Cited by 135Motor Control and AdaptationMuscle activation and electromyography studiesNeuroscience and Neuropharmacology Research

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Serotonin Affects Movement Gain Control in the Spinal Cord

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Wei, K., Glaser, J. I., Deng, L., Thompson, C. K., Stevenson, I. H., Wang, Q., Hornby, T. G., Heckman, C. J., Kording, K. P.·2014·Journal of Neuroscience

DOI 10.1523/jneurosci.1855-14.2014PMC PMC4166156

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Abstract

A fundamental challenge for the nervous system is to encode signals spanning many orders of magnitude with neurons of limited bandwidth. To meet this challenge, perceptual systems use gain control. However, whether the motor system uses an analogous mechanism is essentially unknown. Neuromodulators, such as serotonin, are prime candidates for gain control signals during force production. Serotonergic neurons project diffusely to motor pools, and, therefore, force production by one muscle should change the gain of others. Here we present behavioral and pharmaceutical evidence that serotonin modulates the input-output gain of motoneurons in humans. By selectively changing the efficacy of serotonin with drugs, we systematically modulated the amplitude of spinal reflexes. More importantly, force production in different limbs interacts systematically, as predicted by a spinal gain control mechanism. Psychophysics and pharmacology suggest that the motor system adopts gain control mechanisms, and serotonin is a primary driver for their implementation in force production.

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Authors: Wei, K., Glaser, J. I., Deng, L., Thompson, C. K., Stevenson, I. H., Wang, Q., Hornby, T. G., Heckman, C. J., & Kording, K. P.
Affiliations: Peking University (CN)
Northwestern University (US)
Shirley Ryan AbilityLab (US)
ORCID: Glaser, J. I.
Thompson, C. K.
Stevenson, I. H.
Wang, Q.
Hornby, T. G.
Heckman, C. J.
Kording, K. P.
Venue: Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2014-09-17
Volume: 34
Issue: 38
Pages: 12690-12700
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.1855-14.2014
PMC: PMC4166156
OpenAlex: W2154554143
Cited by: 135
References: 117
Citations by year: 2026: 11 · 2025: 13 · 2024: 15 · 2023: 13 · 2022: 17 · 2021: 13 · 2020: 8 · 2019: 11 · 2018: 12 · 2017: 8 · 2016: 12 · 2015: 1 · 2014: 1
FWCI: 4.09
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (31328010, 31371020, J1103602, 863 Program, 61005082, 2012AA011602, 61020106005)
National Institutes of Health
Beijing Nova Program (Z141101001814001)
National High-tech Research and Development Program
National Institute of Neurological Disorders and Stroke (P01NS044393, R01NS063399, R01NS034382)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: serotonin, gain control, spinal motoneurons, spinal reflexes, neuromodulation, motor system, psychophysics
MeSH terms: Cyproheptadine, Double-Blind Method, Humans, Motor Neurons, Movement, Psychophysics, Reflex, Stretch, Serotonin, Serotonin Antagonists, Spinal Cord, Wrist, Citalopram, Selective Serotonin Reuptake Inhibitors

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Serotonin Affects Movement Gain Control in the Spinal Cord

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