UNC-31 (CAPS) is required for dense-core vesicle but not synaptic vesicle exocytosis in Caenorhabditis elegans
Open accessAbstract
Previous studies indicated that CAPS (calcium-dependent activator protein for secretion) functions as an essential component for the Ca2+-dependent exocytosis of dense-core vesicles in neuroendocrine cells. However, recent mouse knock-out studies suggested an alternative role in the vesicular uptake or storage of catecholamines. To genetically assess the functional role of CAPS, we characterized the sole Caenorhabditis elegans CAPS ortholog UNC-31 (uncoordinated family member) and determined its role in dense-core vesicle-mediated peptide secretion and in synaptic vesicle recycling. Novel assays for dense-core vesicle exocytosis were developed by expressing a prepro-atrial natriuretic factor-green fluorescent protein fusion protein in C. elegans. unc-31 mutants exhibited reduced peptide release in vivo and lacked evoked peptide release in cultured neurons. In contrast, cultured neurons from unc-31 mutants exhibited normal stimulated synaptic vesicle recycling measured by FM4-64 [N-(3-triethylammoniumpropyl)-4-(6-(4-diethylamino)phenyl)hexatrienyl)pyridinium dibromide] dye uptake. Conversely, UNC-13, which exhibits sequence homology to CAPS/UNC-31, was found to be essential for synaptic vesicle but not dense-core vesicle exocytosis. These findings indicate that CAPS/UNC-31 function is not restricted to catecholaminergic vesicles but is generally required for and specific to dense-core vesicle exocytosis. Our results suggest that CAPS/UNC-31 and UNC-13 serve parallel and dedicated roles in dense-core vesicle and synaptic vesicle exocytosis, respectively, in the C. elegans nervous system.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
rund-1 and unc-31 mutants have defects in egg-laying and defecation and enter the dauer diapause stage at high temperature.
“rund-1 and unc-31 mutants also have defects in egg-laying and defecation, and enter the dauer diapause stage at high temperature”
From Two Rab2 Interactors Regulate Dense-Core Vesicle Maturation (2014) · cites this paper as Speese et al., 2007
The Discussion and Results (pages unavailable in our copy) report egg-laying and defecation defects in unc-31 mutants. They describe reduced recovery from the dauer state, not entry into dauer diapause at high temperature. Our copy does not address rund-1 mutants. (LLM, conf=0.88)
Experimental — accuracy not yet measuredCAPS is required for dense-core vesicle fusion and may also regulate synaptic vesicle exocytosis.
“CAPS is required for DCV fusion”
From Two Rab2 Interactors Regulate Dense-Core Vesicle Maturation (2014) · cites this paper as Speese et al., 2007
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
THE GENETICS OF CAENORHABDITIS ELEGANS
Brenner, S. (1974) · Genetics · doi:10.1093/genetics/77.1.71 · Cited by 14,984 · see citing works
The structure of the nervous system of the nematode <i>Caenorhabditis elegans</i>
White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1986) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1986.0056 · Cited by 5,589 · see citing works
Mello, C. C., Kramer, J. M., Stinchcomb, D. T., & Ambros, V. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb04966.x · Cited by 3,069 · see citing works
Wilschut, J. (1990) · Cited by 2,407 · see citing works
[C. elegans: of neurons and genes].
Gally, C., & Bessereau, J. (2003) · Medecine sciences : M/S · doi:10.1051/medsci/20031967725 · Cited by 2,194 · see citing works
Jahn, R., Lang, T., & Südhof, T. C. (2003) · Cell · doi:10.1016/s0092-8674(03)00112-0 · Cited by 1,331 · see citing works
[Genetics of Caenorhabditis elegans].
Munakata, N. (1989) · PubMed · Cited by 886 · see citing works
Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles
Augustin, I., Rosenmund, C., Südhof, T. C., & Brose, N. (1999) · Nature · doi:10.1038/22768 · Cited by 787 · see citing works
Optical Analysis of Synaptic Vesicle Recycling at the Frog Neuromuscular Junction
Betz, W. J., & Bewick, G. S. (1992) · Science · doi:10.1126/science.1553547 · Cited by 763 · see citing works
Pierce, S. B., Costa, M. A., Wisotzkey, R. G., Devadhar, S., Homburger, S. A., Buchman, A. R., Ferguson, K. C., Heller, J., Platt, D., Pasquinelli, A. E., et al. (2001) · Genes & Development · doi:10.1101/gad.867301 · Cited by 639 · see citing works
UNC-13 is required for synaptic vesicle fusion in C. elegans
Richmond, J. E., Davis, W. S., & Jørgensen, E. M. (1999) · Nature Neuroscience · doi:10.1038/14755 · Cited by 617 · see citing works
Serotonin and Octopamine in the Nematode Caenorhabditis elegans
Horvitz, H. R., Chalfie, M., Trent, C., Sulston, J., & Evans, P. D. (1982) · Science · doi:10.1126/science.6805073 · Cited by 580 · see citing works
Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin
Nonet, M. L., Grundahl, K. M., Meyer, B. J., & Rand, J. B. (1993) · Cell · doi:10.1016/0092-8674(93)90357-v · Cited by 537 · see citing works
A genetic pathway for the development of the Caenorhabditis elegans HSN motor neurons
Desai, C. J., Garriga, G., Mclntire, S. L., & Horvitz, H. R. (1988) · Nature · doi:10.1038/336638a0 · Cited by 479 · see citing works
Dopaminergic neurons in the nematode Caenorhabditis elegans
Sulston, J., Dew, M., & Brenner, S. (1975) · The Journal of Comparative Neurology · doi:10.1002/cne.901630207 · Cited by 477 · see citing works
An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming
Richmond, J. E., Weimer, R. M., & Jorgensen, E. M. (2001) · Nature · doi:10.1038/35085583 · Cited by 437 · see citing works
A genetic selection for Caenorhabditis elegans synaptic transmission mutants.
