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Cited by 107Motor Control and AdaptationVestibular and auditory disordersNeural dynamics and brain function

Position, direction of movement, and speed tuning of cerebellar Purkinje cells during circular manual tracking in monkey

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Roitman, Alexander V., Pasalar, Siavash, Johnson, Michael T. V., Ebner, Timothy J.·2005·The Journal of Neuroscience
DOI 10.1523/jneurosci.1886-05.2005PMC PMC6725746
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Abstract

The cerebellum plays an essential role in pursuit tracking with the eye and with the hand. During smooth pursuit eye movements, both tracking position and velocity are signaled by Purkinje cells. Purkinje cell simple spike discharge is also modulated by direction and speed during linear manual tracking. This study evaluated how all three parameters, position, movement direction, and speed, are signaled in the simple spike discharge of Purkinje cells during circular manual tracking. Three rhesus monkeys intercepted and then tracked a target moving in a circle in both counterclockwise and clockwise directions across a range of constant target speeds. Two sets of analyses of the simple spike firing of 97 Purkinje cells examined the effects of position, movement direction, and speed. The first approach was the incremental improvement of regression models, initially modeling a pure position dependence, then incorporating movement direction, and finally incorporating speed dependence. The second was a model-independent approach, without any explicit assumptions about the character of the directional tuning or speed effects. Both analyses revealed the same three results: (1) Purkinje cell discharge is spatially tuned, to both the position and direction of movement, and (2) this spatial tuning is not altered by the speed, except (3) the speed scales the average firing and/or depth of modulation. The results suggest that the population of Purkinje cells forms a representation of the entire position-direction space of arm movements, and that the speed modulates the scale of that representation. This speed scaling provides insights into the cerebellar processing of movement-related timing.

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Crossref · 10.1523/jneurosci.1886-05.2005

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  • Kinematic representations in the simple spike firing are conserved across different behaviors.

    “Also, kinematic representations in the SS firing are conserved across different behaviors (Roitman et al., 2005; Hewitt et al., 2011).”

    From Cerebellum, Predictions and Errors (2019) · cites this paper as Roitman et al., 2005

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Authors
Roitman, A. V., Pasalar, S., Johnson, M. T. V., & Ebner, T. J.
Affiliations
  • University of Minnesota (US)
  • University of Minnesota, Duluth (US)
ORCID
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
2005-10-05
Volume
25
Issue
40
Pages
9244-9257
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
DOI
10.1523/jneurosci.1886-05.2005
PMC
PMC6725746
OpenAlex
W2058352117
Cited by
107
References
59
Citations by year
2026: 4 · 2025: 3 · 2024: 1 · 2023: 4 · 2021: 7 · 2020: 7 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 3 · 2015: 7 · 2014: 7 · 2013: 7 · 2012: 3
FWCI
3.14
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation (9873478)
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (5R01-NS-18338, R01NS018338)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
Purkinje cells, smooth pursuit eye movements, velocity tuning, arm movement, rhesus monkeys
MeSH terms
Action Potentials, Animals, Behavior, Animal, Biomechanical Phenomena, Brain Mapping, Cerebellum, Electromyography, Eye Movements, Hand, Macaca mulatta, Models, Neurological, Movement, Orientation, Psychomotor Performance, Purkinje Cells, Reaction Time, Task Performance and Analysis, Models, Statistical, Muscle, Skeletal

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