The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Electrochemical Analysis of Protein Nitrotyrosine and Dityrosine in the Alzheimer Brain Indicates Region-Specific Accumulation
Open accessAbstract
HPLC with electrochemical array detection (HPLC-ECD) was used to quantify 3,3′-dityrosine (diTyr) and 3-nitrotyrosine (3-NO 2-Tyr) in four regions of the human brain that are differentially affected in Alzheimer’s disease (AD). DiTyr and 3-NO 2-Tyr levels were elevated consistently in the hippocampus and neocortical regions of the AD brain and in ventricular cerebrospinal fluid (VF), reaching quantities five- to eightfold greater than mean concentrations in brain and VF of cognitively normal subjects. Uric acid, a proposed peroxynitrite scavenger, was decreased globally in the AD brain and VF. The results suggest that AD pathogenesis may involve the activation of oxidant-producing inflammatory enzyme systems, including nitric oxide synthase.
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Cited by
Nitric Oxide and Peroxynitrite in Health and Disease
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Oxidative stress in neurodegeneration: Cause or consequence?
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Halliwell, B. (2001) · Drugs & Aging · doi:10.2165/00002512-200118090-00004 · Cited by 1,502
Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid β-peptide
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Metadata
- Authors
- Hensley, K., Maidt, M. L., Yu, Z., Sang, H., Markesbery, W. R., & Floyd, R. A.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1998-10-15
- Volume
- 18
- Issue
- 20
- Pages
- 8126-8132
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2104194752
- Cited by
- 507
- References
- 76
- FWCI
- 15.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Electrochemical Analysis of Protein Nitrotyrosine and Dityrosine in the Alzheimer Brain Indicates Region-Specific Accumulation. https://app.cochat.ai/papers/10.1523/jneurosci.18-20-08126.1998
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- Hensley, K., Maidt, M. L., Yu, Z., Sang, H., Markesbery, W. R., & Floyd, R. A. (1998). Electrochemical Analysis of Protein Nitrotyrosine and Dityrosine in the Alzheimer Brain Indicates Region-Specific Accumulation. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.18-20-08126.1998
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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