Miller, K. G., Alfonso, A., Nguyen, M., Crowell, J. A., Johnson, C. D., & Rand, J. B. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12593 · Cited by 437 · see citing works
Tyramine Functions Independently of Octopamine in the Caenorhabditis elegans Nervous System
Alkema, M. J., Hunter-Ensor, M., Ringstad, N., & Horvitz, H. R. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.024 · Cited by 402 · see citing works
Genetic analysis of defecation in Caenorhabditis elegans.
Thomas, J. H. (1990) · Genetics · doi:10.1016/0168-9525(90)90166-4 · Cited by 341 · see citing works
Nathoo, A. N., Moeller, R. A., Westlund, B. A., & Hart, A. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241231298 · Cited by 340 · see citing works
Drosophila Unc-13 is essential for synaptic transmission
Aravamudan, B., Fergestad, T., Davis, W. S., Rodesch, C. K., & Broadie, K. S. (1999) · Nature Neuroscience · doi:10.1038/14764 · Cited by 335 · see citing works
Genetic analysis of defecation in Caenorhabditis elegans.
Thomas, J. H. (1990) · Genetics · doi:10.1093/genetics/124.4.855 · Cited by 327 · see citing works
Emerging Roles of Presynaptic Proteins in Ca ++ -Triggered Exocytosis
Rettig, J., & Neher, E. (2002) · Science · doi:10.1126/science.1075375 · Cited by 327 · see citing works
Mechanism of extrasynaptic dopamine signaling in Caenorhabditis elegans
Chase, D. L., Pepper, J. S., & Koelle, M. R. (2004) · Nature Neuroscience · doi:10.1038/nn1316 · Cited by 296 · see citing works
Expression and regulation of an FMRFamide‐related neuropeptide gene family in Caenorhabditis elegans
Kim, K., & Li, C. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20189 · Cited by 294 · see citing works
Duerr, J. S., Frisby, D. L., Gaskin, J., Duke, A. L., Asermely, K. E., Huddleston, D., Eiden, L. E., & Rand, J. B. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-01-00072.1999 · Cited by 282 · see citing works
PKC-1 regulates secretion of neuropeptides
Sieburth, D., Madison, J. M., & Kaplan, J. M. (2006) · Nature Neuroscience · doi:10.1038/nn1810 · Cited by 268 · see citing works
Walent, J. H., Porter, B. W., & Martin, T. F. J. (1992) · Cell · doi:10.1016/0092-8674(92)90310-9 · Cited by 264 · see citing works
Self-citationInhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1
Rogers, C. M., Reale, V., Kim, K., Chatwin, H. M., Li, C., Evans, P. D., & de Bono, M. (2003) · Nature Neuroscience · doi:10.1038/nn1140 · Cited by 258 · see citing works
Nonet, M. L. (1999) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(99)00031-x · Cited by 231 · see citing works
FMRFamide-related neuropeptide gene family in Caenorhabditis elegans
Li, C., Kim, K., & Nelson, L. S. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01972-1 · Cited by 228 · see citing works
A Primary Culture System for Functional Analysis of C. elegans Neurons and Muscle Cells
Christensen, M., Estevez, A. Y., Yin, X., Fox, R., Morrison, R., McDonnell, M. A., Gleason, C., Miller, D. M., & Strange, K. B. (2002) · Neuron · doi:10.1016/s0896-6273(02)00591-3 · Cited by 225 · see citing works
Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients
Sadakata, T., Washida, M., Iwayama, Y., Shoji, S., Sato, Y., Ohkura, T., Katoh-Semba, R., Nakajima, M., Sekine, Y., Tanaka, M., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29031 · Cited by 218 · see citing works
A minimal domain responsible for Munc13 activity
Basu, J., Shen, N., Dulubova, I., Lu, J., Guan, R., Guryev, O., Grishin, N. V., Rosenmund, C., & Rizo, J. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1001 · Cited by 213 · see citing works
Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis
Ann, K., Kowalchyk, J. A., Loyet, K. M., & Martin, T. F. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.32.19637 · Cited by 182 · see citing works
Self-citationCAPS Acts at a Prefusion Step in Dense-Core Vesicle Exocytosis as a PIP2 Binding Protein
Grishanin, R. N., Kowalchyk, J. A., Klenchin, V. A., Ann, K., Earles, C. A., Chapman, E. R., Gerona, R. R. L., & Martin, T. F. J. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.028 · Cited by 182 · see citing works
Self-citationFormation, stabilisation and fusion of the readily releasable pool of secretory vesicles
S∅rensen, J. C. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-004-1247-8 · Cited by 177 · see citing works
Nelson, L. S., Rosoff, M. L., & Li, C. (1998) · Science · doi:10.1126/science.281.5383.1686 · Cited by 171 · see citing works
Jacob, T. C., & Kaplan, J. M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-06-02122.2003 · Cited by 164 · see citing works
Sadakata, T., Kakegawa, W., Mizoguchi, A., Washida, M., Katoh‐Semba, R., Shutoh, F., Okamoto, T., Nakashima, H., Kimura, K., Tanaka, M., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2279-06.2007 · Cited by 157 · see citing works
Dempsey, C. M., Mackenzie, S. M., Gargus, A., Blanco, G., & Sze, J. Y. (2005) · Genetics · doi:10.1534/genetics.104.032540 · Cited by 157 · see citing works
Neuronal Peptide Release Is Limited by Secretory Granule Mobility
Burke, N. V., Han, W., Li, D., Takimoto, K., Watkins, S. C., & Levitan, E. S. (1997) · Neuron · doi:10.1016/s0896-6273(00)80400-6 · Cited by 156 · see citing works
CAPS (Mammalian UNC-31) Protein Localizes to Membranes Involved in Dense-Core Vesicle Exocytosis
