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Serotonin Affects Movement Gain Control in the Spinal Cord
Open accessAbstract
A fundamental challenge for the nervous system is to encode signals spanning many orders of magnitude with neurons of limited bandwidth. To meet this challenge, perceptual systems use gain control. However, whether the motor system uses an analogous mechanism is essentially unknown. Neuromodulators, such as serotonin, are prime candidates for gain control signals during force production. Serotonergic neurons project diffusely to motor pools, and, therefore, force production by one muscle should change the gain of others. Here we present behavioral and pharmaceutical evidence that serotonin modulates the input-output gain of motoneurons in humans. By selectively changing the efficacy of serotonin with drugs, we systematically modulated the amplitude of spinal reflexes. More importantly, force production in different limbs interacts systematically, as predicted by a spinal gain control mechanism. Psychophysics and pharmacology suggest that the motor system adopts gain control mechanisms, and serotonin is a primary driver for their implementation in force production.
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“Furthermore, changes in the activity of the serotonergic system appear to modulate the responsiveness of the motor neurones (Wei et al. 2014).”
From Rate of force development: physiological and methodological considerations (2016) · cites this paper as Wei et al. 2014
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Metadata
- Authors
- Wei, K., Glaser, J. I., Deng, L., Thompson, C. K., Stevenson, I. H., Wang, Q., Hornby, T. G., Heckman, C. J., & Kording, K. P.
- Affiliations
- Peking University (CN)
- Northwestern University (US)
- Shirley Ryan AbilityLab (US)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2014-09-17
- Volume
- 34
- Issue
- 38
- Pages
- 12690-12700
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC4166156
- OpenAlex
- W2154554143
- Cited by
- 135
- References
- 117
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 15 · 2023: 13 · 2022: 17 · 2021: 13 · 2020: 8 · 2019: 11 · 2018: 12 · 2017: 8 · 2016: 12 · 2015: 1 · 2014: 1
- FWCI
- 4.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31328010, 31371020, J1103602, 863 Program, 61005082, 2012AA011602, 61020106005)
- National Institutes of Health
- Beijing Nova Program (Z141101001814001)
- National High-tech Research and Development Program
- National Institute of Neurological Disorders and Stroke (P01NS044393, R01NS063399, R01NS034382)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- serotonin, gain control, spinal motoneurons, spinal reflexes, neuromodulation, motor system, psychophysics
- MeSH terms
- Cyproheptadine, Double-Blind Method, Humans, Motor Neurons, Movement, Psychophysics, Reflex, Stretch, Serotonin, Serotonin Antagonists, Spinal Cord, Wrist, Citalopram, Selective Serotonin Reuptake Inhibitors
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