The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The cat-1 Gene of Caenorhabditis elegans Encodes a Vesicular Monoamine Transporter Required for Specific Monoamine-Dependent Behaviors
Open accessAbstract
We have identified the Caenorhabditis elegans homolog of the mammalian vesicular monoamine transporters (VMATs); it is 47% identical to human VMAT1 and 49% identical to human VMAT2.C. elegans VMAT is associated with synaptic vesicles in ∼25 neurons, including all of the cells reported to contain dopamine and serotonin, plus a few others. When C. elegans VMAT is expressed in mammalian cells, it has serotonin and dopamine transport activity; norepinephrine, tyramine, octopamine, and histamine also have high affinity for the transporter. The pharmacological profile of C. elegans VMAT is closer to mammalian VMAT2 than VMAT1. The C. elegans VMAT gene is cat-1;cat-1 knock-outs are totally deficient for VMAT immunostaining and for dopamine-mediated sensory behaviors, yet they are viable and grow relatively well. The cat-1 mutant phenotypes can be rescued by C. elegans VMAT constructs and also (at least partially) by human VMAT1 or VMAT2 transgenes. It therefore appears that the function of amine neurotransmitters can be completely dependent on their loading into synaptic vesicles.
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Cites
The structure of the nervous system of the nematode Caenorhabditis elegans
White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1986) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1986.0056 · Cited by 5,589 · cited 10×
“VC4 and VC5, the members of the class closest to the vulva, make numerous neuromuscular synapses onto the vulval muscles; the other VC cells are reported to have less extensive output to the same muscles (White et al., 1976, 1986).”
BackgroundInfluentialGenetic control of programmed cell death in the nematode C. elegans
Ellis, H. (1986) · Cell · doi:10.1016/0092-8674(86)90004-8 · Cited by 1,828
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The pharynx of Caenorhabditis elegans
Albertson, D. G., & Thompson, J. N. (1976) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1976.0085 · Cited by 649 · cited 1×
“By ultrastructural analysis, they have sensory endings and neuromuscular output, as well as varicosities, fine branches, and endings on the surface of the pharynx (Albertson and Thomson, 1976), suggesting that serotonin might be released into the pseudocoelom and have a humoral function.”
BackgroundThe structure of the ventral nerve cord of Caenorhabditis elegans
White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1976) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1976.0086 · Cited by 616
Cited by
Sawin, E. R., Ranganathan, R., & Horvitz, H. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)81199-x · Cited by 1,076
Connectomes across development reveal principles of brain maturation
Witvliet, D., Mulcahy, B., Mitchell, J. K., Meirovitch, Y., Berger, D. R., Wu, Y., Liu, Y., Koh, W. X., Parvathala, R., Holmyard, D., et al. (2021) · Nature · doi:10.1038/s41586-021-03778-8 · Cited by 393
A cellular and regulatory map of the cholinergic nervous system of C. elegans
Pereira, L., Kratsios, P., Serrano-Saiz, E., Sheftel, H., Mayo, A. E., Hall, D. H., White, J. G., LeBoeuf, B., Garcia, L. R., Alon, U., et al. (2015) · eLife · doi:10.7554/elife.12432 · Cited by 365
Speese, S., Petrie, M., Schuske, K., Ailion, M., Ann, K., Iwasaki, K., Jorgensen, E. M., & Martin, T. F. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1466-07.2007 · Cited by 333
The Multilayer Connectome of Caenorhabditis elegans
Bentley, B., Branicky, R., Barnes, C. L., Chew, Y. L., Yemini, E., Bullmore, E. T., Vértes, P. E., & Schafer, W. R. (2016) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1005283 · Cited by 269
Metadata
- Authors
- Duerr, J. S., Frisby, D. L., Gaskin, J., Duke, A., Asermely, K., Huddleston, D., Eiden, L. E., & Rand, J. B.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1999-01-01
- Volume
- 19
- Issue
- 1
- Pages
- 72-84
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2120726784
- Cited by
- 282
- References
- 5
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Duerr, J. S., Frisby, D. L., Gaskin, J., Duke, A., Asermely, K., Huddleston, D., Eiden, L. E., & Rand, J. B. (1999). The cat-1 Gene of Caenorhabditis elegans Encodes a Vesicular Monoamine Transporter Required for Specific Monoamine-Dependent Behaviors. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.19-01-00072.1999
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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