Berwin, B. L., Floor, E., & Martin, T. F. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80521-8 · Cited by 153 · see citing works
Self-citationThe EGL-3 Proprotein Convertase Regulates Mechanosensory Responses ofCaenorhabditis elegans
Kass, J., Jacob, T. C., Kim, P., & Kaplan, J. M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-23-09265.2001 · Cited by 152 · see citing works
UNC-13 Interaction with Syntaxin Is Required for Synaptic Transmission
Madison, J. M., Nurrish, S., & Kaplan, J. M. (2005) · Current Biology · doi:10.1016/j.cub.2005.10.049 · Cited by 149 · see citing works
Identification of the minimal protein domain required for priming activity of Munc13-1
Stevens, D. R., Wu, Z.-X., Matti, U., Junge, H. J., Schirra, C., Becherer, U., Wojcik, S. M., Brose, N., & Rettig, J. (2005) · Current Biology · doi:10.1016/j.cub.2005.10.055 · Cited by 149 · see citing works
Renden, R., Berwin, B. L., Davis, W., Ann, K., Chin, C.-T., Kreber, R. A., Ganetzky, B., Martin, T. F. J., & Broadie, K. (2001) · Neuron · doi:10.1016/s0896-6273(01)00382-8 · Cited by 143 · see citing works
Self-citationThe Caenorhabditis elegans unc-31 gene affects multiple nervous system-controlled functions
Avery, L., Bargmann, C. I., & Horvitz, H. R. (1993) · Genetics · doi:10.1093/genetics/134.2.455 · Cited by 137 · see citing works
Tuning exocytosis for speed: fast and slow modes
Martin, T. F. J. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(03)00093-4 · Cited by 132 · see citing works
Self-citationDifferential Regulation of Exocytosis by Calcium and CAPS in Semi-Intact Synaptosomes
Tandon, A., Bannykh, S. I., Kowalchyk, J. A., Banerjee, A., Martin, T. F. J., & Balch, W. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)80522-x · Cited by 129 · see citing works
Self-citationSerotonin regulates repolarization of theC. eleganspharyngeal muscle
Niacaris, T. R., & Avery, L. (2002) · Journal of Experimental Biology · doi:10.1242/jeb.00101 · Cited by 127 · see citing works
Neurosecretory control of aging in <i>Caenorhabditis</i> <i>elegans</i>
Ailion, M., Inoue, T., Weaver, C. I., Holdcraft, R. W., & Thomas, J. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7394 · Cited by 121 · see citing works
Self-citationActivity-dependent liberation of synaptic neuropeptide vesicles
Shakiryanova, D. M., Tully, A., Hewes, R. S., Deitcher, D. L., & Levitan, E. S. (2005) · Nature Neuroscience · doi:10.1038/nn1377 · Cited by 120 · see citing works
Hellmann, B., & Güntürkün, O. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20000101)429:1 · Cited by 116 · see citing works
An activating mutation in a Caenorhabditis elegans Gs protein induces neural degeneration.Preprint
Korswagen, H. C., Park, J.-H., Ohshima, Y., & Plasterk, R. H. A. (1997) · Genes & Development · doi:10.1101/gad.11.12.1493 · Cited by 111 · see citing works
Dense Core Vesicle Dynamics in Caenorhabditis elegans Neurons and the Role of Kinesin UNC‐104
Zahn, T. R., Angleson, J. K., MacMorris, M., Domke, E., Hutton, J. F., Schwartz, C., & Hutton, J. C. (2004) · Traffic · doi:10.1111/j.1600-0854.2004.00195.x · Cited by 109 · see citing works
CAPS1 Regulates Catecholamine Loading of Large Dense-Core Vesicles
Speidel, D., Bruederle, C. E., Enk, C., Voets, T., Varoqueaux, F., Reim, K., Becherer, U., Fornai, F., Ruggieri, S. A., Holighaus, Y., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.019 · Cited by 108 · see citing works
A Family of Ca2+-Dependent Activator Proteins for Secretion
Speidel, D., Varoqueaux, F., Enk, C., Nojiri, M., Grishanin, R. N., Martin, T. F. J., Hofmann, K., Brose, N., & Reim, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304727200 · Cited by 107 · see citing works
Self-citationMunc13-1 Deficiency Reduces Insulin Secretion and Causes Abnormal Glucose Tolerance
Kwan, E. P., Xie, L., Sheu, L., Nolan, C. J., Prentki, M., Betz, A., Brose, N., & Gaisano, H. Y. (2006) · Diabetes · doi:10.2337/db05-1263 · Cited by 107 · see citing works
Activity-dependent synaptic capture of transiting peptidergic vesicles
Shakiryanova, D. M., Tully, A., & Levitan, E. S. (2006) · Nature Neuroscience · doi:10.1038/nn1719 · Cited by 105 · see citing works
Effect of a Neuropeptide Gene on Behavioral States in Caenorhabditis elegans Egg-Laying
Waggoner, L. E., Lowery, L. A., Golik, S., & Schafer, W. R. (2000) · Genetics · doi:10.1093/genetics/154.3.1181 · Cited by 103 · see citing works
Charlie, N. K., Schade, M. A., Thomure, A. M., & Miller, K. G. (2006) · Genetics · doi:10.1534/genetics.105.049577 · Cited by 98 · see citing works
Munc13-1 is required for the sustained release of insulin from pancreatic β cells
Kang, L., He, Z., Xu, P., Fan, J., Betz, A., Brose, N., & Xu, T. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.012 · Cited by 96 · see citing works
Rapid regulated dense-core vesicle exocytosis requires the CAPS protein
Rupnik, M. S., Kreft, M., Sikdar, S. K., Grilc, S., Romih, R., Zupanc̆ic̆, G., Martin, T. F. J., & Zorec, R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.090359097 · Cited by 93 · see citing works
Self-citationGrishanin, R. N., Klenchin, V. A., Loyet, K. M., Kowalchyk, J. A., Ann, K., & Martin, T. F. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201614200 · Cited by 93 · see citing works
Self-citationExpression of multiple UNC-13 proteins in the Caenorhabditis elegans nervous system.
