemsen, R. (2012) · Progress in brain research · doi:10.1016/b978-0-444-54299-1.00008-x · Cited by 37 · see citing works
Miroci, H., Schob, C., Kindler, S., Ölschläger‐Schütt, J., Fehr, S., Jungenitz, T., Schwarzacher, S. W., Bagni, C., & Mohr, E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.315291 · Cited by 36 · see citing works
P-Body Components, microRNA Regulation, and Synaptic Plasticity
Hillebrand, J., Barbee, S. A., & Ramaswami, M. (2007) · The Scientific World JOURNAL · doi:10.1100/tsw.2007.206 · Cited by 35 · see citing works
- Authors
- Schuman, E. M., Dynes, J. L., & Steward, O.
- Affiliations
- California Institute of Technology (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-07-05
- Volume
- 26
- Issue
- 27
- Pages
- 7143-7146
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6673937
- OpenAlex
- W1985362922
- Cited by
- 230
- References
- 36
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 12 · 2016: 14 · 2015: 10 · 2014: 10 · 2013: 20 · 2012: 14
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- National Institutes of Health (NS12333)
- National Institute of Mental Health (R01MH065537, MH65537)
- National Institute of Neurological Disorders and Stroke (NS-12333)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- long-term potentiation, long-term depression, synaptic plasticity, translational regulation, dendritic mRNA
- MeSH terms
- Animals, Dendrites, Gene Expression Regulation, Humans, Neuronal Plasticity, RNA, Messenger, Synapses, Protein Biosynthesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review