The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Mechanisms of Cortical Reorganization in Lower-Limb Amputees
Open accessAbstract
The human motor system undergoes reorganization after amputation, but the site of motor reorganization and the mechanisms involved are unknown. We studied the site and mechanisms of motor reorganization in 16 subjects with traumatic lower-limb amputation. Stimulation at different levels in the CNS was used to determine the site of reorganization. The mechanisms involved were evaluated by measuring the thresholds for transcranial magnetic stimulation (TMS) and by testing intracortical inhibition and facilitation. With TMS, the threshold for muscle activation on the amputated side was lower than that of the intact side, but with transcranial electrical stimulation there was no difference in motor threshold between the two sides. TMS at the maximal output of the stimulator activated a higher percentage of the motor neuron pool (%MNP) on the amputated side than on the intact side. The %MNP activated by spinal electrical stimulation was similar on the two sides. Paired TMS study showed significantly less intracortical inhibition on the amputated side. Our findings suggest that motor reorganization after lower-limb amputation occurs predominately at the cortical level. The mechanisms involved are likely to include reduction of GABAergic inhibition.
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Nudo, R. J., Wise, B. M., SiFuentes, F., & Milliken, G. W. (1996) · Science · doi:10.1126/science.272.5269.1791 · Cited by 1,911
Effects of phenytoin on cortical excitability in humans
Chen, R., Samii, A., Caños, M., Wassermann, E. M., & Hallett, M. (1997) · Neurology · doi:10.1212/wnl.49.3.881 · Cited by 204
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Cited by
Theta Burst Stimulation of the Human Motor Cortex
Huang, Y.-Z., Edwards, M. J., Rounis, E., Bhatia, K. P., & Rothwell, J. C. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.033 · Cited by 4,158
Plasticity of motor systems after incomplete spinal cord injury
Raineteau, O., & Schwab, M. E. (2001) · Nature Reviews Neuroscience · doi:10.1038/35067570 · Cited by 803
Role of adaptive plasticity in recovery of function after damage to motor cortex
Nudo, R. J., Plautz, E. J., & Frost, S. B. (2001) · Muscle & Nerve · doi:10.1002/mus.1104 · Cited by 561
Intracortical Inhibition and Facilitation in Different Representations of the Human Motor Cortex
Chen, R., Tam, A., Bütefisch, C., Corwell, B., Ziemann, U., Rothwell, J. C., & Cohen, L. G. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.6.2870 · Cited by 495
Self-citationDysfunctional neural plasticity in patients with schizophrenia
Daskalakis, Z. J., Christensen, B. K., Fitzgerald, P. B., & Chen, R. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.4.378 · Cited by 130
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Metadata
- Authors
- Chen, R., Corwell, B., Yaseen, Z., Hallett, M., & Cohen, L. G.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1998-05-01
- Volume
- 18
- Issue
- 9
- Pages
- 3443-3450
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1516622142
- Cited by
- 309
- References
- 2
- FWCI
- 9.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Chen, R., Corwell, B., Yaseen, Z., Hallett, M., & Cohen, L. G. (1998). Mechanisms of Cortical Reorganization in Lower-Limb Amputees. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.18-09-03443.1998
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