Kohn, R., Duerr, J., McManus, J. R., Duke, A., Rakow, T. L., Maruyama, H., Moulder, G., Maruyama, I., Barstead, R., & Rand, J. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.10.3441 · Cited by 93 · see citing works
Cisternas, F. A., Vincent, J. B., Scherer, S. W., & Ray, P. N. (2003) · Genomics · doi:10.1016/s0888-7543(02)00040-x · Cited by 79 · see citing works
Docked Secretory Vesicles Undergo Ca2+-activated Exocytosis in a Cell-free System
Martin, T. F. J., & Kowalchyk, J. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.22.14447 · Cited by 78 · see citing works
Self-citationElhamdani, A., Martin, T. F. J., Kowalchyk, J. A., & Artalejo, C. R. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-17-07375.1999 · Cited by 67 · see citing works
Self-citationMartin, T. F. J., & Walent, J. H. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81800-2 · Cited by 63 · see citing works
Self-citationReply to Re-examination of P-PTEN staining patterns in the intestinal crypt
He, X., & Li, L. (2005) · Nature Genetics · doi:10.1038/ng1005-1017 · Cited by 48 · see citing works
Genetic and cellular analysis of modulated behaviors in Caenorhabditis elegans
Sawin, E. R. (1996) · DSpace@MIT (Massachusetts Institute of Technology) · Cited by 43 · see citing works
Ng, Y., Lu, X., & Levitan, E. S. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.021733 · Cited by 39 · see citing works
Role of CAPS in Dense‐Core Vesicle Exocytosis
Wassenberg, J. J., & Martin, T. F. J. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04464.x · Cited by 24 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Livingstone D (1991) Studies on the unc-31 gene of Caenorhabditis elegans. PhD thesis, University of Cambridge.
Cited by
Sorted by citations
XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity
Taylor, R. C., & Dillin, A. G. (2013) · Cell · doi:10.1016/j.cell.2013.05.042 · Cited by 570 · see citing works
The Morphological and Molecular Nature of Synaptic Vesicle Priming at Presynaptic Active Zones
Imig, C., Min, S.-W., Krinner, S., Arancillo, M., Rosenmund, C., Südhof, T. C., Rhee, J., Brose, N., & Cooper, B. H. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.009 · Cited by 389 · see citing works
Suzuki, H., Thiele, T. R., Faumont, S., Ezcurra, M., Lockery, S. R., & Schafer, W. R. (2008) · Nature · doi:10.1038/nature06927 · Cited by 256 · see citing works
Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis
Berendzen, K. M., Durieux, J., Shao, L.-W., Tian, Y., Kim, H.-E., Wolff, S., Liu, Y., & Dillin, A. G. (2016) · Cell · doi:10.1016/j.cell.2016.08.042 · Cited by 239 · see citing works
CAPS-1 and CAPS-2 Are Essential Synaptic Vesicle Priming Proteins
Jockusch, W. J., Speidel, D., Sigler, A., Sørensen, J. B., Varoqueaux, F., Rhee, J., & Brose, N. (2007) · Cell · doi:10.1016/j.cell.2007.11.002 · Cited by 210 · see citing works
Regulation of Organismal Proteostasis by Transcellular Chaperone Signaling
van Oosten‐Hawle, P., Porter, R. S., & Morimoto, R. I. (2013) · Cell · doi:10.1016/j.cell.2013.05.015 · Cited by 197 · see citing works
Beverly, M., Anbil, S. R., & Sengupta, P. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1098-11.2011 · Cited by 186 · see citing works
Systemic stress signalling: understanding the cell non-autonomous control of proteostasis
Taylor, R. C., Berendzen, K. M., & Dillin, A. G. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3752 · Cited by 172 · see citing works
Neural signal propagation atlas of Caenorhabditis elegans
Randi, F., Sharma, A. K., Dvali, S., & Leifer, A. M. (2023) · Nature · doi:10.1038/s41586-023-06683-4 · Cited by 153 · see citing works
Frakes, A. E., Metcalf, M. G., Tronnes, S. U., Bar‐Ziv, R., Durieux, J., Gildea, H. K., Kandahari, N., Monshietehadi, S., & Dillin, A. G. (2020) · Science · doi:10.1126/science.aaz6896 · Cited by 146 · see citing works
Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins
Prahlad, V., & Morimoto, R. I. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106557108 · Cited by 143 · see citing works
Bretscher, A. J., Kodama, E., Busch, K. E., Murphy, R. J., Soltész, Z., Laurent, P., & de Bono, M. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.023 · Cited by 135 · see citing works
Chen, C., Tuck, S., & Byström, A. S. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000561 · Cited by 130 · see citing works
Xiao, R., Chun, L., Ronan, E. A., Friedman, D. I., Liu, J., & Xu, X. Z. S. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.024 · Cited by 125 · see citing works
Kawli, T., & Tan, M. (2008) · Nature Immunology · doi:10.1038/ni.1672 · Cited by 124 · see citing works
Ziegler, K., Kurz, C. L., Cypowyj, S., Couillault, C., Pophillat, M., Pujol, N., & Ewbank, J. J. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.03.006 · Cited by 117 · see citing works
