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Activity-Dependent Regulation of Surface Glucose Transporter-3
Abstract
Glucose transporter 3 (GLUT3) is the main facilitative glucose transporter in neurons. Glucose provides neurons with a critical energy source for neuronal activity. However, the mechanism by which neuronal activity controls glucose influx via GLUT3 is unknown. We investigated the influence of synaptic stimulation on GLUT3 surface expression and glucose import in primary cultured cortical and hippocampal neurons. Synaptic activity increased surface expression of GLUT3 leading to an elevation of intracellular glucose. The effect was blocked by NMDA receptor (NMDAR) and neuronal nitric oxide synthase (nNOS) inhibition. The Akt inhibitor I (Akt-I) blocked NMDAR-induced GLUT3 surface expression while a nNOS-phosphomimetic mutant (S1412D) enhanced GLUT3 expression at cell surface. These results suggest that NMDAR/Akt-dependent nNOS phosphorylation is coupled to GLUT3 trafficking. We demonstrated that activation of cGMP-dependent protein kinase (cGK) increased the surface expression of GLUT3, which was repressed by Rp-8-pCPT-cGMPS, a potent cell-permeable inhibitor of cGKs. These studies characterize the molecular basis for activity-dependent increases in surface GLUT3 after stimulation of the NMDARs. NMDAR-induced increase in surface GLUT3 represents a novel pathway for control of energy supply during neuronal activity that is critical for maintaining glucose homeostasis during neuronal transmission.
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Stimuli that activate NMDA receptors induce Glut3 translocation from intracellular compartments to cell surfaces.
“Stimuli that activate NMDA receptors induce Glut3 translocation from intracellular compartments to cell surfaces [29].”
From Glucose transporter 3 is a rab11-dependent trafficking cargo and its transport to the cell surface is reduced in neurons of CAG140 Huntington’s disease mice (2014) · cites this paper as [29]
Glut3 is predominantly intracellular in neurons at steady state, as suggested by Ferreira et al.'s data.
“Although not specifically noted by the authors, a predominantly intracellular localization of Glut3 in neurons is suggested by their data, which revealed extremely low levels of Glut3 on neuronal surfaces at steady state [29].”
From Glucose transporter 3 is a rab11-dependent trafficking cargo and its transport to the cell surface is reduced in neurons of CAG140 Huntington’s disease mice (2014) · cites this paper as [29]
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Oligodendroglial NMDA receptors regulate glucose import and axonal energy metabolism
Saab, A. S., Tzvetavona, I. D., Trevisiol, A., Baltan, S., Dibaj, P., Kusch, K., Möbius, W., Goetze, B., Jahn, H. M., Huang, W., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.05.016 · Cited by 590
“Cultured neurons mobilize glucose transporter GLUT3 in response to glutamate (Ferreira et al., 2011).”
Brain lactate metabolism: the discoveries and the controversies
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Regulation of neuron-astrocyte metabolic coupling across the sleep-wake cycle
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Metadata
- Authors
- Ferreira, J. M., Burnett, A. L., & Rameau, G. A.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-02-09
- Volume
- 31
- Issue
- 6
- Pages
- 1991-1999
- ISSN
- 0270-6474
- 1529-2401
- PMC
- PMC3045034
- Cited by
- 115
- References
- 1
- Language
- en
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