The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Exacerbation of Facial Motoneuron Loss after Facial Nerve Transection in Severe Combined Immunodeficient (scid) Mice
Open accessAbstract
The immune system functions to protect an organism against microbial infections and may be involved in the reparative response to nerve injury. The goal of this study was to determine whether the immune system plays a role in regulating motoneuron survival after a peripheral nerve injury. After a right facial nerve axotomy, facial motoneuron (FMN) survival in C.B-17 (+/+) wild-type mice was found to be 87 +/- 3.0% of the unaxotomized left side control. In contrast, facial nerve axotomy in C.B-17 (-/-) severe combined immunodeficient (scid) mice, lacking functional T and B lymphocytes, resulted in an average FMN survival of 55 +/- 3.5% relative to the unaxotomized left side control. This represented an approximately 40% decrease in FMN survival compared with wild-type controls. The reconstitution of scid mice with wild-type splenocytes containing T and B lymphocytes restored FMN survival in these mice to the level of the wild-type controls. These results suggest that immune cells associated with acquired immunity play a role in regulating motoneuron survival after a peripheral nerve injury.
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Citations
Cites
Immune-neuro-endocrine interactions: facts and hypotheses.
BESEDOVSKY, H. O., & REY, A. D. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-1-64 · Cited by 1,564
Cited by
Brochard, V., Combadière, B., Prigent, A., Laouar, Y., Perrin, A., Beray-Berthat, V., Bonduelle, O., Alvarez-Fischer, D., Callebert, J., Launay, J.-M., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36470 · Cited by 1,172
Donnelly, D. J., & Popovich, P. G. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2007.06.009 · Cited by 995
The AP-1 Transcription Factor c-Jun Is Required for Efficient Axonal Regeneration
Raivich, G., Bohatschek, M., Da Costa, C., Iwata, O., Galiano, M., Hristova, M., Nateri, A. S., Makwana, M., Riera-Sans, L., Wolfer, D. P., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.005 · Cited by 489
Chemokine Expression by Glial Cells Directs Leukocytes to Sites of Axonal Injury in the CNS
Babcock, A. A., Kuziel, W. A., Rivest, S., & Owens, T. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-21-07922.2003 · Cited by 472
Stadelmann, C., Kerschensteiner, M., Misgeld, T., Brück, W., Hohlfeld, R., & Lassmann, H. (2002) · Brain · doi:10.1093/brain/awf015 · Cited by 425
Metadata
- Authors
- Serpe, C. J., Kohm, A. P., Huppenbauer, C. B., Sanders, V. M., & Jones, K. J.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1999-06-01
- Volume
- 19
- Issue
- 11
- Pages
- RC7-RC7
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1494722082
- Cited by
- 160
- References
- 1
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Exacerbation of Facial Motoneuron Loss after Facial Nerve Transection in Severe Combined Immunodeficient (scid) Mice. https://app.cochat.ai/papers/10.1523/jneurosci.19-11-j0004.1999
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- Serpe, C. J., Kohm, A. P., Huppenbauer, C. B., Sanders, V. M., & Jones, K. J. (1999). Exacerbation of Facial Motoneuron Loss after Facial Nerve Transection in Severe Combined Immunodeficient (scid) Mice. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.19-11-j0004.1999
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