Synaptic scaffolding protein SYD-2 clusters and activates kinesin-3 UNC-104 in C. elegans
Wagner, O. I., Esposito, A., Köhler, B., Chen, C., Shen, C.-P., Wu, G., Butkevich, E., Mandalapu, S., Wenzel, D., Wouters, F. S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902949106 · Cited by 116 · see citing works
CAPS and syntaxin dock dense core vesicles to the plasma membrane in neurons
Hammarlund, M., Watanabe, S., Schuske, K. R., & Jørgensen, E. M. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200708018 · Cited by 106 · see citing works
Self-citationThe chemical brain hypothesis for the origin of nervous systems
Jékely, G. (2021) · Philosophical Transactions of the Royal Society B · doi:10.1098/rstb.2019.0761 · Cited by 108 · see citing works
Two Rab2 Interactors Regulate Dense-Core Vesicle Maturation
Ailion, M., Hannemann, M., Dalton, S., Pappas, A., Watanabe, S., Hegermann, J., Liu, Q., Han, H.-F., Gu, M., Goulding, M. Q., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.017 · Cited by 86 · see citing works
Self-citationA Self-Regulating Feed-Forward Circuit Controlling C. elegans Egg-Laying Behavior
Zhang, M., Chung, S., Fang-Yen, C. M., Craig, C., Kerr, R. A., Suzuki, H., Samuel, A. D. T., Mazur, E., & Schafer, W. R. (2008) · Current Biology · doi:10.1016/j.cub.2008.08.047 · Cited by 103 · see citing works
Hypoxia and the Hypoxic Response Pathway Protect against Pore-Forming Toxins in C. elegans
Bellier, A., Chen, C., Kao, C., Cinar, H. N., & Aroian, R. V. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000689 · Cited by 101 · see citing works
Neuropeptide signaling remodels chemosensory circuit composition in Caenorhabditis elegans
Leinwand, S. G., & Chalasani, S. H. (2013) · Nature Neuroscience · doi:10.1038/nn.3511 · Cited by 99 · see citing works
A Cold-Sensing Receptor Encoded by a Glutamate Receptor Gene
Gong, J., Liu, J., Ronan, E. A., He, F., Cai, W., Fatima, M., Zhang, W., Lee, H. K., Li, Z., Kim, G.-H., et al. (2019) · Cell · doi:10.1016/j.cell.2019.07.034 · Cited by 92 · see citing works
A TRPV Channel Modulates C. elegans Neurosecretion, Larval Starvation Survival, and Adult Lifespan
Lee, B. H., & Ashrafi, K. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000213 · Cited by 94 · see citing works
Profiling Synaptic Proteins Identifies Regulators of Insulin Secretion and Lifespan
Ch'ng, Q.-L., Sieburth, D., & Kaplan, J. M. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000283 · Cited by 94 · see citing works
Impaired dense core vesicle maturation in <i>Caenorhabditis elegans</i> mutants lacking Rab2
Edwards, S. L., Charlie, N. K., Richmond, J. E., Hegermann, J., Eimer, S., & Miller, K. G. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200902095 · Cited by 83 · see citing works
Liu, S., Schulze, E., & Baumeister, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032360 · Cited by 91 · see citing works
Mutlu, A. S., Gao, S. M., Zhang, H., & Wang, M. C. (2020) · Nature Communications · doi:10.1038/s41467-020-15296-8 · Cited by 90 · see citing works
Hu, Z., Pym, E. C. G., Babu, K., Murray, A. V., & Kaplan, J. M. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.021 · Cited by 90 · see citing works
Chang, A. J., & Bargmann, C. I. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802164105 · Cited by 90 · see citing works
Zhou, K.-M., Dong, Y., Ge, Q., Zhu, D. Y., Zhou, W., Lin, X., Liang, T., Wu, Z., & Xu, T. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.015 · Cited by 88 · see citing works
Neuropeptide Secreted from a Pacemaker Activates Neurons to Control a Rhythmic Behavior
Wang, H., Girskis, K. M., Janssen, T. A. H., Chan, J., Dasgupta, K., Knowles, J. A., Schoofs, L., & Sieburth, D. (2013) · Current Biology · doi:10.1016/j.cub.2013.03.049 · Cited by 89 · see citing works
Flavell, S. W., Raizen, D. M., & You, Y. (2020) · Genetics · doi:10.1534/genetics.120.303539 · Cited by 80 · see citing works
Vérièpe, J., Fossouo, L., & Parker, J. A. (2015) · Nature Communications · doi:10.1038/ncomms8319 · Cited by 86 · see citing works
Seidel, H. S., & Kimble, J. E. (2015) · eLife · doi:10.7554/elife.10832 · Cited by 81 · see citing works
CAPS Facilitates Filling of the Rapidly Releasable Pool of Large Dense-Core Vesicles
Liu, Y., Schirra, C., Stevens, D. R., Matti, U., Speidel, D., Hof, D., Bruns, D., Brose, N., & Rettig, J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5672-07.2008 · Cited by 87 · see citing works
Khan, M., Hartmann, A. H., O’Donnell, M. P., Piccione, M., Pandey, A., Chao, P.-H., Dwyer, N. D., Bargmann, C. I., & Sengupta, P. (2022) · PLoS Biology · doi:10.1371/journal.pbio.3001677 · Cited by 86 · see citing works
Estradiol Facilitates the Release of Neuropeptide Y to Suppress Hippocampus-Dependent Seizures
