The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Isolectin B4-Positive and -Negative Nociceptors Are Functionally Distinct
Open accessAbstract
Small-diameter sensory neurons that are primarily nociceptors can be divided neurochemically into two populations: isolectin B 4(IB 4)-positive nonpeptidergic neurons, and IB 4-negative peptidergic neurons. It has been shown that IB 4-positive neurons depend on glial-derived neurotrophic factor (GDNF), whereas IB 4-negative neurons depend on NGF for survival during postnatal development (Molliver et al., 1997). Furthermore, these two populations of nociceptors terminate in distinct regions of the superficial spinal cord. To date, however, no evidence exists that indicates whether these two groups of nociceptors have distinct functional roles in the process of nociception (Snider and McMahon, 1998). To search for functional differences, we performed whole-cell voltage and current-clamp recordings on acutely isolated adult mouse dorsal root ganglion neurons that were labeled with fluorescent IB 4. We found that IB 4-positive neurons have longer-duration action potentials, higher densities of TTX-resistant sodium currents, and smaller noxious heat-activated currents than IB 4-negative neurons. Furthermore, we show that NGF, but not GDNF, directly increases the number of neurons that respond to noxious heat. The different electrophysiological properties expressed by IB 4-positive and -negative small neurons, including their different heat sensitivities, indicates that they may relay distinct aspects of noxious stimuli both acutely and after injury in vivo.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The capsaicin receptor: a heat-activated ion channel in the pain pathway
Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. (1997) · Nature · doi:10.1038/39807 · Cited by 9,107
The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli
Tominaga, M., Caterina, M. J., Malmberg, A. B., Rosen, T. A., Gilbert, H., Skinner, K., Raumann, B. E., Basbaum, A. I., & Julius, D. (1998) · Neuron · doi:10.1016/s0896-6273(00)80564-4 · Cited by 3,081
A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons
Akopian, A. N., Sivilotti, L., & Wood, J. N. (1996) · Nature · doi:10.1038/379257a0 · Cited by 1,103
Tackling Pain at the Source: New Ideas about Nociceptors
Snider, W. D., & McMahon, S. B. (1998) · Neuron · doi:10.1016/s0896-6273(00)81003-x · Cited by 853
IB4-Binding DRG Neurons Switch from NGF to GDNF Dependence in Early Postnatal Life
Molliver, D. C., Wright, D. E., Leitner, M. L., Parsadanian, A. S., Doster, K., Wen, D., Yan, Q., & Snider, W. D. (1997) · Neuron · doi:10.1016/s0896-6273(00)80966-6 · Cited by 735
Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity
Woolf, C. J., Safieh-Garabedian, B., Ma, Q.-P., Crilly, P., & Winter, J. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90366-2 · Cited by 694
Preserved Acute Pain and Reduced Neuropathic Pain in Mice Lacking PKCγ
Malmberg, A. B., Chen, C., Tonegawa, S., & Basbaum, A. I. (1997) · Science · doi:10.1126/science.278.5336.279 · Cited by 690
Lindsay, R. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02394.1988 · Cited by 662
Mantyh, P. W., Rogers, S. D., Honore, P., Allen, B. J., Ghilardi, J. R., Li, J., Daughters, R. S., Lappi, D. A., Wiley, R. G., & Simone, D. A. (1997) · Science · doi:10.1126/science.278.5336.275 · Cited by 634
Averill, S., McMahon, S. B., Clary, D. O., Reichardt, L. F., & Priestley, J. V. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb01143.x · Cited by 629
Cited by
Neurotrophins: Roles in Neuronal Development and Function
Huang, E. J., & Reichardt, L. F. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.677 · Cited by 4,394
Intervertebral disc, sensory nerves and neurotrophins: who is who in discogenic pain?
García‐Cosamalón, J., Del Valle, M. E., Calavia, M. G., García‐Suárez, O., López‐Muñiz, A., Otero, J., & Vega, J. A. (2010) · Journal of Anatomy · doi:10.1111/j.1469-7580.2010.01227.x · Cited by 278
Development, plasticity and modulation of visceral afferents
Christianson, J. A., Bielefeldt, K., Altier, C., Cenac, N., Davis, B. M., Gebhart, G. F., High, K. W., Kollarik, M., Randich, A., Undem, B., et al. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.12.004 · Cited by 80
Huang, H., Xu, Y., & van den Pol, A. N. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00740.2010 · Cited by 70
Metadata
- Authors
- Stucky, C. L., & Lewin, G. R.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1999-08-01
- Volume
- 19
- Issue
- 15
- Pages
- 6497-6505
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1831892029
- Cited by
- 465
- References
- 42
- FWCI
- 9.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Isolectin B4-Positive and -Negative Nociceptors Are Functionally Distinct. https://app.cochat.ai/papers/10.1523/jneurosci.19-15-06497.1999
- The paper
- Stucky, C. L., & Lewin, G. R. (1999). Isolectin B4-Positive and -Negative Nociceptors Are Functionally Distinct. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.19-15-06497.1999
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
