Preserved Acute Pain and Reduced Neuropathic Pain in Mice Lacking PKCγ
Abstract
In normal animals, peripheral nerve injury produces a persistent, neuropathic pain state in which pain is exaggerated and can be produced by nonpainful stimuli. Here, mice that lack protein kinase C gamma (PKCγ) displayed normal responses to acute pain stimuli, but they almost completely failed to develop a neuropathic pain syndrome after partial sciatic nerve section, and the neurochemical changes that occurred in the spinal cord after nerve injury were blunted. Also, PKCγ was shown to be restricted to a small subset of dorsal horn neurons, thus identifying a potential biochemical target for the prevention and therapy of persistent pain.
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The Prkcg dorsal excitatory family comprised Excit-3 and Excit-4 and likely corresponded to neurons involved in light static touch and allodynic pain in pathological situations.
“The Prkcg dorsal, excitatory family was comprised of Excit-3 and Excit-4 and likely corresponded to neurons involved in light static touch and allodynic pain in pathological situations46,48–56.”
From A harmonized atlas of mouse spinal cord cell types and their spatial organization (2021) · cites this paper as [55]
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- Authors
- Malmberg, A. B., Chen, C., Tonegawa, S., & Basbaum, A. I.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Malmberg, Annika B.
- Venue
- Science
- Published
- 1997-10-10
- Volume
- 278
- Issue
- 5336
- Pages
- 279-283
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2031811175
- Cited by
- 690
- References
- 33
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 12 · 2023: 11 · 2022: 16 · 2021: 11 · 2020: 15 · 2019: 10 · 2018: 18 · 2017: 11 · 2016: 29 · 2015: 25 · 2014: 20 · 2013: 35 · 2012: 21
- FWCI
- 17.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2r01da008377-06)
- National Institute on Drug Abuse (DA 08377)
- National Institute of Neurological Disorders and Stroke (NS21445, NS 14627)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- protein kinase C gamma, neuropathic pain, acute pain, peripheral nerve injury, sciatic nerve section, dorsal horn neurons, chronic pain, pain sensitization
- MeSH terms
- Animals, Ganglia, Spinal, Hyperalgesia, Inflammation, Interneurons, Isoenzymes, Ligation, Neuropeptide Y, Pain, Protein Kinase C, Sciatic Nerve, Spinal Cord, Substance P, Signal Transduction, Pain Threshold, Gene Deletion, Receptors, Neurokinin-1, Mice, Knockout, Mice, Pain Management
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