Ledoux, V. A., Smejkalová, T., May, R. M., Cooke, B. M., & Woolley, C. S. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4688-08.2009 · Cited by 85 · see citing works
CAPS and Munc13: CATCHRs that SNARE Vesicles
James, D. J., & Martin, T. F. J. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00187 · Cited by 83 · see citing works
Self-citationJafari, G., Xie, Y., Kullyev, A., Liang, B., & Sze, J. Y. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1692-11.2011 · Cited by 82 · see citing works
Remote Homology between Munc13 MUN Domain and Vesicle Tethering Complexes
Pei, J., Ma, C., Rizo, J., & Grishin, N. V. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.06.054 · Cited by 83 · see citing works
Sexual Dimorphism and Sex Differences in Caenorhabditis elegans Neuronal Development and Behavior
Barr, M. M., Garcia, L. R., & Portman, D. (2018) · Genetics · doi:10.1534/genetics.117.300294 · Cited by 81 · see citing works
Zhang, B., Gong, J., Zhang, W., Xiao, R., Liu, J., & Xu, X. Z. S. (2018) · Genes & Development · doi:10.1101/gad.309625.117 · Cited by 82 · see citing works
Monoamines and neuropeptides interact to inhibit aversive behaviour in Caenorhabditis elegans
Mills, H., Wragg, R. T., Hapiak, V., Castelletto, M. L., Zahratka, J. A., Harris, G. P., Summers, P., Korchnak, A. C., Law, W., Bamber, B. A., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.422 · Cited by 81 · see citing works
Chen, Y.-C., Chen, H.-J., Tseng, W.-C., Hsu, J.-M., Huang, T., Chen, C., & Pan, C. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.08.021 · Cited by 76 · see citing works
Harris, G., Mills, H., Wragg, R. T., Hapiak, V., Castelletto, M. L., Korchnak, A. C., & Komuniecki, R. W. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0497-10.2010 · Cited by 79 · see citing works
Jia, Q., & Sieburth, D. (2021) · Nature Communications · doi:10.1038/s41467-021-22561-x · Cited by 77 · see citing works
Fast cAMP Modulation of Neurotransmission via Neuropeptide Signals and Vesicle Loading
Costa, W. S., Yu, S.-C., Liewald, J. F., & GOTTSCHALK, A. R. (2017) · Current Biology · doi:10.1016/j.cub.2016.12.055 · Cited by 76 · see citing works
CAPS1 and CAPS2 Regulate Stability and Recruitment of Insulin Granules in Mouse Pancreatic β Cells
Speidel, D., Salehi, A., Obermueller, S., Lundquist, I., Brose, N., Renström, E., & Rorsman, P. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.009 · Cited by 75 · see citing works
The neuropeptide NLP-22 regulates a sleep-like state in Caenorhabditis elegans
Nelson, M. D., Trojanowski, N. F., George-Raizen, J. B., Smith, C. J., Yu, C.-C., Fang-Yen, C. M., & Raizen, D. M. (2013) · Nature Communications · doi:10.1038/ncomms3846 · Cited by 78 · see citing works
Bhatla, N., Droste, R., Sando, S. R., Huang, A., & Horvitz, H. R. (2015) · Current Biology · doi:10.1016/j.cub.2015.06.052 · Cited by 71 · see citing works
Yeon, J., Kim, J., Kim, D., Kim, H., Kim, J., Du, E. J., Kang, K., Lim, H., Moon, D., & Kim, K. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2004929 · Cited by 70 · see citing works
Chen, L., Lin, C.-T., Lin, L.-Y., Hsu, J.-M., Wu, Y., & Pan, C. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.04.021 · Cited by 70 · see citing works
RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway
Asensio, C. S., Sirkis, D. W., & Edwards, R. H. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201006131 · Cited by 68 · see citing works
Transfer characteristics of a thermosensory synapse in Caenorhabditis elegans
Narayan, A., Laurent, G., & Sternberg, P. W. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106617108 · Cited by 69 · see citing works
Chew, Y. L., Tanizawa, Y., Cho, Y., Zhao, B., Yu, A. J., Ardiel, E. L., Rabinowitch, I., Bai, J., Rankin, C. H., Lu, H., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.08.003 · Cited by 70 · see citing works
Tomosyn Negatively Regulates CAPS-Dependent Peptide Release at<i>Caenorhabditis elegans</i>Synapses
Gracheva, E. O., Burdina, A. O., Touroutine, D., Berthelot-Grosjean, M., Parekh, H., & Richmond, J. E. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2339-07.2007 · Cited by 65 · see citing works
Two distinct secretory vesicle–priming steps in adrenal chromaffin cells
Liu, Y., Schirra, C., Edelmann, L., Matti, U., Rhee, J., Hof, D., Bruns, D., Brose, N., Rieger, H., Stevens, D. R., et al. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201001164 · Cited by 67 · see citing works
Nagy, S., Tramm, N., Sanders, J., Iwanir, S., Shirley, I. A., Levine, E., & Biron, D. (2014) · eLife · doi:10.7554/elife.04380 · Cited by 62 · see citing works
Kim, S., & Sieburth, D. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.08.037 · Cited by 65 · see citing works
Sadakata, T., & Furuichi, T. (2009) · The Cerebellum · doi:10.1007/s12311-009-0097-5 · Cited by 63 · see citing works
Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signalling
Finger, F., Ottens, F., Springhorn, A., Drexel, T., Proksch, L., Metz, S., Cochella, L., & Hoppe, T. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0033-z · Cited by 65 · see citing works
Neurotransmitter signaling through heterotrimeric G proteins: insights from studies in C. elegans
Koelle, M. R. (2016) · WormBook · doi:10.1895/wormbook.1.75.2 · Cited by 57 · see citing works
RAB-5 and RAB-10 cooperate to regulate neuropeptide release in Caenorhabditis elegans
Sasidharan, N., Sumakovic, M., Hannemann, M., Hegermann, J., Liewald, J. F., Olendrowitz, C., Koenig, S., Grant, B. D., Rizzoli, S. O., GOTTSCHALK, A. R., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203306109 · Cited by 58 · see citing works
Molina-García, L., Lloret-Fernández, C., Cook, S. J., Kim, B., Bonnington, R. C., Sammut, M., O’Shea, J. M., Gilbert, S. P. R., Elliott, D. J. S., Hall, D. H., et al. (2020) · eLife · doi:10.7554/elife.48361 · Cited by 58 · see citing works
Parasite neuropeptide biology: Seeding rational drug target selection?
McVeigh, P., Atkinson, L. E., Marks, N. J., Mousley, A., Dalzell, J. J., Sluder, A. E., Hammerland, L. G., & Maule, A. G. (2011) · International Journal for Parasitology Drugs and Drug Resistance · doi:10.1016/j.ijpddr.2011.10.004 · Cited by 56 · see citing works
UNC-108/Rab2 Regulates Postendocytic Trafficking in<i>Caenorhabditis elegans</i>
Chun, D. K., McEwen, J. M., Burbea, M., & Kaplan, J. M. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-11-1120 · Cited by 56 · see citing works
Fenk, L. A., & de Bono, M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1423808112 · Cited by 55 · see citing works
The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles
Topalidou, I., Cattin‐Ortolá, J., Pappas, A. L., Cooper, K., Merrihew, G. E., MacCoss, M. J., & Ailion, M. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006074 · Cited by 53 · see citing works
Self-citationMinnerly, J., Zhang, J., Parker, T., Kaul, T. K., & Jia, K. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006764 · Cited by 55 · see citing works
Concerted pulsatile and graded neural dynamics enables efficient chemotaxis in C. elegans
Itskovits, E., Ruach, R., Kazakov, A., & Zaslaver, A. (2018) · Nature Communications · doi:10.1038/s41467-018-05151-2 · Cited by 55 · see citing works
Zhang, B., Jun, H., Wu, J., Liu, J., & Xu, X. Z. S. (2021) · Nature Aging · doi:10.1038/s43587-021-00039-1 · Cited by 57 · see citing works
Uno, M., Tani, Y., Nono, M., Okabe, E., Kishimoto, S., Takahashi, C., Abe, R., Kurihara, T., & Nishida, E. (2021) · iScience · doi:10.1016/j.isci.2021.102706 · Cited by 54 · see citing works
Investigating the molecular mechanisms of learning and memory using Caenorhabditis elegans
Rahmani, A., & Chew, Y. L. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15510 · Cited by 52 · see citing works
Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis
Man, K. N. M., Imig, C., Walter, A. M., Pinheiro, P. S., Stevens, D. R., Rettig, J., Sørensen, J. B., Cooper, B. H., Brose, N., & Wojcik, S. M. (2015) · eLife · doi:10.7554/elife.10635 · Cited by 63 · see citing works
Leinwand, S. G., Yang, C. J., Bazopoulou, D., Chronis, N., Srinivasan, J., & Chalasani, S. H. (2015) · eLife · doi:10.7554/elife.10181 · Cited by 52 · see citing works
Neuropeptidergic Signaling and Active Feeding State Inhibit Nociception inCaenorhabditis elegans
Ezcurra, M., Walker, D. S., Beets, I., Swoboda, P., & Schafer, W. R. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1128-15.2016 · Cited by 52 · see citing works
Sugita, S. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01803.x · Cited by 52 · see citing works
Watteyne, J., Peymen, K., der Auwera, P. V., Borghgraef, C., Vandewyer, E., Damme, S. V., Rutten, I., Lammertyn, J., Jelier, R., Schoofs, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15964-9 · Cited by 52 · see citing works
Molecular biology of thermosensory transduction in C. elegans
Aoki, I., & Mori, I. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2015.03.011 · Cited by 49 · see citing works
Hapiak, V., Summers, P., Ortega, A., Law, W. J., Stein, A., & Komuniecki, R. W. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1324-13.2013 · Cited by 49 · see citing works
Role of Phosphoinositides at the Neuronal Synapse
Frère, S. G. A., Chang-Ileto, B., & Paolo, G. D. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-3015-1_5 · Cited by 48 · see citing works
Khodthong, C., Kabachinski, G., James, D. J., & Martin, T. F. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.07.002 · Cited by 48 · see citing works
Self-citationTolstenkov, O. O., der Auwera, P. V., Liewald, J. F., Costa, W. S., Bazhanova, O., Gemeinhard, T., Bergs, A. C. F., & GOTTSCHALK, A. R. (2018) · eLife · doi:10.7554/elife.34997 · Cited by 48 · see citing works
Decoding the intensity of sensory input by two glutamate receptors in one C. elegans interneuron
Zou, W., Fu, J., Zhang, H., Du, K., Huang, W., Yu, J., Li, S., Fan, Y., Baylis, H. A., Gao, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06819-5 · Cited by 47 · see citing works
Volovik, Y., Moll, L., Marques, F. C., Maman, M., Bejerano‐Sagie, M., & Cohen, E. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.11.028 · Cited by 45 · see citing works
UNC-31/CAPS docks and primes dense core vesicles in C. elegans neurons
Lin, X., Ming, M., Chen, M., Niu, W., Zhang, Y., Liu, B., Jiu, Y., Yu, J.-W., Xu, T., & Wu, Z. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.05.148 · Cited by 44 · see citing works
Endocrine aspects of organelle stress — cell non-autonomous signaling of mitochondria and the ER
Schinzel, R. T., & Dillin, A. G. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2015.01.006 · Cited by 42 · see citing works
Resident CAPS on dense-core vesicles docks and primes vesicles for fusion
Kabachinski, G., Kielar-Grevstad, D. M., Zhang, X., James, D. J., & Martin, T. F. J. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-07-0509 · Cited by 42 · see citing works
Self-citationThe nematode C. elegans senses airborne sound
Iliff, A. J., Wang, C., Ronan, E. A., Hake, A. E., Guo, Y., Li, X., Zhang, X., Zheng, M., Liu, J., Grosh, K., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.08.035 · Cited by 41 · see citing works
Neural-Immune Communication in Caenorhabditis elegans
Zhang, X., & Zhang, Y. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.05.003 · Cited by 40 · see citing works
Sato, H., Kunitomo, H., Fei, X., Hashimoto, K., & Iino, Y. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109177 · Cited by 39 · see citing works
Genetic dissection of neuropeptide cell biology at high and low activity in a defined sensory neuron
Laurent, P., Ch'ng, Q.-L., Jospin, M., Chen, C., Lorenzo, R., & de Bono, M. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1714610115 · Cited by 39 · see citing works
Gruner, M., Nelson, D., Winbush, A., Hintz, R., Ryu, L., Chung, S., Kim, K., Gabel, C. V., & van der Linden, A. M. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004707 · Cited by 38 · see citing works
Sowa, J. N., Mutlu, A. S., Xia, F., & Wang, M. C. (2015) · Current Biology · doi:10.1016/j.cub.2015.07.023 · Cited by 35 · see citing works
C. elegans neurons have functional dendritic spines
Cuentas-Condori, A., Mulcahy, B., He, S., Palumbos, S. D., Zhen, M., & Miller, D. M. (2019) · eLife · doi:10.7554/elife.47918 · Cited by 36 · see citing works
Presynaptic Inhibition Selectively Weakens Peptidergic Cotransmission in a Small Motor System
DeLong, N. D., Beenhakker, M. P., & Nusbaum, M. P. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00833.2009 · Cited by 36 · see citing works
Dallière, N., Bhatla, N., Luedtke, Z., Dengke, K., Woolman, J., Walker, R. J., Holden-Dye, L. M., & O'Connor, V. M. (2015) · The FASEB Journal · doi:10.1096/fj.15-279257 · Cited by 34 · see citing works
Hoover, C., Edwards, S. L., Yu, S.-C., Kittelmann, M., Richmond, J. E., Eimer, S., Yorks, R. M., & Miller, K. G. (2014) · Genetics · doi:10.1534/genetics.113.158568 · Cited by 32 · see citing works
- Authors
- Speese, S., Petrie, M., Schuske, K., Ailion, M., Ann, K., Iwasaki, K., Jorgensen, E. M., & Martin, T. F. J.
- Affiliations
- University of Utah (US)
- University of Wisconsin–Madison (US)
- Northwestern University (US)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-06-06
- Volume
- 27
- Issue
- 23
- Pages
- 6150-6162
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6672138
- OpenAlex
- W2025681452
- Cited by
- 333
- References
- 74
- Citations by year
- 2026: 18 · 2025: 26 · 2024: 35 · 2023: 19 · 2022: 22 · 2021: 24 · 2020: 15 · 2019: 10 · 2018: 17 · 2017: 13 · 2016: 12 · 2015: 16 · 2014: 18 · 2013: 14 · 2012: 11
- FWCI
- 6.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- U.S. Department of Agriculture
- McKnight Foundation
- National Institutes of Health
- Cooperative State Research, Education, and Extension Service
- National Institute of Mental Health (MH60997, R01MH060997)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 40428, R01DK040428)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- unc-31, CAPS, synaptic vesicle recycling, UNC-13, peptide secretion, atrial natriuretic peptide, Caenorhabditis elegans neurons, calcium-dependent exocytosis, neuroendocrine cells
- MeSH terms
- Amino Acid Sequence, Animals, Calcium-Binding Proteins, Carrier Proteins, Exocytosis, Molecular Sequence Data, Synaptic Vesicles, Caenorhabditis elegans, Secretory Vesicles, Caenorhabditis elegans Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review